Raja M. Flores
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View article: Stop Canceling Surgery for Esophageal Cancer: An Analysis of Treatment Related Mortality in 60 000 Patients
Stop Canceling Surgery for Esophageal Cancer: An Analysis of Treatment Related Mortality in 60 000 Patients Open
Background and Methods Surgical esophagectomy is falsely regarded as contributing little survival in resectable, early‐stage disease in favor of nonsurgical treatment with definitive chemoradiation (dCR). We examine surgery in treatment by…
View article: Emphysema at Baseline Low-Dose CT Lung Cancer Screening Predicts Death from Chronic Obstructive Pulmonary Disease and Cardiovascular Disease Up to 25 Years Later
Emphysema at Baseline Low-Dose CT Lung Cancer Screening Predicts Death from Chronic Obstructive Pulmonary Disease and Cardiovascular Disease Up to 25 Years Later Open
Emphysema identified at baseline low-dose CT in a lung cancer screening program was predictive of all-cause, chronic obstructive pulmonary disease, and cardiovascular disease mortality 25 years later in 9047 asymptomatic adults with a smok…
View article: Superior surgical tolerance and effectiveness among lung cancer patients who have never versus ever smoked: a retrospective cohort analysis using real-world clinical data
Superior surgical tolerance and effectiveness among lung cancer patients who have never versus ever smoked: a retrospective cohort analysis using real-world clinical data Open
LCNS and LCES surgical patients differ meaningfully in terms of clino-demographic factors. Our results support surgery as a safe and effective treatment option for LCNS.
View article: HEs Consciousness Scale: a rapid and promising classification for early assessment of post-anesthesia consciousness recovery
HEs Consciousness Scale: a rapid and promising classification for early assessment of post-anesthesia consciousness recovery Open
Postoperative cognitive dysfunction (POCD) is a common complication after thoracic surgery, especially after complex surgeries involving general anesthesia, such as lung transplantation. Improving anesthetic strategies may offer an effecti…
View article: Incongruence Between Prerequisite Molecular Testing and Treatment with Personalized Therapies for Non-Small Cell Lung Cancer: A Surveillance, Epidemiology and End Results-Medicare Study
Incongruence Between Prerequisite Molecular Testing and Treatment with Personalized Therapies for Non-Small Cell Lung Cancer: A Surveillance, Epidemiology and End Results-Medicare Study Open
Personalized medicine, including targeted and immunotherapy, has substantially changed the landscape of non-small cell lung cancer (NSCLC). About 30% of NSCLC tumors have targetable mutations, like EGFR, and 28% of tumors will have a PD-L1…
View article: Race, gender, and safety: exposing biases in minimally invasive lung cancer surgery research
Race, gender, and safety: exposing biases in minimally invasive lung cancer surgery research Open
There are multiple differences between MIS and open surgery, but it is unclear if any confer a clinical benefit. Patients undergoing MIS tend to be healthier with earlier-stage disease, suggesting biases in patient selection. The data sugg…
View article: Palliative surgery is effective in patients with EGFR-mutant lung adenocarcinoma with pleural metastasis
Palliative surgery is effective in patients with EGFR-mutant lung adenocarcinoma with pleural metastasis Open
Compared with EGFR-TKI monotherapy, palliative surgery combined with EGFR-TKI treatment prolonged the PFS of pleural metastatic EGFR-LUADm patients. A subset of EGFR-LUADm patients with pleural metastasis might be suitable for palliative s…
View article: Quality of life outcomes after robotic-assisted and video-assisted thoracoscopic surgery for early-stage non–small cell lung cancer
Quality of life outcomes after robotic-assisted and video-assisted thoracoscopic surgery for early-stage non–small cell lung cancer Open
RATS and VATS offer similar long-term QoL outcomes for early-stage NSCLC patients, though RATS patients may experience a sharper initial decline in physical health.
View article: Ultra-remote robot-assisted right upper lobectomy between the Shanghai and Kashi Prefectures: a case report
Ultra-remote robot-assisted right upper lobectomy between the Shanghai and Kashi Prefectures: a case report Open
We reported the first case in which a remote robot-assisted lobectomy was performed using a robotic surgical system, 5G technology, and corresponding procedures. More cohorts or clinical studies need to be conducted to further clarify the …
View article: Paradoxical Improvement in Malignant Pleural Mesothelioma Outcomes Following Delayed Treatment Initiation
Paradoxical Improvement in Malignant Pleural Mesothelioma Outcomes Following Delayed Treatment Initiation Open
Background/Objectives: Time to treatment initiation (TTI) has been identified as a predictor of survival in many cancers, but its impact on malignant pleural mesothelioma (MPM) is unknown. This study investigates factors influencing TTI in…
View article: Supplementary Table S5 from Single-Cell View of Tumor Microenvironment Gradients in Pleural Mesothelioma
Supplementary Table S5 from Single-Cell View of Tumor Microenvironment Gradients in Pleural Mesothelioma Open
Gene signatures for all 54 de novo discovered PM cNMF modules
View article: Data from Single-Cell View of Tumor Microenvironment Gradients in Pleural Mesothelioma
Data from Single-Cell View of Tumor Microenvironment Gradients in Pleural Mesothelioma Open
Immunotherapies have shown great promise in pleural mesothelioma (PM), yet most patients still do not achieve significant clinical response, highlighting the importance of improving the understanding of the tumor microenvironment (TME). He…
View article: Supplementary Figure S6 from Single-Cell View of Tumor Microenvironment Gradients in Pleural Mesothelioma
Supplementary Figure S6 from Single-Cell View of Tumor Microenvironment Gradients in Pleural Mesothelioma Open
NK cell IC blockade targeting NKG2A as a novel therapeutic strategy in PM
View article: Supplementary Figure S5 from Single-Cell View of Tumor Microenvironment Gradients in Pleural Mesothelioma
Supplementary Figure S5 from Single-Cell View of Tumor Microenvironment Gradients in Pleural Mesothelioma Open
Molecular dissection of T cell programs and IC molecules shows association with scS-score
View article: Supplementary Table S4 from Single-Cell View of Tumor Microenvironment Gradients in Pleural Mesothelioma
Supplementary Table S4 from Single-Cell View of Tumor Microenvironment Gradients in Pleural Mesothelioma Open
De novo markers discovered for each detailed cell type annotation in the peripheral blood samples
View article: Supplementary Table S2 from Single-Cell View of Tumor Microenvironment Gradients in Pleural Mesothelioma
Supplementary Table S2 from Single-Cell View of Tumor Microenvironment Gradients in Pleural Mesothelioma Open
De novo markers discovered for each major cell type annotation in tumor samples
View article: Supplementary Figure S2 from Single-Cell View of Tumor Microenvironment Gradients in Pleural Mesothelioma
Supplementary Figure S2 from Single-Cell View of Tumor Microenvironment Gradients in Pleural Mesothelioma Open
Unbiased discovery of PM cancer programs and association with patient survival
View article: Supplementary Table S1 from Single-Cell View of Tumor Microenvironment Gradients in Pleural Mesothelioma
Supplementary Table S1 from Single-Cell View of Tumor Microenvironment Gradients in Pleural Mesothelioma Open
Patients clinical information
View article: Supplementary Figure S3 from Single-Cell View of Tumor Microenvironment Gradients in Pleural Mesothelioma
Supplementary Figure S3 from Single-Cell View of Tumor Microenvironment Gradients in Pleural Mesothelioma Open
Fetal-like, cancer-specific PLVAP+ endothelial cells associate with angiogenesis