Explanipedia

Estimating the opportunity cost of seasonal malaria chemoprevention implementation in Burkina Faso, Mali and Senegal Open

Richmond Owusu, Colin Gilmartin, Halimatou Diawara, Fadima Yaya Bocoum, Oumy Ndiaye , et al. · 2025

Background Seasonal malaria chemoprevention (SMC) is a widely implemented malaria prevention strategy for children under five in the Sahel and sub-Sahel regions of Africa. This study aimed to estimate the full opportunity costs associated …

The cost of delivering COVID-19 vaccines in four districts in Malawi Open

Anika Ruisch, Simon Ntopi, Ishani Mathur, Maeve Conlin, Anna McCaffrey , et al. · 2025

Reflections on the Lancet Commission on Investing in Health's Global Health 2050 report Open

Damian Walker, Justice Nonvignon, Saba Waseem, Dan Schwarz · 2025

Supporting local ownership of transition processes: a key pathway to sustaining the HIV response Open

Lindsay Moore Murphy, Deborah Stenoien, Eliza Love, Hilary Mwale, Vu Thi Tuong , et al. · 2025

Globally, an increasing number of countries have made progress towards HIV epidemic control, yet decreasing donor funding and insufficient domestic investments threaten these strides. Within this context, the global community is interested…

Towards institutionalizing HTA in Ethiopia: using a political economy analysis to explore stakeholder perspectives and assessing capacity needs Open

Daniel Erku, Desalegn Ararso, Teweldemedhn Mekonnen, Erimias Dessie, Firmaye Bogale Wolde , et al. · 2025

Background As Ethiopia advances towards efficient resource utilization and UHC through strategic health purchasing, the institutionalization of HTA will play a critical role. This study aims to identify key stakeholders, analyze the politi…

Systematic review on the cost of seasonal malaria chemoprevention (SMC) Open

Anika Ruisch, Maddalena Iodice, Ishani Mathur, Sara Harris, Damian Walker , et al. · 2024

The level of detail for reporting SMC costs and cost categories varied greatly by study as did the scale of intervention, limiting comparability as well as an understanding of the complete costs and resource requirements for SMC implementa…

Impact of the 100 days mission for vaccines on COVID-19: a mathematical modelling study Open

Gregory Barnsley, Daniela Olivera Mesa, Alexandra B. Hogan, Peter Winskill, Andrew A Torkelson , et al. · 2024

The cost of delivering COVID-19 vaccines in four districts in Malawi Open

Anika Ruisch, Simon Ntopi, Ishani Mathur, Maeve Conlin, Anna McCaffrey , et al. · 2024

While COVID-19 vaccines became available in late 2020, low-income countries (LICs) faced challenging COVID-19 vaccine distribution efforts both in terms of a delayed and scarce vaccine supply and barriers reaching the target populations. T…

The cost of mass drug administration for trachoma in two counties of the Republic of South Sudan Open

Tim Jesudason, Angelia M. Sanders, Stephen Ohidor, Alexis S. Delahunt, Andrew R. Deathe , et al. · 2024

Community-wide distribution of azithromycin, otherwise known as mass drug administration (MDA), is a component of the World Health Organization-endorsed SAFE strategy for the elimination of trachoma as a public health problem. In the Repub…

Costs and resource needs for primary health care in Ethiopia: evidence to inform planning and budgeting for universal health coverage Open

Alebachew Abebe, Engida Abdella, Samuel Abera, Ermias Dessie, Tesfaye Mesele , et al. · 2023

Introduction The Government of Ethiopia (GoE) has made significant progress in expanding access to primary health care (PHC) over the past 15 years. However, achieving national PHC targets for universal health coverage will require a signi…

An assessment of primary health care costs and resource requirements in Kaduna and Kano, Nigeria Open

Yewande Kofoworola Ogundeji, Hamza Abubakar, Uche Ezeh, Tijjani Hussaini, Nelson Kamau , et al. · 2023

Introduction The availability of quality primary health care (PHC) services in Nigeria is limited. The PHC system faces significant challenges and the improvement and expansion of PHC services is constrained by low government spending on h…

The costs and financing needs of delivering Kenya’s primary health care service package Open

Agatha Olago, Christian Suharlim, Salim Hussein, David Njuguna, Stephen Macharia , et al. · 2023

Introduction For many Kenyans, high-quality primary health care (PHC) services remain unavailable, inaccessible, or unaffordable. To address these challenges, the Government of Kenya has committed to strengthening the country’s PHC system …

Insights to COVID-19 vaccine delivery: Results from a survey of 27 countries Open

Ishani Mathur, Rachael Church, Anika Ruisch, Karina Noyes, Anna McCaffrey , et al. · 2023

Most countries rolled out COVID-19 vaccination during 2021-2022. However, COVID-19 vaccine delivery cost estimates are still needed to support planning and budgeting to integrate COVID-19 vaccines into routine programs and to target high r…

Supplemental Figures and Table from Preclinical Antitumor Activity of a Novel Anti–c-KIT Antibody–Drug Conjugate against Mutant and Wild-type c-KIT–Positive Solid Tumors Open

Tinya J. Abrams, Anu Connor, Christie Fanton, Steven B. Cohen, Thomas S. Huber , et al. · 2023

Figure S1. RNASeq data across multiple tumor types indicate c-KIT overexpression in a subset of cancer types such as AML, melanoma, testicular germ cell cancer and lung cancer. This was obtained from the TCGA data set. Figure S2. Western b…

Data from Preclinical Antitumor Activity of a Novel Anti–c-KIT Antibody–Drug Conjugate against Mutant and Wild-type c-KIT–Positive Solid Tumors Open

Tinya J. Abrams, Anu Connor, Christie Fanton, Steven B. Cohen, Thomas S. Huber , et al. · 2023

Purpose: c-KIT overexpression is well recognized in cancers such as gastrointestinal stromal tumors (GIST), small cell lung cancer (SCLC), melanoma, non–small cell lung cancer (NSCLC), and acute myelogenous leukemia (AML). Treatment…

Supplemental Figures and Table from Preclinical Antitumor Activity of a Novel Anti–c-KIT Antibody–Drug Conjugate against Mutant and Wild-type c-KIT–Positive Solid Tumors Open

Tinya J. Abrams, Anu Connor, Christie Fanton, Steven B. Cohen, Thomas S. Huber , et al. · 2023

Figure S1. RNASeq data across multiple tumor types indicate c-KIT overexpression in a subset of cancer types such as AML, melanoma, testicular germ cell cancer and lung cancer. This was obtained from the TCGA data set. Figure S2. Western b…

Data from Preclinical Antitumor Activity of a Novel Anti–c-KIT Antibody–Drug Conjugate against Mutant and Wild-type c-KIT–Positive Solid Tumors Open

Tinya J. Abrams, Anu Connor, Christie Fanton, Steven B. Cohen, Thomas S. Huber , et al. · 2023

Purpose: c-KIT overexpression is well recognized in cancers such as gastrointestinal stromal tumors (GIST), small cell lung cancer (SCLC), melanoma, non–small cell lung cancer (NSCLC), and acute myelogenous leukemia (AML). Treatment…

Cost and community acceptability of enhanced antibiotic distribution approaches for trachoma in the Republic of South Sudan: enhancing the A in SAFE (ETAS) study protocol Open

Angelia M. Sanders, Samuel Yibi Makoy, Andrew R. Deathe, Stephen Ohidor, Timothy C. Jesudason , et al. · 2023

Institutionalizing health technology assessment in Ethiopia: seizing the window of opportunity Open

Daniel Erku, Damian Walker, Ana Amaris Caruso, Befikadu Legesse Wubishet, Yibeltal Assefa , et al. · 2023

Ethiopia’s commitment to achieving universal health coverage (UHC) requires an efficient and equitable health priority-setting practice. The Ministry of Health aims to institutionalize health technology assessment (HTA) to support evidence…

Modelling the Potential Impact of 100 Days Mission and Broader Investments on the Covid-19 Pandemic Open

Andrew A. Torkleson, Gregory Barnsley, Daniela Olivera Mesa, Damian Walker, Azra C. Ghani , et al. · 2023

Impact of 100 Days Vaccination Mission on COVID-19: A Mathematical Modelling Study Open

Gregory Barnsley, Daniela Olivera Mesa, Alexandra B. Hogan, Peter Winskill, Andrew A. Torkleson , et al. · 2023

The Impact of COVID-19 on Hospital Admissions for Twelve High-Burden Diseases and Five Common Procedures in the Philippines: A National Health Insurance Database Study 2019-2020 Open

Jhanna Uy, Vanessa T. Siy Van, Valerie Gilbert Ulep, Diana Beatriz Bayani, Damian Walker · 2021

PAX8 lineage-driven T cell engaging antibody for the treatment of high-grade serous ovarian cancer Open

Emily Lee, Sarah Szvetecz, Ryan Polli, Angelo L. Grauel, Jayson Chen , et al. · 2021

COVID-19's lost generation of unvaccinated children Open

Damian Walker, Subhash Chandir · 2021

Lockdown is not egalitarian: the costs fall on the global poor Open

Alexander Broadbent, Damian Walker, Kalipso Chalkidou, Richard Sullivan, Amanda Glassman · 2020

Adherence to the iDSI reference case among published cost-per-DALY averted studies Open

Joanna Emerson, Ari D. Panzer, Joshua T. Cohen, Kalipso Chalkidou, Yot Teerawattananon , et al. · 2019

The iDSI reference case has substantial potential to serve as a useful resource for researchers and policy-makers in global health settings, but greater effort to promote adherence and awareness is needed to achieve its potential.

Household Costs of Diarrhea by Etiology in 7 Countries, The Global Enterics Mulitcenter Study (GEMS) Open

Marita Zimmermann, Karen L. Kotloff, Dilruba Nasrin, Anna Roose, Myron M. Levine , et al. · 2019

We found no significant differences in household costs by pathogen. Despite data limitations, understanding pathogen-specific household costs (or lack thereof) is useful, as decision-makers could consider broader illness cost information a…

Antibiotic treatment for newborns with congenital syphilis Open

Godfrey JA Walker, Damian Walker, Daniel Molano-Franco, Carlos Fernando Grillo‐Ardila · 2019

At present, the evidence on the effectiveness and safety of antibiotic treatment for newborns with confirmed, highly probable or possible congenital syphilis is sparse, implying that we are uncertain about the estimated effect. One trial c…

Method development and laboratory intercomparison of an RP-HPLC-UV method for energetic chemicals in marine tissues Open

Harry D. Craig, Thomas F. Jenkins, Mitch T. Johnson, Damian Walker, David E. Dobb , et al. · 2019

International Decision Support Initiative reference case for health economic evaluation Open

Thomas Wilkinson, Kalipso Chalkidou, Damian Walker, Ruth Lopert, Yot Teerawattananon , et al. · 2019

The International Decision Support Initiative (iDSI) Reference Case for Health Economic Evaluation is a second edition of a report previously titled Bill and Melinda Gates Foundation (BMGF) Methods for Economic Evaluation Project (MEEP) Fi…

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