Cyrielle Bouchez
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View article: The Warburg effect and mitochondrial oxidative phosphorylation: Friends or foes?
The Warburg effect and mitochondrial oxidative phosphorylation: Friends or foes? Open
View article: Lactate dehydrogenases promote glioblastoma growth and invasion via a metabolic symbiosis
Lactate dehydrogenases promote glioblastoma growth and invasion via a metabolic symbiosis Open
View article: Refining the Role of Pyruvate Dehydrogenase Kinases in Glioblastoma Development
Refining the Role of Pyruvate Dehydrogenase Kinases in Glioblastoma Development Open
Glioblastoma (GB) are the most frequent brain cancers. Aggressive growth and limited treatment options induce a median survival of 12–15 months. In addition to highly proliferative and invasive properties, GB cells show cancer-associated m…
View article: NADH-independent enzymatic assay to quantify extracellular and intracellular L-lactate levels
NADH-independent enzymatic assay to quantify extracellular and intracellular L-lactate levels Open
View article: Specific expression of lactate dehydrogenases in glioblastoma controls intercellular lactate transfer to promote tumor growth and invasion
Specific expression of lactate dehydrogenases in glioblastoma controls intercellular lactate transfer to promote tumor growth and invasion Open
Lactate is a central metabolite in brain physiology, involved in the astrocyte-neuron lactate shuttle, but also contributes to tumor development. Glioblastoma (GBM) is the most common and malignant primary brain tumor in adults, recognized…
View article: MOMC-2. Glioblastoma Metabolic Symbiosis: When Lactate Takes The Lead
MOMC-2. Glioblastoma Metabolic Symbiosis: When Lactate Takes The Lead Open
Glioblastoma (GBM) is a common and devastating brain tumor, associated with a low median survival, despite standard therapeutic management. Among its major features, GBMs are highly angiogenic and exhibit paradoxically an elevated glycolys…
View article: Étude de la régulation de la biogénèse mitochondriale chez la levure Saccharomyces cerevisiae
Étude de la régulation de la biogénèse mitochondriale chez la levure Saccharomyces cerevisiae Open
Dans la cellule, les fonctions cellulaires majeures, telles que la prolifération cellulaire, impliquent une consommation très importante d’énergie sous forme d’Adénosine Triphosphate (ATP). Pour répondre à l’augmentation de la demande éner…
View article: The Warburg Effect in Yeast: Repression of Mitochondrial Metabolism Is Not a Prerequisite to Promote Cell Proliferation
The Warburg Effect in Yeast: Repression of Mitochondrial Metabolism Is Not a Prerequisite to Promote Cell Proliferation Open
O. Warburg conducted one of the first studies on tumor energy metabolism. His early discoveries pointed out that cancer cells display a decreased respiration and an increased glycolysis proportional to the increase in their growth rate, su…
View article: Cell energy metabolism: An update
Cell energy metabolism: An update Open
View article: “Labile” heme critically regulates mitochondrial biogenesis through the transcriptional co-activator Hap4p in Saccharomyces cerevisiae
“Labile” heme critically regulates mitochondrial biogenesis through the transcriptional co-activator Hap4p in Saccharomyces cerevisiae Open
View article: Mitochondrial Biogenesis and Mitochondrial Reactive Oxygen Species (ROS): A Complex Relationship Regulated by the cAMP/PKA Signaling Pathway
Mitochondrial Biogenesis and Mitochondrial Reactive Oxygen Species (ROS): A Complex Relationship Regulated by the cAMP/PKA Signaling Pathway Open
Mitochondrial biogenesis is a complex process. It requires the contribution of both the nuclear and the mitochondrial genomes and therefore cross talk between the nucleus and mitochondria. Cellular energy demand can vary by great length an…