A. David Edwards
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View article: C-reactive protein levels and behavioural outcomes in mid-childhood in very preterm and term born children
C-reactive protein levels and behavioural outcomes in mid-childhood in very preterm and term born children Open
We show no evidence that prematurity or perinatal inflammation are associated with salivary CRP in mid-childhood, nor that perinatal inflammatory insults are related to later behavioural outcomes in our cohort of preterm children. Our find…
View article: 7 Tesla fMRI characterisation of the cortical-depth-dependent BOLD response in early human development
7 Tesla fMRI characterisation of the cortical-depth-dependent BOLD response in early human development Open
Human cortical development leading up to and around birth is crucial for lifelong brain function. Cortical activity can be studied using BOLD fMRI, however, previously limited sensitivity and spatial specificity has constrained understandi…
View article: Profiling brain morphology for autism spectrum disorder with two cross-culture large-scale consortia
Profiling brain morphology for autism spectrum disorder with two cross-culture large-scale consortia Open
We explore neurodevelopmental heterogeneity in Autism Spectrum Disorder (ASD) through normative modeling of cross-cultural cohorts. By leveraging large-scale datasets from Autism Brain Imaging Data Exchange (ABIDE) and China Autism Brain I…
View article: Why take the eye? A systematic review of corneal retrieval methods and donor consent: implications for the UK
Why take the eye? A systematic review of corneal retrieval methods and donor consent: implications for the UK Open
Aim To evaluate the effect of the corneal retrieval method on three outcome domains: donor consent rate, tissue quality and microbial contamination. Methods A systematic literature review was conducted using the Scopus, PubMed and Web of S…
View article: Charting structural brain asymmetry across the human lifespan
Charting structural brain asymmetry across the human lifespan Open
Lateralization is a fundamental principle of structural brain organization. In vivo imaging of brain asymmetry is essential for deciphering lateralized brain functions and their disruption in neurodevelopmental and neurodegenerative disord…
View article: Associations Between Neonatal Brain Structure and Neurodevelopmental Outcomes Following Very Preterm Birth
Associations Between Neonatal Brain Structure and Neurodevelopmental Outcomes Following Very Preterm Birth Open
BackgroundVery preterm (VPT) children have high risks of neurodevelopmental delays, yet early predictors for specific impairments are poorly understood. This study investigated how neonatal brain structure relates to neurodevelopmental del…
View article: Rethinking place in ethnic and migrant health outcomes: environmental racialisation in Auckland City Centre <sup>1</sup> (CBD)
Rethinking place in ethnic and migrant health outcomes: environmental racialisation in Auckland City Centre <sup>1</sup> (CBD) Open
The healthy migrant effect scholarship makes limited, if any, connections between the impacts of the physical environments of the host country on the health outcomes of migrants. The aim of this paper is to understand environmental racism/…
View article: Differential maturation of the brain networks required for the sensory, emotional, and cognitive aspects of pain in human newborns
Differential maturation of the brain networks required for the sensory, emotional, and cognitive aspects of pain in human newborns Open
Pain is multidimensional, including sensory-discriminative, affective-motivational, and cognitive-evaluative components. Although the concept of pain is learned through life, it is not known when and how the brain networks that are require…
View article: Common genetic variation associated with adult subcortical brain volume is also associated with subcortical brain volume at birth
Common genetic variation associated with adult subcortical brain volume is also associated with subcortical brain volume at birth Open
Introduction Recent genome-wide association studies have identified numerous single nucleotide polymorphisms (SNPs) associated with subcortical brain volumes. These studies have been undertaken in largely adult cohorts. In this work we exp…
View article: Genome-wide association meta-analysis of age at onset of walking in over 70,000 infants of European ancestry
Genome-wide association meta-analysis of age at onset of walking in over 70,000 infants of European ancestry Open
Age at onset of walking is an important early childhood milestone which is used clinically and in public health screening. In this genome-wide association study meta-analysis of age at onset of walking ( N = 70,560 European-ancestry infant…
View article: Cortical scaling of the neonatal brain in typical and altered development
Cortical scaling of the neonatal brain in typical and altered development Open
Theoretically derived scaling laws capture the nonlinear relationships between rapidly expanding brain volume and cortical gyrification across mammalian species and in adult humans. However, the preservation of these laws has not been comp…
View article: Infant Subcortical Brain Volumes Associated with Maternal Obesity and Diabetes: A Large Multicohort Study
Infant Subcortical Brain Volumes Associated with Maternal Obesity and Diabetes: A Large Multicohort Study Open
Importance Maternal diabetes (MD) and maternal obesity (MO) have been robustly established to confer health risks in offspring. Additionally, mounting evidence suggests that these fetal programming effects vary by sex, but whether these fa…
View article: Gestational age at birth and cognitive outcomes in term-born children: Evidence from Chinese and British cohorts
Gestational age at birth and cognitive outcomes in term-born children: Evidence from Chinese and British cohorts Open
Older GA in term-born toddlers is associated with more favourable developmental outcomes across different cultural contexts.
View article: The developing Human Connectome Project fetal functional MRI release: Methods and data structures
The developing Human Connectome Project fetal functional MRI release: Methods and data structures Open
Recent advances in fetal fMRI present a new opportunity for neuroscience to study functional human brain connectivity at the time of its emergence. Progress in the field, however, has been hampered by the lack of openly available datasets …
View article: Exploring functional connectivity in clinical and data-driven groups of preterm and term adults
Exploring functional connectivity in clinical and data-driven groups of preterm and term adults Open
Adults born very preterm (i.e. at <33 weeks’ gestation) are more susceptible to long-lasting structural and functional brain alterations and cognitive and socio-emotional difficulties, compared with full-term controls. However, behaviou…
View article: Early predictors of late childhood behavioural outcomes following very preterm birth
Early predictors of late childhood behavioural outcomes following very preterm birth Open
Background Children born very preterm (VPT; ≤32 weeks’ gestation) are at higher risk of developing behavioural problems, encompassing socio-emotional processing and attention, compared to term-born children. This study aimed to examine mul…
View article: <scp>T<sub>1</sub></scp> and <scp>T<sub>2</sub></scp> measurements of the neonatal brain at <scp>7 T</scp>
<span>T<sub>1</sub></span> and <span>T<sub>2</sub></span> measurements of the neonatal brain at <span>7 T</span> Open
Purpose To determine the expected range of NMR relaxation times (T 1 and T 2 ) in the neonatal brain at 7 T. Methods Data were acquired in a total of 40 examinations on infants in natural sleep. The cohort included 34 unique subjects with …
View article: Environmental variables influence the relationship between maternal depressive symptoms and toddlers' neurocognitive and affective outcomes
Environmental variables influence the relationship between maternal depressive symptoms and toddlers' neurocognitive and affective outcomes Open
Motherhood is often associated with joy, but it can pose significant challenges, and in some instances lead to perinatal mental health problems. Maternal depressive symptoms can hinder a mother's ability to attune to her infant's needs, po…
View article: Harmonizing multisite neonatal diffusion-weighted brain MRI data for developmental neuroscience
Harmonizing multisite neonatal diffusion-weighted brain MRI data for developmental neuroscience Open
Large diffusion-weighted brain MRI (dMRI) studies in neonates are crucial for developmental neuroscience. Our aim was to investigate the utility of ComBat, an empirical Bayes tool for multisite harmonization, in removing site effects from …
View article: Dynamic changes in subplate and cortical plate microstructure at the onset of cortical folding in vivo
Dynamic changes in subplate and cortical plate microstructure at the onset of cortical folding in vivo Open
Cortical gyrification takes place predominantly during the second to third trimester, alongside other fundamental developmental processes, such as the development of white matter connections, lamination of the cortex and formation of neura…
View article: Dynamic changes in subplate and cortical plate microstructure at the onset of cortical folding in vivo
Dynamic changes in subplate and cortical plate microstructure at the onset of cortical folding in vivo Open
Cortical gyrification takes place predominantly during the second to third trimester, alongside other fundamental developmental processes, such as the development of white matter connections, lamination of the cortex and formation of neura…
View article: Structural Covariance Networks in the Fetal Brain Reveal Altered Neurodevelopment for Specific Subtypes of Congenital Heart Disease
Structural Covariance Networks in the Fetal Brain Reveal Altered Neurodevelopment for Specific Subtypes of Congenital Heart Disease Open
Background Altered structural brain development has been identified in fetuses with congenital heart disease (CHD), suggesting that the neurodevelopmental impairment observed later in life might originate in utero. There are many interacti…
View article: Exploring alternative practice placement models: perspectives and experiences of learners and practice educators. A qualitative systematic review.
Exploring alternative practice placement models: perspectives and experiences of learners and practice educators. A qualitative systematic review. Open
Within physiotherapy and occupational therapy practice placements, there is a predominance of the one-to-one supervision model which creates limitations for placement capacity expansion. Alternative placement models must be considered to f…
View article: Cortical scaling of the neonatal brain in typical and altered development
Cortical scaling of the neonatal brain in typical and altered development Open
Theoretically derived scaling laws capture the non-linear relationships between rapidly expanding brain volume and cortical gyrification across mammalian species and in adult humans. However, the preservation of these laws has not been com…
View article: Autism spectrum disorder common variants associated with regional lobe volume variations at birth: cross-sectional study in 273 European term neonates in developing Human Connectome Project
Autism spectrum disorder common variants associated with regional lobe volume variations at birth: cross-sectional study in 273 European term neonates in developing Human Connectome Project Open
Increasing lines of evidence suggest cerebral overgrowth in autism spectrum disorder (ASD) children in early life, but few studies have examined the effect of ASD common genetic variants on brain volumes in a general paediatric population.…