Donald W. Black
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View article: Treatment Moderators of Symptom Severity in Psychotherapy for People with Borderline Personality Disorder: Systematic Review with Meta-Analyses of Individual Participant Data
Treatment Moderators of Symptom Severity in Psychotherapy for People with Borderline Personality Disorder: Systematic Review with Meta-Analyses of Individual Participant Data Open
Introduction: Borderline personality disorder (BPD) is a complex and heterogeneous condition. Psychotherapy reduces symptom severity; however, characteristics of the individual may influence treatment outcomes. This systematic review exami…
View article: Genome-wide analyses identify 30 loci associated with obsessive–compulsive disorder
Genome-wide analyses identify 30 loci associated with obsessive–compulsive disorder Open
Obsessive–compulsive disorder (OCD) affects ~1% of children and adults and is partly caused by genetic factors. We conducted a genome-wide association study (GWAS) meta-analysis combining 53,660 OCD cases and 2,044,417 controls and identif…
View article: Distinct genetic liability profiles define clinically relevant patient strata across common diseases
Distinct genetic liability profiles define clinically relevant patient strata across common diseases Open
Stratified medicine holds great promise to tailor treatment to the needs of individual patients. While genetics holds great potential to aid patient stratification, it remains a major challenge to operationalize complex genetic risk factor…
View article: Genome-wide analyses identify 30 loci associated with obsessive-compulsive disorder
Genome-wide analyses identify 30 loci associated with obsessive-compulsive disorder Open
Obsessive-compulsive disorder (OCD) affects ∼1% of children and adults and is partly caused by genetic factors. We conducted a genome-wide association study (GWAS) meta-analysis combining 53,660 OCD cases and 2,044,417 controls and identif…
View article: Interaction Testing and Polygenic Risk Scoring to Estimate the Association of Common Genetic Variants With Treatment Resistance in Schizophrenia
Interaction Testing and Polygenic Risk Scoring to Estimate the Association of Common Genetic Variants With Treatment Resistance in Schizophrenia Open
In this GWAS, common genetic variants were differentially associated with TRS, and these associations may have been obscured through the amalgamation of large GWAS samples in previous studies of broadly defined schizophrenia. Findings of t…
View article: Genome-wide association study identifies new locus associated with OCD
Genome-wide association study identifies new locus associated with OCD Open
Obsessive-compulsive disorder (OCD) is a heritable disorder, but no definitive, replicated OCD susceptibility loci have yet been identified by any genome-wide association study (GWAS). Here, we report results from a GWAS in the largest OCD…
View article: Negative symptoms of schizophrenia: An update
Negative symptoms of schizophrenia: An update Open
T he negative symptoms of schizophrenia have been recog- nized for 100 years.Characterized by a loss of a function that should be present, negative symptoms include anhedonia, asociality, amotivation, and affective blunting.Individuals wit…
View article: No Reliable Association between Runs of Homozygosity and Schizophrenia in a Well-Powered Replication Study
No Reliable Association between Runs of Homozygosity and Schizophrenia in a Well-Powered Replication Study Open
It is well known that inbreeding increases the risk of recessive monogenic diseases, but it is less certain whether it contributes to the etiology of complex diseases such as schizophrenia. One way to estimate the effects of inbreeding is …
View article: Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects
Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects Open
Copy number variants (CNVs) have been strongly implicated in the genetic etiology of schizophrenia (SCZ). However, genome-wide investigation of the contribution of CNV to risk has been hampered by limited sample sizes. We sought to address…
View article: SummaryAUC: a tool for evaluating the performance of polygenic risk prediction models in validation datasets with only summary level statistics
SummaryAUC: a tool for evaluating the performance of polygenic risk prediction models in validation datasets with only summary level statistics Open
Motivation Polygenic risk score (PRS) methods based on genome-wide association studies (GWAS) have a potential for predicting the risk of developing complex diseases and are expected to become more accurate with larger training datasets an…
View article: Genome‐wide and digital polymerase chain reaction epigenetic assessments of alcohol consumption
Genome‐wide and digital polymerase chain reaction epigenetic assessments of alcohol consumption Open
The lack of readily employable biomarkers of alcohol consumption is a problem for clinicians and researchers. In 2014, we published a preliminary DNA methylation signature of heavy alcohol consumption that remits as a function of abstinenc…
View article: Dose Response and Prediction Characteristics of a Methylation Sensitive Digital PCR Assay for Cigarette Consumption in Adults
Dose Response and Prediction Characteristics of a Methylation Sensitive Digital PCR Assay for Cigarette Consumption in Adults Open
The tobacco use disorders are the largest preventable cause of morbidity and mortality in the world. A substantial barrier to the development of better intervention and screening measures is the lack of clinically employable biomarkers to …
View article: Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes
Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes Open
Schizophrenia (SCZ) and bipolar disorder (BD) are highly heritable disorders that share a significant proportion of common risk variation. Understanding the genetic factors underlying the specific symptoms of these disorders will be crucia…