Jun Chen
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View article: Refining adjuvant immunotherapy strategy for resectable ESCCA call for exposure definition, MRD integration, and value-based models — letter to the editor
Refining adjuvant immunotherapy strategy for resectable ESCCA call for exposure definition, MRD integration, and value-based models — letter to the editor Open
View article: Relationship between obesity, sleep duration and rheumatoid arthritis in middle-aged and elderly of China: Evidence from a nationally representative cross-sectional study
Relationship between obesity, sleep duration and rheumatoid arthritis in middle-aged and elderly of China: Evidence from a nationally representative cross-sectional study Open
Obesity and insufficient sleep have been linked to increased rheumatoid arthritis risk, but evidence on their combined effects remains limited. This study examined the joint association of body mass index (BMI), nap duration, and nighttime…
View article: Letter to the editor——intratumoral and peritumoral heterogeneity based on CT to predict the pathological response after neoadjuvant chemoimmunotherapy in esophageal squamous cell carcinoma
Letter to the editor——intratumoral and peritumoral heterogeneity based on CT to predict the pathological response after neoadjuvant chemoimmunotherapy in esophageal squamous cell carcinoma Open
View article: An Association Between GLP-1 Receptor Expression on Regulatory T Cells and the Severity of Coronary Artery Stenosis and Inflammatory Dysregulation in Coronary Heart Disease
An Association Between GLP-1 Receptor Expression on Regulatory T Cells and the Severity of Coronary Artery Stenosis and Inflammatory Dysregulation in Coronary Heart Disease Open
Background: Regulatory T cells (Tregs) play pivotal roles in immune homeostasis; however, the association between Tregs and the pathogenesis of coronary heart disease (CHD) remains unclear. Thus, this study aimed to investigate the relatio…
View article: Prevalence of and factors influencing elevated blood pressure among Chinese adolescents: a cross-sectional study
Prevalence of and factors influencing elevated blood pressure among Chinese adolescents: a cross-sectional study Open
Objective This study aims to examine the prevalence of elevated blood pressure (BP) among adolescents aged 13–17 years in Shiyan city, Hubei province, China. Additionally, it analyses the distribution characteristics and potential factors …
View article: miR-872 Protection Against Renal Ischemia-Reperfusion Injury via Targeting HMOX1
miR-872 Protection Against Renal Ischemia-Reperfusion Injury via Targeting HMOX1 Open
Background Renal ischemia-reperfusion (IR) is an inevitable process in kidney transplantation and a main cause of acute kidney injury (AKI). The present study aimed to explore the potential miRNA-mRNA network in the development of renal IR…
View article: Non-traditional lipid biomarkers in atherosclerotic cardiovascular disease: pathophysiological mechanisms and strategies to address residual risk
Non-traditional lipid biomarkers in atherosclerotic cardiovascular disease: pathophysiological mechanisms and strategies to address residual risk Open
Atherosclerotic cardiovascular disease (ASCVD) pathogenesis is fundamentally driven by dyslipidemia, characterized by lipid metabolism disorders that facilitate cholesterol deposition within damaged vascular endothelia. This process culmin…
View article: The next frontier in antibody-drug conjugates: challenges and opportunities in cancer and autoimmune therapy
The next frontier in antibody-drug conjugates: challenges and opportunities in cancer and autoimmune therapy Open
Antibody-Drug Conjugates (ADCs) have achieved significant success in cancer therapy by combining the targeting specificity of monoclonal antibodies with cytotoxic payloads. However, the concomitant issue of drug resistance has become incre…
View article: A Comprehensive Review of Mock Circulation Loop Systems for Experimental Hemodynamics of Cardiovascular Diseases
A Comprehensive Review of Mock Circulation Loop Systems for Experimental Hemodynamics of Cardiovascular Diseases Open
Cardiovascular diseases remain the leading cause of morbidity and mortality worldwide, underscoring the need for continuous innovation in diagnostics and treatment. Mock circulation loops (MCLs) systems have recently emerged as new researc…
View article: Immune Dysregulation at the Maternal–Fetal Interface Exacerbates Adverse Pregnancy Outcomes in an Inflammatory Arthritis Murine Model
Immune Dysregulation at the Maternal–Fetal Interface Exacerbates Adverse Pregnancy Outcomes in an Inflammatory Arthritis Murine Model Open
Objective: Inflammatory arthritis (IA) has been linked to a number of adverse pregnancy outcomes (APOs), but the mechanisms linking IA-related immune dysregulation to compromised reproductive success remain poorly understood. This project …
View article: Deciphering the regulatory networks of human male germline development from embryo to adulthood
Deciphering the regulatory networks of human male germline development from embryo to adulthood Open
Male germline development is crucial for the proper establishment of spermatogonial stem cell pool and life-long production of spermatozoa, but the full-term developmental profiling of human male germline is not fully understood. Here, by …
View article: The clinical significance of T-cell regulation in hypertension treatment
The clinical significance of T-cell regulation in hypertension treatment Open
Hypertension, a globally prevalent condition, is closely associated with T cell-mediated inflammatory responses. Studies have shown that T cells, by secreting pro-inflammatory cytokines such as interferon-gamma (IFN-γ), Interleukin-17 (IL-…
View article: Evaluation of aortic arch calcification to predict prognosis after transcatheter aortic valve replacement
Evaluation of aortic arch calcification to predict prognosis after transcatheter aortic valve replacement Open
Few centers routinely report aortic arch calcification (AAC) due to the lack of an easy and effective evaluation method. The association between AAC and the clinical prognosis of patients who undergo transcatheter aortic valve replacement …
View article: Recent Clinical Updates of Hypertrophic Cardiomyopathy and Future Therapeutic Strategies
Recent Clinical Updates of Hypertrophic Cardiomyopathy and Future Therapeutic Strategies Open
Hypertrophic cardiomyopathy (HCM) is the most prevalent inherited cardiomyopathy transmitted in an autosomal dominant manner to offspring. It is characterized by unexplained asymmetrical hypertrophy primarily affecting the left ventricle a…
View article: The correlation between the atherogenic index of plasma and the severity of coronary artery disease in acute myocardial infarction patients under different glucose metabolic states
The correlation between the atherogenic index of plasma and the severity of coronary artery disease in acute myocardial infarction patients under different glucose metabolic states Open
View article: Evaluating compliance in three-dimensional-printed polymeric vascular grafts compared to human arteries and commercial grafts in a mock circulation loop compliance in three-dimensional-printed polymeric vascular grafts
Evaluating compliance in three-dimensional-printed polymeric vascular grafts compared to human arteries and commercial grafts in a mock circulation loop compliance in three-dimensional-printed polymeric vascular grafts Open
View article: APOE genotype modifies benefits of calorie restriction against aging
APOE genotype modifies benefits of calorie restriction against aging Open
Background The efficacy of Calorie Restriction (CR) in enhancing cognition, promoting healthy aging, and extending lifespan is well‐established. Yet, it remains unclear whether the apolipoprotein E ( APOE ) genotype, a known modifier for a…
View article: The functions of apolipoproteins and lipoproteins in health and disease
The functions of apolipoproteins and lipoproteins in health and disease Open
View article: Circulating CCRR serves as potential novel biomarker for predicting acute myocardial infarction
Circulating CCRR serves as potential novel biomarker for predicting acute myocardial infarction Open
Objective Cold regions exhibit a high prevalence of cardiovascular disease, particularly acute myocardial infarction (AMI), which is one of the leading causes of death associated with cardiovascular conditions. Cardiovascular disease is cl…
View article: Impact of repositioning on brain injury following transcatheter aortic valve replacement with a self-expanding valve
Impact of repositioning on brain injury following transcatheter aortic valve replacement with a self-expanding valve Open
View article: Relationship between the severity of functional mitral regurgitation at admission and one-year outcomes in patients hospitalized for acute heart failure with mildly reduced ejection fraction
Relationship between the severity of functional mitral regurgitation at admission and one-year outcomes in patients hospitalized for acute heart failure with mildly reduced ejection fraction Open
Background The epidemiological distribution of functional mitral regurgitation (FMR) in heart failure (HF) and mildly reduced ejection fraction (HFmrEF) patients and its impact on outcomes remains unclear. We attempt to investigate the pro…
View article: A self-reported symptom-based decision-making model helps to rule out outpatient cases at low risk for CRC before colonoscopy
A self-reported symptom-based decision-making model helps to rule out outpatient cases at low risk for CRC before colonoscopy Open
View article: Mid1 promotes synovitis in rheumatoid arthritis via ubiquitin-dependent post-translational modification
Mid1 promotes synovitis in rheumatoid arthritis via ubiquitin-dependent post-translational modification Open
Overall, our findings suggest that the ubiquitination of DPP4 by Mid1 promotes synovial cell proliferation and invasion, exacerbating synovitis in RA. These results reveal a novel mechanism that controls synovial activation, positioning Mi…
View article: Corrigendum: NmFGF1-regulated glucolipid metabolism and angiogenesis improves functional recovery in a mouse model of diabetic stroke and acts via the AMPK signaling pathway
Corrigendum: NmFGF1-regulated glucolipid metabolism and angiogenesis improves functional recovery in a mouse model of diabetic stroke and acts via the AMPK signaling pathway Open
[This corrects the article DOI: 10.3389/fphar.2021.680351.].
View article: Precision Medicine in Rheumatic Diseases: Unlocking the Potential of Antibody-Drug Conjugates
Precision Medicine in Rheumatic Diseases: Unlocking the Potential of Antibody-Drug Conjugates Open
View article: Association between left ventricular remodeling and lipid profiles in obese children: an observational study
Association between left ventricular remodeling and lipid profiles in obese children: an observational study Open
Objective Childhood obesity has become a prominent issue in the society, which can lead to left ventricular remodeling and severe cardiovascular complications in adulthood. It is beneficial to identify the causes of left ventricular remode…
View article: The participation of global DNA demethylation in human male meiotic recombination
The participation of global DNA demethylation in human male meiotic recombination Open
View article: Diagnostic Accuracy of Left Atrial/Left Atrial Appendage Thrombus in Patients with Atrial Fibrillation: A Systematic Review and Network Meta-Analysis
Diagnostic Accuracy of Left Atrial/Left Atrial Appendage Thrombus in Patients with Atrial Fibrillation: A Systematic Review and Network Meta-Analysis Open
Background: This paper aimed to appraise the diagnostic precision of assorted methodologies to identify left atrial/left atrial appendage (LA/LAA) thrombus through a network meta-assessment. Methods: Methodologically, we conducted a compre…
View article: Macrophage CAPN4 regulates CVB3-induced cardiac inflammation and injury by promoting NLRP3 inflammasome activation and phenotypic transformation to the inflammatory subtype
Macrophage CAPN4 regulates CVB3-induced cardiac inflammation and injury by promoting NLRP3 inflammasome activation and phenotypic transformation to the inflammatory subtype Open
Exploring the immune mechanism of coxsackievirus B3 (CVB3)-induced myocarditis may provide a promising therapeutic strategy. Here, we investigated the regulatory role of macrophage CAPN4 in the phenotypic transformation of macrophages and …
View article: Nursing Interventions and Care Strategies for Patients with Coronary Heart Disease: A Comprehensive Review
Nursing Interventions and Care Strategies for Patients with Coronary Heart Disease: A Comprehensive Review Open
Cardiovascular diseases are a major cause of death worldwide, and coronary heart disease (CHD) is a prevalent cardiovascular condition and a significant health burden for the population. In this disease, insufficient blood flow to the hear…