Ananya Choudhury
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View article: Supplementary Data 1 from Integration of Dose Surface Maps and Genetic Data Identifies the Lower Posterior Rectum as a Key Region for Toxicity after Prostate Cancer Radiotherapy
Supplementary Data 1 from Integration of Dose Surface Maps and Genetic Data Identifies the Lower Posterior Rectum as a Key Region for Toxicity after Prostate Cancer Radiotherapy Open
Supplementary material
View article: Intra-voxel incoherent motion biomarker repeatability in healthy volunteers and sensitivity to chemoradiotherapy-induced changes in patients with uterine cervical cancer
Intra-voxel incoherent motion biomarker repeatability in healthy volunteers and sensitivity to chemoradiotherapy-induced changes in patients with uterine cervical cancer Open
Intra-voxel incoherent motion (IVIM) biomarkers require validation for translation into clinical practice. This work evaluates repeatability and sensitivity to treatment of IVIM biomarkers in the uterine cervix, and assesses suitability of…
View article: Integration of Dose Surface Maps and Genetic Data Identifies the Lower Posterior Rectum as a Key Region for Toxicity after Prostate Cancer Radiotherapy
Integration of Dose Surface Maps and Genetic Data Identifies the Lower Posterior Rectum as a Key Region for Toxicity after Prostate Cancer Radiotherapy Open
Purpose: Genome-wide association studies are the gold standard for identifying SNP associated with rectal toxicity after prostate cancer radiotherapy. However, they often neglect the radiotherapy dose distribution, which is a key contribut…
View article: Sensitivity analysis of dose-response model parameters for the bladder in prostate cancer radiotherapy
Sensitivity analysis of dose-response model parameters for the bladder in prostate cancer radiotherapy Open
Parameter selection significantly influences high-risk subregion identification in DRMs, emphasizing the need for standardized parameter reporting for meaningful external comparisons.
View article: WSB-1 regulates DNA repair and the response to DNA damage response inhibitors in breast cancer
WSB-1 regulates DNA repair and the response to DNA damage response inhibitors in breast cancer Open
Tumour hypoxia is a poor prognostic factor and linked with metastatic spread and treatment resistance in most solid tumours, including breast cancer. We previously showed hypoxia-regulated E3 ligase WSB-1s association with poor prognosis i…
View article: Continuous β− particle exposure: A study of DNA damage in ex vivo peripheral blood mononuclear cells irradiation with Radioiodine
Continuous β− particle exposure: A study of DNA damage in ex vivo peripheral blood mononuclear cells irradiation with Radioiodine Open
View article: Retrospective review of patient factors impacting free-breathing respiratory motion magnitude for MR-guided radiotherapy
Retrospective review of patient factors impacting free-breathing respiratory motion magnitude for MR-guided radiotherapy Open
Patient factors may influence motion management strategy selection for abdominal stereotactic ablative radiotherapy (SABR). This retrospective evaluation investigated the impact of body mass index (BMI), sex, and cirrhosis in 16 patients i…
View article: Gene Expression in Muscle-Invasive and Non-Muscle-Invasive Bladder Cancer Cells Exposed to Hypoxia
Gene Expression in Muscle-Invasive and Non-Muscle-Invasive Bladder Cancer Cells Exposed to Hypoxia Open
Introduction: Hypoxic cancers are radioresistant, but biomarkers based on expression of multiple genes can identify patients who will benefit from hypoxia modification. Most studies identifying relevant genes exposed cells in culture to 1%…
View article: Cell Surface Proteomics Reveals Hypoxia-Regulated Pathways in Cervical and Bladder Cancer
Cell Surface Proteomics Reveals Hypoxia-Regulated Pathways in Cervical and Bladder Cancer Open
Background Plasma membrane proteins (PMPs) play key roles in cell signalling, adhesion, and trafficking, and are attractive therapeutic targets in cancer due to their surface accessibility. However, their typically low abundance limits det…
View article: Starting Solo: Experiences and Challenges of Early Career Psychiatrists in Private Practice in India
Starting Solo: Experiences and Challenges of Early Career Psychiatrists in Private Practice in India Open
Background As India faces a severe shortage of psychiatrists, a growing number of early career psychiatrists are opting for private practice. However, limited literature explores their experiences, challenges, and preparedness in this sett…
View article: Radiation-induced extracellular matrix remodelling drives prognosis and predicts radiotherapy response in muscle-invasive bladder cancer
Radiation-induced extracellular matrix remodelling drives prognosis and predicts radiotherapy response in muscle-invasive bladder cancer Open
Muscle-invasive bladder cancer (MIBC) is a prevalent disease that can be treated with radiotherapy, but has a poor prognosis. Radiation-induced extracellular matrix (ECM) remodelling and fibrosis can induce tumour resistance and recurrence…
View article: Apparatus and Experiments Towards Fully Automated Medical Isotope Production Using an Ion Beam Accelerator
Apparatus and Experiments Towards Fully Automated Medical Isotope Production Using an Ion Beam Accelerator Open
Zirconium-89 (89Zr) is a widely used radionuclide in immune-PET imaging due to its physical decay characteristics. Despite its importance, the production of 89Zr radiopharmaceuticals remains largely manual, with limited cost-effective auto…
View article: Combining MRI radiomics, hypoxia gene signature score and clinical variables for prediction of biochemical recurrence-free survival after radiotherapy in prostate cancer
Combining MRI radiomics, hypoxia gene signature score and clinical variables for prediction of biochemical recurrence-free survival after radiotherapy in prostate cancer Open
View article: Elucidating the mechanisms of lifestyle interventions in mitigating radiotherapy adverse effects: a scoping review
Elucidating the mechanisms of lifestyle interventions in mitigating radiotherapy adverse effects: a scoping review Open
The aim of this work was to review the literature on the mechanisms by which lifestyle interventions attenuate radiation therapy-induced side effects. A scoping review based on the Joanna Briggs Institute methodological framework was under…
View article: Enzalutamide plus radium-223 in metastatic castration-resistant prostate cancer: results of the EORTC 1333/PEACE-3 trial
Enzalutamide plus radium-223 in metastatic castration-resistant prostate cancer: results of the EORTC 1333/PEACE-3 trial Open
PEACE-3 demonstrates that combining enzalutamide with Ra223 as first-line therapy for mCRPC significantly improves rPFS. Although statistically significant at the OS interim boundary, the study will continue to the final OS analysis.
View article: Quantifying the dosimetric impact of online daily adaptation for MR-guided RT in cervical cancer
Quantifying the dosimetric impact of online daily adaptation for MR-guided RT in cervical cancer Open
Purpose: This study assessed the inter- and intra-fractional dosimetric impact of MR-Linac-based adaptive radiotherapy for cervical cancer (CC). Methods: A retrospective analysis of five node-negative, locally advanced cervical cancer pati…
View article: Supplementary Table S3 from A Polygenic Risk Score for Late Bladder Toxicity Following Radiotherapy for Non-Metastatic Prostate Cancer
Supplementary Table S3 from A Polygenic Risk Score for Late Bladder Toxicity Following Radiotherapy for Non-Metastatic Prostate Cancer Open
Table S3 shows bivariate associations of patient, cancer, and treatment factors with hematuria
View article: Supplementary Table S1 from A Polygenic Risk Score for Late Bladder Toxicity Following Radiotherapy for Non-Metastatic Prostate Cancer
Supplementary Table S1 from A Polygenic Risk Score for Late Bladder Toxicity Following Radiotherapy for Non-Metastatic Prostate Cancer Open
Table S1 lists the SNVs included in the PRS
View article: Supplementary Figure S1 from A Polygenic Risk Score for Late Bladder Toxicity Following Radiotherapy for Non-Metastatic Prostate Cancer
Supplementary Figure S1 from A Polygenic Risk Score for Late Bladder Toxicity Following Radiotherapy for Non-Metastatic Prostate Cancer Open
Figure S1 shows principal components analysis of participants from the RGC and REQUITE+URWCI cohorts.
View article: Supplementary Figure S3 from A Polygenic Risk Score for Late Bladder Toxicity Following Radiotherapy for Non-Metastatic Prostate Cancer
Supplementary Figure S3 from A Polygenic Risk Score for Late Bladder Toxicity Following Radiotherapy for Non-Metastatic Prostate Cancer Open
Figure S3 shows a Manhattan plot from the GWAS
View article: Supplementary Table S4 from A Polygenic Risk Score for Late Bladder Toxicity Following Radiotherapy for Non-Metastatic Prostate Cancer
Supplementary Table S4 from A Polygenic Risk Score for Late Bladder Toxicity Following Radiotherapy for Non-Metastatic Prostate Cancer Open
Table S4 shows a multivariable model of hematuria including the PRS, rare variants, and clinical factors
View article: Supplementary Figure S2 from A Polygenic Risk Score for Late Bladder Toxicity Following Radiotherapy for Non-Metastatic Prostate Cancer
Supplementary Figure S2 from A Polygenic Risk Score for Late Bladder Toxicity Following Radiotherapy for Non-Metastatic Prostate Cancer Open
Figure S2 shows a quantile-quantile plot from the GWAS
View article: Data from A Polygenic Risk Score for Late Bladder Toxicity Following Radiotherapy for Non-Metastatic Prostate Cancer
Data from A Polygenic Risk Score for Late Bladder Toxicity Following Radiotherapy for Non-Metastatic Prostate Cancer Open
Background:Late bladder toxicity is a concern for patients receiving prostate cancer radiotherapy and negatively affects survivors. Few risk factors are known beyond the radiation dose and volume of bladder exposed. A polygenic risk score …
View article: Supplementary Table S2 from A Polygenic Risk Score for Late Bladder Toxicity Following Radiotherapy for Non-Metastatic Prostate Cancer
Supplementary Table S2 from A Polygenic Risk Score for Late Bladder Toxicity Following Radiotherapy for Non-Metastatic Prostate Cancer Open
Table S2 shows the association of known prognostic factors with time to biochemical recurrence
View article: The value of post radiotherapy prostate specific antigen dynamics for prostate cancer risk stratification models
The value of post radiotherapy prostate specific antigen dynamics for prostate cancer risk stratification models Open
View article: The Promise of Radiotherapy in High-Risk Non-Muscle Invasive Bladder Cancer
The Promise of Radiotherapy in High-Risk Non-Muscle Invasive Bladder Cancer Open
Global shortages, toxicities, and high levels of incomplete treatment with Bacillus Calmette Guerin (BCG) for non-muscle invasive bladder cancer has resulted in increasing interest in alternative treatments. Radiotherapy is not the standar…
View article: Whole-body integral dose and post-radiotherapy lymphocytopaenia in solid tumours
Whole-body integral dose and post-radiotherapy lymphocytopaenia in solid tumours Open
Objective Since modern radiotherapy techniques such as intensity-modulated radiotherapy (IMRT) pivot on a strategy of dose redistribution, it may increase integral dose and consequently worsening of lymphocytopaenia. In this study, our obj…
View article: Association of radiation-induced normal tissue toxicity with a high genetic risk for rheumatoid arthritis
Association of radiation-induced normal tissue toxicity with a high genetic risk for rheumatoid arthritis Open
Background Overlapping genes are involved with rheumatoid arthritis (RA) and DNA repair pathways. Therefore, we hypothesized that patients with a high polygenic risk score for RA will have an increased risk of radiotherapy toxicity given t…
View article: Patient Factors Impacting Free-Breathing Respiratory Motion Magnitude for Magnetic Resonance-Guided Radiotherapy
Patient Factors Impacting Free-Breathing Respiratory Motion Magnitude for Magnetic Resonance-Guided Radiotherapy Open
View article: Supplementary Figure S2 from Oxygen-Enhanced MRI Detects Incidence, Onset, and Heterogeneity of Radiation-Induced Hypoxia Modification in HPV-Associated Oropharyngeal Cancer
Supplementary Figure S2 from Oxygen-Enhanced MRI Detects Incidence, Onset, and Heterogeneity of Radiation-Induced Hypoxia Modification in HPV-Associated Oropharyngeal Cancer Open
Supplementary Figure S2. Illustration of the data that is used to derive the ΔR1, HFMRI and HVMRI parameters.