Derek P. Chew
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View article: Prevention of Adverse Cardiovascular Events Using the 23-Valent Pneumococcal Polysaccharide Vaccine
Prevention of Adverse Cardiovascular Events Using the 23-Valent Pneumococcal Polysaccharide Vaccine Open
Importance Animal studies and meta-analysis of human observational data suggest that pneumococcal polysaccharide vaccination (PPV) could be protective against atherosclerosis; however, to the authors’ knowledge, no randomized clinical tria…
View article: The assessment and management of patients with type 2 myocardial infarction: an international Delphi study
The assessment and management of patients with type 2 myocardial infarction: an international Delphi study Open
Aims Type 2 myocardial infarction due to myocardial oxygen supply–demand imbalance is associated with poor outcomes. There are no guidelines to inform care for these patients. The consensus on the assessment and management of type 2 myocar…
View article: Peak Troponin Level and Revascularisation Rate in Type 2 MI
Peak Troponin Level and Revascularisation Rate in Type 2 MI Open
Background: Peak troponin level has been shown to predict benefit from early invasive management in type 1 MI (T1MI), but this relationship has not been established for type 2 MI (T2MI). The aim of this study was to investigate whether pea…
View article: Family history of premature CHD and risk factor control in patients with a recent ACS
Family history of premature CHD and risk factor control in patients with a recent ACS Open
Individuals with a family history of premature coronary heart disease (CHD) have increased cardiac morbidity and mortality, which may motivate them to modify their health behaviours. This analysis examines whether patients with self-report…
View article: Variation in Availability of Continuous Ambulatory Electrocardiographic Monitors Across Canadian Provinces
Variation in Availability of Continuous Ambulatory Electrocardiographic Monitors Across Canadian Provinces Open
The availability of continuous, ambulatory, ECG monitoring across Canadian provinces has considerable variability. Measures are needed to ensure equitable access to ambulatory ECG monitoring services nationwide. Creating national monitorin…
View article: Asian Pacific Society of Cardiology Examinees’ Performance in the European Examination in Core Cardiology (APSC Exit Exam) from 2020 to 2023
Asian Pacific Society of Cardiology Examinees’ Performance in the European Examination in Core Cardiology (APSC Exit Exam) from 2020 to 2023 Open
Background: In response to the need for harmonisation of cardiology training in the Asia-Pacific region, the Asian Pacific Society of Cardiology (APSC) approached the European Society of Cardiology in 2020 to allow its members to take the …
View article: Risk Prediction Modelling of 30-day all-cause mortality following percutaneous coronary intervention in an Australian population: Leveraging Machine Learning
Risk Prediction Modelling of 30-day all-cause mortality following percutaneous coronary intervention in an Australian population: Leveraging Machine Learning Open
Background Pre-procedural risk prediction of 30-day all-cause mortality after percutaneous coronary intervention (PCI) aids in clinical decision-making and benchmarking hospital performance. This study aimed to identify pre-procedural fact…
View article: Re-engineering the clinical approach to suspected cardiac chest pain assessment in the emergency department by expediting research evidence to practice using artificial intelligence. (RAPIDx AI)—a cluster randomized study design
Re-engineering the clinical approach to suspected cardiac chest pain assessment in the emergency department by expediting research evidence to practice using artificial intelligence. (RAPIDx AI)—a cluster randomized study design Open
ANZCTR, Registration Number: ACTRN12620001319965, https://www.anzctr.org.au/.
View article: Prognostic Implications of Machine Learning Algorithm–Supported Diagnostic Classification of Myocardial Injury Using the Fourth Universal Definition of Myocardial Infarction
Prognostic Implications of Machine Learning Algorithm–Supported Diagnostic Classification of Myocardial Injury Using the Fourth Universal Definition of Myocardial Infarction Open
The substantial and persistent rate of late cardiac events highlights the need to establish an evidence base for the therapeutic management of "non-T1MI" diagnostic classifications and suggests opportunity to improve late outcomes using ex…
View article: Human-centred AI for emergency cardiac care: Evaluating RAPIDx AI with PROLIFERATE_AI
Human-centred AI for emergency cardiac care: Evaluating RAPIDx AI with PROLIFERATE_AI Open
RAPIDx AI enhances diagnostic accuracy and efficiency for experienced users, but usability challenges for novices highlight the need for targeted training and interface refinements. The PROLIFERATE_AI framework offers a robust methodology …
View article: Assessing the Likelihood of Procedural Intubation During Percutaneous Coronary Intervention
Assessing the Likelihood of Procedural Intubation During Percutaneous Coronary Intervention Open
Background Preprocedural fasting is widely used before percutaneous coronary intervention (PCI). However, the incidence of procedural intubation during PCI is unknown. This study aims to identify the incidence and predictors for procedural…
View article: Complete Percutaneous Revascularization in Patients Presenting With ST‐Segment Myocardial Infarction Who Have Multivessel Coronary Disease: A Meta‐Analysis of Randomized Trials
Complete Percutaneous Revascularization in Patients Presenting With ST‐Segment Myocardial Infarction Who Have Multivessel Coronary Disease: A Meta‐Analysis of Randomized Trials Open
Background: In patients presenting with ST‐segment elevation myocardial infarction (STEMI) and multivessel coronary artery disease (MVD), the benefit of complete revascularization (CR) with respect to hard endpoints (death or myocardial in…
View article: Effectiveness of the GRACE risk score according to troponin elevation in patients admitted with non-ST elevation acute coronary syndrome: a post hoc analysis of the UKGRIS parallel group cluster randomised controlled trial
Effectiveness of the GRACE risk score according to troponin elevation in patients admitted with non-ST elevation acute coronary syndrome: a post hoc analysis of the UKGRIS parallel group cluster randomised controlled trial Open
Background The effectiveness of risk stratification using the Global Registry of Acute Coronary Events (GRACE) Risk Score (GRS) for patients presenting to hospital with suspected non-ST elevation acute coronary syndrome (NSTEACS) according…
View article: Sodium-glucose cotransporter-2 inhibitor use in type 2 diabetes mellitus is associated with a lower rate of atrial arrhythmias in a hospitalized real-world population
Sodium-glucose cotransporter-2 inhibitor use in type 2 diabetes mellitus is associated with a lower rate of atrial arrhythmias in a hospitalized real-world population Open
In this real-world, comorbid inpatient cohort, SGLT2i treatment was associated with a lower incidence of atrial arrhythmias. Prospective randomized trials evaluating SGLT2i as specific atrial fibrillation pharmacotherapy are underway.
View article: Current Emergency Medical Service Vasoactive Use for the Management of Shock
Current Emergency Medical Service Vasoactive Use for the Management of Shock Open
OBJECTIVES: We sought to describe the indications for vasoactive medication administration, hemodynamic treatment targets, and specific agents used by various international emergency medical service (EMS) providers. DESIGN AND SETTING: In …
View article: Single high-sensitivity troponin-I for ruling out acute coronary syndrome: a detection limit approach
Single high-sensitivity troponin-I for ruling out acute coronary syndrome: a detection limit approach Open
Aims The aim of this study was determine the incidence of major adverse cardiac events within 30 and 365-days among patients discharged from emergency departments (EDs), following a single high-sensitivity cardiac troponin I test result be…
View article: Coronary artery bypass grafting vs. percutaneous coronary intervention in severe ischaemic cardiomyopathy: long-term survival
Coronary artery bypass grafting vs. percutaneous coronary intervention in severe ischaemic cardiomyopathy: long-term survival Open
Background and Aims The optimal revascularization strategy in patients with ischaemic cardiomyopathy remains unclear with no contemporary randomized trial data to guide clinical practice. This study aims to assess long-term survival in pat…
View article: High-Sensitivity Cardiac Troponin T Reporting, Clinical Outcomes, and Health Care Resource Use
High-Sensitivity Cardiac Troponin T Reporting, Clinical Outcomes, and Health Care Resource Use Open
Importance Despite being recommended by clinical guidelines, substantial concerns remain regarding the use of high-sensitivity cardiac troponin assays and whether it is associated with increased resource use, myocardial infarction (MI) or …
View article: Emergency Department Patient Journey Prediction with Machine Learning (Preprint)
Emergency Department Patient Journey Prediction with Machine Learning (Preprint) Open
UNSTRUCTURED N/A Would not let me proceed without entering an abstract despite this paper being a Letter to the Editor.
View article: Cardiac rehabilitation attendance and outcomes 3 years after acute coronary syndrome (ACS): Linked national data of the SNAPSHOT ACS audit
Cardiac rehabilitation attendance and outcomes 3 years after acute coronary syndrome (ACS): Linked national data of the SNAPSHOT ACS audit Open
Background In international guidelines, cardiac rehabilitation is recommended to reduce readmissions, mortality and improve disease management. However, evidence from a long-term follow-up in a representative cohort is scarce. Purpose To c…
View article: Prehospital factors predicting mortality in patients with shock: state-wide linkage study
Prehospital factors predicting mortality in patients with shock: state-wide linkage study Open
Background Patients with shock treated by emergency medical services (EMS) have high morbidity and mortality. Knowledge of prehospital factors predicting outcomes in patients with shock remains limited. We aimed to describe the prehospital…