Quynh‐Nhu Nguyen
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View article: Evaluation of organ-specific relative biological effectiveness of proton therapy using radiation-induced pneumonitis as an endpoint
Evaluation of organ-specific relative biological effectiveness of proton therapy using radiation-induced pneumonitis as an endpoint Open
View article: P-401 Predicting fertility in young boys after gonadotoxic treatments: recovery of spermatogenesis
P-401 Predicting fertility in young boys after gonadotoxic treatments: recovery of spermatogenesis Open
Study question Can the cyclophosphamide equivalent dose (CED) given to young boys be used to predict future infertility? Summary answer Our data suggests that CED alone is not a good predictor of subsequent infertility. What is known alrea…
View article: Survival outcomes of pulmonary metastasis‐directed local therapy in adenoid cystic carcinoma
Survival outcomes of pulmonary metastasis‐directed local therapy in adenoid cystic carcinoma Open
Background Adenoid cystic carcinoma (ACC) frequently has pulmonary metastasis (PM). Given limited systemic therapy options, these metastases are often treated with pulmonary metastasis–directed local therapy (PM‐LT), although with unknown …
View article: Impact of recent clinical trials on meta-analysis of stereotactic body radiation therapy for spine metastases and urgent call for consistent study endpoints
Impact of recent clinical trials on meta-analysis of stereotactic body radiation therapy for spine metastases and urgent call for consistent study endpoints Open
Pain from spinal metastases can result in significant impact to patients' quality of life. Conventional external beam radiation therapy (cEBRT) has long been shown to be effective in the pain control of patients with spinal metastases. Wit…
View article: Evaluation of Organ-Specific Relative Biological Effectiveness of Proton Therapy Using Radiation-Induced Pneumonitis as an Endpoint
Evaluation of Organ-Specific Relative Biological Effectiveness of Proton Therapy Using Radiation-Induced Pneumonitis as an Endpoint Open
View article: Evaluation of Organ-Specific Relative Biological Effectiveness of Proton Therapy Using Radiation-Induced Pneumonitis as an Endpoint
Evaluation of Organ-Specific Relative Biological Effectiveness of Proton Therapy Using Radiation-Induced Pneumonitis as an Endpoint Open
View article: Heterogeneity of study endpoints in stereotactic body radiation therapy studies for bone metastases: A systematic review.
Heterogeneity of study endpoints in stereotactic body radiation therapy studies for bone metastases: A systematic review. Open
Considerable heterogeneity in endpoint selection, definitions, and measurement tools across SBRT reflects diverse clinical objectives. Consensus-driven standardisation of endpoints, response criteria, and follow-up schedules is essential t…
View article: Salvage Reirradiation with Proton Beam Therapy for Locoregionally Recurrent Non-Small Cell Lung Cancer
Salvage Reirradiation with Proton Beam Therapy for Locoregionally Recurrent Non-Small Cell Lung Cancer Open
Background/Objectives: This retrospective study evaluates outcomes of 66 patients who underwent reirradiation (re-RT) with proton beam therapy (PBT) for recurrent non-small cell lung cancer. Methods: Toxicity was scored via the CTCAE v5.0,…
View article: Superior antitumor immune response achieved with proton over photon immunoradiotherapy is amplified by the nanoradioenhancer NBTXR3
Superior antitumor immune response achieved with proton over photon immunoradiotherapy is amplified by the nanoradioenhancer NBTXR3 Open
View article: Proton therapy toxicity outcomes for localized prostate cancer: Long-term results at a comprehensive cancer center
Proton therapy toxicity outcomes for localized prostate cancer: Long-term results at a comprehensive cancer center Open
View article: E-026 Does size really matter? Comparing PVA particle size in MMA embolization
E-026 Does size really matter? Comparing PVA particle size in MMA embolization Open
View article: Optimizing Outpatient Radiation Oncology Consult Workflow by Using Time-Driven Activity-Based Costing: Efficiency and Financial Impacts
Optimizing Outpatient Radiation Oncology Consult Workflow by Using Time-Driven Activity-Based Costing: Efficiency and Financial Impacts Open
PURPOSE Clinical efficiency is a key component of value-based health care. Our objective here was to identify workflow inefficiencies by using time-driven activity-based costing (TDABC) and evaluate the implementation of a new clinical wor…
View article: Survival outcomes and toxicity of adjuvant immunotherapy after definitive concurrent chemotherapy with proton beam radiation therapy for patients with inoperable locally advanced non-small cell lung carcinoma
Survival outcomes and toxicity of adjuvant immunotherapy after definitive concurrent chemotherapy with proton beam radiation therapy for patients with inoperable locally advanced non-small cell lung carcinoma Open
View article: A Novel Polymer-Encapsulated Multi-Imaging Modality Fiducial Marker with Positive Signal Contrast for Image-Guided Radiation Therapy
A Novel Polymer-Encapsulated Multi-Imaging Modality Fiducial Marker with Positive Signal Contrast for Image-Guided Radiation Therapy Open
Background: Current fiducial markers (FMs) in external-beam radiotherapy (EBRT) for prostate cancer (PCa) cannot be positively visualized on magnetic resonance imaging (MRI) and create dose perturbation and significant imaging artifacts on…
View article: Impact of an enteral nutrition protocol in critically ill patients with burn injuries
Impact of an enteral nutrition protocol in critically ill patients with burn injuries Open
The institutions protocol achieved high protein administration while still being consistent with recommendations from the American Society of Enteral and Parenteral Nutrition (ASPEN).
View article: Practice and principles of stereotactic body radiation therapy for spine and non-spine bone metastases
Practice and principles of stereotactic body radiation therapy for spine and non-spine bone metastases Open
View article: Addressing concerns and uncertainties surrounding the application of palliative radiotherapy in cases with a 30-day expected mortality
Addressing concerns and uncertainties surrounding the application of palliative radiotherapy in cases with a 30-day expected mortality Open
Inmaculada Navarro-Domenech, Tara Behroozian, Peter Hoskin, Candice Johnstone, Abram Recht, Johan Menten, Eva Oldenburger, Yvette M. van der Linden, Joanne M. van der Velden, Quynh-Nhu Nguyen, Charles B. Simone II, Peter Johnstone, Stephen…
View article: SABR for Sarcoma Lung Metastases: Indications for Treatment and Guidance for Patient Selection
SABR for Sarcoma Lung Metastases: Indications for Treatment and Guidance for Patient Selection Open
View article: Nanoparticle-enhanced proton beam immunoradiotherapy drives immune activation and durable tumor rejection
Nanoparticle-enhanced proton beam immunoradiotherapy drives immune activation and durable tumor rejection Open
The combination of radiation therapy (RT) and immunotherapy has emerged as a promising treatment option in oncology. Historically, x-ray radiation (XRT) has been the most commonly used form of RT. However, proton beam therapy (PBT) is gain…
View article: A critical appraisal of the four systematic reviews and meta-analysis on stereotactic body radiation therapy versus external beam radiotherapy for painful bone metastases and where we go from here
A critical appraisal of the four systematic reviews and meta-analysis on stereotactic body radiation therapy versus external beam radiotherapy for painful bone metastases and where we go from here Open
Radiotherapy is an important treatment modality for pain control in patients with bone metastases. Stereotactic body radiation therapy (SBRT), which allows delivering a much higher dose per fraction while sparing critical structures compar…
View article: Appropriateness of the 30-day expected mortality metric in palliative radiation treatment: a narrative review
Appropriateness of the 30-day expected mortality metric in palliative radiation treatment: a narrative review Open
Single-fraction palliative RT should be offered to eligible patients if they are able to attend treatment and could potentially benefit from symptom palliation, irrespective of predicted life expectancy. We discourage the routine use of th…
View article: The future of fertility preservation for women treated with chemotherapy
The future of fertility preservation for women treated with chemotherapy Open
Cytotoxic chemotherapies have been a mainstay of cancer treatment but are associated with numerous systemic adverse effects, including impacts on fertility and endocrine health. Irreversible ovarian damage and follicle depletion are the si…
View article: Figure S1 from Triple Therapy with MerTK and PD1 Inhibition Plus Radiotherapy Promotes Abscopal Antitumor Immune Responses
Figure S1 from Triple Therapy with MerTK and PD1 Inhibition Plus Radiotherapy Promotes Abscopal Antitumor Immune Responses Open
High dose RT induced higher apoptosis. Mice were inoculated in the right leg with 344SQ for establishment of primary tumor. Tumors were treated locally by intermediate dose RT (15 Gy in three 5-Gy fractions) or High dose RT (36 Gy in three…
View article: Figure S1 from Triple Therapy with MerTK and PD1 Inhibition Plus Radiotherapy Promotes Abscopal Antitumor Immune Responses
Figure S1 from Triple Therapy with MerTK and PD1 Inhibition Plus Radiotherapy Promotes Abscopal Antitumor Immune Responses Open
High dose RT induced higher apoptosis. Mice were inoculated in the right leg with 344SQ for establishment of primary tumor. Tumors were treated locally by intermediate dose RT (15 Gy in three 5-Gy fractions) or High dose RT (36 Gy in three…
View article: Figure S2 from Triple Therapy with MerTK and PD1 Inhibition Plus Radiotherapy Promotes Abscopal Antitumor Immune Responses
Figure S2 from Triple Therapy with MerTK and PD1 Inhibition Plus Radiotherapy Promotes Abscopal Antitumor Immune Responses Open
The triple therapy expresses high levels of TNF-α and IL-12 β cytokines. The NanoString results showed significant increase in IL-12 and TNF-α with the triple therapy group compared to no treatment. On the other hand, IL-6 was not signific…
View article: Figure S3 from Triple Therapy with MerTK and PD1 Inhibition Plus Radiotherapy Promotes Abscopal Antitumor Immune Responses
Figure S3 from Triple Therapy with MerTK and PD1 Inhibition Plus Radiotherapy Promotes Abscopal Antitumor Immune Responses Open
CD8+ CD103+ TRM cells express high levels of PD1. Flow cytometric analysis for TILs on day 29 from the triple therapy group (RT + α-PD1 + α-MerTK). Cells were gated on CD45 population then on CD4 and CD8, followed by CD8 and CD103 to check…
View article: Data from Triple Therapy with MerTK and PD1 Inhibition Plus Radiotherapy Promotes Abscopal Antitumor Immune Responses
Data from Triple Therapy with MerTK and PD1 Inhibition Plus Radiotherapy Promotes Abscopal Antitumor Immune Responses Open
Purpose:Radiotherapy (RT) traditionally has been used for local tumor control in the treatment of cancer. The recent discovery that radiotherapy can have anticancer effects on the immune system has led to recognition of its ability to sens…
View article: Data from Triple Therapy with MerTK and PD1 Inhibition Plus Radiotherapy Promotes Abscopal Antitumor Immune Responses
Data from Triple Therapy with MerTK and PD1 Inhibition Plus Radiotherapy Promotes Abscopal Antitumor Immune Responses Open
Purpose:Radiotherapy (RT) traditionally has been used for local tumor control in the treatment of cancer. The recent discovery that radiotherapy can have anticancer effects on the immune system has led to recognition of its ability to sens…
View article: Figure S3 from Triple Therapy with MerTK and PD1 Inhibition Plus Radiotherapy Promotes Abscopal Antitumor Immune Responses
Figure S3 from Triple Therapy with MerTK and PD1 Inhibition Plus Radiotherapy Promotes Abscopal Antitumor Immune Responses Open
CD8+ CD103+ TRM cells express high levels of PD1. Flow cytometric analysis for TILs on day 29 from the triple therapy group (RT + α-PD1 + α-MerTK). Cells were gated on CD45 population then on CD4 and CD8, followed by CD8 and CD103 to check…
View article: Figure S2 from Triple Therapy with MerTK and PD1 Inhibition Plus Radiotherapy Promotes Abscopal Antitumor Immune Responses
Figure S2 from Triple Therapy with MerTK and PD1 Inhibition Plus Radiotherapy Promotes Abscopal Antitumor Immune Responses Open
The triple therapy expresses high levels of TNF-α and IL-12 β cytokines. The NanoString results showed significant increase in IL-12 and TNF-α with the triple therapy group compared to no treatment. On the other hand, IL-6 was not signific…