David V. Conti
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View article: Supplementary Data from Beyond GWAS of Colorectal Cancer: Evidence of Interaction with Alcohol Consumption and Putative Causal Variant for the 10q24.2 Region
Supplementary Data from Beyond GWAS of Colorectal Cancer: Evidence of Interaction with Alcohol Consumption and Putative Causal Variant for the 10q24.2 Region Open
Supplementary Data from Beyond GWAS of Colorectal Cancer: Evidence of Interaction with Alcohol Consumption and Putative Causal Variant for the 10q24.2 Region
View article: Figure S1 from Genome-wide Interaction Study with Smoking for Colorectal Cancer Risk Identifies Novel Genetic Loci Related to Tumor Suppression, Inflammation, and Immune Response
Figure S1 from Genome-wide Interaction Study with Smoking for Colorectal Cancer Risk Identifies Novel Genetic Loci Related to Tumor Suppression, Inflammation, and Immune Response Open
This figure depicts the flowchart of the two-step interaction test.
View article: Table S6 from Genome-wide Interaction Study with Smoking for Colorectal Cancer Risk Identifies Novel Genetic Loci Related to Tumor Suppression, Inflammation, and Immune Response
Table S6 from Genome-wide Interaction Study with Smoking for Colorectal Cancer Risk Identifies Novel Genetic Loci Related to Tumor Suppression, Inflammation, and Immune Response Open
This file includes the association parameters (OR [95% CI]) for the identified SNPs with significant interaction term for smoking intensity by genotypes.
View article: Table S7 from Genome-wide Interaction Study with Smoking for Colorectal Cancer Risk Identifies Novel Genetic Loci Related to Tumor Suppression, Inflammation, and Immune Response
Table S7 from Genome-wide Interaction Study with Smoking for Colorectal Cancer Risk Identifies Novel Genetic Loci Related to Tumor Suppression, Inflammation, and Immune Response Open
This file includes the association parameters of the interaction component (OR [95% CI]) for the identified SNPs for smoking habits further adjusted for body-mass index.
View article: Supplementary Methods from Genome-wide Interaction Study with Smoking for Colorectal Cancer Risk Identifies Novel Genetic Loci Related to Tumor Suppression, Inflammation, and Immune Response
Supplementary Methods from Genome-wide Interaction Study with Smoking for Colorectal Cancer Risk Identifies Novel Genetic Loci Related to Tumor Suppression, Inflammation, and Immune Response Open
This file details the two-step interaction tests, and the gene-based aggregate test.
View article: Supplementary Figure from Beyond GWAS of Colorectal Cancer: Evidence of Interaction with Alcohol Consumption and Putative Causal Variant for the 10q24.2 Region
Supplementary Figure from Beyond GWAS of Colorectal Cancer: Evidence of Interaction with Alcohol Consumption and Putative Causal Variant for the 10q24.2 Region Open
Supplementary Figure from Beyond GWAS of Colorectal Cancer: Evidence of Interaction with Alcohol Consumption and Putative Causal Variant for the 10q24.2 Region
View article: Table S5 from Genome-wide Interaction Study with Smoking for Colorectal Cancer Risk Identifies Novel Genetic Loci Related to Tumor Suppression, Inflammation, and Immune Response
Table S5 from Genome-wide Interaction Study with Smoking for Colorectal Cancer Risk Identifies Novel Genetic Loci Related to Tumor Suppression, Inflammation, and Immune Response Open
This file includes the association parameters (OR [95% CI]) for the identified SNPs with suggestive interaction term for smoking status by genotypes.
View article: Supplementary Figure from Beyond GWAS of Colorectal Cancer: Evidence of Interaction with Alcohol Consumption and Putative Causal Variant for the 10q24.2 Region
Supplementary Figure from Beyond GWAS of Colorectal Cancer: Evidence of Interaction with Alcohol Consumption and Putative Causal Variant for the 10q24.2 Region Open
Supplementary Figure from Beyond GWAS of Colorectal Cancer: Evidence of Interaction with Alcohol Consumption and Putative Causal Variant for the 10q24.2 Region
View article: Table S1 from Genome-wide Interaction Study with Smoking for Colorectal Cancer Risk Identifies Novel Genetic Loci Related to Tumor Suppression, Inflammation, and Immune Response
Table S1 from Genome-wide Interaction Study with Smoking for Colorectal Cancer Risk Identifies Novel Genetic Loci Related to Tumor Suppression, Inflammation, and Immune Response Open
This table includes the smoking habits descriptives per studies included in the analysis.
View article: Supplementary Figure from Beyond GWAS of Colorectal Cancer: Evidence of Interaction with Alcohol Consumption and Putative Causal Variant for the 10q24.2 Region
Supplementary Figure from Beyond GWAS of Colorectal Cancer: Evidence of Interaction with Alcohol Consumption and Putative Causal Variant for the 10q24.2 Region Open
Supplementary Figure from Beyond GWAS of Colorectal Cancer: Evidence of Interaction with Alcohol Consumption and Putative Causal Variant for the 10q24.2 Region
View article: Supplementary Data from A Genetic Locus within the FMN1/GREM1 Gene Region Interacts with Body Mass Index in Colorectal Cancer Risk
Supplementary Data from A Genetic Locus within the FMN1/GREM1 Gene Region Interacts with Body Mass Index in Colorectal Cancer Risk Open
supplementary materials
View article: Ultra-processed food intake is associated with altered glucose homeostasis in young adults with a history of overweight or obesity: a longitudinal study
Ultra-processed food intake is associated with altered glucose homeostasis in young adults with a history of overweight or obesity: a longitudinal study Open
UPF consumption may increase the risk for T2D among young adults. Our findings suggest that limiting UPF consumption could be an important strategy for T2D prevention in this population.
View article: Integrating Pathogenic Variants, Polygenic Risk Score, and Family History for Prostate Cancer Risk Estimation in Men of African Ancestry
Integrating Pathogenic Variants, Polygenic Risk Score, and Family History for Prostate Cancer Risk Estimation in Men of African Ancestry Open
Integration of PV status, PRS, and family history enables more refined PCa risk estimates. The wide range of PCa risk observed among men of African ancestry in our study supports future prospective studies in the development of risk-strati…
View article: Translational framework linking perfluoroheptanoic acid (PFHpA) exposure to metabolic dysfunction associated steatotic liver disease in adolescents
Translational framework linking perfluoroheptanoic acid (PFHpA) exposure to metabolic dysfunction associated steatotic liver disease in adolescents Open
This study offers evidence implicating PFHpA, a short-chain unregulated PFAS congener, in MASLD development in adolescents, and highlights the critical role of protein dysregulation in disease pathogenesis. The molecular mechanisms identif…
View article: An Efficient Lasso Framework for Admixture-Aware Polygenic Scores
An Efficient Lasso Framework for Admixture-Aware Polygenic Scores Open
Polygenic scores (PGS) have promising clinical applications for risk stratification, disease screening, and personalized medicine. However, most PGS are trained on predominantly European ancestry cohorts and have limited portability to ext…
View article: Characterizing cancer patterns in Okinawan vs. mainland Japanese Americans: The Multiethnic Cohort Study
Characterizing cancer patterns in Okinawan vs. mainland Japanese Americans: The Multiethnic Cohort Study Open
Differences in cancer rates have been documented in Japan between Okinawa and mainland Japan. Limited data exist on whether these differences are also present for established populations of Okinawans and mainland Japanese in the United Sta…
View article: Ultra-Processed Food Intake is Associated with Altered Glucose Homeostasis in Young Adults
Ultra-Processed Food Intake is Associated with Altered Glucose Homeostasis in Young Adults Open
View article: TGF-β-pathway-based polygenic risk score modifies the association between red meat intake and colorectal cancer risk: Application of a novel pathway-based PRS method
TGF-β-pathway-based polygenic risk score modifies the association between red meat intake and colorectal cancer risk: Application of a novel pathway-based PRS method Open
Background Red and/or processed meat are established colorectal cancer (CRC) risk factors. Genome-wide association studies (GWAS) have reported over 200 variants associated with CRC risk. We used functional annotation data to identify subs…
View article: The Multiethnic Cohort: A Resource for the study of Genetic and non-Genetic Cancer Risk Across Populations
The Multiethnic Cohort: A Resource for the study of Genetic and non-Genetic Cancer Risk Across Populations Open
Introduction The Multiethnic Cohort Study (MEC) is a U.S. prospective cohort of over 215,000 participants, designed to investigate variation in risk factors and disease across diverse racial and ethnic groups. Over 74,000 participants cont…
View article: African Genetic Ancestry, Structural and Social Determinants of Health, and Mortality in Black Adults
African Genetic Ancestry, Structural and Social Determinants of Health, and Mortality in Black Adults Open
Importance Although structural and social determinants of health (SSDH) have been consistently associated with health disparities, percentage African genetic ancestry (AGA) has been suggested as a risk factor associated with common disease…
View article: Corrigendum to “Associations of dietary intake and longitudinal measures of per- and polyfluoroalkyl substances (PFAS) in predominantly Hispanic young Adults: a multicohort study” [Environ. Int 185 (2024) 108454]
Corrigendum to “Associations of dietary intake and longitudinal measures of per- and polyfluoroalkyl substances (PFAS) in predominantly Hispanic young Adults: a multicohort study” [Environ. Int 185 (2024) 108454] Open
View article: Dysregulated maternal and newborn fatty acid, sugar and amino acid metabolism associated with high birth weight
Dysregulated maternal and newborn fatty acid, sugar and amino acid metabolism associated with high birth weight Open
View article: Repetitive Transcranial Magnetic Stimulation (rTMS) an an augmentation strategy in a sample of patients with treatment-resistant depression: a comparison of traditional and accelerated protocols
Repetitive Transcranial Magnetic Stimulation (rTMS) an an augmentation strategy in a sample of patients with treatment-resistant depression: a comparison of traditional and accelerated protocols Open
Introduction Repetitive transcranial magnetic stimulation (rTMS) is a clinically validated treatment, included in international guidelines for managing treatment-resistant depression (TRD). The conventional daily administration of rTMS pro…
View article: Integrated Spheroid-to-Population Framework for Evaluating PFHpA-Associated Metabolic Dysfunction and Steatotic Liver Disease
Integrated Spheroid-to-Population Framework for Evaluating PFHpA-Associated Metabolic Dysfunction and Steatotic Liver Disease Open
View article: Race and Ethnicity, Lifestyle, Diet, and Survival in Patients With Prostate Cancer
Race and Ethnicity, Lifestyle, Diet, and Survival in Patients With Prostate Cancer Open
Importance Prostate cancer (PCa) remains a leading cause of cancer-related death among men in the US. Objective To evaluate the association of healthy lifestyle and dietary behaviors with survival after a nonmetastatic PCa diagnosis in a m…
View article: Metabolic Signatures in Adipose Tissue Linking Lipophilic Persistent Organic Pollutant Mixtures to Blood Pressure Five Years After Bariatric Surgery Among Adolescents
Metabolic Signatures in Adipose Tissue Linking Lipophilic Persistent Organic Pollutant Mixtures to Blood Pressure Five Years After Bariatric Surgery Among Adolescents Open
Persistent organic pollutants (POPs) are lipophilic environmental contaminants accumulated in the adipose tissue. Weight loss interventions, such as bariatric surgery, can mobilize POPs from adipose tissue into the bloodstream. We hypothes…
View article: Data from Evaluation of Multiple Breast Cancer Polygenic Risk Score Panels in Women of Latin American Heritage
Data from Evaluation of Multiple Breast Cancer Polygenic Risk Score Panels in Women of Latin American Heritage Open
Background:A substantial portion of the genetic predisposition for breast cancer is explained by multiple common genetic variants of relatively small effect. A subset of these variants, which have been identified mostly in individuals of E…
View article: Supplemental Figure S1 from Evaluation of Multiple Breast Cancer Polygenic Risk Score Panels in Women of Latin American Heritage
Supplemental Figure S1 from Evaluation of Multiple Breast Cancer Polygenic Risk Score Panels in Women of Latin American Heritage Open
Supplemental Figure S1 shows global ancestry distribution of individuals by countries across seven studies included in this analysis.
View article: Supplemental Figure S7 from Evaluation of Multiple Breast Cancer Polygenic Risk Score Panels in Women of Latin American Heritage
Supplemental Figure S7 from Evaluation of Multiple Breast Cancer Polygenic Risk Score Panels in Women of Latin American Heritage Open
Supplemental Figure S7 shows performance of PRS panels in H/L samples with matched age in cases and controls.
View article: Supplemental Table S5 from Evaluation of Multiple Breast Cancer Polygenic Risk Score Panels in Women of Latin American Heritage
Supplemental Table S5 from Evaluation of Multiple Breast Cancer Polygenic Risk Score Panels in Women of Latin American Heritage Open
Supplemental Table S5 shows Comparisons of Areas under the receiver operating characteristics curve (AUC) and odd ratios (OR) per standard deviation of the PRS panels.