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View article: Cellular and Molecular Mechanisms of Oxidative DNA Damage and Repair
Cellular and Molecular Mechanisms of Oxidative DNA Damage and Repair Open
DNA is continuously exposed to endogenous and exogenous factors that induce oxidative modifications leading to mutations and genomic instability. Oxidative DNA damage plays a dual role, contributing to physiological signaling at low levels…
View article: Protective Effects of Chrysin Against Diclofenac‐Induced Nephrotoxicity in Rats via Attenuation of Oxidative Stress, Apoptosis and Endoplasmic Reticulum Stress
Protective Effects of Chrysin Against Diclofenac‐Induced Nephrotoxicity in Rats via Attenuation of Oxidative Stress, Apoptosis and Endoplasmic Reticulum Stress Open
Diclofenac (DCL) is a broadly prescribed non‐steroidal anti‐inflammatory drug (NSAID) for pain management and has been linked to nephrotoxicity despite its therapeutic benefits. This study provides new insights into the palliative impacts …
View article: Assessment of lipocalin-1, resistin, cathepsin-D, neurokinin A, agmatine, NGF, and BDNF serum levels in children with Autism Spectrum Disorder
Assessment of lipocalin-1, resistin, cathepsin-D, neurokinin A, agmatine, NGF, and BDNF serum levels in children with Autism Spectrum Disorder Open
Objectives Autism Spectrum Disorder (ASD) is a neurological and developmental disorder that affects all aspects of social communication, with stereotypical and limited interest and atypical responses to sensory stimuli. There isn’t a relia…
View article: Hepatoprotective Effects of Royal Jelly Against Vincristine-Induced Hepatotoxicity in Rats: A Biochemical and Molecular Study
Hepatoprotective Effects of Royal Jelly Against Vincristine-Induced Hepatotoxicity in Rats: A Biochemical and Molecular Study Open
Vincristine (VCR) is a chemotherapeutic agent classified as a vinca alkaloid. Royal jelly (RJ) is a significant bee product produced by worker bees, characterized by its high protein content. This study aims to investigate the protective e…
View article: Determination of Antioxidant, Antidiabetic, Anticholinergic, Antiglaucoma Properties and Comprehensive Phytochemical Content by <scp>LC</scp>‐<scp>MS</scp>/<scp>MS</scp> of Bingöl Honeybee Pollen
Determination of Antioxidant, Antidiabetic, Anticholinergic, Antiglaucoma Properties and Comprehensive Phytochemical Content by <span>LC</span>‐<span>MS</span>/<span>MS</span> of Bingöl Honeybee Pollen Open
Honeybee pollen is the most important food and protein source for bees. It is a highly nutritious natural product for humans due to its content. Pollen shows different phytochemical content and variable biological activity according to dif…
View article: Could the Systemic Inflammatory Response Index be a Marker for the Non-Dipper Pattern in Newly Diagnosed Hypertensive Patients?
Could the Systemic Inflammatory Response Index be a Marker for the Non-Dipper Pattern in Newly Diagnosed Hypertensive Patients? Open
Systemic inflammatory response index (SIRI), is associated with prognosis in coronary artery disease (CAD), heart failure (HF), and acute myocardial infarction. This study investigated the relationship between SIRI and non-dipper hypertens…
View article: 18β-glycyrrhetinic acid Mitigates bisphenol A-induced liver and renal damage: Inhibition of TNF-α/NF-κB/p38-MAPK, JAK1/STAT1 pathways, oxidative stress and apoptosis
18β-glycyrrhetinic acid Mitigates bisphenol A-induced liver and renal damage: Inhibition of TNF-α/NF-κB/p38-MAPK, JAK1/STAT1 pathways, oxidative stress and apoptosis Open
Bisphenol A (BPA) has been commonly used in various consumer products, including water bottles, food containers, and canned food linings. However, there are concerns about its potential toxicity to human health, particularly its impact on …
View article: Investigation of the effects of apilarnil and imatinib use on liver and kidney tissues in rats via PI3K/AKT/mTOR and JAK2/STAT3 pathways
Investigation of the effects of apilarnil and imatinib use on liver and kidney tissues in rats via PI3K/AKT/mTOR and JAK2/STAT3 pathways Open
Imatinib, used in the field of molecular targeted therapy, has been reported to cause serious side effects, including liver and kidney failure. However, the mechanism of imatinib-induced liver and kidney toxicity remains unclear due to lim…
View article: Determination of in vitro Antioxidant, Anticholinergic, and Antiepileptic Activities of some Medicinal and Aromatic Plant Extracts
Determination of in vitro Antioxidant, Anticholinergic, and Antiepileptic Activities of some Medicinal and Aromatic Plant Extracts Open
Medicinal and aromatic plants such as Crocus cancellatus, Scilla Siberica subsp. armena, Juniperus oxycedrus subsp. oxycedrus and Anthriscus nemorosa have many different biological activities. While antioxidants are significant in preventi…
View article: Protective Effects of Carvacrol on Mercuric Chloride‐Induced Lung Toxicity Through Modulating Oxidative Stress, Apoptosis, Inflammation, and Autophagy
Protective Effects of Carvacrol on Mercuric Chloride‐Induced Lung Toxicity Through Modulating Oxidative Stress, Apoptosis, Inflammation, and Autophagy Open
Mercuric chloride (HgCl 2 ) is extremely toxic to both humans and animals. It could be absorbed via ingestion, inhalation, and skin contact. Exposure to HgCl 2 can cause severe health effects, including damages to the gastrointestinal, res…
View article: Therapeutic Potential of Silymarin in Mitigating Paclitaxel-Induced Hepatotoxicity and Nephrotoxicity: Insights into Oxidative Stress, Inflammation, and Apoptosis in Rats
Therapeutic Potential of Silymarin in Mitigating Paclitaxel-Induced Hepatotoxicity and Nephrotoxicity: Insights into Oxidative Stress, Inflammation, and Apoptosis in Rats Open
Our findings indicate the potential of SIL to alleviate PAX-induced liver and kidney damage in rats by reducing oxidative stress, inflammation, and apoptotic processes.
View article: Could the systemic inflammatory response index be a marker for the non- dipper pattern in newly diagnosed hypertensive patients?
Could the systemic inflammatory response index be a marker for the non- dipper pattern in newly diagnosed hypertensive patients? Open
Background The Systemic Inflammatory Response Index (SIRI),has been shown to be associated with prognosis in coronary artery disease (CAD), heart failure (HF), and acute myocardial infarction.This study investigated the relationship betwee…
View article: Evaluation of various blood biomarkers associated with the outcomes of patients with COVID‑19 treated in intensive care units
Evaluation of various blood biomarkers associated with the outcomes of patients with COVID‑19 treated in intensive care units Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and the resulting coronavirus disease 2019 (COVID-19) represented a global public health crisis and the most significant pandemic in modern times. Transmission characte…
View article: Protective effects of naringin against oxaliplatin-induced testicular damage in rats: Involvement of oxidative stress, inflammation, endoplasmic reticulum stress, apoptosis, and histopathology.
Protective effects of naringin against oxaliplatin-induced testicular damage in rats: Involvement of oxidative stress, inflammation, endoplasmic reticulum stress, apoptosis, and histopathology. Open
Our results demonstrated that NRG can protect against OXL-induced testicular toxicity by enhancing the anti-oxidant defense system and suppressing apoptosis, inflammation, and endoplasmic reticulum stress.
View article: The effects of morin and methotrexate on pentose phosphate pathway enzymes and GR/GST/TrxR enzyme activities: An in vivo and in silico study
The effects of morin and methotrexate on pentose phosphate pathway enzymes and GR/GST/TrxR enzyme activities: An in vivo and in silico study Open
In this study, the mechanisms by which the enzymes glucose‐6‐phosphate dehydrogenase (G6PD), 6‐phosphogluconate dehydrogenase (6PGD), glutathione reductase (GR), glutathione‐S‐transferase (GST), and thioredoxin reductase (TrxR) are inhibit…
View article: Does Decreased Vitamin D Level Trigger Bipolar Manic Attacks?
Does Decreased Vitamin D Level Trigger Bipolar Manic Attacks? Open
Background: Bipolar disorder is a chronic psychiatric disorder with depression and manic episodes. It is one of the leading causes of disease-related disability worldwide. Despite the presence of various alternative drug options for bipola…
View article: The Relationship of Cognitive Dysfunction with Inflammatory Markers and Carotid Intima Media Thickness in Schizophrenia
The Relationship of Cognitive Dysfunction with Inflammatory Markers and Carotid Intima Media Thickness in Schizophrenia Open
Objectives: Schizophrenia is a devastating and chronic mental disorder that affects 1% of the population worldwide. It is also associated with cognitive dysfunction and cardiovascular risk factors. The aim of this study is to investigate t…
View article: Caffeic acid phenethyl ester: A review on its pharmacological importance, and its association with free radicals, <scp>COVID</scp>‐19, and radiotherapy
Caffeic acid phenethyl ester: A review on its pharmacological importance, and its association with free radicals, <span>COVID</span>‐19, and radiotherapy Open
Caffeic acid phenethyl ester (CAPE), a main active component of propolis and a flavonoid, is one of the natural products that has attracted attention in recent years. CAPE, which has many properties such as anti‐cancer, anti‐inflammatory, …
View article: Hepatoprotective effect of morin against methotrexate-induced hepatotoxicity via targeting Nrf2/HO-1 and Bax/Bcl2/Caspase-3 signaling pathways
Hepatoprotective effect of morin against methotrexate-induced hepatotoxicity via targeting Nrf2/HO-1 and Bax/Bcl2/Caspase-3 signaling pathways Open
Background Organ toxicity limits the therapeutic efficacy of methotrexate (MTX), an anti-metabolite therapeutic that is frequently used as an anti-cancer and immunosuppressive medicine. Hepatocellular toxicity is among the most severe side…
View article: Effects of favipiravir on hematologic parameters and bone marrow in the rats
Effects of favipiravir on hematologic parameters and bone marrow in the rats Open
Favipiravir, a selective RNA polymerase inhibitor agent, is an antiviral drug currently used effectively in treating pandemic diseases such as Covid-19. The present study aims to determine the effects of favipiravir use on bone marrow and …
View article: Neuroprotective Properties of Carvacrol Against Cadmium-induced Neurotoxicity in Male Rats
Neuroprotective Properties of Carvacrol Against Cadmium-induced Neurotoxicity in Male Rats Open
Cadmium (Cd), is a heavy metal reported to be associated with oxidative stress and inflammation. In this paper, we investigated the possible protective effects of carvacrol (CRV) against Cd-induced neurotoxicity in rats. Adult male Sprague…
View article: Protective Effects of Rutin Against Deltamethrin-Induced Hepatotoxicity and Nephrotoxicity in Rats via Regulation of Oxidative Stress, Inflammation and Apoptosis
Protective Effects of Rutin Against Deltamethrin-Induced Hepatotoxicity and Nephrotoxicity in Rats via Regulation of Oxidative Stress, Inflammation and Apoptosis Open
Deltamethrin (DLM) is a type-II pyrethroid synthetic insecticide that is extensively used for controlling mosquitoes, flies, pests, insects worldwide. Oxidative stress is one of the DLM toxicity mechanisms. This study was carried out to ev…
View article: Alterations in Enzyme Activity of Carbonic Anhydrase, 6-phosphogluconate Dehydrogenase and Thioredoxin Reductase in Rats Exposed to Doxorubicin and Morin
Alterations in Enzyme Activity of Carbonic Anhydrase, 6-phosphogluconate Dehydrogenase and Thioredoxin Reductase in Rats Exposed to Doxorubicin and Morin Open
Objective:Carbonic anhydrase (CA), 6-phosphogluconate dehydrogenase (6PGD) andthioredoxin reductase (TrxR) enzymes are the essential biological molecules needed for metabolic processes in all livingcells. This study was designed to investi…
View article: Chrysin Protects Rat Kidney from Paracetamol-Induced Oxidative Stress, Inflammation, Apoptosis, and Autophagy: A Multi-Biomarker Approach
Chrysin Protects Rat Kidney from Paracetamol-Induced Oxidative Stress, Inflammation, Apoptosis, and Autophagy: A Multi-Biomarker Approach Open
Paracetamol (PC) is a safe analgesic and antipyretic drug at therapeutic doses, and it is widely used in clinics. However, at high doses, it can induce hepatotoxicity and nephrotoxicity. Chrysin (CR) is a natural flavonoid that has biologi…