Daniel S. Berman
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View article: Evaluating the Effectiveness of Parameter-Efficient Fine-Tuning in Genomic Classification Tasks
Evaluating the Effectiveness of Parameter-Efficient Fine-Tuning in Genomic Classification Tasks Open
Foundation models are increasingly being leveraged for biological tasks. To address the high memory requirements of fine-tuning large pre-trained language models, parameter efficient fine-tuning (PEFT) methods are also being increasingly u…
View article: Incremental diagnostic value of AI-derived coronary artery calcium in <sup>18</sup>F-flurpiridaz PET Myocardial Perfusion Imaging
Incremental diagnostic value of AI-derived coronary artery calcium in <sup>18</sup>F-flurpiridaz PET Myocardial Perfusion Imaging Open
Background Positron Emission Tomography (PET) myocardial perfusion imaging (MPI) is a powerful tool for predicting coronary artery disease (CAD). Coronary artery calcium (CAC) provides incremental risk stratification to PET-MPI and enhance…
View article: AI-based identification of patients who benefit from revascularization: a multicenter study
AI-based identification of patients who benefit from revascularization: a multicenter study Open
Background and Aims Revascularization in stable coronary artery disease often relies on ischemia severity, but we introduce an AI-driven approach that uses clinical and imaging data to estimate individualized treatment effects and guide pe…
View article: Association of medical therapies with survival according to SPECT MPI findings
Association of medical therapies with survival according to SPECT MPI findings Open
ACE/ARB prescription was significantly associated with improved survival. Beta-blocker prescription was associated with greater survival in patients with ischemia and statins were in patients with coronary calcification. Findings from MPI …
View article: Automated Deep Learning Phenotyping of Tricuspid Regurgitation in Echocardiography
Automated Deep Learning Phenotyping of Tricuspid Regurgitation in Echocardiography Open
Importance Accurate assessment of tricuspid regurgitation (TR) is necessary for identification and risk stratification. Objective To design a deep learning computer vision workflow for identifying color Doppler echocardiogram videos and ch…
View article: Deep learning-quantified body composition from positron emission tomography/computed tomography and cardiovascular outcomes: a multicentre study
Deep learning-quantified body composition from positron emission tomography/computed tomography and cardiovascular outcomes: a multicentre study Open
Background and Aims Positron emission tomography (PET)/computed tomography (CT) myocardial perfusion imaging (MPI) is a vital diagnostic tool, especially in patients with cardiometabolic syndrome. Low-dose CT scans are routinely performed …
View article: Intracoronary acetylcholine for vasospasm provocation in women with ischemia and no obstructive coronary artery disease
Intracoronary acetylcholine for vasospasm provocation in women with ischemia and no obstructive coronary artery disease Open
Among women with suspected INOCA, intracoronary Ach spasm testing provoked epicardial vasospasm in one fourth. Women with epicardial vasospasm overwhelmingly had concomitant endothelial dysfunction, worse QoL but not more frequent myocardi…
View article: Artificial Intelligence–Enhanced Perfusion Scoring Improves the Diagnostic Accuracy of Myocardial Perfusion Imaging
Artificial Intelligence–Enhanced Perfusion Scoring Improves the Diagnostic Accuracy of Myocardial Perfusion Imaging Open
We previously demonstrated that a deep learning (DL) model of myocardial perfusion SPECT imaging improved accuracy for detection of obstructive coronary artery disease (CAD). We aimed to improve the clinical translatability of this artific…
View article: Impact of diabetes mellitus on coronary artery plaque characteristics and outcomes in the SCOT-HEART trial
Impact of diabetes mellitus on coronary artery plaque characteristics and outcomes in the SCOT-HEART trial Open
Diabetes mellitus was an independent predictor of quantitatively assessed plaque burden, particularly calcified plaque, and was associated with an increased risk of myocardial infarction.
View article: Myocardial Fibroblast Activation After Acute Myocardial Infarction
Myocardial Fibroblast Activation After Acute Myocardial Infarction Open
Myocardial fibroblast activation peaks within a week of acute myocardial infarction and extends beyond the infarct region. It declines slowly with time, persists for years, and is associated with subsequent left ventricular remodeling. (PR…
View article: Imaging small dynamic lesions using positron emission tomography and computed tomography: an 18F-sodium fluoride valvular phantom study
Imaging small dynamic lesions using positron emission tomography and computed tomography: an 18F-sodium fluoride valvular phantom study Open
Aims 18F-sodium fluoride (18F-NaF) positron emission tomography (PET) detects active microcalcification and predicts adverse outcomes including bioprosthetic valve deterioration. However, measuring small areas of 18F-NaF uptake within movi…
View article: The Relationship Between Quantitative Ischemia, Early Revascularization, and Major Adverse Cardiovascular Events
The Relationship Between Quantitative Ischemia, Early Revascularization, and Major Adverse Cardiovascular Events Open
Early revascularization was associated with reduced risk in patients with a higher burden of quantitative ischemia in more recent populations. These findings suggest that methods integrating more factors than just ischemia are needed to im…
View article: Relationship Between Severity of Ischemia and Coronary Artery Disease for Different Stress Test Modalities in the ISCHEMIA Trial
Relationship Between Severity of Ischemia and Coronary Artery Disease for Different Stress Test Modalities in the ISCHEMIA Trial Open
BACKGROUND: The relationship between the extent and severity of stress-induced ischemia and the extent and severity of anatomic coronary artery disease (CAD) in patients with obstructive CAD is multifactorial and includes the intensity of …
View article: Automatic motion correction for myocardial blood flow estimation improves diagnostic performance for coronary artery disease in 18F-flurpiridaz positron emission tomography-myocardial perfusion imaging
Automatic motion correction for myocardial blood flow estimation improves diagnostic performance for coronary artery disease in 18F-flurpiridaz positron emission tomography-myocardial perfusion imaging Open
Automatic MC can be performed rapidly, with diagnostic performance for predicting obstructive CAD comparable to manual MC. This method could be utilized for analysis of MBF/MFR in patients undergoing 18F-flurpiridaz PET-MPI.
View article: Use of a single-item exercise questionnaire predicts prognostic risk among patients undergoing stress PET-MPI
Use of a single-item exercise questionnaire predicts prognostic risk among patients undergoing stress PET-MPI Open
Patients with higher exercise activity assessed by a practical single-item questionnaire had higher MFR and HRR. Exercise activity was an independent predictor of hard events in patients undergoing PET-MPI. Because of its ease of use, this…
View article: Patient-Specific Myocardial Infarction Risk Thresholds From AI-Enabled Coronary Plaque Analysis
Patient-Specific Myocardial Infarction Risk Thresholds From AI-Enabled Coronary Plaque Analysis Open
BACKGROUND: Plaque quantification from coronary computed tomography angiography has emerged as a valuable predictor of cardiovascular risk. Deep learning can provide automated quantification of coronary plaque from computed tomography angi…