Christina Chambers
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View article: Varied human milk oligosaccharides in human milk from mothers treated with antidepressants and anti-inflammatories
Varied human milk oligosaccharides in human milk from mothers treated with antidepressants and anti-inflammatories Open
Background Human milk oligosaccharides (HMOs) are abundant carbohydrates in human milk, providing infants with numerous health benefits, but it is not known whether maternal medications could affect them. We aimed to study the association …
View article: Genome x Environment analysis of Sudden Unexpected Infant Death unveils etiologic heterogeneity and strong cannabis and genetic disease risks
Genome x Environment analysis of Sudden Unexpected Infant Death unveils etiologic heterogeneity and strong cannabis and genetic disease risks Open
Sudden Unexpected Infant Death (SUID), the third leading cause of infant death, has increasing incidence and multifactorial etiology. Identification of preventative interventions has hitherto been hindered by etiologic studies limited to g…
View article: Cognitive Outcomes of Children Exposed to Selective Serotonin Reuptake Inhibitors Through Breast Milk
Cognitive Outcomes of Children Exposed to Selective Serotonin Reuptake Inhibitors Through Breast Milk Open
Importance The cognitive performance of children prenatally exposed to selective serotonin reuptake inhibitors (SSRIs) has in some studies been shown to be reduced compared with that of unexposed children, potentially by factors associated…
View article: Association between census‐tract Social Vulnerability Index and preterm birth rates
Association between census‐tract Social Vulnerability Index and preterm birth rates Open
Importance Preterm birth (PTB) is a leading cause of neonatal morbidity and mortality. Understanding how sociodemographic factors alter the risk of PTB, as quantified by the Social Vulnerability Index (SVI), can guide the development of ta…
View article: Endometriosis and Adverse Pregnancy Outcomes: A Dual-Cohort Study of Over 4 Million California Births
Endometriosis and Adverse Pregnancy Outcomes: A Dual-Cohort Study of Over 4 Million California Births Open
Although endometriosis is increasingly recognized as a risk factor for adverse pregnancy outcomes, large-scale analyses in U.S. populations remain limited. In this retrospective dual-cohort study, we analyzed over 4 million singleton birth…
View article: First trimester maternal infections and offspring congenital heart defects: a meta-analysis
First trimester maternal infections and offspring congenital heart defects: a meta-analysis Open
Background and Aims Maternal infections have been proposed to play a role in the development of congenital heart defects (CHD). This study aims to synthesize contemporary evidence on the association between first-trimester maternal infecti…
View article: Metformin for the Prevention of Hyperemesis Gravidarum: An Observational Cohort Study
Metformin for the Prevention of Hyperemesis Gravidarum: An Observational Cohort Study Open
Objective To evaluate if metformin treatment prior to pregnancy reduces the likelihood of nausea and vomiting in pregnancy (NVP) and hyperemesis gravidarum (HG) compared to no exposure. Design Observational cohort study. Setting The Mother…
View article: Lower Adherence to Breastfeeding Recommendations in Mothers Treated With Antirheumatic and Antidepressant Medications
Lower Adherence to Breastfeeding Recommendations in Mothers Treated With Antirheumatic and Antidepressant Medications Open
Background: Exclusive breastfeeding for 6 months is recommended, but breastfeeding safety data is insufficient for several medications. Aim: To determine if mothers treated with chronic medications are less likely to breastfeed. Methods: F…
View article: STUDY DESIGN AND RECRUITMENT INTO THE BELIMUMAB MOTHERTOBABY PREGNANCY EXPOSURE STUDY: AN OTIS AUTOIMMUNE DISEASES IN PREGNANCY PROJECT
STUDY DESIGN AND RECRUITMENT INTO THE BELIMUMAB MOTHERTOBABY PREGNANCY EXPOSURE STUDY: AN OTIS AUTOIMMUNE DISEASES IN PREGNANCY PROJECT Open
PV187 / #637 Poster Topic: AS21 - Pregnancy and Reproductive Health Background/Purpose Belimumab is a human monoclonal antibody that inhibits B lymphocyte stimulator protein (BLyS). Among other countries, belimumab is approved in the Unite…
View article: OXSeg: Multidimensional attention UNet-based lip segmentation using semi-supervised lip contours
OXSeg: Multidimensional attention UNet-based lip segmentation using semi-supervised lip contours Open
Lip segmentation plays a crucial role in various domains, such as lip synchronization, lipreading, and diagnostics. However, the effectiveness of supervised lip segmentation is constrained by the availability of lip contour in the training…
View article: In Reply
In Reply Open
status: Published
View article: Improving data harmonization in pregnancy safety studies: Demonstrating the feasibility of standardized data analysis of pregnancy reports–A contribution from the conception project
Improving data harmonization in pregnancy safety studies: Demonstrating the feasibility of standardized data analysis of pregnancy reports–A contribution from the conception project Open
Introduction: Aligned with the Innovative Medicines Initiative (IMI) ConcePTION project’s goal of advancing drug safety research in pregnancy, we explored the feasibility of employing a standardized list of core data elements (CDEs) and st…
View article: Macronutrients in Human Milk Exposed to Antidepressant and Anti-Inflammatory Medications
Macronutrients in Human Milk Exposed to Antidepressant and Anti-Inflammatory Medications Open
Importance The association between maternal medications and the macronutrient composition of human milk has not been studied. Objective To compare macronutrient levels in milk samples from mothers treated with long-term medications with sa…
View article: OXSeg: Multidimensional Attention UNet-Based Lip Segmentation Using Semi-Supervised Lip Contours
OXSeg: Multidimensional Attention UNet-Based Lip Segmentation Using Semi-Supervised Lip Contours Open
Lip segmentation plays a crucial role in various domains, such as lip synchronization, lip-reading, and diagnostics. However, the effectiveness of supervised lip segmentation is constrained by the availability of lip contour in the trainin…
View article: Adverse pregnancy outcomes across SLE subgroups: significance of cardiovascular events
Adverse pregnancy outcomes across SLE subgroups: significance of cardiovascular events Open
Objective SLE is associated with increased risks of maternal cardiovascular events (CVEs) as well as adverse pregnancy outcomes. The influence of maternal CVEs on pregnancy complications in lupus is not clearly known. Our primary aim was t…
View article: Acetaminophen in Pregnancy and Attention-Deficit and Hyperactivity Disorder and Autism Spectrum Disorder
Acetaminophen in Pregnancy and Attention-Deficit and Hyperactivity Disorder and Autism Spectrum Disorder Open
Acetaminophen is a common over-the-counter medication that recently gained substantial media attention regarding its use by pregnant individuals. In this clinical perspective, we discuss the strengths and limitations of the published liter…
View article: Identification of Chronic Hypertension in Pregnancy in Three Administrative Data Sources Among Medicaid‐Funded Births in California
Identification of Chronic Hypertension in Pregnancy in Three Administrative Data Sources Among Medicaid‐Funded Births in California Open
Purpose Administrative data sources are used to describe the epidemiology of chronic hypertension in pregnancy and its consequences. Differences in identification across sources may affect research estimates. We compared identification of …
View article: Prenatal homelessness, food insecurity, and unemployment and adverse infant outcomes in a California cohort, 2007–2020
Prenatal homelessness, food insecurity, and unemployment and adverse infant outcomes in a California cohort, 2007–2020 Open
Objectives Characterize the relationship between infant outcomes and prenatal homelessness, food insecurity and unemployment. Study design California live births between 22- and 44-weeks’ gestation comprised 6,089,327 pregnancies (2007–202…
View article: The University of California Study of Outcomes in Mothers and Infants (a Population-Based Research Resource): Retrospective Cohort Study
The University of California Study of Outcomes in Mothers and Infants (a Population-Based Research Resource): Retrospective Cohort Study Open
Background Population-based databases are valuable for perinatal research. The California Department of Health Care Access and Information (HCAI) created a linked birth file covering the years 1991 through 2012. This file includes birth an…
View article: Early Maternal Prenatal Cannabis Use and Child Developmental Delays
Early Maternal Prenatal Cannabis Use and Child Developmental Delays Open
Importance Maternal prenatal cannabis use is associated with adverse neonatal health effects, yet little is known about its association with child developmental outcomes. Objective To evaluate associations between maternal prenatal cannabi…
View article: Risk and Protective Factors for Preterm Birth Among Racial, Ethnic, and Socioeconomic Groups in California
Risk and Protective Factors for Preterm Birth Among Racial, Ethnic, and Socioeconomic Groups in California Open
Importance Preterm birth (PTB) (gestational age <37 weeks) is a major cause of infant mortality and morbidity in the US and is marked by racial and ethnic and socioeconomic inequities. Further research is needed to elucidate the ass…
View article: The Association Between Maternal Psychological Health and Human Milk Oligosaccharide Composition
The Association Between Maternal Psychological Health and Human Milk Oligosaccharide Composition Open
Background and Objective: Human milk oligosaccharides (HMOs) are carbohydrates abundant in human breast milk. Their composition varies widely among women, and prior research has identified numerous factors contributing to this variation. H…
View article: An introduction to the HEALthy Brain and Child Development Study (HBCD) study
An introduction to the HEALthy Brain and Child Development Study (HBCD) study Open
The fundamental organization of the human brain is established before birth, with rapid growth continuing over the first postnatal years. Children exposed before or after birth to various biological (e.g., substance exposure) or psychosoci…
View article: Altered circadian expression of clock genes and clock-regulatory epigenetic modifiers in saliva of children with fetal alcohol spectrum disorders
Altered circadian expression of clock genes and clock-regulatory epigenetic modifiers in saliva of children with fetal alcohol spectrum disorders Open
Prenatal alcohol-exposed (AE) infants and children often demonstrate disrupted sleep patterns, including more frequent awakenings, reduced total sleep time, and more night-to-night sleep variability. Despite the strong connection between s…