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View article: Interleukin 10 controls the balance between tolerance, pathogen elimination, and immunopathology in birds
Interleukin 10 controls the balance between tolerance, pathogen elimination, and immunopathology in birds Open
Effective mucosal immunity in the intestine involves a fine balance between tolerance of the microbiome, recognition, and elimination of pathogens, and inflammatory tissue injury. The anti-inflammatory cytokine IL10 regulates these process…
View article: Interleukin 10 controls the balance between tolerance, pathogen elimination and immunopathology in birds
Interleukin 10 controls the balance between tolerance, pathogen elimination and immunopathology in birds Open
Effective mucosal immunity in the intestine involves a fine balance between tolerance of the microbiome, recognition and elimination of pathogens, and inflammatory tissue injury. The anti-inflammatory cytokine IL10 regulates these processe…
View article: A conserved upstream element in the mouse <i>Csf1r</i> locus contributes to transcription in hematopoietic and trophoblast cells
A conserved upstream element in the mouse <i>Csf1r</i> locus contributes to transcription in hematopoietic and trophoblast cells Open
Expression of the Csf1r gene in mice is restricted to cells of the mononuclear phagocyte system and placental trophoblasts. A conserved element ( Csf1r upstream regulatory element A, CUREA) in the mouse Csf1r locus contains transcription s…
View article: CSF1R regulates monocyte subset differentiation and intracellular metabolism
CSF1R regulates monocyte subset differentiation and intracellular metabolism Open
Monocytes are key circulating effectors of vascular homeostasis, innate immunity and inflammation. Following their generation in mouse bone marrow, classical (Ly6C high ) monocytes are mobilized into the blood circulation where they mature…
View article: Correction: Mutation in the rat interleukin 34 gene impacts macrophage development, homeostasis and inflammation
Correction: Mutation in the rat interleukin 34 gene impacts macrophage development, homeostasis and inflammation Open
Characterization of a novel IL34 loss-of-function model reveals overlapping functions of CSF1 and IL34 on CSF1R in the brain and periphery of the rat.
View article: Homozygous kinase-dead <i>Csf1r</i> mutation in outbred mice reveals essential and redundant functions of tissue resident macrophages
Homozygous kinase-dead <i>Csf1r</i> mutation in outbred mice reveals essential and redundant functions of tissue resident macrophages Open
The proliferation, differentiation and survival of cells of the macrophage lineage depends on signals from the macrophage colony-stimulating factor receptor (CSF1R). On a C57BL/6J background homozygous kinase-dead Csf1r mutation ( Csf1r E6…
View article: Perisurgical colony stimulating factor one treatment ameliorates liver ischaemia/reperfusion injury in rats
Perisurgical colony stimulating factor one treatment ameliorates liver ischaemia/reperfusion injury in rats Open
BACKGROUND In the context of hepatobiliary and liver transplant surgery, ischemia-reperfusion (I/R) injury can occur due to temporary interruption of blood flow to the organ followed by a potentially damaging inflammatory response to reper…
View article: Mutation in the rat interleukin 34 gene impacts macrophage development, homeostasis, and inflammation
Mutation in the rat interleukin 34 gene impacts macrophage development, homeostasis, and inflammation Open
Interleukin 34 (IL34) and colony-stimulating factor 1 (CSF1) signal through a shared receptor (CSF1R) to control macrophage survival, differentiation, and function. Here, we describe the impact of loss-of-function mutation in the rat Il34 …
View article: The Involvement of IL-34 in Inflammatory and Malignant Skin Diseases
The Involvement of IL-34 in Inflammatory and Malignant Skin Diseases Open
The mononuclear phagocyte system depends upon CSF1R and its 2 ligands, CSF1 and IL-34. IL-34 is expressed constitutively in the skin in mice and humans from a conserved keratinocyte-specific promoter, suggesting a specific function in epid…
View article: Interleukin 10 controls the balance between tolerance, pathogen elimination and immunopathology in birds
Interleukin 10 controls the balance between tolerance, pathogen elimination and immunopathology in birds Open
Effective mucosal immunity in the intestine involves a fine balance between tolerance of the microbiome, recognition and elimination of pathogens, and inflammatory tissue injury. The anti-inflammatory cytokine IL10 regulates these processe…
View article: Interleukin 10 controls the balance between tolerance, pathogen elimination, and immunopathology in birds
Interleukin 10 controls the balance between tolerance, pathogen elimination, and immunopathology in birds Open
Effective mucosal immunity in the intestine involves a fine balance between tolerance of the microbiome, recognition, and elimination of pathogens, and inflammatory tissue injury. The anti-inflammatory cytokine IL10 regulates these process…
View article: Transcriptomic signatures of host immune responses in aphthous ulcers, the earliest lesions of Crohn's disease, suggest that bacterial uptake, rather than global dysbiosis, is the initiating factor
Transcriptomic signatures of host immune responses in aphthous ulcers, the earliest lesions of Crohn's disease, suggest that bacterial uptake, rather than global dysbiosis, is the initiating factor Open
Crohn's disease is a chronic, transmural inflammatory disease of the human gut. Changes in the fecal microbial composition and dysbiosis are consistent features in studies of Crohn's disease patients, but whether dysbiosis is a cause or co…
View article: Perisurgical Colony Stimulating Factor 1 (CSF1) treatment ameliorates liver ischaemia/reperfusion injury in rats
Perisurgical Colony Stimulating Factor 1 (CSF1) treatment ameliorates liver ischaemia/reperfusion injury in rats Open
Background In the context of hepatobiliary and liver transplant surgery, ischemia-reperfusion (I/R) injury can occur due to temporary interruption of blood flow to the organ followed by a potentially damaging inflammatory response to reper…
View article: Wild-type bone marrow cells repopulate tissue resident macrophages and reverse the impacts of homozygous CSF1R mutation
Wild-type bone marrow cells repopulate tissue resident macrophages and reverse the impacts of homozygous CSF1R mutation Open
Adaptation to existence outside the womb is a key event in the life of a mammal. The absence of macrophages in rats with a homozygous mutation in the colony-stimulating factor 1 receptor ( Csf1r) gene ( Csf1rko ) severely compromises pre-w…
View article: Repopulation of the brain with microglia-like cells following intraperitoneal bone marrow cell transfer in microglia-deficient mice
Repopulation of the brain with microglia-like cells following intraperitoneal bone marrow cell transfer in microglia-deficient mice Open
Germ-line deletion of a conserved enhancer (the Fms intrinsic regulatory element, FIRE) in the mouse Csf1r locus causes congenital absence of microglia. Homozygous FIRE deletion on a C57BL/6J background leads to perinatal lethality and hyd…
View article: Interleukin 10 controls the balance between tolerance, pathogen elimination and immunopathology in birds
Interleukin 10 controls the balance between tolerance, pathogen elimination and immunopathology in birds Open
Effective mucosal immunity in the intestine involves a fine balance between tolerance of the microbiome, recognition and elimination of pathogens, and inflammatory tissue injury. The anti-inflammatory cytokine IL10 regulates these processe…
View article: The Relationship Between CSF1R Signaling, Monocyte-Macrophage Differentiation, and Susceptibility to Inflammatory Bowel Disease
The Relationship Between CSF1R Signaling, Monocyte-Macrophage Differentiation, and Susceptibility to Inflammatory Bowel Disease Open
More than 300 genomic loci have been associated with increased susceptibility to inflammatory bowel disease (IBD) through genome-wide association studies. A major challenge in the translation of genome-wide association studies to mechanist…
View article: The effect of a dominant kinase-dead Csf1r mutation associated with adult-onset leukoencephalopathy on brain development and neuropathology
The effect of a dominant kinase-dead Csf1r mutation associated with adult-onset leukoencephalopathy on brain development and neuropathology Open
Amino acid substitutions in the kinase domain of the human CSF1R protein are associated with autosomal dominant adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP). To model the human disease, we created a disea…
View article: An Inactivating Mutation in Rat IL-34 Reveals Redundant and Nonredundant Functions of CSF1-IL-34 Signalling in Homeostasis and Inflammation
An Inactivating Mutation in Rat IL-34 Reveals Redundant and Nonredundant Functions of CSF1-IL-34 Signalling in Homeostasis and Inflammation Open
Colony stimulating factor 1 receptor (CSF1R) is required for the differentiation and maintenance of many mononuclear phagocyte lineage cells and is a definitive marker of this lineage in humans and mice. CSF1R signaling is activated by two…
View article: Blood Cell Homeostasis Is Maintained in the Absence of Resident Mononuclear Phagocytes in Fetal Liver and Bone Marrow in CSF1R Knockout Rats
Blood Cell Homeostasis Is Maintained in the Absence of Resident Mononuclear Phagocytes in Fetal Liver and Bone Marrow in CSF1R Knockout Rats Open
Erythrocytes are produced through a highly regulated process that requires an adequate supply of iron to develop properly. The constant production of red blood cells occurs in erythroblastic island (EBI) niches, which exist in the fetal li…
View article: Visualizing the spatial organization of monocytes, interstitial macrophages, and tissue-specific macrophages in situ
Visualizing the spatial organization of monocytes, interstitial macrophages, and tissue-specific macrophages in situ Open
Tissue-resident mononuclear phagocytes (MPs) are an abundant cell population whose localization in situ reflects their identity. To enable assessment of their heterogeneity, we developed the red/green/blue (RGB)-Mac mouse based upon combin…
View article: Microglia determine ß-amyloid plaque burden but are non-essential for downstream pathology
Microglia determine ß-amyloid plaque burden but are non-essential for downstream pathology Open
Evidence points to a role for microglia in Alzheimer’s disease (AD) risk, although their position in the pathological cascade is incompletely understood, prompting us to generate a model of ß-amyloidopathy lacking microglia. We find eviden…
View article: Wild-type bone marrow cells repopulate tissue resident macrophages and reverse the impacts of homozygous CSF1R mutation
Wild-type bone marrow cells repopulate tissue resident macrophages and reverse the impacts of homozygous CSF1R mutation Open
Adaptation to existence outside the womb is a key event in the life of a mammal. The absence of macrophages in rats with a homozygous mutation in the Csf1r gene ( Csf1rko ) severely compromises pre-weaning somatic growth and maturation of …
View article: The effect of a dominant kinase-dead<i>Csf1r</i>mutation associated with adult-onset leukoencephalopathy on brain development and neuropathology
The effect of a dominant kinase-dead<i>Csf1r</i>mutation associated with adult-onset leukoencephalopathy on brain development and neuropathology Open
Amino acid substitutions in the kinase domain of the human CSF1R protein are associated with autosomal dominant adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP). To model the human disease, we created a disea…
View article: Relative contributions of osteal macrophages and osteoclasts to postnatal bone development in CSF1R-deficient rats and phenotype rescue following wild-type bone marrow cell transfer
Relative contributions of osteal macrophages and osteoclasts to postnatal bone development in CSF1R-deficient rats and phenotype rescue following wild-type bone marrow cell transfer Open
Macrophage and osteoclast proliferation, differentiation and survival are regulated by colony-stimulating factor 1 receptor (CSF1R) signaling. Osteopetrosis associated with Csf1 and Csf1r mutations has been attributed to the loss of osteoc…
View article: The relationship between extreme inter-individual variation in macrophage gene expression and genetic susceptibility to inflammatory bowel disease
The relationship between extreme inter-individual variation in macrophage gene expression and genetic susceptibility to inflammatory bowel disease Open
The differentiation of resident intestinal macrophages from blood monocytes depends upon signals from the macrophage colony-stimulating factor receptor (CSF1R). Analysis of genome-wide association studies (GWAS) indicates that dysregulatio…