Marc D. Binder
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View article: Shared genetic and environmental influences on altered functional connectivity and schizophrenia liability
Shared genetic and environmental influences on altered functional connectivity and schizophrenia liability Open
Schizophrenia is characterised by dysconnectivity of several resting-state functional brain networks, potentially reflecting reduced efficiency of brain communication. It remains unclear to what extent dysconnectivity is influenced by gene…
View article: Examining psychological protective mechanisms as moderators of the association between autistic traits and psychosis expression in a general population twin sample
Examining psychological protective mechanisms as moderators of the association between autistic traits and psychosis expression in a general population twin sample Open
Engagement coping, extraversion, and optimal parenting may mitigate psychosis vulnerability in individuals with higher ATs, while passive-reactive coping and avoidance may heighten psychosis vulnerability. Although further research is need…
View article: Obesity and Schizophrenia: Results of a Feasibility Study with Semaglutide to Assist Weight Loss
Obesity and Schizophrenia: Results of a Feasibility Study with Semaglutide to Assist Weight Loss Open
In this feasibility study, weekly semaglutide treatment was associated with improvement in self-rated overall QOL and reductions in BMI, HbA1c and blood pressure at up to 6 months follow-up. Even in patients who discontinued treatment befo…
View article: The moderating role of childhood adversity subtypes on the relationship between autistic traits and psychotic experiences in the general population
The moderating role of childhood adversity subtypes on the relationship between autistic traits and psychotic experiences in the general population Open
Introduction Childhood trauma (CT) and bullying have been shown to be associated with autistic traits (AT) and to mediate the relationship between AT and psychotic experiences (PEs). Understanding how different childhood adversity subtypes…
View article: The time has come for revising the rules of clozapine blood monitoring in Europe. A joint expert statement from the European Clozapine Task Force
The time has come for revising the rules of clozapine blood monitoring in Europe. A joint expert statement from the European Clozapine Task Force Open
The European Clozapine Task Force is a group of psychiatrists and pharmacologists practicing in 18 countries under European Medicines Agency (EMA) regulation, who are deeply concerned about the underuse of clozapine in European countries. …
View article: Prevalence, nature, and determinants of COVID-19-related conspiracy theories among healthcare workers: a scoping review
Prevalence, nature, and determinants of COVID-19-related conspiracy theories among healthcare workers: a scoping review Open
Background COVID-19-related conspiracy theories (CTs) have been observed among healthcare workers (HCWs). There exists, however, a lack of research investigating the extent, nature, and determinants of CTs among HCWs worldwide. Methods A s…
View article: End-of-life care for people with severe and persistent mental illness and a life-limiting disease: An umbrella review
End-of-life care for people with severe and persistent mental illness and a life-limiting disease: An umbrella review Open
Background It is widely known that people with a severe and persistent mental illness (SPMI) are more at risk of poor physical health outcomes because of disparities in healthcare access and provision. Less is known about the quality of en…
View article: The epidemiology and phenomenology of non-antipsychotic-induced dystonia: a hybrid systematic-narrative review
The epidemiology and phenomenology of non-antipsychotic-induced dystonia: a hybrid systematic-narrative review Open
Background Medication-induced dystonia (MID) is a movement disorder (MD), characterized by involuntary sustained or intermittent muscle contractions, causing abnormal, often repetitive, movements, postures, or both. Although MID is commonl…
View article: The Moderating Role of Genetic and Environmental Risk Factors for Schizophrenia on the Relationship between Autistic Traits and Psychosis Expression in the General Population
The Moderating Role of Genetic and Environmental Risk Factors for Schizophrenia on the Relationship between Autistic Traits and Psychosis Expression in the General Population Open
Background Psychosis-related environmental risks in autism, along with genetic overlaps between autism and psychosis, have been well-established. However, their moderating roles in the relationship between autistic traits (ATs) and psychot…
View article: The Moderating Role of Genetic and Environmental Risk Factors for Schizophrenia on the Relationship between Autistic Traits and Psychosis Expression in the General Population
The Moderating Role of Genetic and Environmental Risk Factors for Schizophrenia on the Relationship between Autistic Traits and Psychosis Expression in the General Population Open
Background and Hypothesis Psychosis-related environmental risks are common in autism, with identified genetic connections to psychosis. Therefore, we hypothesized these risks may moderate the relationship between autistic traits (ATs) and …
View article: Further evidence for the association between childhood trauma and suicidal ideation in young individuals: A twin based study
Further evidence for the association between childhood trauma and suicidal ideation in young individuals: A twin based study Open
View article: The association between aberrant salience and psychotic experiences in general population twins, and genetic vulnerability as a modifier
The association between aberrant salience and psychotic experiences in general population twins, and genetic vulnerability as a modifier Open
Background Previous studies assessing the hypothesis that the construct of ‘aberrant salience’ is associated with psychosis and psychotic symptoms showed conflicting results. For this reason, the association between measures to index aberr…
View article: Characterizing the dynamics, reactivity and controllability of moods in depression with a Kalman filter
Characterizing the dynamics, reactivity and controllability of moods in depression with a Kalman filter Open
Background Mood disorders involve a complex interplay between multifaceted internal emotional states, and complex external inputs. Dynamical systems theory suggests that this interplay between aspects of moods and environmental stimuli may…
View article: Impact of a Vision-Based Smoothing Filter on Schizophrenia Classification
Impact of a Vision-Based Smoothing Filter on Schizophrenia Classification Open
sponsorship: This research was funded by the research project QG (QG.23.35) of Vietnam National University Hanoi. Quang Manh Doan was funded by the Master, PhD Scholarship Programme of Vingroup Innovation Foundation (VINIF), code VINIF.202…
View article: Homelessness and housing problems in admitted psychiatric patients in Flanders, Belgium
Homelessness and housing problems in admitted psychiatric patients in Flanders, Belgium Open
Homelessness in psychiatric patients in Flanders, Belgium, has never been investigated. Advocacy groups from patients with lived experience of psychiatric disorders have sounded the alarm on the scarcity of suitable housing options, the st…
View article: Euthanasia for unbearable suffering caused by a psychiatric disorder: improving the regulatory framework
Euthanasia for unbearable suffering caused by a psychiatric disorder: improving the regulatory framework Open
View article: Alert prescribing of clozapine: a comparison of five drug–drug interaction sources
Alert prescribing of clozapine: a comparison of five drug–drug interaction sources Open
Introduction: Clozapine, an antipsychotic used in the treatment of schizophrenia, is known for its serious side effects. In order to promote patient safety, drug–drug interaction (DDI) databases can be consulted by clinicians. In this stud…
View article: Associations between childhood adversity, psychiatric symptoms, and self‐esteem outcomes in adolescents and young adults: An experience sampling study
Associations between childhood adversity, psychiatric symptoms, and self‐esteem outcomes in adolescents and young adults: An experience sampling study Open
Objectives Self‐esteem and self‐esteem stability are important factors during adolescence and young adulthood that can be negatively impacted by childhood adversity and psychiatric symptoms. We examined whether childhood adversity and psyc…
View article: O.4.2-1 The within-person bidirectional association between physical activity and loneliness in the daily lives of adolescents and young adults
O.4.2-1 The within-person bidirectional association between physical activity and loneliness in the daily lives of adolescents and young adults Open
Purpose Adolescents and young adults are at high risk for experiencing loneliness, a well-established risk factor for mental health symptoms. Previous cross-sectional studies show an inverse association between loneliness and physical acti…
View article: Gender differences in the associations between childhood adversity and psychopathology in the general population
Gender differences in the associations between childhood adversity and psychopathology in the general population Open
Purpose To explore gender differences of the associations between childhood adversity (CA) subtypes and psychiatric symptoms in the general population. Methods Data of 791 participants were retrieved from a general population twin cohort. …
View article: Viewpoint: Psychiatrists and other medical professionals in Belgium show a substantial lack of knowledge about poverty
Viewpoint: Psychiatrists and other medical professionals in Belgium show a substantial lack of knowledge about poverty Open
The bidirectional relationship between poverty and poor physical and mental health is well-known. All physicians should have sufficient knowledge on poverty as a social determinant and its impact on (mental) health. The knowledge of povert…
View article: The association between aberrant salience and psychotic experiences in general population twins, and genetic vulnerability as a modifier.
The association between aberrant salience and psychotic experiences in general population twins, and genetic vulnerability as a modifier. Open
Background. Previous studies assessing the hypothesis that the construct of ‘aberrant salience’ is associated with psychosis and psychotic symptoms showed conflicting results. For this reason, the association between measures to index aber…
View article: Affective wellbeing moderates the association between polygenic risk score for neuroticism and change in neuroticism
Affective wellbeing moderates the association between polygenic risk score for neuroticism and change in neuroticism Open
Introduction Neuroticism has societal, mental and physical health relevance, with an etiology involving genetic predisposition, psychological influence, and their interaction. Objectives To understand whether the association between polyge…
View article: Differential associations of childhood adversity subtypes and psychopathology in men and women
Differential associations of childhood adversity subtypes and psychopathology in men and women Open
Introduction Prior evidence suggests that men and women might be differentially susceptible to distinct types of childhood adversity (CA), but research on gender-specific associations between CA subtypes and psychiatric symptoms is limited…
View article: Sustainability in Dutch and Flemish mental healthcare: A descriptive and comparative study
Sustainability in Dutch and Flemish mental healthcare: A descriptive and comparative study Open
Introduction There is an urgent need for sustainable thinking and practices in healthcare systems to meet the challenge of climate change (Charlesworth & Jamieson, 2019; Corvalan et al., 2020; Luykx & Voetterl, 2022; Madden et al., 2020). …
View article: Coping and sleep quality in youth: An Experience Sampling study
Coping and sleep quality in youth: An Experience Sampling study Open
Introduction Sleep quality is closely linked with mental health. Two factors that influence sleep are coping style and locus of control, yet these have not been investigated in daily life. In this study, we examined associations between co…
View article: Media coverage of Belgium’s first criminal case concerning euthanasia for psychiatric patients: A content analysis of Flemish newspapers and magazines
Media coverage of Belgium’s first criminal case concerning euthanasia for psychiatric patients: A content analysis of Flemish newspapers and magazines Open
Background Belgium is one of the few countries worldwide where euthanasia on the grounds of unbearable suffering caused by a psychiatric disorder is legally possible. In April 2010 euthanasia was carried out on a 38-year-old Belgian woman …
View article: Further Evidence for the Association between Childhood Trauma and Suicidal Ideation in Young Individuals: A Twin Based Study
Further Evidence for the Association between Childhood Trauma and Suicidal Ideation in Young Individuals: A Twin Based Study Open
View article: Gene–environment interaction study on the polygenic risk score for neuroticism, childhood adversity, and parental bonding
Gene–environment interaction study on the polygenic risk score for neuroticism, childhood adversity, and parental bonding Open
The present study examines whether neuroticism is predicted by genetic vulnerability, summarized as polygenic risk score for neuroticism (PRS N ), in interaction with bullying, parental bonding, and childhood adversity. Data were derived f…
View article: The within-person bidirectional association between physical activity and loneliness in the daily lives of adolescents and young adults
The within-person bidirectional association between physical activity and loneliness in the daily lives of adolescents and young adults Open