David M. Findlay
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View article: Tracking gaseous radioactivity through a spallation neutron source from origin to discharge
Tracking gaseous radioactivity through a spallation neutron source from origin to discharge Open
An exercise has been carried out at the ISIS Spallation Neutron Source to track quantitatively the progress of radioactive air all the way from the machine areas where gaseous radioactivity is generated to the discharge stack from which ga…
View article: Delivery of evidence-based critical care practices across the United Kingdom: A UK-wide multi-site service evaluation in adult units
Delivery of evidence-based critical care practices across the United Kingdom: A UK-wide multi-site service evaluation in adult units Open
Background: The ICU Liberation Bundle was developed to improve outcomes for patients admitted to critical care. Despite a lack of Bundle adoption in the UK, the individual evidence-based practices (EBPs) within the bundle are defined as st…
View article: Is RANKL a potential molecular target in osteoarthritis?
Is RANKL a potential molecular target in osteoarthritis? Open
This review further makes the case for SCB remodelling as important in OA and for additional study of RANKL in OA, both its pathophysiological role and its potential as an OA disease target.
View article: Microstructural and cellular characterisation of the subchondral trabecular bone in human knee and hip osteoarthritis using synchrotron tomography
Microstructural and cellular characterisation of the subchondral trabecular bone in human knee and hip osteoarthritis using synchrotron tomography Open
Objective It is unclear if different factors influence osteoarthritis (OA) progression and the changes characterising OA disease in hip and knee. We investigated the difference between hip OA and knee OA at the subchondral bone tissue and …
View article: Hip osteoarthritis: A novel network analysis of subchondral trabecular bone structures
Hip osteoarthritis: A novel network analysis of subchondral trabecular bone structures Open
Hip osteoarthritis (HOA) is a degenerative joint disease that leads to the progressive destruction of subchondral bone and cartilage at the hip joint. Development of effective treatments for HOA remains an open problem, primarily due to th…
View article: The Effects of Vitamin E Analogues α-Tocopherol and γ-Tocotrienol on the Human Osteocyte Response to Ultra-High Molecular Weight Polyethylene Wear Particles
The Effects of Vitamin E Analogues α-Tocopherol and γ-Tocotrienol on the Human Osteocyte Response to Ultra-High Molecular Weight Polyethylene Wear Particles Open
Polyethylene (PE) liners are a common bearing surface of orthopaedic prostheses. Wear particles of ultra-high molecular weight PE (UHMWPE) contribute to periprosthetic osteolysis, a major cause of aseptic loosening. Vitamin E is added to s…
View article: RT-qPCR for detection of SARS-CoV-2 in wastewater v2
RT-qPCR for detection of SARS-CoV-2 in wastewater v2 Open
As part of the global response to the 2019 novel Coronavirus (SARS-CoV-2) pandemic, it was determined that SARS-CoV-2 RNA was detectable in the faeces of both symptomatic and asymptomatic patients (1). Further analysis demonstrated that a …
View article: SARS-CoV-2 RNA levels in Scotland’s wastewater
SARS-CoV-2 RNA levels in Scotland’s wastewater Open
Nationwide, wastewater-based monitoring was newly established in Scotland to track the levels of SARS-CoV-2 viral RNA shed into the sewage network, during the COVID-19 pandemic. We present a curated, reference data set produced by this nat…
View article: The Effects of Vitamin E Analogues α-Tocopherol and γ-Tocotrienol on the Human Osteocyte Response to Ultra-high Molecular Weight Polyethylene Wear Particles
The Effects of Vitamin E Analogues α-Tocopherol and γ-Tocotrienol on the Human Osteocyte Response to Ultra-high Molecular Weight Polyethylene Wear Particles Open
Polyethylene (PE) liners are a common bearing surface of orthopaedic prostheses. Wear particles of ultra-high molecular weight PE (UHMWPE) contribute to periprosthetic osteolysis, a major cause of aseptic loosening. Vitamin E is added to s…
View article: Hip osteoarthritis: A novel network analysis of subchondral trabecular bone structures
Hip osteoarthritis: A novel network analysis of subchondral trabecular bone structures Open
Hip osteoarthritis (HOA) is a degenerative joint disease that leads to the progressive destruction of subchondral bone and cartilage at the hip joint. Development of effective treatments for HOA remains an open problem, primarily due to th…
View article: RT-qPCR for detection of SARS-CoV-2 in wastewater v1
RT-qPCR for detection of SARS-CoV-2 in wastewater v1 Open
As part of the global response to the 2019 novel Coronavirus (SARS-CoV-2) pandemic, it was determined that SARS-CoV-2 RNA was detectable in the faeces of both symptomatic and asymptomatic patients (1). Further analysis demonstrated that a …
View article: RNA extraction from wastewater for detection of SARS-CoV-2 v1
RNA extraction from wastewater for detection of SARS-CoV-2 v1 Open
As part of the global response to the 2019 novel Coronavirus (SARS-CoV-2) pandemic, it was determined that SARS-CoV-2 RNA was detectable in the faeces of both symptomatic and asymptomatic patients (1). Further analysis demonstrated that a …
View article: Site Specific Relationships between COVID-19 Cases and SARS-CoV-2 Viral Load in Wastewater Treatment Plant Influent
Site Specific Relationships between COVID-19 Cases and SARS-CoV-2 Viral Load in Wastewater Treatment Plant Influent Open
Wastewater based epidemiology (WBE) has become an important tool during the COVID-19 pandemic, however the relationship between SARS-CoV-2 RNA in wastewater treatment plant influent (WWTP) and cases in the community is not well-defined. We…
View article: Elevated levels of active Transforming Growth Factor β1 in the subchondral bone relate spatially to cartilage loss and impaired bone quality in human knee osteoarthritis
Elevated levels of active Transforming Growth Factor β1 in the subchondral bone relate spatially to cartilage loss and impaired bone quality in human knee osteoarthritis Open
Objective Over-activity of transforming growth factor β1 (TGFβ1) in subchondral bone has a direct causal role in rodent models of knee osteoarthritis (OA), which can be blocked by TGFβ1 neutralisation. In this study, we investigated whethe…
View article: A case of autosomal dominant osteopetrosis type II with a severe bone phenotype but no amino acid converting mutation in the <i>CLCN7</i> gene
A case of autosomal dominant osteopetrosis type II with a severe bone phenotype but no amino acid converting mutation in the <i>CLCN7</i> gene Open
Autosomal Dominant Osteopetrosis type II (ADOII), also known as Albers-Schönberg disease, is caused by mutation of the CLCN7 chloride channel gene and is characterized by reduced bone resorption. Here we report on an individual with the cl…
View article: COVID-19 mass testing: harnessing the power of wastewater epidemiology
COVID-19 mass testing: harnessing the power of wastewater epidemiology Open
Summary Background COVID-19 patients shed SARS-CoV-2 RNA in their faeces. We hypothesised that detection of SARS-CoV-2 RNA in wastewater treatment plant (WWTP) influent could be a valuable tool to assist in public health decision making. W…
View article: On oversampling imbalanced data with deep conditional generative models
On oversampling imbalanced data with deep conditional generative models Open
Class imbalanced datasets are common in real-world applications ranging from credit card fraud detection to rare disease diagnosis. Recently, deep generative models have proved successful for an array of machine learning problems such as s…
View article: Raman microspectroscopy demonstrates reduced mineralization of subchondral bone marrow lesions in knee osteoarthritis patients
Raman microspectroscopy demonstrates reduced mineralization of subchondral bone marrow lesions in knee osteoarthritis patients Open
As measured by Raman microspectroscopy, SCTB tissue in BML zones in KOA is significantly less mineralized than the corresponding zones in individuals without OA. These data are consistent with those obtained using other methods (e.g. Fouri…
View article: ISIS spallation neutron targets - confirmation of Monte Carlo activity calculations by measurement
ISIS spallation neutron targets - confirmation of Monte Carlo activity calculations by measurement Open
Comparisons between measurements and calculations of activities of radionuclides in spent tantalum-clad tungsten targets from the ISIS Spallation Neutron Source are presented. Uncertainties in the measurements and the calculations are disc…
View article: Evidence for Gender-Specific Bone Loss Mechanisms in Periprosthetic Osteolysis
Evidence for Gender-Specific Bone Loss Mechanisms in Periprosthetic Osteolysis Open
Osteolysis adjacent to total hip replacement (THR) prostheses is a major cause of their eventual failure. Periprosthetic osteolysis is associated with the production of bioactive particles, produced by the wear of articulating prosthesis s…