D. Elizabeth Le
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View article: Social Determinants of Cardiovascular Aging
Social Determinants of Cardiovascular Aging Open
Social determinants of health are major drivers of adverse cardiovascular outcomes throughout the life course. As the population ages, understanding how social determinants influence vascular, myocardial, valvular, and electrophysiologic a…
View article: A Narrative Review of the Clinical Applications of Echocardiography in Right Heart Failure
A Narrative Review of the Clinical Applications of Echocardiography in Right Heart Failure Open
Background/Objectives: Historically, echocardiographic imaging of the right heart has been challenging because its abnormal geometry is not conducive to reproducible anatomical and functional assessment. With the development of advanced ec…
View article: Concurrent inferior stemi with third-degree AV block and acute intracranial haemorrhage: how we overcame this clinical challenge—a case report
Concurrent inferior stemi with third-degree AV block and acute intracranial haemorrhage: how we overcame this clinical challenge—a case report Open
Background The concurrent management of ST-elevation myocardial infarction (STEMI) and acute intracerebral haemorrhage (ICH) poses a significant clinical challenge due to conflicting treatment goals. While the management of STEMI requires …
View article: A Review of Momordica charantia L., Botanical Characteristics, Nutritional Properties, and Bioactive Compounds: Insights for Type 2 Diabetes Mellitus
A Review of Momordica charantia L., Botanical Characteristics, Nutritional Properties, and Bioactive Compounds: Insights for Type 2 Diabetes Mellitus Open
The prevalence of metabolic disorders, particularly Type 2 Diabetes Mellitus (T2DM), is rising at an alarming rate worldwide. T2DM, a complex metabolic condition characterized by hyperglycemia and glucose intolerance, remains one of the mo…
View article: 7 Stop Sucking Us Dry: Decreasing Unnecessary Blood Draws in the Intensive Care Unit
7 Stop Sucking Us Dry: Decreasing Unnecessary Blood Draws in the Intensive Care Unit Open
View article: The Quality of Veterans Healthcare Administration Cardiovascular Care
The Quality of Veterans Healthcare Administration Cardiovascular Care Open
A total of 9 million veterans receive care in a unique healthcare system, the Veterans Healthcare Administration (VHA), with nearly 50% reporting at least one cardiovascular disease. Despite evidence for high quality of health care in the …
View article: Hospitalization Trends and Healthcare Resource Utilization for Fecal Impactions in Pediatric Patients with Functional Constipation
Hospitalization Trends and Healthcare Resource Utilization for Fecal Impactions in Pediatric Patients with Functional Constipation Open
Objectives: To analyze the clinical characteristics, trends in hospitalization, and healthcare resource utilization of pediatric patients with fecal impaction. Methods: We utilized the Healthcare Cost and Utilization Project (HCUP) databas…
View article: TUMOUR-RELATED COMPLICATIONS IN PATIENTS WITH STAGE IV COLORECTAL CANCER TREATED WITH CHEMOTHERAPY WITHOUT PRIMARY TUMOR RESECTION
TUMOUR-RELATED COMPLICATIONS IN PATIENTS WITH STAGE IV COLORECTAL CANCER TREATED WITH CHEMOTHERAPY WITHOUT PRIMARY TUMOR RESECTION Open
Background: Although the typical treatment of patients with stage IV colorectal cancer comprises removal of the primary tumor followed by chemotherapy, some studies suggest that in patients with limited symptoms, the first and only treatme…
View article: Metabolomics of repetitive myocardial stunning in chronic multivessel coronary artery stenosis: Effect of non‐selective and selective β1‐receptor blockers
Metabolomics of repetitive myocardial stunning in chronic multivessel coronary artery stenosis: Effect of non‐selective and selective β1‐receptor blockers Open
Chronic coronary artery stenosis can lead to regional myocardial dysfunction in the absence of myocardial infarction by repetitive stunning, hibernation or both. The molecular mechanisms underlying repetitive stunning‐associated myocardial…
View article: Persistent Coronary Vasomotor Tone During Myocardial Ischemia Occurs at the Capillary Level and May Involve Pericytes
Persistent Coronary Vasomotor Tone During Myocardial Ischemia Occurs at the Capillary Level and May Involve Pericytes Open
Background There is persistent coronary vasomotor tone during myocardial ischemia, despite ongoing coronary arteriolar dilatation. The mechanism underlying this vasodilatory tone, which can be unmasked by coronary vasodilators, is unclear.…
View article: Plasma Oxylipins: A Potential Risk Assessment Tool in Atherosclerotic Coronary Artery Disease
Plasma Oxylipins: A Potential Risk Assessment Tool in Atherosclerotic Coronary Artery Disease Open
Background: While oxylipins have been linked to coronary artery disease (CAD), little is known about their diagnostic and prognostic potential. Objective: We tested whether plasma concentration of specific oxylipins may discriminate among …
View article: Ranolazine may exert its beneficial effects by increasing myocardial adenosine levels
Ranolazine may exert its beneficial effects by increasing myocardial adenosine levels Open
We hypothesized that ranolazine-induced adenosine release is responsible for its beneficial effects in ischemic heart disease. Sixteen open-chest anesthetized dogs with noncritical coronary stenosis were studied at rest, during dobutamine …
View article: Therapeutic Ultrasound Increases Myocardial Blood Flow in Ischemic Myocardium and Cardiac Endothelial Cells: Results of In Vivo and In Vitro Experiments
Therapeutic Ultrasound Increases Myocardial Blood Flow in Ischemic Myocardium and Cardiac Endothelial Cells: Results of In Vivo and In Vitro Experiments Open
View article: High molecular weight chitosan derivative polymeric micelles encapsulating superparamagnetic iron oxide for tumor-targeted magnetic resonance imaging
High molecular weight chitosan derivative polymeric micelles encapsulating superparamagnetic iron oxide for tumor-targeted magnetic resonance imaging Open
Magnetic resonance imaging (MRI) contrast agents based on chitosan derivatives have great potential for diagnosing diseases. However, stable tumor-targeted MRI contrast agents using micelles prepared from high molecular weight chitosan der…