Fadi Hammal
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View article: Protocol for an economic evaluation alongside the Re-Evaluating the Inhibition of Stress Erosions (E-REVISE) trial
Protocol for an economic evaluation alongside the Re-Evaluating the Inhibition of Stress Erosions (E-REVISE) trial Open
Introduction Economic evaluations in healthcare can guide practice and inform policy. The objective of this paper is to present the protocol for a health economic evaluation comparing the cost-effectiveness of prophylactic treatment using …
View article: Frailty and the risk of ICU-acquired infections in a randomised trial: a protocol and statistical analysis plan
Frailty and the risk of ICU-acquired infections in a randomised trial: a protocol and statistical analysis plan Open
Introduction Dysregulated immunity may account for an increased risk of infection and other adverse outcomes among frail hospitalised persons. The primary objective of this study is to examine whether baseline frailty is associated with th…
View article: Cost-Effectiveness of In-Bed Cycling and Routine Physiotherapy for Patients Receiving Mechanical Ventilation
Cost-Effectiveness of In-Bed Cycling and Routine Physiotherapy for Patients Receiving Mechanical Ventilation Open
Importance The cost-effectiveness of adding early in-bed cycling to usual physiotherapy among adults receiving mechanical ventilation in the intensive care unit (ICU) compared with usual physiotherapy alone is unknown. Objective To evaluat…
View article: Midodrine for the early liberation from vasopressor support in the ICU (LIBERATE): A Vanguard Randomized Clinical Trial
Midodrine for the early liberation from vasopressor support in the ICU (LIBERATE): A Vanguard Randomized Clinical Trial Open
Background Intravenous (IV) vasopressors are the mainstay of hemodynamic physiological support for critically ill patients. However, the role of oral vasopressors in the management of IV vasopressor-dependent shock remains unclear. The LIB…
View article: Coenrolment in a Stress Ulcer Prophylaxis Trial: Protocol for a Substudy of Characteristics and Consequences
Coenrolment in a Stress Ulcer Prophylaxis Trial: Protocol for a Substudy of Characteristics and Consequences Open
Background Coenrolment is defined as the enrolment of an individual patient into more than one study. This protocol describes a study of coenrolment nested in a randomized, blinded, parallel-group trial of stress ulcer prophylaxis comparin…
View article: Protocol for an Economic Evaluation Alongside the Re-Evaluating the Inhibition of Stress Erosions (E-REVISE) Trial
Protocol for an Economic Evaluation Alongside the Re-Evaluating the Inhibition of Stress Erosions (E-REVISE) Trial Open
Introduction Economic evaluations in healthcare can guide practice and inform policy. The objective of this paper is to present the protocol for a health economic evaluation comparing the cost-effectiveness of prophylactic treatment using …
View article: Cuff leak test and airway obstruction in mechanically ventilated ICU patients (COSMIC): a pilot feasibility randomized controlled trial protocol
Cuff leak test and airway obstruction in mechanically ventilated ICU patients (COSMIC): a pilot feasibility randomized controlled trial protocol Open
Introduction The cuff leak test (CLT) is hypothesised to help optimise extubation by assessing for laryngeal oedema which, if unrecognised and untreated, could lead to post-extubation stridor, post-extubation airway obstruction, and reintu…
View article: The effect of enteral nutrition strategy and non-invasive ventilation on diarrhea and nutritional goals in the critically ill: A protocol for a multicentre retrospective cohort study (ENND GOALS)
The effect of enteral nutrition strategy and non-invasive ventilation on diarrhea and nutritional goals in the critically ill: A protocol for a multicentre retrospective cohort study (ENND GOALS) Open
Enteral nutrition (EN) has become the standard of care for nutritional support among critically ill patients. However, little is known about whether continuous delivery (CEN) or intermittent delivery (IEN) is preferable or the consequences…
View article: Risk factors for patient-important upper gastrointestinal bleeding: A protocol and statistical analysis plan for a secondary analysis of the REVISE (Re-Evaluating the Inhibition of Stress Erosions) trial
Risk factors for patient-important upper gastrointestinal bleeding: A protocol and statistical analysis plan for a secondary analysis of the REVISE (Re-Evaluating the Inhibition of Stress Erosions) trial Open
Background: While studies have reported risk factors for clinically-important upper gastrointestinal bleeding among critically ill patients, the risk factors for patient-important upper gastrointestinal bleeding, as defined by ICU survivor…
View article: Coenrollment of Critically Ill Patients in PROSPECT: A Protocol and Statistical Analysis Plan
Coenrollment of Critically Ill Patients in PROSPECT: A Protocol and Statistical Analysis Plan Open
Introduction The enrollment of a patient into more than one study (i.e., coenrollment) has risks which warrant exploration, particularly with respect to possible effects on trial outcomes. This pre-planned secondary analysis will examine t…
View article: Leg Cycle Ergometry in Critically Ill Patients — An Updated Systematic Review and Meta-Analysis
Leg Cycle Ergometry in Critically Ill Patients — An Updated Systematic Review and Meta-Analysis Open
In this meta-analysis, we found that cycling with critically ill patients may improve physical function at ICU discharge and after hospital discharge, may reduce ICU length of stay, and probably reduces hospital length of stay, with no eff…
View article: Barriers, Solutions, and Opportunities for Adapting Critical Care Clinical Trials in the COVID-19 Pandemic
Barriers, Solutions, and Opportunities for Adapting Critical Care Clinical Trials in the COVID-19 Pandemic Open
Importance The COVID-19 pandemic created unprecedented challenges for clinical trials worldwide, threatening premature closure and trial integrity. Every phase of research operations was affected, often requiring modifications to protocol …
View article: Early In-Bed Cycle Ergometry With Critically Ill, Mechanically Ventilated Patients: Statistical Analysis Plan for CYCLE (Critical Care Cycling to Improve Lower Extremity Strength), an International, Multicenter, Randomized Clinical Trial
Early In-Bed Cycle Ergometry With Critically Ill, Mechanically Ventilated Patients: Statistical Analysis Plan for CYCLE (Critical Care Cycling to Improve Lower Extremity Strength), an International, Multicenter, Randomized Clinical Trial Open
Background Survivors of critical illness are at risk of developing physical dysfunction following intensive care unit (ICU) discharge. ICU-based rehabilitation interventions, such as early in-bed cycle ergometry, may improve patients’ shor…
View article: The response of Canada’s clinical health research ecosystem to the COVID-19 pandemic
The response of Canada’s clinical health research ecosystem to the COVID-19 pandemic Open
A minority of Canadian hospitals enrolled the majority of participants in CIHR-funded studies on COVID-19. This analysis sheds light on the Canadian health research ecosystem and provides information for multiple key partners to consider w…
View article: Frailty, Outcomes, Recovery and Care Steps of Critically Ill Patients (FORECAST): a prospective, multi-centre, cohort study
Frailty, Outcomes, Recovery and Care Steps of Critically Ill Patients (FORECAST): a prospective, multi-centre, cohort study Open
Frailty severity was dynamic, can be measured during recovery from critical illness using the CFS and FI which were both associated with worse outcomes. Although the CFS is a global measure, a CGA FI based may have advantages of being able…
View article: Incontinentia Pigmenti In a Female Infant: A Case Report
Incontinentia Pigmenti In a Female Infant: A Case Report Open
Incontinentia pigmenti (IP) is an X-linked disorder characterized by a variety of findings that affect different systems, including cutaneous, ophthalmologic, neurologic, and dental. The cutaneous findings occur in 4 consecutive stages, ge…
View article: Respiratory drive heterogeneity associated with systemic inflammation and vascular permeability in acute respiratory distress syndrome
Respiratory drive heterogeneity associated with systemic inflammation and vascular permeability in acute respiratory distress syndrome Open
Background In acute respiratory distress syndrome (ARDS), respiratory drive often differs among patients with similar clinical characteristics. Readily observable factors like acid–base state, oxygenation, mechanics, and sedation depth do …
View article: Early in-bed cycle ergometry with critically ill, mechanically ventilated patients - Statistical Analysis Plan for CYCLE (Critical care cycling to improve lower extremity strength), an international, multi-centre, randomized clinical trial (Preprint)
Early in-bed cycle ergometry with critically ill, mechanically ventilated patients - Statistical Analysis Plan for CYCLE (Critical care cycling to improve lower extremity strength), an international, multi-centre, randomized clinical trial (Preprint) Open
BACKGROUND Survivors of critical illness are at risk of developing physical dysfunction following intensive care unit (ICU) discharge. ICU-based rehabilitation interventions, such as early-in bed cycle ergometry, may improve patients’ sho…
View article: Proton pump inhibitors for gastrointestinal bleeding prophylaxis in critically ill patients: A systematic review protocol
Proton pump inhibitors for gastrointestinal bleeding prophylaxis in critically ill patients: A systematic review protocol Open
Background Proton pump inhibitors (PPIs) are the most commonly prescribed drugs for preventing upper gastrointestinal bleeding in critically ill patients. However, concerns have arisen about the possible harms of using PPIs, including pote…
View article: Timing of Major Postoperative Bleeding Among Patients Undergoing Surgery
Timing of Major Postoperative Bleeding Among Patients Undergoing Surgery Open
Importance Although major bleeding is among the most common and prognostically important perioperative complications, the relative timing of bleeding events is not well established. This information is critical for preventing bleeding comp…
View article: Patient-important upper gastrointestinal bleeding in the ICU: A mixed-methods study of patient and family perspectives
Patient-important upper gastrointestinal bleeding in the ICU: A mixed-methods study of patient and family perspectives Open
Survivors of critical illness and family members described patient-important upper gastrointestinal bleeding differently than current definitions of clinically-important upper gastrointestinal bleeding.
View article: REVISE: re-evaluating the inhibition of stress erosions in the ICU—statistical analysis plan for a randomized trial
REVISE: re-evaluating the inhibition of stress erosions in the ICU—statistical analysis plan for a randomized trial Open
Background The REVISE ( R e- Ev aluating the I nhibition of S tress E rosions in the ICU) trial will evaluate the impact of the proton pump inhibitor pantoprazole compared to placebo in invasively ventilated critically ill patients. Object…
View article: Overnight staffing in Canadian neonatal and pediatric intensive care units
Overnight staffing in Canadian neonatal and pediatric intensive care units Open
Aim Infants and children who require specialized medical attention are admitted to neonatal and pediatric intensive care units (ICUs) for continuous and closely supervised care. Overnight in-house physician coverage is frequently considere…
View article: REVISE: <i>R</i> e- <i>Ev</i> aluating the <i>I</i> nhibition of <i>S</i> tress <i>E</i> rosions in the ICU: a randomised trial protocol
REVISE: <i>R</i> e- <i>Ev</i> aluating the <i>I</i> nhibition of <i>S</i> tress <i>E</i> rosions in the ICU: a randomised trial protocol Open
Introduction The R e- Ev aluating the I nhibition of S tress E rosions (REVISE) Trial aims to determine the impact of the proton pump inhibitor pantoprazole compared with placebo on clinically important upper gastrointestinal (GI) bleeding…