Cunrong Chen
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View article: Association between enoxaparin administration and ICU 28-day mortality in sepsis patients: A comparative study
Association between enoxaparin administration and ICU 28-day mortality in sepsis patients: A comparative study Open
Enoxaparin administration was associated with a lower risk of ICU 28-day mortality among sepsis patients requiring MV with platelet counts ≥150 × 109/L. Given the observational nature of the study, further research is needed to confirm the…
View article: Nationwide expert survey on transfusion and coagulation management strategies for bleeding critically ill patients in China
Nationwide expert survey on transfusion and coagulation management strategies for bleeding critically ill patients in China Open
This study aimed to investigate coagulation management strategies by experienced critical care physicians across China. The questionnaire was independently designed referencing current guidelines and literature, and refined through five ro…
View article: The association between Albumin-Corrected Anion Gap (ACAG) and the risk of acute kidney injury in patients with acute pancreatitis: A retrospective analysis based on the MIMIC-IV database
The association between Albumin-Corrected Anion Gap (ACAG) and the risk of acute kidney injury in patients with acute pancreatitis: A retrospective analysis based on the MIMIC-IV database Open
Purpose Acute kidney injury (AKI), a common and severe complication of acute pancreatitis (AP), is significantly linked to patient prognosis. Albumin-corrected anion gap (ACAG) is a modified acid-base balance assessment metric with potenti…
View article: The gut-lung axis in critical illness: microbiome composition as a predictor of mortality at day 28 in mechanically ventilated patients
The gut-lung axis in critical illness: microbiome composition as a predictor of mortality at day 28 in mechanically ventilated patients Open
Background Microbial communities are of critical importance in the human host. The lung and gut microbial communities represent the most essential microbiota within the human body, collectively referred to as the gut-lung axis. However, th…
View article: The Gut-Lung Axis in Critical Illness: Microbiome Composition as a Pr edictor of Mortality at Day 28 in Mechanically Ventilated Patients
The Gut-Lung Axis in Critical Illness: Microbiome Composition as a Pr edictor of Mortality at Day 28 in Mechanically Ventilated Patients Open
Background The gut-lung axis is a crucial interface in the complex interplay between microbial communities and their human hosts. Despite being two of the most important microbial populations in the human body, there is still a significant…
View article: Decoding the biological properties and transcriptomic landscapes of human natural killer cells derived from bone marrow and umbilical cord blood.
Decoding the biological properties and transcriptomic landscapes of human natural killer cells derived from bone marrow and umbilical cord blood. Open
Longitudinal studies have highlighted allogeneic natural killer (NK) cell-based cytotherapy for cancer immunosurveillance and immunotherapy, yet the deficiency of systematic and detailed comparison of NK cells from candidate sources includ…
View article: Nanomaterials as Novel Biomarkers for Cancer Nanotheranostics: State of the Art
Nanomaterials as Novel Biomarkers for Cancer Nanotheranostics: State of the Art Open
Cancers including hematological malignancies and metastatic solid tumors are one of the life-threatening diseases to the general population, which have become a heavy burden for patients and their caregivers physically and mentally. Despit…
View article: Statistical Analysis and Machine Learning Prediction of Disease Outcomes for COVID-19 and Pneumonia Patients
Statistical Analysis and Machine Learning Prediction of Disease Outcomes for COVID-19 and Pneumonia Patients Open
The Coronavirus Disease 2019 (COVID-19) has spread all over the world and impacted many people’s lives. The characteristics of COVID-19 and other types of pneumonia have both similarities and differences, which confused doctors initially t…
View article: Exosomes from human induced pluripotent stem cells derived mesenchymal stem cells improved myocardial injury caused by severe acute pancreatitis through activating Akt/Nrf2/HO-1 axis
Exosomes from human induced pluripotent stem cells derived mesenchymal stem cells improved myocardial injury caused by severe acute pancreatitis through activating Akt/Nrf2/HO-1 axis Open
Human induced pluripotent stem cell-derived mesenchymal stem cells (iMSCs) have been believed to be a promising alternative for the stem cell transplantation therapy. The exosomes (Exo) from iMSCs play an important role in several kinds of…
View article: Association Among the Gut Microbiome, the Serum Metabolomic Profile and RNA m6A Methylation in Sepsis-Associated Encephalopathy
Association Among the Gut Microbiome, the Serum Metabolomic Profile and RNA m6A Methylation in Sepsis-Associated Encephalopathy Open
Objective: To investigate the relationship among the gut microbiome, serum metabolomic profile and RNA m6A methylation in patients with sepsis-associated encephalopathy (SAE), 16S rDNA technology, metabolomics and gene expression validatio…
View article: Improvement of cardiac function by mesenchymal stem cells derived extracellular vesicles through targeting miR-497/Smad7 axis
Improvement of cardiac function by mesenchymal stem cells derived extracellular vesicles through targeting miR-497/Smad7 axis Open
We found that EVs isolated from MSCs might improve the cardiac injury caused by MI through targeting miR497/Smad7. This study provides novel potential therapeutic thought for the prevention and treatment of MI through targeting miR-497/Sma…
View article: Performance of CURB-65, PSI, and APACHE-II for predicting COVID-19 pneumonia severity and mortality
Performance of CURB-65, PSI, and APACHE-II for predicting COVID-19 pneumonia severity and mortality Open
No prognostic tools for the prediction of COVID-19 pneumonia severity and mortality are available. We explored whether CURB-65, PSI, and APACHE-II could predict COVID-19 pneumonia severity and mortality. We included 167 patients with confi…
View article: Transcriptomic study of lipopolysaccharide‑induced sepsis damage in a mouse heart model
Transcriptomic study of lipopolysaccharide‑induced sepsis damage in a mouse heart model Open
Sepsis is an emergency systemic illness caused by pathogen infection and the combined result of the underactivity and overactivity of a patient's own immune system. However, the molecular mechanism of this illness remains largely unknown. …
View article: SARS-CoV-2 infection induces sustained humoral immune responses in convalescent patients following symptomatic COVID-19
SARS-CoV-2 infection induces sustained humoral immune responses in convalescent patients following symptomatic COVID-19 Open
Long-term antibody responses and neutralizing activities following SARS-CoV-2 infections have not yet been elucidated. We quantified immunoglobulin M (IgM) and G (IgG) antibodies recognizing the SARS-CoV-2 receptor-binding domain (RBD) of …
View article: MicroRNA‑127‑5p attenuates severe pneumonia via tumor necrosis factor receptor‑associated factor 1
MicroRNA‑127‑5p attenuates severe pneumonia via tumor necrosis factor receptor‑associated factor 1 Open
Pneumonia is a persistent and pervasive disease, the effects of which can be severe. MicroRNA (miR)-127-5p has been utilized as a novel biomarker for the diagnosis of severe pneumonia. The present study aimed to investigate the function of…
View article: High positive end expiratory pressure levels affect hemodynamics in elderly patients with hypertension admitted to the intensive care unit: a prospective cohort study
High positive end expiratory pressure levels affect hemodynamics in elderly patients with hypertension admitted to the intensive care unit: a prospective cohort study Open
Background To study the effects of different positive end expiratory pressure (PEEP) on blood pressure and heart function in elderly patients with hypertension. Methods Forty elderly patients above 65 years of age treated with mechanical v…
View article: Morusin alleviates mycoplasma pneumonia via the inhibition of Wnt/β-catenin and NF-κB signaling
Morusin alleviates mycoplasma pneumonia via the inhibition of Wnt/β-catenin and NF-κB signaling Open
Morusin has been traditionally used for the treatment of Mycoplasma pneumoniae pneumonia (MPP), but the underlying mechanism remains elusive. The present study aimed to explore the mechanism by which morusin achieves efficacy on mycoplasma…
View article: Long noncoding RNA CNALPTC1 promotes cell proliferation and migration of papillary thyroid cancer via sponging miR-30 family.
Long noncoding RNA CNALPTC1 promotes cell proliferation and migration of papillary thyroid cancer via sponging miR-30 family. Open
Several somatic copy number variations (CNVs) have been identified in papillary thyroid cancer (PTC). However, the functional roles of CNVs and the genes responsible for the roles of CNVs are largely unknown. In this study, we identified a…