Daniel G. Bausch
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Stakeholder Perspectives on Evaluating Emergency Medical Teams Deployments Open
Objective A standardized framework for evaluating Emergency Medical Teams (EMT) deployments is currently lacking. This study aimed to identify evaluation practices and elucidate stakeholder perspectives on evaluating EMT deployments. Metho…
Consensus on Key Domains for Emergency Medical Teams Deployment Evaluation: A Delphi Method Study Open
Background Emergency Medical Teams (EMT) deploy to provide urgent care during and after sudden onset disasters. Although the World Health Organisation has set standards for EMTs on training, personnel, and operations, there is presently no…
Laboratory evaluation of antigen rapid diagnostic tests to detect Ebola and Sudan viruses Open
Although none of the evaluated Ag-RDTs are suitable for routine diagnosis, some may be useful in high viral load contexts such as cadaver testing. Our findings highlight the need to improve Ag-RDT sensitivity or develop high-sensitivity po…
Establishment of a Lassa Fever Specimen Biobank in Nigeria Open
Despite being a dangerous disease found across West Africa, with occasional cases imported elsewhere, few medical countermeasures for Lassa fever are available, with no vaccine or validated treatment, and limited regulatory-approved diagno…
Using an analogue-digital hybrid clinical data management platform during a two-dose preventive Ebola virus vaccine trial in Goma, the Democratic Republic of the Congo Open
Clinical trials in settings with intermittent or non-existent internet and power connectivity, for example during humanitarian emergencies, present challenges in the synchronisation of data across different sites, in addition to accessing …
Evaluation of the diagnostic accuracy of the ReLASV Pan-Lassa Antigen Rapid Test for Lassa Fever in Nigeria Open
Lassa fever is a zoonotic disease found in several countries across West Africa, with estimates of up to 300,000 infections and 10,000 deaths yearly. The highest incidence is in Nigeria. Suspected cases are often seen in areas with limited…
Pregnancy and neonatal outcomes in Eastern Democratic Republic of the Congo: a systematic review Open
Background Conflict is known to impact maternal and neonatal health in Eastern Democratic Republic of the Congo (DRC), an area of longstanding insecurity. We conducted a systematic review on pregnancy and neonatal outcomes in this region t…
View article: Linear field-resolved spectroscopy approaching ultimate detection sensitivity
Linear field-resolved spectroscopy approaching ultimate detection sensitivity Open
Electric-field oscillations are now experimentally accessible in the THz-to-PHz frequency range. Their measurement delivers the most comprehensive information content attainable by optical spectroscopy – if performed with high sensitivity.…
Evaluating and implementing new diagnostics Open
Accurate diagnostics are key for surveillance and response to epidemics and pandemics. However, especially in these urgent and challenging settings, many diagnostic tests may come to the market without extensive evaluation. Their accuracy …
Systematic review and meta-analysis of antigen rapid diagnostic tests to detect Zaire ebolavirus Open
We conducted a systematic review and meta-analysis of studies and reports comparing the performance of antigen rapid diagnostic tests (Ag RDT) for diagnosing Ebola disease (EVD). We searched PubMed, EMBASE, and Web of Science for diagnosti…
View article: Linear field-resolved spectroscopy approaching ultimate detection sensitivity
Linear field-resolved spectroscopy approaching ultimate detection sensitivity Open
Electric-field oscillations are now experimentally accessible in the THz-to-PHz frequency range. Their measurement delivers the most comprehensive information content attainable by optical spectroscopy – if performed with high sensitivity.…
Immunogenicity of an Extended Dose Interval for the Ad26.ZEBOV, MVA-BN-Filo Ebola Vaccine Regimen in Adults and Children in the Democratic Republic of the Congo Open
During the 2018–2020 Ebola virus disease outbreak in Democratic Republic of the Congo, a phase 3 trial of the Ad26.ZEBOV, MVA-BN-Filo Ebola vaccine (DRC-EB-001) commenced in Goma, with participants being offered the two-dose regimen given …
Delivery and Safety of a Two-Dose Preventive Ebola Virus Disease Vaccine in Pregnant and Non-Pregnant Participants during an Outbreak in the Democratic Republic of the Congo Open
During the 2018–2020 Ebola virus disease (EVD) outbreak, residents in Goma, Democratic Republic of the Congo, were offered a two-dose prophylactic EVD vaccine. This was the first study to evaluate the safety of this vaccine in pregnant wom…
View article: Sub-attosecond-precision optical-waveform stability measurements using electro-optic sampling
Sub-attosecond-precision optical-waveform stability measurements using electro-optic sampling Open
The generation of laser pulses with controlled optical waveforms, and their measurement, lie at the heart of both time-domain and frequency-domain precision metrology. Here, we obtain mid-infrared waves via intra-pulse difference-frequency…
View article: Summary of WHO infection prevention and control guideline for Ebola and Marburg disease: a call for evidence based practice
Summary of WHO infection prevention and control guideline for Ebola and Marburg disease: a call for evidence based practice Open
Contains fulltext : 305572.pdf (Publisher’s version ) (Open Access)
Building Partnerships and Confronting Challenges: Implementation of an Ebola Virus Vaccine Clinical Study During an Outbreak in the Democratic Republic of the Congo Open
Research, especially clinical trials, during outbreaks often poses enormous challenges, and up until very recent times was often considered almost impossible. However, for diseases such as Ebola virus disease, which are seen almost exclusi…
Protection, health seeking, or a laissez-passer: Participants’ decision-making in an EVD vaccine trial in the eastern Democratic Republic of the Congo Open
During the 10th Ebola virus disease (EVD) epidemic in the eastern Democratic Republic of the Congo (DRC) (2018-2020), two experimental EVD vaccines were deployed in North Kivu. This province has been at the centre of conflict in the region…