Dario Greco
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View article: Unmasking metabolic disruptors: The NEMESIS project's quest for Novel Biomarkers, Evidence on Adverse Effects, and Efficient Methodologies
Unmasking metabolic disruptors: The NEMESIS project's quest for Novel Biomarkers, Evidence on Adverse Effects, and Efficient Methodologies Open
Metabolism disrupting chemicals (MDCs) elicit negative effects on metabolically active organs such as the liver and the pancreas, altering normal metabolic processes. Chemicals that are known, or suspected MDCs include compounds found in …
View article: Transforming Infection Management with Organic Bioelectronic Materials and Devices
Transforming Infection Management with Organic Bioelectronic Materials and Devices Open
Synergies between the emerging field of organic bioelectronics and microbiology are paving the way for significant advances in biomedical research and medical technology. While in vitro models of infections form the foundation of our curre…
View article: BMDx2: A Tool for Integrating Toxicogenomics‐Based Dose‐Dependency Analysis and AOP‐Based Mechanistic Insights
BMDx2: A Tool for Integrating Toxicogenomics‐Based Dose‐Dependency Analysis and AOP‐Based Mechanistic Insights Open
Despite the advent of mechanistic toxicology using omics data to link molecular perturbations with systemic outcomes, regulatory toxicology still lacks the application of mechanism‐anchored metrics from such data. This is partially because…
View article: OpTiles: an R package for adaptive tiling and methylation variability profiling
OpTiles: an R package for adaptive tiling and methylation variability profiling Open
Summary OpTiles is an R package that dynamically defines tiling windows based on the distribution of sequenced CpGs, addressing the limitations of traditional fixed-tiling approaches in targeted methylation datasets. By integrating CpG den…
View article: Same model, better performance: the impact of shuffling on DNA Language Models benchmarking
Same model, better performance: the impact of shuffling on DNA Language Models benchmarking Open
Large Language Models are increasingly popular in genomics due to their potential to decode complex biological sequences. Hence, researchers require a standardized benchmark to evaluate DNA Language Models (DNA LMs) capabilities. However, …
View article: OpTiles: An R Package for Adaptive Tiling and Methylation Variability Profiling
OpTiles: An R Package for Adaptive Tiling and Methylation Variability Profiling Open
Summary OpTiles is an R package that dynamically defines tiling windows based on the distribution of sequenced CpGs, addressing the limitations of traditional fixed-tiling approaches in targeted methylation datasets. By integrating CpG den…
View article: Comparison of Lung Inflammatory and Transcriptional Responses in Mice and Rats Following Pulmonary Exposure to a Fiber Paradigm-Compatible and Non-Compatible MWCNT
Comparison of Lung Inflammatory and Transcriptional Responses in Mice and Rats Following Pulmonary Exposure to a Fiber Paradigm-Compatible and Non-Compatible MWCNT Open
Inhalation of multi-walled carbon nanotubes (MWCNTs) poses potential health risks due to their structural similarity to asbestos and their ability to induce chronic lung inflammation, fibrosis, and lung cancer in animal models. This study …
View article: Multi-omic triangulation identifies molecular candidates of atopic dermatitis severity
Multi-omic triangulation identifies molecular candidates of atopic dermatitis severity Open
Atopic dermatitis (AD) is a common skin disease with most of the health, social and economic impact driven by those with more severe disease. Determining the molecular pathways that influence severity is therefore crucial, offering opportu…
View article: Wisdom of Crowds for Supporting the Safety Evaluation of Nanomaterials.
Wisdom of Crowds for Supporting the Safety Evaluation of Nanomaterials. Open
The development of new approach methodologies (NAMs) to replace current in vivo testing for the safety assessment of engineered nanomaterials (ENMs) is hindered by the scarcity of validated experimental data for many ENMs. We introduce a f…
View article: Two roads to fibrosis: Contrasting initiating mechanisms of Bleomycin and TGFβ-1 in lung fibroblasts
Two roads to fibrosis: Contrasting initiating mechanisms of Bleomycin and TGFβ-1 in lung fibroblasts Open
Pulmonary fibrosis, a progressive and debilitating disease, presents a significant global health challenge. Even though often idiopathic, drug-induced fibrosis is increasing its incidence. Traditional chemical safety assessments, relying o…
View article: Endothelial sensitivity to pro-fibrotic signals links systemic exposure to pulmonary fibrosis
Endothelial sensitivity to pro-fibrotic signals links systemic exposure to pulmonary fibrosis Open
Pulmonary fibrosis (PF) is a life-threatening condition characterised by excessive extracellular matrix deposition and tissue scarring. While much of PF research has focused on alveolar epithelial cells and fibroblasts, endothelial cells h…
View article: BTK inhibitor ibrutinib reduces LPS-induced inflammation in C8-B4 microglia
BTK inhibitor ibrutinib reduces LPS-induced inflammation in C8-B4 microglia Open
In this study, we examined the potential of Bruton tyrosine kinase (BTK) inhibitor ibrutinib to mitigate neuroinflammation in C8-B4 microglial cells activated by the bacterial endotoxin lipopolysaccharide (LPS). Our objective was to enhanc…
View article: Bruton’s Tyrosine Kinase: A Potential Novel Target for Neurological Disorders
Bruton’s Tyrosine Kinase: A Potential Novel Target for Neurological Disorders Open
Bruton’s tyrosine kinase (BTK) is a crucial part of the B-cell receptor signaling pathway that has been extensively studied in various types of malignancies. Recent studies have extended our knowledge on its role in metabolism as well as n…
View article: Curated and harmonised transcriptomics datasets of interstitial lung diseases
Curated and harmonised transcriptomics datasets of interstitial lung diseases Open
This study provides manually curated and homogenised transcriptomics data of interstitial lung disease (ILD) patients retrieved from the NCBI Gene Expression Omnibus and European Nucleotide Archive repositories. The compendium includes 30 …
View article: Novel PD-1-targeted, activity-optimized IL-15 mutein SOT201 acting in cis provides antitumor activity superior to PD1-IL2v
Novel PD-1-targeted, activity-optimized IL-15 mutein SOT201 acting in cis provides antitumor activity superior to PD1-IL2v Open
Background SOT201 and its murine surrogate mSOT201 are novel cis-acting immunocytokines consisting of a humanized/murinized/, Fc-silenced anti-programmed cell death protein 1 (PD-1) monoclonal antibody (mAb) fused to an attenuated human in…
View article: MUUMI: an R package for statistical and network-based meta-analysis for MUlti-omics data Integration
MUUMI: an R package for statistical and network-based meta-analysis for MUlti-omics data Integration Open
Summary Disentangling physiopathological mechanisms of biological systems through high-level integration of omics data has become a standard procedure in life sciences. However, platform heterogeneity, batch effects, and the lack of unifie…
View article: The role of cardiovascular aging in heart failure
The role of cardiovascular aging in heart failure Open
Cardiovascular aging represents a critical factor contributing to the rising prevalence of heart failure in aging populations, as structural and functional changes occurring in the heart and vasculature during aging result in an increased …
View article: Endothelial Sensitivity to Pro-Fibrotic Signals Links Systemic exposure to Pulmonary Fibrosis
Endothelial Sensitivity to Pro-Fibrotic Signals Links Systemic exposure to Pulmonary Fibrosis Open
Summary Pulmonary fibrosis (PF) is a life-threatening condition characterised by excessive extracellular matrix deposition and tissue scarring. While much of PF research has focused on alveolar epithelial cells and fibroblasts, endothelial…
View article: CHIASMA: Advancing chemicals and materials safety and sustainability assessments through innovative integration of in vitro and in silico (new approach) methodologies
CHIASMA: Advancing chemicals and materials safety and sustainability assessments through innovative integration of in vitro and in silico (new approach) methodologies Open
Traditional in vivo methodologies have long formed the foundation of chemical and material safety assessment, yet they are increasingly inadequate to meet modern regulatory, ethical, and sustainability demands. These conventional approache…
View article: Taxonomic and functional profiling of skin microbiome in psoriasis
Taxonomic and functional profiling of skin microbiome in psoriasis Open
This research utilizes whole metagenomic shotgun sequencing to analyse the skin microbiome in patients with psoriasis, comparing lesional and nonlesional skin with those of healthy individuals. The study identifies significant differences …
View article: Toxicogenomic assessment of in vitro macrophages exposed to profibrotic challenge reveals a sustained transcriptomic immune signature
Toxicogenomic assessment of in vitro macrophages exposed to profibrotic challenge reveals a sustained transcriptomic immune signature Open
Immune signalling is a crucial component in the progression of fibrosis. However, approaches for the safety assessment of potentially profibrotic substances, that provide information on mechanistic immune responses, are underdeveloped. Thi…