Chen‐Yang Shen
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View article: Follicular helper T cells (Tfh): heterogeneity in spatial distribution and phenotypic characteristics
Follicular helper T cells (Tfh): heterogeneity in spatial distribution and phenotypic characteristics Open
Follicular helper T cells (Tfh) are a Th cell subset that directly assists B cells in functioning, and their development is regulated by various factors. Among them, the initial regulation leads to phenotypic heterogeneity, while the regul…
View article: LdIL-2 treatment in ASD: a novel immunotherapeutic approach targeting Th/Treg dysfunction and neuroinflammation
LdIL-2 treatment in ASD: a novel immunotherapeutic approach targeting Th/Treg dysfunction and neuroinflammation Open
A significant proportion of children with Autism Spectrum Disorder (ASD) present with immune imbalances. In this study, we sought to alleviate the core symptoms of autism by addressing immune dysregulation, especially T-cell subpopulation …
View article: An extraction-free and one-pot two-temperature CRISPR/Cas12b system for visual detection of Group B <i>Streptococcus</i> by integrating with RPA
An extraction-free and one-pot two-temperature CRISPR/Cas12b system for visual detection of Group B <i>Streptococcus</i> by integrating with RPA Open
Group B Streptococcus (GBS) is a major cause of neonatal infections, and rapid detection is essential for timely clinical intervention. In this study, we developed an extraction-free, one-pot CRISPR/Cas12b assay for visual detection of GBS…
View article: Post-COVID-19 disruption of the respiratory microbiome modulates <i>Mycoplasma pneumoniae</i> : a multi-center retrospective investigation study
Post-COVID-19 disruption of the respiratory microbiome modulates <i>Mycoplasma pneumoniae</i> : a multi-center retrospective investigation study Open
Since the COVID-19 pandemic, there has been a notable resurgence of Mycoplasma pneumoniae pneumonia (MPP) in children, with a concerning rise in the severity of cases. Although changes in post-pandemic respiratory infection patterns have b…
View article: Integrating clinical trial landscapes and bibliometric analysis: unveiling the impact of PD-1/PD-L1 inhibitors on renal cell carcinoma research and therapeutic trajectories summary
Integrating clinical trial landscapes and bibliometric analysis: unveiling the impact of PD-1/PD-L1 inhibitors on renal cell carcinoma research and therapeutic trajectories summary Open
Background Renal cell carcinoma (RCC) is a prevalent tumor of the urinary system. Beyond surgical treatment, targeted therapies and immunotherapies are the primary therapeutic options for RCC. Although immunotherapy has been extensively st…
View article: Dynamic changes of serum matrix metalloproteinases and tissue inhibitors in Kawasaki disease: implications for coronary artery lesions persistence
Dynamic changes of serum matrix metalloproteinases and tissue inhibitors in Kawasaki disease: implications for coronary artery lesions persistence Open
MMPs and TIMPs have dynamic changes in children with CALs caused by KD. A low level of TIMP-1 after treatment may be related to CALs persistence, offering novel insights into the underlying mechanism.
View article: AI-Assisted Decision-Making for Clinical Assessment of Auto-Segmented Contour Quality
AI-Assisted Decision-Making for Clinical Assessment of Auto-Segmented Contour Quality Open
Purpose: This study presents a Deep Learning (DL)-based quality assessment (QA) approach for evaluating auto-generated contours (auto-contours) in radiotherapy, with emphasis on Online Adaptive Radiotherapy (OART). Leveraging Bayesian Ordi…
View article: Integrative Analysis of DNA Methylation and microRNA Reveals GNPDA1 and SLC25A16 Related to Biopsychosocial Factors Among Taiwanese Women with a Family History of Breast Cancer
Integrative Analysis of DNA Methylation and microRNA Reveals GNPDA1 and SLC25A16 Related to Biopsychosocial Factors Among Taiwanese Women with a Family History of Breast Cancer Open
Biopsychosocial factors, including family history, influence the development of breast cancer. Malignancies in women with a family history of breast cancer may be detectable based on DNA methylation and microRNA. Objectives: The present st…
View article: Systematic review and meta-analysis: diagnostic accuracy of exosomes in pancreatic cancer
Systematic review and meta-analysis: diagnostic accuracy of exosomes in pancreatic cancer Open
Overall, exosomes are still valuable in the diagnosis of pancreatic cancer. In subgroup analyses, the proteoglycan found on exosomal cell surfaces is highly valuable for diagnosing pancreatic cancer. The more frequent separation method use…
View article: Analysis of gradual diameter thrombectomy stent <i>in vitro</i>
Analysis of gradual diameter thrombectomy stent <i>in vitro</i> Open
Objective To analyze the effect of gradient thrombectomy stent in vitro . Methods The cerebrovascular fluid circulation model was made and fixed on the test table. About 0.9% sodium chloride injection was injected to the vascular model thr…
View article: Characterizing ADRs of Enfortumab vedotin and Erdafitinib in bladder cancer treatment: a descriptive analysis from WHO-VigiAccess
Characterizing ADRs of Enfortumab vedotin and Erdafitinib in bladder cancer treatment: a descriptive analysis from WHO-VigiAccess Open
Introduction Enfortumab vedotin (EV) and Erdafitinib are effective therapeutic drugs for bladder cancer patients following post-chemotherapy and immunotherapy. This study assessed adverse drug reactions (ADRs) from both drugs, comparing th…
View article: Comparison of Demographic and Clinical Characteristics of Taiwan Biobank Participants With Nonparticipants
Comparison of Demographic and Clinical Characteristics of Taiwan Biobank Participants With Nonparticipants Open
The TWBB cohort exhibits disparities in sociodemographic and health-related attributes compared to the general population, comprising participants who were older, female, married, higher educated, higher income, and predominantly resided i…
View article: Instance-adaptive Zero-shot Chain-of-Thought Prompting
Instance-adaptive Zero-shot Chain-of-Thought Prompting Open
Zero-shot Chain-of-Thought (CoT) prompting emerges as a simple and effective strategy for enhancing the performance of large language models (LLMs) in real-world reasoning tasks. Nonetheless, the efficacy of a singular, task-level prompt u…
View article: Mitogenome-Based Phylogeny with Divergence Time Estimates Revealed the Presence of Cryptic Species within Heptageniidae (Insecta, Ephemeroptera)
Mitogenome-Based Phylogeny with Divergence Time Estimates Revealed the Presence of Cryptic Species within Heptageniidae (Insecta, Ephemeroptera) Open
Heptageniidae are known for their flat heads and bodies and are divided into three subfamilies. Despite the extensive diversity within this group and considerable efforts made to understand their evolutionary history, the internal classifi…
View article: Validation of Self-reported Medical Condition in the Taiwan Biobank
Validation of Self-reported Medical Condition in the Taiwan Biobank Open
The concordance between self-reports in the TWBB and NHI claims records varied across clinical diagnoses, showing inconsistencies depending on participant characteristics. These findings underscore the need for further investigation, espec…
View article: From Redundancy to Relevance: Information Flow in LVLMs Across Reasoning Tasks
From Redundancy to Relevance: Information Flow in LVLMs Across Reasoning Tasks Open
Large Vision Language Models (LVLMs) achieve great performance on visual-language reasoning tasks, however, the black-box nature of LVLMs hinders in-depth research on the reasoning mechanism. As all images need to be converted into image t…
View article: LdIL-2 Treatment in ASD: A Novel Immunotherapeutic Approach Targeting Th/Treg Dysfunction and Neuroinflammation
LdIL-2 Treatment in ASD: A Novel Immunotherapeutic Approach Targeting Th/Treg Dysfunction and Neuroinflammation Open
There was a large part of children with Autism Spectrum Disorder (ASD) were accompanied with immune imbalances. In this study, we attempted to ameliorate the core symptoms of autism by correcting the immune imbalance, especially the T-cell…
View article: Metabolic heterogeneity in clear cell renal cell carcinoma revealed by single-cell RNA sequencing and spatial transcriptomics
Metabolic heterogeneity in clear cell renal cell carcinoma revealed by single-cell RNA sequencing and spatial transcriptomics Open
Background Clear cell renal cell carcinoma is a prototypical tumor characterized by metabolic reprogramming, which extends beyond tumor cells to encompass diverse cell types within the tumor microenvironment. Nonetheless, current research …
View article: miR-622 Increases miR-30a Expression through Inhibition of Hypoxia-Inducible Factor 1α to Improve Metastasis and Chemoresistance in Human Invasive Breast Cancer Cells
miR-622 Increases miR-30a Expression through Inhibition of Hypoxia-Inducible Factor 1α to Improve Metastasis and Chemoresistance in Human Invasive Breast Cancer Cells Open
Hypoxia-inducible factor 1α (HIF-1α) plays a pivotal role in the survival, metastasis, and response to treatment of solid tumors. Autophagy serves as a mechanism for tumor cells to eliminate misfolded proteins and damaged organelles, thus …
View article: Genetic insights into carbohydrate sulfotransferase 8 and its impact on the immunotherapy efficacy of cancer
Genetic insights into carbohydrate sulfotransferase 8 and its impact on the immunotherapy efficacy of cancer Open
Immune checkpoint blockade (ICB) is a promising therapy for solid tumors, but its effectiveness depends on biomarkers that are not precise. Here, we utilized genome-wide association study to investigate the association between genetic vari…
View article: Identification of hub gene and lncRNA signature related to entotic cell death in cutaneous melanoma for prognostic and immune prediction
Identification of hub gene and lncRNA signature related to entotic cell death in cutaneous melanoma for prognostic and immune prediction Open
Entotic cell death (ECD), a cell death program observed in cancer cell competition, predominantly occurs in an autophagy protein-dependent, non-apoptotic manner. However, the relationship between cutaneous melanoma (CM) and ECD-associated …