Cyrille de Joussineau
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View article: LXR pathway drives hormonal response intensity in polycystic ovary syndrome
LXR pathway drives hormonal response intensity in polycystic ovary syndrome Open
Gonadotropin injections used to stimulate oocyte production during assisted reproductive technology (ART) procedures are associated with the risk of an abnormal response in predisposed patients suffering polycystic ovary syndrome (PCOS). L…
View article: Loss of control of epithelial basal extrusion leads to tumor resistance in <i>Drosophila</i>
Loss of control of epithelial basal extrusion leads to tumor resistance in <i>Drosophila</i> Open
Basal extrusion allows an epithelial cell to leave its compartment, making it a necessary step in the local invasion of all epithelial cancers. Here, we determined which effect sex steroid deprivation plays on basal extrusion, and the resu…
View article: Liver X Receptors Enhance Epithelial to Mesenchymal Transition in Metastatic Prostate Cancer Cells
Liver X Receptors Enhance Epithelial to Mesenchymal Transition in Metastatic Prostate Cancer Cells Open
Prostate cancer (PCa) is one of the most common cancers in men. Metastasis is the leading cause of death in prostate cancer patients. One of the crucial processes involved in metastatic spread is the “epithelial–mesenchymal transition” (EM…
View article: Cholesterol Dietary Intake and Tumor Cell Homeostasis Drive Early Epithelial Tumorigenesis: A Potential Modelization of Early Prostate Tumorigenesis
Cholesterol Dietary Intake and Tumor Cell Homeostasis Drive Early Epithelial Tumorigenesis: A Potential Modelization of Early Prostate Tumorigenesis Open
Epidemiological studies point to cholesterol as a possible key factor for both prostate cancer incidence and progression. It could represent a targetable metabolite as the most aggressive tumors also appear to be sensitive to therapies des…
View article: Cholesterol Dietary Intake and Tumour Cell Metabolism Drive Early Epithelial Tumorigenesis
Cholesterol Dietary Intake and Tumour Cell Metabolism Drive Early Epithelial Tumorigenesis Open
Epidemiological studies point cholesterol as a possible key factor for both prostate cancer incidence and progression. So, it could represent a targetable metabolite as the most aggressive tumors also appear to be sensitive to therapies de…
View article: Let’s talk about sex (steroids): Steroid deprivation promotes the emergence of a new resistant population in prostate-like Drosophila accessory gland
Let’s talk about sex (steroids): Steroid deprivation promotes the emergence of a new resistant population in prostate-like Drosophila accessory gland Open
View article: Mechanisms of epithelial mesenchymal transition by TGF-ß and LXRs in metastatic prostate cancer
Mechanisms of epithelial mesenchymal transition by TGF-ß and LXRs in metastatic prostate cancer Open
View article: Drosophila Accessory Gland: A Complementary In Vivo Model to Bring New Insight to Prostate Cancer
Drosophila Accessory Gland: A Complementary In Vivo Model to Bring New Insight to Prostate Cancer Open
Prostate cancer is the most common cancer in aging men. Despite recent progress, there are still few effective treatments to cure its aggressive and metastatic stages. A better understanding of the molecular mechanisms driving disease init…
View article: Absence of nuclear receptors LXRs impairs immune response to androgen deprivation and leads to prostate neoplasia
Absence of nuclear receptors LXRs impairs immune response to androgen deprivation and leads to prostate neoplasia Open
Chronic inflammation is now a well-known precursor for cancer development. Infectious prostatitis are the most common causes of prostate inflammation, but emerging evidence points the role of metabolic disorders as a potential source of ca…
View article: Screening for liver X receptor modulators: Where are we and for what use?
Screening for liver X receptor modulators: Where are we and for what use? Open
Liver X receptors (LXRs) are members of the nuclear receptor superfamily that are canonically activated by oxidized derivatives of cholesterol. Since the mid‐90s, numerous groups have identified LXRs as endocrine receptors that are involve…
View article: Pharmacological Modulation of Steroid Activity in Hormone-Dependent Breast and Prostate Cancers: Effect of Some Plant Extract Derivatives
Pharmacological Modulation of Steroid Activity in Hormone-Dependent Breast and Prostate Cancers: Effect of Some Plant Extract Derivatives Open
The great majority of breast and prostate tumors are hormone-dependent cancers; hence, estrogens and androgens can, respectively, drive their developments, making it possible to use pharmacological therapies in their hormone-dependent phas…
View article: Sequential Ras/MAPK and PI3K/AKT/mTOR pathways recruitment drives basal extrusion in the prostate-like gland of Drosophila
Sequential Ras/MAPK and PI3K/AKT/mTOR pathways recruitment drives basal extrusion in the prostate-like gland of Drosophila Open
View article: New Insights in Prostate Cancer Development and Tumor Therapy: Modulation of Nuclear Receptors and the Specific Role of Liver X Receptors
New Insights in Prostate Cancer Development and Tumor Therapy: Modulation of Nuclear Receptors and the Specific Role of Liver X Receptors Open
Prostate cancer (PCa) incidence has been dramatically increasing these last years in westernized countries. Though localized PCa is usually treated by radical prostatectomy, androgen deprivation therapy is preferred in locally advanced dis…
View article: SPOT-011 Studying the implication of the RAS/MAPK and PI3K/AKT/TOR pathways in prostate cancer through an in vivo model of drosophila accessory glands tumorigenesis
SPOT-011 Studying the implication of the RAS/MAPK and PI3K/AKT/TOR pathways in prostate cancer through an in vivo model of drosophila accessory glands tumorigenesis Open
Introduction Clinical studies have demonstrated that, in prostate cancer, Ras/MAPK and PI3K/AKT/TOR signalling pathways are often aberrantly co-activated in tumours, their activation levels increasing again in resistance phases. As these …
View article: mTOR transcriptionally and post-transcriptionally regulates Npm1 gene expression to contribute to enhanced proliferation in cells with Pten inactivation
mTOR transcriptionally and post-transcriptionally regulates Npm1 gene expression to contribute to enhanced proliferation in cells with Pten inactivation Open
The mammalian target of rapamycin (mTOR) plays essential roles in the regulation of growth-related processes such as protein synthesis, cell sizing and metabolism in both normal and pathological growing conditions. These functions of mTOR …
View article: mTOR transcriptionally and post-transcriptionally regulates Npm1 gene expression to contribute to enhanced proliferation in cells with Pten inactivation
mTOR transcriptionally and post-transcriptionally regulates Npm1 gene expression to contribute to enhanced proliferation in cells with Pten inactivation Open
The mammalian target of rapamycin (mTOR) plays essential roles in the regulation of growth-related processes such as protein synthesis, cell sizing and metabolism in both normal and pathological growing conditions. These functions of mTOR …
View article: mTOR transcriptionally and post-transcriptionally regulates <i>Npm1</i> gene expression to contribute to enhanced proliferation in cells with <i>Pten</i> inactivation
mTOR transcriptionally and post-transcriptionally regulates <i>Npm1</i> gene expression to contribute to enhanced proliferation in cells with <i>Pten</i> inactivation Open
The mammalian target of rapamycin (mTOR) plays essential roles in the regulation of growth-related processes such as protein synthesis, cell sizing and metabolism in both normal and pathological growing conditions. These functions of mTOR …