Explanipedia

Molecular insights into ligand recognition and receptor activation of GPR15 Open

Shutian Chen, Xu Han, Yiming Zhang, Limin Ma, Cuiying Yi , et al. · 2025

Structural basis of allosteric and bitopic ligands binding in sphingosine-1-phosphate receptors 2 and 3 Open

Yanhong Wu, Qiuru Chen, Hongyu Wang, K. Liu, Jiaxin Wei , et al. · 2025

Structural insights into the distinct ligand recognition and signaling of the chemerin receptors CMKLR1 and GPR1 Open

Xiaowen Lin, Liguo Zhao, Heng Cai, Xuhua Chang, Yuxuan Tang , et al. · 2024

Structural insights into endogenous ligand selectivity and activation mechanisms of FFAR1 and FFAR2 Open

Yao‐Jin Ke, Yin Huang, Cuiying Yi, Limin Ma, Xiaojing Chu , et al. · 2024

Free fatty acid receptors (FFARs) play critical roles in metabolic regulation and are potential therapeutic targets for metabolic and inflammatory diseases. A comprehensive understanding of the activation mechanisms and endogenous ligand s…

Tail engagement of arrestin at the glucagon receptor Open

Kun Chen, Chenhui Zhang, Shuling Lin, Xinyu Yan, Heng Cai , et al. · 2023

Ligand recognition and activation of neuromedin U receptor 2 Open

Wenli Zhao, Wenru Zhang, Mu Wang, Minmin Lu, Shutian Chen , et al. · 2022

Activation of the human chemokine receptor CX3CR1 regulated by cholesterol Open

Minmin Lu, Wenli Zhao, Shuo Han, Xiaowen Lin, Tingyu Xu , et al. · 2022

As the only member of the CX3C chemokine receptor subfamily, CX3CR1 binds to its sole endogenous ligand CX3CL1, which shows notable potential as a therapeutic target in atherosclerosis, cancer, and neuropathy. However, the drug development…

Structural insights into ligand recognition and selectivity of somatostatin receptors Open

Wenli Zhao, Shuo Han, Na Qiu, Wenbo Feng, Mengjie Lu , et al. · 2022

Receptor-specific recognition of NPY peptides revealed by structures of NPY receptors Open

Tingting Tang, Qiuxiang Tan, Shuo Han, Anne Diemar, Kristin Löbner , et al. · 2022

In response to three highly conserved neuropeptides, neuropeptide Y (NPY), peptide YY, and pancreatic polypeptide (PP), four G protein–coupled receptors mediate multiple essential physiological processes, such as food intake, vasoconstrict…

Structural basis of tethered agonism of the adhesion GPCRs ADGRD1 and ADGRF1 Open

Xiangli Qu, Na Qiu, Mu Wang, Bingjie Zhang, Juan Du , et al. · 2022

Adhesion G protein-coupled receptors (aGPCRs) are essential for a variety of physiological processes such as immune responses, organ development, cellular communication, proliferation and homeostasis 1–7 . An intrinsic manner of activation…

Structural basis of FPR2 in recognition of Aβ42 and neuroprotection by humanin Open

Ya Zhu, Xiaowen Lin, Xin Zong, Shuo Han, Mu Wang , et al. · 2022

Formyl peptide receptor 2 (FPR2) has been shown to mediate the cytotoxic effects of the β amyloid peptide Aβ 42 and serves as a receptor for humanin, a peptide that protects neuronal cells from damage by Aβ 42 , implying its involvement in…

Structural basis for chemokine recognition and receptor activation of chemokine receptor CCR5 Open

Hui Zhang, Kun Chen, Qiuxiang Tan, Qiang Shao, Shuo Han , et al. · 2021

Structures of human mGlu2 and mGlu7 homo- and heterodimers Open

Juan Du, Dejian Wang, Hongcheng Fan, Chanjuan Xu, Linhua Tai , et al. · 2021

Structural basis for ligand recognition of the neuropeptide Y Y2 receptor Open

Tingting Tang, Christin Hartig, Qiuru Chen, Wenli Zhao, Anette Kaiser , et al. · 2021

Structural basis of ligand binding modes at the human formyl peptide receptor 2 Open

Tong Chen, Muya Xiong, Xin Zong, Yunjun Ge, Hui Zhang , et al. · 2020

The human formyl peptide receptor 2 (FPR2) plays a crucial role in host defense and inflammation, and has been considered as a drug target for chronic inflammatory diseases. A variety of peptides with different structures and origins have …

Human substance P receptor binding mode of the antagonist drug aprepitant by NMR and crystallography Open

Shuanghong Chen, Mengjie Lu, Dongsheng Liu, Lingyun Yang, Cuiying Yi , et al. · 2019

Neurokinin 1 receptor (NK1R) has key regulating functions in the central and peripheral nervous systems, and NK1R antagonists such as aprepitant have been approved for treating chemotherapy-induced nausea and vomiting. However, the lack of…

Structural basis of ligand binding modes at the neuropeptide Y Y1 receptor Open

Zhenlin Yang, Shuo Han, Max Keller, Anette Kaiser, Brian J. Bender , et al. · 2018

Two disparate ligand-binding sites in the human P2Y1 receptor Open

Dandan Zhang, Zhan‐Guo Gao, Kaihua Zhang, Evgeny Kiselev, Steven Crane , et al. · 2015

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