Douglas S. Lee
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View article: Early Life Exposure to the Great Chinese Famine and Cardiometabolic Outcomes
Early Life Exposure to the Great Chinese Famine and Cardiometabolic Outcomes Open
Importance Epidemiologic studies suggest that people who were exposed to famine during early life but now live in nutrient-abundant environments have an elevated risk of type 2 diabetes (T2D) and other cardiometabolic conditions. Although …
View article: Emergency Department Visits Following Transcatheter Cardiac Interventions: A Systematic Review and Meta‐Analysis
Emergency Department Visits Following Transcatheter Cardiac Interventions: A Systematic Review and Meta‐Analysis Open
While hospital readmission is the most common health system performance metric after transcatheter cardiac interventions, emergency department (ED) visits are rarely evaluated. We aimed to synthesize the incidence, causes, predictors, cost…
View article: Exploring the Feasibility of the Creyos Cognitive Assessment Tool Among Patients With Heart Failure
Exploring the Feasibility of the Creyos Cognitive Assessment Tool Among Patients With Heart Failure Open
Objective The objective of this study is to explore the feasibility of the Creyos Cognitive Assessment Tool (Creyos, Toronto, Canada) as a cognitive testing instrument for patients with heart failure (HF). Background Identifying appropriat…
View article: Visceral adipose tissue and hepatic fat as determinants of carotid atherosclerosis
Visceral adipose tissue and hepatic fat as determinants of carotid atherosclerosis Open
Visceral fat, and to a lesser extent, hepatic fat, are associated with increased carotid atherosclerosis.
View article: Association of Albuminuria With 1‐Year Risk of Heart Failure and Other Adverse Outcomes in Atrial Fibrillation
Association of Albuminuria With 1‐Year Risk of Heart Failure and Other Adverse Outcomes in Atrial Fibrillation Open
Background Albuminuria is associated with increased stroke risk in atrial fibrillation (AF), but its relationship with heart failure (HF) and other adverse outcomes in AF is less well understood. Methods Using linked administrative databas…
View article: Real-world effectiveness of early revascularization in stable coronary artery disease with moderate or severe ischemia
Real-world effectiveness of early revascularization in stable coronary artery disease with moderate or severe ischemia Open
Patients with stable coronary artery disease treated with early revascularization after MPI showing moderate or severe ischemia experienced lower risks of cardiovascular death and composite of cardiovascular hospitalization or cardiovascul…
View article: Predicting outcomes following endovascular aortoiliac revascularization using machine learning
Predicting outcomes following endovascular aortoiliac revascularization using machine learning Open
Endovascular aortoiliac revascularization is a common treatment option for peripheral artery disease that carries non-negligible risks. Outcome prediction tools may support clinical decision-making but remain limited. We developed machine …
View article: Cholesterol Levels and Cardiovascular Outcomes Following Statin Initiation for Primary Prevention
Cholesterol Levels and Cardiovascular Outcomes Following Statin Initiation for Primary Prevention Open
These findings support the residual risk associated with incompletely controlled LDL-C or non-HDL-C levels after statin initiation for primary prevention.
View article: Association between dipeptidyl peptidase-4 inhibitors and glucagon-like peptide-1 receptor agonists and COVID-19 infection and adverse outcomes: a cohort study
Association between dipeptidyl peptidase-4 inhibitors and glucagon-like peptide-1 receptor agonists and COVID-19 infection and adverse outcomes: a cohort study Open
Introduction People with type 2 diabetes (T2DM) have an elevated risk of adverse outcomes from COVID-19. Dipeptidyl peptidase-4 inhibitors (DPP4is) and glucagon-like peptide-1 receptor agonists (GLP1RAs) might have favorable effects on COV…
View article: Predicting outcomes following open abdominal aortic aneurysm repair using machine learning
Predicting outcomes following open abdominal aortic aneurysm repair using machine learning Open
Patients undergoing open surgical repair of abdominal aortic aneurysm (AAA) have a high risk of post-operative complications. However, there are no widely used tools to predict surgical risk in this population. We used machine learning (ML…
View article: Predicting Outcomes Following Carotid Artery Stenting Using Machine Learning
Predicting Outcomes Following Carotid Artery Stenting Using Machine Learning Open
Background: Carotid artery stenting (CAS) carries important perioperative risks. Outcome prediction tools may help guide clinical decision-making but remain limited. We developed machine learning (ML) algorithms that predict 30-day outcome…
View article: Using Machine Learning to Predict Outcomes Following Thoracic and Complex Endovascular Aortic Aneurysm Repair
Using Machine Learning to Predict Outcomes Following Thoracic and Complex Endovascular Aortic Aneurysm Repair Open
Background Thoracic endovascular aortic repair (TEVAR) and complex endovascular aneurysm repair (EVAR) are complex procedures that carry a significant risk of complications. While risk prediction tools can aid in clinical decision making, …
View article: Bleeding and New Malignancy Diagnoses After Anticoagulation for Atrial Fibrillation: A Population-Based Cohort Study
Bleeding and New Malignancy Diagnoses After Anticoagulation for Atrial Fibrillation: A Population-Based Cohort Study Open
BACKGROUND: Bleeding after starting anticoagulation for atrial fibrillation (AF) may be the first sign of malignancy, especially in elderly individuals. There are no recommendations to guide investigations for malignancy after new-onset bl…
View article: Uptake of novel evidence-based therapies in patients with type 2 diabetes after a cardiovascular event: insights from CANHEART
Uptake of novel evidence-based therapies in patients with type 2 diabetes after a cardiovascular event: insights from CANHEART Open
A rise in the use of novel GDMT suggests increasing adoption of therapies to optimize secondary prevention in patients with T2DM and CV disease after index CV events.
View article: Incident prescriptions for common cardiovascular medications: comparison of recent versus pre-2020 medication adherence and discontinuation in three universal health care systems
Incident prescriptions for common cardiovascular medications: comparison of recent versus pre-2020 medication adherence and discontinuation in three universal health care systems Open
Background Health system disruptions since onset of the COVID-19 pandemic may have adversely impacted adherence to medications for common cardiovascular risk factors. Methods We examined adherence to and discontinuation of incident prescri…