Cyrus Daruwalla
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View article: Ageing and remyelination failure in people with multiple sclerosis
Ageing and remyelination failure in people with multiple sclerosis Open
One of the most promising strategies to delay, prevent, or reverse disability progression in multiple sclerosis (MS) is enhancing endogenous remyelination. While preclinical research has established a strong connection between ageing and r…
View article: The Cambridge Centre for Myelin Repair trial Two (CCMR Two): a trial protocol for a phase 2a, randomised, double-blind, placebo-controlled clinical trial of the ability of the combination of metformin and clemastine to promote remyelination in people with relapsing-remitting multiple sclerosis already on disease-modifying therapy
The Cambridge Centre for Myelin Repair trial Two (CCMR Two): a trial protocol for a phase 2a, randomised, double-blind, placebo-controlled clinical trial of the ability of the combination of metformin and clemastine to promote remyelination in people with relapsing-remitting multiple sclerosis already on disease-modifying therapy Open
Background: In multiple sclerosis (MS) progressive disability occurs following degeneration of demyelinated axons. A tractable approach to delay, prevent, or reverse disability progression is through enhancement of endogenous remyelination…
View article: The profile of gastrointestinal dysfunction in prodromal to late-stage Parkinson’s disease
The profile of gastrointestinal dysfunction in prodromal to late-stage Parkinson’s disease Open
Gastrointestinal dysfunction (GID) may play a key role in Parkinson’s disease (PD) but its relationship with disease progression remains unclear. We recruited 404 PD cases, 37 iRBD (isolated REM Sleep Behaviour Disorder) and 105 controls. …
View article: Robust real-world evidence: optimising disease-modifying treatments for multiple sclerosis
Robust real-world evidence: optimising disease-modifying treatments for multiple sclerosis Open
View article: Early depressive symptoms and disability accrual in Multiple Sclerosis: a UK MS Register study
Early depressive symptoms and disability accrual in Multiple Sclerosis: a UK MS Register study Open
Understanding the associations and potential drivers of long-term disability in Multiple Sclerosis (MS) is of clinical and prognostic value. Previous data have suggested a link between depression and disability accrual in MS. We aimed to d…
View article: Early non-disabling relapses are important predictors of disability accumulation in people with relapsing-remitting multiple sclerosis
Early non-disabling relapses are important predictors of disability accumulation in people with relapsing-remitting multiple sclerosis Open
Background: The prognostic significance of non-disabling relapses in people with relapsing-remitting multiple sclerosis (RRMS) is unclear. Objective: To determine whether early non-disabling relapses predict disability accumulation in RRMS…
View article: A rare presentation of rapidly progressing myopathy in an adolescent
A rare presentation of rapidly progressing myopathy in an adolescent Open
We present a case of severe juvenile dermatomyositis with limited response to steroids in an adolescent who developed symptoms within hours after receiving Pfizer BNT162b2 coronavirus disease 2019 vaccine. The patient presented with severe…
View article: Remyelination varies between and within lesions in multiple sclerosis following bexarotene
Remyelination varies between and within lesions in multiple sclerosis following bexarotene Open
Objective In multiple sclerosis chronic demyelination is associated with axonal loss, and ultimately contributes to irreversible progressive disability. Enhancing remyelination may slow, or even reverse, disability. We recently trialled be…
View article: An unusual presentation of propylthiouracil-induced anti-MPO and PR3 positive ANCA vasculitis with associated anti-GBM antibodies, IgA nephropathy and an IgG4 interstitial infiltrate: a case report
An unusual presentation of propylthiouracil-induced anti-MPO and PR3 positive ANCA vasculitis with associated anti-GBM antibodies, IgA nephropathy and an IgG4 interstitial infiltrate: a case report Open