Explanipedia

CT Images of the Pancreas for Beginners Open

Yusuf Bayta, David C. Whitcomb, Anil K. Dasyam · 2025

Imaging is critical to determining the etiology and progression of pancreatic diseases. The most commonly utilized modality is computed tomography (CT), typically, contrast enhanced CT (CECT). Here we present a primer for health care provi…

Circulating Molecular Drivers of Bone Remodeling in Pancreatitis Open

Rachel L. Hill, Dhiraj Yadav, Phil A. Hart, David C. Whitcomb, Kristen McQuerry , et al. · 2025

INTRODUCTION: Pancreatitis-associated osteopathy is a clinically significant but mechanistically underexplored complication of pancreatic disease. We aimed to characterize stage-specific alterations in bone remodeling biomarkers across the…

Adoption of a “Pathogenic, Predisposing, Risk and Benign” classification of DNA variants for precision medicine – a step forward Open

David C. Whitcomb · 2025

Precision medicine is often at odds with medical genetics in classifying gene mutations that have high impact on protein expression or function but do not “cause” disease. A new proposal aims to expand the terminology for genetic variants …

SPINK1 Genetic Variants in Pancreatitis. Open

Maham Waqar, David C. Whitcomb, Vinciane Rebours · 2025

Genetic variants disrupting the expression or function of the Serine Protease Inhibitor, Kazal Type 1 (SPINK1) gene—encoding the pancreatic secretory trypsin inhibitor (PSTI, also called SPINK1)—elevate the risk of pancreatitis and pancrea…

Protocol and Study Population of a Prospective Study of Patients With Chronic Pancreatitis and Exocrine Pancreatic Insufficiency: Preliminary Findings From the PACT-CP Registry Show Reduced Health-related Quality of Life Open

Jodie A. Barkin, Samer Alkaade, Rahul Pannala, Yasmin G. Hernandez‐Barco, Janine Twal , et al. · 2025

Machine Learning–Guided Fluid Resuscitation for Acute Pancreatitis Improves Outcomes Open

Niwen Kong, Patrick Chang, Ira Spiro, Ubayd Haq, Maziar Amini , et al. · 2025

INTRODUCTION: Ariel Dynamic Acute Pancreatitis Tracker (ADAPT) is an artificial intelligence tool using mathematical algorithms to predict severity and manage fluid resuscitation needs based on the physiologic parameters of individual pati…

Identifying Complex High-Risk Individuals (HRI-C) for Early Detection of Occult Pancreatic Cancers Using Risk Models and Biomarkers. Open

Randall E. Brand, David C. Whitcomb, Bechien Wu · 2024

Early detection and diagnosis of pancreatic cancer (pancreatic ductal adenocarcinoma, PDAC) offers the best option for effective treatment and prolonged survival. Image-based screening programs are useful in early detection of pancreatic c…

Genetics of constant and severe pain in the NAPS2 cohort of recurrent acute and chronic pancreatitis patients Open

Ellyn Dunbar, Phil J. Greer, Jami L. Saloman, Kathryn M. Albers, Dhiraj Yadav , et al. · 2024

Recurrent acute and chronic pancreatitis (RAP, CP) are complex, progressive inflammatory diseases with variable pain experiences impacting patient function and quality of life. The genetic variants and pain pathways in patients contributin…

Chronic pancreatitis patient-derived organoids reveal new paths to precision therapeutics Open

Victoria Osorio-Vasquez, Jonathan Zhu, Jan Lumibao, Kathryn Lande, Kristina Peck , et al. · 2024

Summary Chronic pancreatitis (CP) affects ∼3 million people worldwide, yet altering the course of disease is challenging. We developed a patient-derived organoid (PDO) platform to investigate the molecular pathogenesis of this disease and …

Table of Contents Open

David C. Whitcomb · 2024

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Editorial: Clinical Decision Support Tools for Precision Medicine Open

David C. Whitcomb · 2024

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Neutrophil to Lymphocyte Ratio Predicts Infections in First Week of Acute Pancreatitis Open

Gauri Kumbhar, Reuben Thomas Kurien, A Joseph, Ebby George Simon, Amit Kumar Dutta , et al. · 2024

Background Differentiating infections from sterile inflammation is crucial in early AP management. Aim This study aimed to analyse the source, microbiological profile, and impact of infections in AP and to assess the capability of Neutroph…

Editorial Welcome to SMART-MD Journal of Precision Medicine Open

David C. Whitcomb · 2024

The founding editor-in-chief provides the justification, motivation and anticipated utility of a new Precision Medicine journal.

3. SMART Medical Review: CA 19-9 and pancreatic ductal adenocarcinoma (PDAC). Open

David C. Whitcomb, Talia DeFrancesco Oranburg, Rhea U. Vallente, Randall E. Brand · 2024

Carbohydrate antigen 19-9 (CA 19-9) is the sole FDA-approved serum biomarker for early detection, progression, and treatment response of pancreatic ductal adenocarcinoma (PDAC, pancreatic cancer). It is more specific than other serum bioma…

2. Diagnosis of Chronic Pancreatitis Open

David C. Whitcomb, Dhiraj Yadav · 2024

Chronic pancreatitis (CP) is a clinically defined, usually progressive chronic inflammatory disease of the pancreas based on a combination of signs and symptoms. Current criteria for diagnosis rely on overt moderate-severe morphologic chan…

Interventions for Pancreatitis—New Approaches, Knowledge Gaps, and Research Opportunities Open

Anna Evans Phillips, Steven J. Hughes, Dana K. Andersen, Adam C. Bell, Randall E. Brand , et al. · 2024

There exists no cure for acute, recurrent acute or chronic pancreatitis and treatments to date have been focused on managing symptoms. A recent workshop held by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) f…

Diagnostic and Prognostic Biomarkers of Chronic Pancreatitis: A Conceptual Framework Based on the PRoBE Design Open

Dhiraj Yadav, Darwin L. Conwell, Stephen J. Pandol, Hanno Steen, Ziding Feng , et al. · 2024

Reply Open

David C. Whitcomb, Anna M. Buchner, Chris E. Forsmark · 2024

Cytokine signatures in post-endoscopic retrograde cholangiopancreatography pancreatitis: a pilot study Open

Jorge D. Machicado, Peter J. Lee, Stacey Culp, Kimberly Stello, Phil A. Hart , et al. · 2024

Pre-ERCP IL-8 and post-ERCP HGF are associated with the development of PEP. Findings from this pilot study can inform the design of translational work in the immunopathogenesis of PEP.

AGA Clinical Practice Update on the Epidemiology, Evaluation, and Management of Exocrine Pancreatic Insufficiency: Expert Review Open

David C. Whitcomb, Anna M. Buchner, Chris E. Forsmark · 2023

Definition and Classification of Chronic Pancreatitis Open

David C. Whitcomb · 2023

Chronic pancreatitis (CP) is a complex inflammatory disease of the pancreas arising from multiple etiologies. No two patients with this disease are alike. Each patient transitions from normal to end-stage disease with multiple complication…

Hereditary Pancreatitis and Complex Genetic Causes Open

Celeste Shelton Ohlsen, David C. Whitcomb · 2023

Hereditary pancreatitis (HP) is a rare genetic disorder characterized by recurrent acute pancreatitis (RAP) and/or chronic pancreatitis (CP) in a family and most often follows an autosomal dominant pattern of inheritance. The primary manif…

Relationship of circulating levels of long-chain fatty acids to persistent organ failure in acute pancreatitis Open

Anna Evans Phillips, Annette Wilson, Phil J. Greer, Alice Hinton, Stacey Culp , et al. · 2023

Drivers of the inflammatory response in acute pancreatitis remain incompletely understood. Unsaturated fatty acids, specifically palmitoleic, appear to have an association with more severe acute pancreatitis. This finding presents a new cl…

Erratum. Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases: Workshop Proceedings. Diabetes 2023;72:433–448 Open

Teresa L. Mastracci, Minoti V. Apte, Laufey T. Ámundadóttir, Alexandra Alvarsson, Steven E. Artandi , et al. · 2023

In the article cited above, the affiliations for authors Stephen J. Pandol and Maike Sander were inadvertently transposed. The correct affiliation for Stephen J. Pandol is Department of Gastroenterology, Cedars-Sinai Medical Center, Los An…

Data from Serum Biomarker Panels for the Detection of Pancreatic Cancer Open