Cyril G. Gay
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View article: African swine fever vaccine ASFV-G-ΔI177L induces solid protection in four-week-old piglets
African swine fever vaccine ASFV-G-ΔI177L induces solid protection in four-week-old piglets Open
African swine fever (ASF) is an important disease of swine currently affecting pig production worldwide. Vietnam is, currently, the only country where commercial live attenuated vaccines are being freely used in the field. One of these vac…
View article: Recombinant Vaccine Strain ASFV-G-Δ9GL/ΔUK Produced in the IPKM Cell Line Is Genetically Stable and Efficacious in Inducing Protection in Pigs Challenged with the Virulent African Swine Fever Virus Field Isolate Georgia 2010
Recombinant Vaccine Strain ASFV-G-Δ9GL/ΔUK Produced in the IPKM Cell Line Is Genetically Stable and Efficacious in Inducing Protection in Pigs Challenged with the Virulent African Swine Fever Virus Field Isolate Georgia 2010 Open
We have previously reported that the recombinant African Swine Fever (ASF) vaccine candidate ASFV-G-Δ9GL/ΔUK efficiently induces protection in domestic pigs challenged with the virulent strain Georgia 2010 (ASFV-G). As reported, ASFV-G-Δ9G…
View article: Deletion of the EP402R Gene from the Genome of African Swine Fever Vaccine Strain ASFV-G-∆I177L Provides the Potential Capability of Differentiating between Infected and Vaccinated Animals
Deletion of the EP402R Gene from the Genome of African Swine Fever Vaccine Strain ASFV-G-∆I177L Provides the Potential Capability of Differentiating between Infected and Vaccinated Animals Open
The African swine fever virus (ASFV) mutant ASFV-G-∆I177L is a safe and efficacious vaccine which induces protection against the challenge of its parental virus, the Georgia 2010 isolate. Although a genetic DIVA (differentiation between in…
View article: African Swine Fever Vaccine Candidate ASFV-G-ΔI177L Produced in the Swine Macrophage-Derived Cell Line IPKM Remains Genetically Stable and Protective against Homologous Virulent Challenge
African Swine Fever Vaccine Candidate ASFV-G-ΔI177L Produced in the Swine Macrophage-Derived Cell Line IPKM Remains Genetically Stable and Protective against Homologous Virulent Challenge Open
ASFV vaccine candidate ASFV-G-ΔI177L has been shown to be highly efficacious in inducing protection against challenges with the parental virus, the Georgia 2010 isolate, as well as against field strains isolated from Vietnam. ASFV-G-ΔI177L…
View article: Hyperimmune egg yolk antibodies developed against Clostridium perfringens antigens protect against necrotic enteritis
Hyperimmune egg yolk antibodies developed against Clostridium perfringens antigens protect against necrotic enteritis Open
Necrotic enteritis (NE) is a widespread infectious disease caused by Clostridium perfringens that inflicts major economic losses on the global poultry industry. Due to regulations on antibiotic use in poultry production, there is an urgent…
View article: Orally delivered Bacillus subtilis expressing chicken NK-2 peptide stabilizes gut microbiota and enhances intestinal health and local immunity in coccidiosis-infected broiler chickens
Orally delivered Bacillus subtilis expressing chicken NK-2 peptide stabilizes gut microbiota and enhances intestinal health and local immunity in coccidiosis-infected broiler chickens Open
We recently reported a stable Bacillus subtilis-carrying chicken NK-lysin peptide (B. subtilis-cNK-2) as an effective oral delivery system of an antimicrobial peptide to the gut with therapeutic effect against Eimeria parasites in broiler …
View article: Evaluation of the Safety Profile of the ASFV Vaccine Candidate ASFV-G-ΔI177L
Evaluation of the Safety Profile of the ASFV Vaccine Candidate ASFV-G-ΔI177L Open
African swine fever (ASF) is the cause of a recent pandemic that is posing a threat to much of the world swine production. The etiological agent, ASF virus (ASFV), infects domestic and wild swine, producing a variety of clinical presentati…
View article: Erratum: Callaway et al. Alternatives to Antibiotics: A Symposium on the Challenges and Solutions for Animal Health and Production. Antibiotics 2021, 10, 471
Erratum: Callaway et al. Alternatives to Antibiotics: A Symposium on the Challenges and Solutions for Animal Health and Production. Antibiotics 2021, 10, 471 Open
The authors would like to make the following corrections to the published paper [...]
View article: Oral Delivery of Bacillus subtilis Expressing Chicken NK-2 Peptide Protects Against Eimeria acervulina Infection in Broiler Chickens
Oral Delivery of Bacillus subtilis Expressing Chicken NK-2 Peptide Protects Against Eimeria acervulina Infection in Broiler Chickens Open
Chicken NK-lysin peptide 2 (cNK-2) is a natural lytic peptide with direct cytotoxicity against many apicomplexan parasites including Eimeria . Developing an effective oral delivery strategy to express cNK-2 in the intestine, where Eimeria …
View article: Editorial: FMD Research: Bridging the Gaps With Novel Tools
Editorial: FMD Research: Bridging the Gaps With Novel Tools Open
EDITORIAL article Front. Vet. Sci., 17 May 2021Sec. Veterinary Epidemiology and Economics https://doi.org/10.3389/fvets.2021.686141
View article: ASFV-G-∆I177L as an Effective Oral Nasal Vaccine against the Eurasia Strain of Africa Swine Fever
ASFV-G-∆I177L as an Effective Oral Nasal Vaccine against the Eurasia Strain of Africa Swine Fever Open
The African swine fever virus (ASFV) is currently causing a pandemic affecting wild and domestic swine from Western Europe to Asia. No commercial vaccines are available to prevent African swine fever (ASF), resulting in overwhelming econom…
View article: Alternatives to Antibiotics: A Symposium on the Challenges and Solutions for Animal Health and Production
Alternatives to Antibiotics: A Symposium on the Challenges and Solutions for Animal Health and Production Open
Antibiotics have improved the length and quality of life of people worldwide and have had an immeasurable influence on agricultural animal health and the efficiency of animal production over the last 60 years. The increased affordability o…
View article: Novel Foot-and-Mouth Disease Vaccine Platform: Formulations for Safe and DIVA-Compatible FMD Vaccines With Improved Potency
Novel Foot-and-Mouth Disease Vaccine Platform: Formulations for Safe and DIVA-Compatible FMD Vaccines With Improved Potency Open
Inactivated, wild-type foot-and-mouth disease virus (FMDV) vaccines are currently used to control FMD around the world. These traditional FMD vaccines are produced using large quantities of infectious, virulent, wild-type FMD viruses, with…
View article: Strategic Priorities for Research on Antibiotic Alternatives in Animal Agriculture—Results From an Expert Workshop
Strategic Priorities for Research on Antibiotic Alternatives in Animal Agriculture—Results From an Expert Workshop Open
The emergence, spread, and expansion of antibiotic resistance and increasing restrictions on the use of antibiotics in animal agriculture have created a need for efficacious alternatives that remains unmet. Prioritizing research needs in t…
View article: Phytochemicals as antibiotic alternatives to promote growth and enhance host health
Phytochemicals as antibiotic alternatives to promote growth and enhance host health Open
There are heightened concerns globally on emerging drug-resistant superbugs and the lack of new antibiotics for treating human and animal diseases. For the agricultural industry, there is an urgent need to develop strategies to replace ant…
View article: Global Foot-and-Mouth Disease Research Update and Gap Analysis: 4 - Diagnostics
Global Foot-and-Mouth Disease Research Update and Gap Analysis: 4 - Diagnostics Open
This study assessed knowledge gaps in foot-and-mouth disease (FMD) research in the field of diagnostics. The study took the form of a literature review (2011-15) combined with research updates collected in 2014 from 33 institutes from arou…
View article: Global Foot-and-Mouth Disease Research Update and Gap Analysis: 5 - Biotherapeutics and Disinfectants
Global Foot-and-Mouth Disease Research Update and Gap Analysis: 5 - Biotherapeutics and Disinfectants Open
We assessed knowledge gaps in foot-and-mouth disease (FMD) research. Findings are reported in a series of papers, and in this article, we consider biotherapeutics and disinfectants. The study took the form of a literature review (2011-2015…
View article: Global Foot-and-Mouth Disease Research Update and Gap Analysis: 3 - Vaccines
Global Foot-and-Mouth Disease Research Update and Gap Analysis: 3 - Vaccines Open
This study assessed research knowledge gaps in the field of FMDV (foot-and-mouth disease virus) vaccines. The study took the form of a literature review (2011-15) combined with research updates collected in 2014 from 33 institutes from acr…
View article: Global Foot-and-Mouth Disease Research Update and Gap Analysis: 6 - Immunology
Global Foot-and-Mouth Disease Research Update and Gap Analysis: 6 - Immunology Open
This study assessed gaps and priorities for FMDV (foot-and-mouth disease virus) research in the field of immunology. The study took the form of a literature review (2011-15) combined with research updates collected in 2014 from 33 institut…
View article: Global Foot-and-Mouth Disease Research Update and Gap Analysis: 1 - Overview of Global Status and Research Needs
Global Foot-and-Mouth Disease Research Update and Gap Analysis: 1 - Overview of Global Status and Research Needs Open
The Global Foot-and-mouth disease (FMD) Research Alliance periodically reviews the state of FMD research to assess progress and to identify new priorities. In this supplement we provide an update of global FMD research, comprising (i) this…