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431. USING THE LIVE RAT STRESS PARADIGM TO INVESTIGATE APPROACH-AVOIDANCE BEHAVIOUR RELEVANT TO PSYCHIATRIC DISORDERS Open
Background Chronic stress is a well-known antecedent to the development of mental health disorders, such as depression. Corticotrophin releasing hormone (CRH) neurons in the paraventricular nucleus of the hypothalamus (PVNCRH) are known to…
Three neurotransmitters regulate diverse inhibitory and excitatory Parvalbumin interneuron circuits in the dorsal horn Open
Parvalbumin-expressing interneurons (PVINs) in the spinal dorsal horn are found primarily in laminae II inner and III. Inhibitory PVINs (iPVINs) play an important in segregating innocuous tactile input from pain-processing circuits, achiev…
Calretinin positive neurons form an excitatory amplifier network in the spinal cord dorsal horn Open
The passage of nociceptive information is relayed through the spinal cord dorsal horn, a critical area in sensory processing. The neuronal circuits in this region that underpin sensory perception must be clarified to better understand how …