Dennis A. Carson
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View article: FZD7 expression marks mammary tumor–initiating cells
FZD7 expression marks mammary tumor–initiating cells Open
The WNT signaling pathway has long been implicated in tumorigenesis across multiple cancer types, including breast cancer. However, the complexity arising from the large number of WNTs and their receptors has made it challenging to pinpoin…
View article: Enhancing vaccine immunogenicity through heterologous prime-boost regimen with multiple nasal boosting with liposomal TLR7 ligand
Enhancing vaccine immunogenicity through heterologous prime-boost regimen with multiple nasal boosting with liposomal TLR7 ligand Open
Intranasal administration of Lipo-1V270 in a heterologous prime-boost vaccination regimen effectively enhances mucosal immunity against influenza virus infection, with an acceptable innate immune-mediated adverse effects profile. This stra…
View article: Harnessing an integrated glyco-nanovaccine technology for enhanced cancer immunotherapy
Harnessing an integrated glyco-nanovaccine technology for enhanced cancer immunotherapy Open
These findings underscore the potential of iGN as a strategy to enhance cancer immunotherapy, particularly when used in combination with immune checkpoint blockade, to bolster anti-tumor immune responses and improve therapeutic outcomes.
View article: Harnessing an integrated glyco-nanovaccine technology for enhanced cancer immunotherapy
Harnessing an integrated glyco-nanovaccine technology for enhanced cancer immunotherapy Open
Cancer immunotherapy, particularly using immune checkpoint inhibitors, has revolutionized cancer treatment; however, its efficacy remains limited to a subset of patients. Nanoparticles have potential in cancer treatment because they offer …
View article: Identification of a Novel Small Molecule That Enhances the Release of Extracellular Vesicles with Immunostimulatory Potency via Induction of Calcium Influx
Identification of a Novel Small Molecule That Enhances the Release of Extracellular Vesicles with Immunostimulatory Potency via Induction of Calcium Influx Open
Extracellular vesicles (EVs) transfer antigens and immunomodulatory molecules in immunologic synapses as a part of intracellular communication, and EVs equipped with immunostimulatory functions have been utilized for vaccine formulation. H…
View article: Data from Irreversible Electroporation Combined with Checkpoint Blockade and TLR7 Stimulation Induces Antitumor Immunity in a Murine Pancreatic Cancer Model
Data from Irreversible Electroporation Combined with Checkpoint Blockade and TLR7 Stimulation Induces Antitumor Immunity in a Murine Pancreatic Cancer Model Open
Irreversible electroporation (IRE) is a nonthermal ablation technique that is used clinically in selected patients with locally advanced pancreatic cancer, but most patients develop recurrent distant metastatic disease. We hypothesize that…
View article: List of KPC Peptides from Irreversible Electroporation Combined with Checkpoint Blockade and TLR7 Stimulation Induces Antitumor Immunity in a Murine Pancreatic Cancer Model
List of KPC Peptides from Irreversible Electroporation Combined with Checkpoint Blockade and TLR7 Stimulation Induces Antitumor Immunity in a Murine Pancreatic Cancer Model Open
List of KPC Peptides
View article: List of KPC Peptides from Irreversible Electroporation Combined with Checkpoint Blockade and TLR7 Stimulation Induces Antitumor Immunity in a Murine Pancreatic Cancer Model
List of KPC Peptides from Irreversible Electroporation Combined with Checkpoint Blockade and TLR7 Stimulation Induces Antitumor Immunity in a Murine Pancreatic Cancer Model Open
List of KPC Peptides
View article: Supplementary Figures and Tables from Irreversible Electroporation Combined with Checkpoint Blockade and TLR7 Stimulation Induces Antitumor Immunity in a Murine Pancreatic Cancer Model
Supplementary Figures and Tables from Irreversible Electroporation Combined with Checkpoint Blockade and TLR7 Stimulation Induces Antitumor Immunity in a Murine Pancreatic Cancer Model Open
Supplementary Figures 1-6 and Supplementary Tables 1 and 2.
View article: Data from Irreversible Electroporation Combined with Checkpoint Blockade and TLR7 Stimulation Induces Antitumor Immunity in a Murine Pancreatic Cancer Model
Data from Irreversible Electroporation Combined with Checkpoint Blockade and TLR7 Stimulation Induces Antitumor Immunity in a Murine Pancreatic Cancer Model Open
Irreversible electroporation (IRE) is a nonthermal ablation technique that is used clinically in selected patients with locally advanced pancreatic cancer, but most patients develop recurrent distant metastatic disease. We hypothesize that…
View article: Supplementary Figures and Tables from Irreversible Electroporation Combined with Checkpoint Blockade and TLR7 Stimulation Induces Antitumor Immunity in a Murine Pancreatic Cancer Model
Supplementary Figures and Tables from Irreversible Electroporation Combined with Checkpoint Blockade and TLR7 Stimulation Induces Antitumor Immunity in a Murine Pancreatic Cancer Model Open
Supplementary Figures 1-6 and Supplementary Tables 1 and 2.
View article: Treatment of pancreatic cancer with irreversible electroporation and intratumoral CD40 antibody stimulates systemic immune responses that inhibit liver metastasis in an orthotopic model
Treatment of pancreatic cancer with irreversible electroporation and intratumoral CD40 antibody stimulates systemic immune responses that inhibit liver metastasis in an orthotopic model Open
Background Pancreatic cancer (PC) has a poor prognosis, and most patients present with either locally advanced or distant metastatic disease. Irreversible electroporation (IRE) is a non-thermal method of ablation used clinically in locally…
View article: 861 Combined irreversible electroporation and local CD40 agonism stimulate neoantigen specific systemic immune responses that inhibit liver metastasis in an orthotopic pancreatic cancer model
861 Combined irreversible electroporation and local CD40 agonism stimulate neoantigen specific systemic immune responses that inhibit liver metastasis in an orthotopic pancreatic cancer model Open
Background Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis, and most patients present with either locally advanced or metastatic disease. Irreversible Electroporation (IRE) is a non-thermal method of ablation, used clinically …
View article: A Dual Adjuvant System for Intranasal Boosting of Local and Systemic Immunity for Influenza Vaccination
A Dual Adjuvant System for Intranasal Boosting of Local and Systemic Immunity for Influenza Vaccination Open
Systemically vaccinated individuals against COVID-19 and influenza may continue to support viral replication and shedding in the upper airways, contributing to the spread of infections. Thus, a vaccine regimen that enhances mucosal immunit…
View article: Treatment of pancreatic cancer with irreversible electroporation and intratumoral CD40 antibody stimulates systemic immune responses that inhibit liver metastasis in an orthotopic model
Treatment of pancreatic cancer with irreversible electroporation and intratumoral CD40 antibody stimulates systemic immune responses that inhibit liver metastasis in an orthotopic model Open
Background Pancreatic cancer (PC) has a poor prognosis, and most patients present with either locally advanced or distant metastatic disease. Irreversible Electroporation (IRE) is a non-thermal method of ablation used clinically in locally…
View article: A Triple High Throughput Screening for Extracellular Vesicle Inducing Agents With Immunostimulatory Activity
A Triple High Throughput Screening for Extracellular Vesicle Inducing Agents With Immunostimulatory Activity Open
Extracellular vesicles (EVs) play an important role in intercellular communication and regulation of cells, especially in the immune system where EVs can participate in antigen presentation and may have adjuvant effects. We aimed to identi…
View article: Small Molecule Calcium Channel Activator Potentiates Adjuvant Activity
Small Molecule Calcium Channel Activator Potentiates Adjuvant Activity Open
There remains an unmet need for reliable fully synthetic adjuvants that increase lasting protective immune responses from vaccines. We previously reported a high-throughput screening for small molecules that extended nuclear factor kappa-l…
View article: A FZD7-specific Antibody–Drug Conjugate Induces Ovarian Tumor Regression in Preclinical Models
A FZD7-specific Antibody–Drug Conjugate Induces Ovarian Tumor Regression in Preclinical Models Open
Although WNT signaling is frequently dysregulated in solid tumors, drugging this pathway has been challenging due to off-tumor effects. Current clinical pan-WNT inhibitors are nonspecific and lead to adverse effects, highlighting the urgen…
View article: Small Molecule Potentiator of Adjuvant Activity Enhancing Survival to Influenza Viral Challenge
Small Molecule Potentiator of Adjuvant Activity Enhancing Survival to Influenza Viral Challenge Open
As viruses continue to mutate the need for rapid high titer neutralizing antibody responses has been highlighted. To meet these emerging threats, agents that enhance vaccine adjuvant activity are needed that are safe with minimal local or …
View article: Mitochondria-dependent synthetic small-molecule vaccine adjuvants for influenza virus infection
Mitochondria-dependent synthetic small-molecule vaccine adjuvants for influenza virus infection Open
Significance Effective vaccine strategies are needed to overcome genetic, physiologic, or age-related deficits in immune responses relevant to vulnerable populations. Vaccine adjuvants that overcome these variants and do not compromise saf…
View article: Structure-activity relationship studies in substituted sulfamoyl benzamidothiazoles that prolong NF-κB activation
Structure-activity relationship studies in substituted sulfamoyl benzamidothiazoles that prolong NF-κB activation Open
View article: Generation and Application of a Reporter Cell Line for the Quantitative Screen of Extracellular Vesicle Release
Generation and Application of a Reporter Cell Line for the Quantitative Screen of Extracellular Vesicle Release Open
Extracellular vesicles (EVs) are identified as mediators of intercellular communication and cellular regulation. In the immune system, EVs play a role in antigen presentation as a part of cellular communication. To enable drug discovery an…
View article: Oral administration of PEGylated TLR7 ligand ameliorates alcohol-associated liver disease via the induction of IL-22
Oral administration of PEGylated TLR7 ligand ameliorates alcohol-associated liver disease via the induction of IL-22 Open
Significance Alcoholic hepatitis (AH) is a severe form of alcohol-associated liver disease (ALD) that is characterized by chronic liver injury and inflammation. The current treatment strategy for AH involves the use of corticosteroids, des…
View article: Selective activation of FZD7 promotes mesendodermal differentiation of human pluripotent stem cells
Selective activation of FZD7 promotes mesendodermal differentiation of human pluripotent stem cells Open
WNT proteins are secreted symmetry breaking signals that interact with cell surface receptors of the FZD family to regulate a multitude of developmental processes. Studying selectivity between WNTs and FZDs has been hampered by the paucity…
View article: Identification of Compounds With Glucocorticoid Sparing Effects on Suppression of Chemokine and Cytokine Production by Rheumatoid Arthritis Fibroblast-Like Synoviocytes
Identification of Compounds With Glucocorticoid Sparing Effects on Suppression of Chemokine and Cytokine Production by Rheumatoid Arthritis Fibroblast-Like Synoviocytes Open
In recent years target based drug discovery has expanded our therapeutic armamentarium in the treatment of inflammatory and autoimmune diseases. Despite these advances and adverse effects, glucocorticoids remain reliable agents that are us…
View article: Author response: Selective activation of FZD7 promotes mesendodermal differentiation of human pluripotent stem cells
Author response: Selective activation of FZD7 promotes mesendodermal differentiation of human pluripotent stem cells Open
View article: Selective activation of FZD7 promotes mesendodermal differentiation of human pluripotent stem cells
Selective activation of FZD7 promotes mesendodermal differentiation of human pluripotent stem cells Open
WNT proteins are secreted symmetry breaking signals that interact with cell surface receptors of the FZD family to regulate a multitude of developmental processes. Studying selectivity between WNTs and FZDs has been hampered by the paucity…
View article: A Novel Synthetic Dual Agonistic Liposomal TLR4/7 Adjuvant Promotes Broad Immune Responses in an Influenza Vaccine With Minimal Reactogenicity
A Novel Synthetic Dual Agonistic Liposomal TLR4/7 Adjuvant Promotes Broad Immune Responses in an Influenza Vaccine With Minimal Reactogenicity Open
The limited efficacy of seasonal influenza vaccines is usually attributed to ongoing variation in the major antigenic targets for protective antibody responses including hemagglutinin (HA) and neuraminidase (NA). Hence, vaccine development…
View article: Editorial: Wnt Signaling in Immune Cell Regulation During Microbial Infection and Cancer
Editorial: Wnt Signaling in Immune Cell Regulation During Microbial Infection and Cancer Open
EDITORIAL article Front. Immunol., 05 June 2020Sec. Cancer Immunity and Immunotherapy Volume 11 - 2020 | https://doi.org/10.3389/fimmu.2020.01133
View article: Immunostimulatory TLR7 Agonist‐Nanoparticles Together with Checkpoint Blockade for Effective Cancer Immunotherapy
Immunostimulatory TLR7 Agonist‐Nanoparticles Together with Checkpoint Blockade for Effective Cancer Immunotherapy Open
Mono‐ or dual‐checkpoint inhibitors for immunotherapy have changed the paradigm of cancer care; however, only a minority of patients responds to such treatment. Combining small molecule immunostimulators can improve treatment efficacy, but…