Cynthia C. Nast
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View article: Membranoproliferative Glomerulonephritis Due to HACEK Endocarditis in a Patient with Cirrhosis: A Case Report
Membranoproliferative Glomerulonephritis Due to HACEK Endocarditis in a Patient with Cirrhosis: A Case Report Open
Introduction: Membranoproliferative glomerulonephritis (MPGN) is a rare pattern of glomerular injury that may be immune complex-mediated (ICM), most often secondary to infections, autoimmune disorders, or hematologic or less often solid tu…
View article: Calcific Changes in an End-Stage Kidney following Long-Term Dialysis, Tertiary Hyperparathyroidism, and Treatment for Complement-Mediated Thrombotic Microangiopathy: A Case Report.
Calcific Changes in an End-Stage Kidney following Long-Term Dialysis, Tertiary Hyperparathyroidism, and Treatment for Complement-Mediated Thrombotic Microangiopathy: A Case Report. Open
Glomerular calcification is rare, and it is unknown if this is related to the treated hyperparathyroidism or other pathogenetic mechanisms. The nephrectomy findings also suggest that patients with pathogenic mutations in CFI may benefit fr…
View article: Temporal and Demographic Trends in Biopsy-Proven Kidney Disease Diagnoses in the Southwestern United States, 1993-2022
Temporal and Demographic Trends in Biopsy-Proven Kidney Disease Diagnoses in the Southwestern United States, 1993-2022 Open
Rationale & Objective: Kidney biopsy is vital to diagnose and manage medical kidney diseases. However, not many large-scale studies for medical kidney disease have been reported worldwide. We describe 30-year temporal and demographic trend…
View article: Punctate Podocyte IgG Staining Does Not Differentiate Primary from Secondary Minimal Change Disease
Punctate Podocyte IgG Staining Does Not Differentiate Primary from Secondary Minimal Change Disease Open
Introduction: Punctate IgG staining of podocytes (“dusting”) identified by immunofluorescence recently has been described in a subset of minimal change disease (MCD), possibly correlating with anti-nephrin or other autoantibodies. Whether …
View article: Risk Factors for Disease Progression for Adults and Children With Membranous Nephropathy in the Cure Glomerulonephropathy Network (CureGN)
Risk Factors for Disease Progression for Adults and Children With Membranous Nephropathy in the Cure Glomerulonephropathy Network (CureGN) Open
This study unveils self-reported Black race, young age (aged < 18 years) and Latinx ethnicity as potential risk factors associated with worse kidney outcomes.
View article: A case of karyomegalic interstitial nephritis without FAN1 mutations in the setting of brentuximab, ifosfamide, and carboplatin exposure
A case of karyomegalic interstitial nephritis without FAN1 mutations in the setting of brentuximab, ifosfamide, and carboplatin exposure Open
This case presents a patient who developed KIN with a progressively rising serum creatinine after ifosfamide, carboplatin and brentuximab treatment. Although ifosfamide and carboplatin have known associations with the development of KIN, t…
View article: Fibrillary Glomerulonephritis Associated With Hashimoto’s Thyroiditis
Fibrillary Glomerulonephritis Associated With Hashimoto’s Thyroiditis Open
View article: Polyomavirus nephropathy: diagnosis, histologic features, and differentiation from acute rejection
Polyomavirus nephropathy: diagnosis, histologic features, and differentiation from acute rejection Open
Polyomaviruses, particularly BK virus, are ubiquitous latent infections that may reactivate with immunosuppression during kidney transplantation, resulting in polyomavirus nephropathy (PVN). The levels of viruria and viremia serve as tools…
View article: Kidney Histopathology of Patients with Hepatitis C Infection and Diabetes Mellitus Before and After Availability of Direct Acting Antiviral Therapy
Kidney Histopathology of Patients with Hepatitis C Infection and Diabetes Mellitus Before and After Availability of Direct Acting Antiviral Therapy Open
Introduction: Type 2 diabetes mellitus (DM) and diabetic kidney disease are increasing. Hepatitis C infection (HCV) occurs in 1% of the world population and can induce several kidney diseases. DM prevalence is increased in individuals with…
View article: Fibronectin glomerulopathy in a kidney allograft biopsy
Fibronectin glomerulopathy in a kidney allograft biopsy Open
View article: Cure Glomerulonephropathy Pathology Classification and Core Scoring Criteria, Reproducibility, and Clinicopathologic Correlations
Cure Glomerulonephropathy Pathology Classification and Core Scoring Criteria, Reproducibility, and Clinicopathologic Correlations Open
Introduction: Cure Glomerulonephropathy (CureGN) is an observational cohort study of patients with minimal change disease (MCD), focal segmental glomerulosclerosis (FSGS), membranous nephropathy (MN), or IgA nephropathy. We d…
View article: Chronic dehydration induces injury pathways in rats, but does not mimic histopathology of chronic interstitial nephritis in agricultural communities
Chronic dehydration induces injury pathways in rats, but does not mimic histopathology of chronic interstitial nephritis in agricultural communities Open
View article: Mayo Clinic consensus report on membranous nephropathy: proposal for a novel classification
Mayo Clinic consensus report on membranous nephropathy: proposal for a novel classification Open
View article: Mayo Clinic Consensus Report on Membranous Nephropathy: Proposal for a Novel Classification
Mayo Clinic Consensus Report on Membranous Nephropathy: Proposal for a Novel Classification Open
View article: Impact of Diabetic Lesions on Pathology, Treatment, and Outcomes of Glomerular Diseases
Impact of Diabetic Lesions on Pathology, Treatment, and Outcomes of Glomerular Diseases Open
Key Points People with glomerular disease (GD) and comorbid diabetes have similar baseline characteristics irrespective of superimposed diabetic lesions. Immunosuppression for GD with comorbid diabetes is the same regardless of superimpose…
View article: Implications of Incomplete Immunostaining in Membranous Lupus Nephritis
Implications of Incomplete Immunostaining in Membranous Lupus Nephritis Open
Membranous lupus nephritis (MLN), International Society of Nephrology/Renal Pathology Society lupus nephritis class V, accounts for 10%–20% of cases of lupus nephritis.1 Although current evidence suggests that pure MLN has a more favorable…
View article: CureGN-Diabetes Study: Rationale, Design, and Methods of a Prospective Observational Study of Glomerular Disease Patients with Diabetes
CureGN-Diabetes Study: Rationale, Design, and Methods of a Prospective Observational Study of Glomerular Disease Patients with Diabetes Open
Glomerular diseases (GDs) represent the third leading cause of end-stage kidney disease (ESKD) in the US Diabetes was excluded from the CureGN Study, an NIH/NIDDK-sponsored observational cohort study of four leading primary GDs: IgA nephro…
View article: Linear <scp>IgA</scp> bullous dermatosis and elevated bullous interleukin‐6 levels: Responsive to treatment with <scp>Anti‐IL</scp>‐6 receptor monoclonals
Linear <span>IgA</span> bullous dermatosis and elevated bullous interleukin‐6 levels: Responsive to treatment with <span>Anti‐IL</span>‐6 receptor monoclonals Open
Linear IgA bullous dermatosis (LABD) is a rare autoimmune/inflammatory skin condition. Here, we report on a patient who developed treatment resistant LABD. At diagnosis, elevations of IL‐6 and C‐reactive protein in the blood and extreme el…
View article: Chronic interstitial nephritis in agricultural communities and pre-eclampsia: Is there a link?
Chronic interstitial nephritis in agricultural communities and pre-eclampsia: Is there a link? Open
View article: Precision nephrology identified tumor necrosis factor activation variability in minimal change disease and focal segmental glomerulosclerosis
Precision nephrology identified tumor necrosis factor activation variability in minimal change disease and focal segmental glomerulosclerosis Open
View article: Influence of Sodium Bicarbonate on Wall Teichoic Acid Synthesis and β-Lactam Sensitization in NaHCO <sub>3</sub> -Responsive and Nonresponsive Methicillin-Resistant Staphylococcus aureus
Influence of Sodium Bicarbonate on Wall Teichoic Acid Synthesis and β-Lactam Sensitization in NaHCO <sub>3</sub> -Responsive and Nonresponsive Methicillin-Resistant Staphylococcus aureus Open
MRSA is generally viewed as resistant to standard β-lactam antibiotics. However, a NaHCO 3 -responsive phenotype is observed in a substantial proportion of clinical MRSA strains in vitro , i.e., isolates which demonstrate enhanced suscepti…
View article: Chronic interstitial nephritis in agricultural communities and pre-eclampsia: Is there a link?
Chronic interstitial nephritis in agricultural communities and pre-eclampsia: Is there a link? Open
View article: Clinicopathologic Significance of Predominant Lambda Light Chain Deposition in IgA Nephropathy
Clinicopathologic Significance of Predominant Lambda Light Chain Deposition in IgA Nephropathy Open
In IgAN, we found an association between lambda predominance and increased endocapillary hypercellularity, but no association with clinical outcomes.
View article: Association of Histologic Parameters with Outcome in C3 Glomerulopathy and Idiopathic Immunoglobulin-Associated Membranoproliferative Glomerulonephritis
Association of Histologic Parameters with Outcome in C3 Glomerulopathy and Idiopathic Immunoglobulin-Associated Membranoproliferative Glomerulonephritis Open
Background and objectives C3 glomerulopathy and idiopathic Ig-associated membranoproliferative GN are kidney diseases characterized by abnormal glomerular complement C3 deposition. These conditions are heterogeneous in outcome, but approxi…
View article: POS-045 Evaluating BCX9930, an Oral Factor D Inhibitor for Treatment of Complement-Mediated Kidney Disease: A Proof-of-Concept Study (RENEW)
POS-045 Evaluating BCX9930, an Oral Factor D Inhibitor for Treatment of Complement-Mediated Kidney Disease: A Proof-of-Concept Study (RENEW) Open
IntroductionBCX9930 is a potent, selective, orally administered, small-molecule inhibitor of complement Factor D being developed for the treatment of complement-mediated diseases. Factor D is the rate-limiting enzyme of the alternative pat…
View article: Chronic Interstitial Nephritis in Agricultural Communities: A Patient in Paraguay
Chronic Interstitial Nephritis in Agricultural Communities: A Patient in Paraguay Open
Chronic interstitial nephritis in agricultural communities (CINAC), also named chronic kidney disease (CKD) of unknown origin or Mesoamerican nephropathy, is defined as a form of CKD affecting young farmers (mainly men). CINAC is not direc…
View article: Quantification of Glomerular Structural Lesions: Associations With Clinical Outcomes and Transcriptomic Profiles in Nephrotic Syndrome
Quantification of Glomerular Structural Lesions: Associations With Clinical Outcomes and Transcriptomic Profiles in Nephrotic Syndrome Open
View article: Detailed Quantification of Glomerular Structural Lesions Associates with Clinical Outcomes and Transcriptomic Profiles in Nephrotic Syndrome
Detailed Quantification of Glomerular Structural Lesions Associates with Clinical Outcomes and Transcriptomic Profiles in Nephrotic Syndrome Open
The current classification system for focal segmental glomerulosclerosis (FSGS) and minimal change disease (MCD) does not fully capture the complex structural changes in kidney biopsies, nor the clinical and molecular heterogeneity of thes…
View article: Multidimensional Data Integration Identifies Tumor Necrosis Factor Activation in Nephrotic Syndrome: A Model for Precision Nephrology
Multidimensional Data Integration Identifies Tumor Necrosis Factor Activation in Nephrotic Syndrome: A Model for Precision Nephrology Open
Background Classification of nephrotic syndrome relies on clinical presentation and descriptive patterns of injury on kidney biopsies. This approach does not reflect underlying disease biology, limiting the ability to predict progression o…
View article: Bartonella-Associated Endocarditis with Severe Active Crescentic Glomerulonephritis and Acute Renal Failure
Bartonella-Associated Endocarditis with Severe Active Crescentic Glomerulonephritis and Acute Renal Failure Open
We report a case of severe acute kidney failure due to crescentic glomerulonephritis who presented initially with culture-negative endocarditis with vegetations on the aortic valve. Anti-nuclear and anti-phospholipid antibodies were positi…