Cun‐Yu Wang
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View article: Multivalent interactions of Septin 6 promote the establishment of epithelial cell polarity
Multivalent interactions of Septin 6 promote the establishment of epithelial cell polarity Open
Septins, components of the fourth cytoskeleton, play an indispensable role in establishing and maintaining epithelial cell polarity. However, the molecular mechanisms underlying the dynamic assembly of higher-order septin structures and th…
View article: Biological biomarkers of oral cancer
Biological biomarkers of oral cancer Open
The oral squamous cell carcinoma (OSCC) 5 year survival rate of 41% has marginally improved in the last few years, with less than a 1% improvement per year from 2005 to 2017, with higher survival rates when detected at early stages. Based …
View article: Data from ERG Is a Critical Regulator of Wnt/LEF1 Signaling in Prostate Cancer
Data from ERG Is a Critical Regulator of Wnt/LEF1 Signaling in Prostate Cancer Open
Chromosomal translocations juxtaposing the androgen-responsive TMPRSS2 promoter with the ETS-family transcription factor ERG result in aberrant ERG upregulation in approximately 50% of prostate cancers. Studies to date have shown important…
View article: Supplementary Figures and Tables from ERG Is a Critical Regulator of Wnt/LEF1 Signaling in Prostate Cancer
Supplementary Figures and Tables from ERG Is a Critical Regulator of Wnt/LEF1 Signaling in Prostate Cancer Open
PDF file, 272K, Figure S1. ERG induces Wnt signaling in prostate cells, which is mediated by LEF1. Figure S2. ERG and beta-catenin synergistically induce Wnt signaling. Figure S3. LEF1 is a critical mediator in ERG-induced Wnt signaling. T…
View article: Supplementary Figures and Tables from ERG Is a Critical Regulator of Wnt/LEF1 Signaling in Prostate Cancer
Supplementary Figures and Tables from ERG Is a Critical Regulator of Wnt/LEF1 Signaling in Prostate Cancer Open
PDF file, 272K, Figure S1. ERG induces Wnt signaling in prostate cells, which is mediated by LEF1. Figure S2. ERG and beta-catenin synergistically induce Wnt signaling. Figure S3. LEF1 is a critical mediator in ERG-induced Wnt signaling. T…
View article: Supplementary Figure 1 from A Glycolytic Mechanism Regulating an Angiogenic Switch in Prostate Cancer
Supplementary Figure 1 from A Glycolytic Mechanism Regulating an Angiogenic Switch in Prostate Cancer Open
Supplementary Figure 1 from A Glycolytic Mechanism Regulating an Angiogenic Switch in Prostate Cancer
View article: Data from A Glycolytic Mechanism Regulating an Angiogenic Switch in Prostate Cancer
Data from A Glycolytic Mechanism Regulating an Angiogenic Switch in Prostate Cancer Open
The generation of an ‘angiogenic switch’ is essential for tumor growth, yet its regulation is poorly understood. In this investigation, we explored the linkage between metastasis and angiogenesis through CXCL12/CXCR4 signaling. We found th…
View article: Supplementary Figure 1 from A Glycolytic Mechanism Regulating an Angiogenic Switch in Prostate Cancer
Supplementary Figure 1 from A Glycolytic Mechanism Regulating an Angiogenic Switch in Prostate Cancer Open
Supplementary Figure 1 from A Glycolytic Mechanism Regulating an Angiogenic Switch in Prostate Cancer
View article: Data from A Glycolytic Mechanism Regulating an Angiogenic Switch in Prostate Cancer
Data from A Glycolytic Mechanism Regulating an Angiogenic Switch in Prostate Cancer Open
The generation of an ‘angiogenic switch’ is essential for tumor growth, yet its regulation is poorly understood. In this investigation, we explored the linkage between metastasis and angiogenesis through CXCL12/CXCR4 signaling. We found th…
View article: Data from ERG Is a Critical Regulator of Wnt/LEF1 Signaling in Prostate Cancer
Data from ERG Is a Critical Regulator of Wnt/LEF1 Signaling in Prostate Cancer Open
Chromosomal translocations juxtaposing the androgen-responsive TMPRSS2 promoter with the ETS-family transcription factor ERG result in aberrant ERG upregulation in approximately 50% of prostate cancers. Studies to date have shown important…
View article: Research highlights in cancer immunotherapy from basic discovery to clinical trial
Research highlights in cancer immunotherapy from basic discovery to clinical trial Open
Cancer research is one of the most active areas in the biomedical sciences. Recently, the tumor immune environment, crosstalk between tumor cells and immune cells, and immunotherapy remain the “hot” topic in the field of cancer research. T…
View article: Correction for Puckett et al., “Integration of Apoptosis Signal-Regulating Kinase 1-Mediated Stress Signaling with the Akt/Protein Kinase B-I<i>k</i> B Kinase Cascade”
Correction for Puckett et al., “Integration of Apoptosis Signal-Regulating Kinase 1-Mediated Stress Signaling with the Akt/Protein Kinase B-I<i>k</i> B Kinase Cascade” Open
This article refers to:Integration of Apoptosis Signal-Regulating Kinase 1-Mediated Stress Signaling with the Akt/Protein Kinase B-IκB Kinase Cascade
View article: Epigenetic Regulation of NGF-Mediated Osteogenic Differentiation in Human Dental Mesenchymal Stem Cells
Epigenetic Regulation of NGF-Mediated Osteogenic Differentiation in Human Dental Mesenchymal Stem Cells Open
Nerve growth factor (NGF) is the best-characterized neurotrophin and is primarily recognized for its key role in the embryonic development of the nervous system and neuronal cell survival/differentiation. Recently, unexpected actions of NG…
View article: Osteoporosis and periodontal diseases – An update on their association and mechanistic links
Osteoporosis and periodontal diseases – An update on their association and mechanistic links Open
Periodontitis and osteoporosis are prevalent inflammation‐associated skeletal disorders that pose significant public health challenges to our aging population. Both periodontitis and osteoporosis are bone disorders closely associated with …
View article: WNT-1 Signaling Inhibits Apoptosis by Activating β-Catenin/T Cell Factor–Mediated Transcription
WNT-1 Signaling Inhibits Apoptosis by Activating β-Catenin/T Cell Factor–Mediated Transcription Open
Wnt signaling plays a critical role in development and oncogenesis. Although significant progress has been made in understanding the downstream signaling cascade of Wnt signaling, little is known regarding Wnt signaling modification of the…
View article: circFAT1 Promotes Cancer Stemness and Immune Evasion by Promoting STAT3 Activation
circFAT1 Promotes Cancer Stemness and Immune Evasion by Promoting STAT3 Activation Open
Cancer stemness and immune evasion are closely associated, and play critical roles in tumor development and resistance to immunotherapy. However, little is known about the underlying molecular mechanisms that coordinate this association. H…