Dale L. Greiner
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View article: Increased longevity of circulating human IgG in an NSG Fc gamma receptor-1 deficient humanized mouse model
Increased longevity of circulating human IgG in an NSG Fc gamma receptor-1 deficient humanized mouse model Open
Monoclonal antibodies (mAbs) are powerful therapeutic tools that are used to treat multiple types of human cancer as well as a diverse set of non-malignant diseases. Humanized NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ (NSG) mice implanted with huma…
View article: Mapping histologic and functional maturation of human endocrine pancreas across early postnatal periods
Mapping histologic and functional maturation of human endocrine pancreas across early postnatal periods Open
Human endocrine cell differentiation and islet morphogenesis play critical roles in determining islet cell mass and function, but the events and timeline of these processes are incompletely defined. To better understand early human islet c…
View article: Interruption of glucagon signaling augments islet non-alpha cell proliferation in SLC7A2- and mTOR-dependent manners
Interruption of glucagon signaling augments islet non-alpha cell proliferation in SLC7A2- and mTOR-dependent manners Open
Our findings demonstrate that interruption of glucagon signaling augments islet non-alpha cell proliferation in zebrafish, rodents, and transplanted human islets in a manner requiring SLC7A2 and mTORC1 activation. An increase in delta cell…
View article: Interruption of glucagon signaling augments islet non-alpha cell proliferation in SLC7A2- and mTOR-dependent manners
Interruption of glucagon signaling augments islet non-alpha cell proliferation in SLC7A2- and mTOR-dependent manners Open
Objective Dysregulated glucagon secretion and inadequate functional beta cell mass are hallmark features of diabetes. While glucagon receptor (GCGR) antagonism ameliorates hyperglycemia and elicits beta cell regeneration in pre-clinical mo…
View article: Author Correction: IFNγ-IL12 axis regulates intercellular crosstalk in metabolic dysfunction-associated steatotic liver disease
Author Correction: IFNγ-IL12 axis regulates intercellular crosstalk in metabolic dysfunction-associated steatotic liver disease Open
The original version of this Article contained an error in the methods, which read "RNA-seq data analysis of TILAM in human subjects with MASLD and MASH".The correct version now states "RNA-seq data analysis of liver genes in human subject…
View article: Nuclear factor kappa B-dependent persistence of <i>Salmonella</i> Typhi and Paratyphi in human macrophages
Nuclear factor kappa B-dependent persistence of <i>Salmonella</i> Typhi and Paratyphi in human macrophages Open
Salmonella serovars Typhi and Paratyphi cause a prolonged illness known as enteric fever, whereas other serovars cause acute gastroenteritis. Mechanisms responsible for the divergent clinical manifestations of nontyphoidal and enteric feve…
View article: Identification of a humanized mouse model for functional testing of immune-mediated biomaterial foreign body response
Identification of a humanized mouse model for functional testing of immune-mediated biomaterial foreign body response Open
Biomedical devices comprise a major component of modern medicine, however immune-mediated fibrosis and rejection can limit their function over time. Here, we describe a humanized mouse model that recapitulates fibrosis following biomateria…
View article: Simultaneous evaluation of treatment efficacy and toxicity for bispecific T‐cell engager therapeutics in a humanized mouse model
Simultaneous evaluation of treatment efficacy and toxicity for bispecific T‐cell engager therapeutics in a humanized mouse model Open
Immuno‐oncology (IO)‐based therapies such as checkpoint inhibitors, bi‐specific antibodies, and CAR‐T‐cell therapies have shown significant success in the treatment of several cancer indications. However, these therapies can result in the …
View article: Data from Inhibition of Bromodomain Proteins for the Treatment of Human Diffuse Large B-cell Lymphoma
Data from Inhibition of Bromodomain Proteins for the Treatment of Human Diffuse Large B-cell Lymphoma Open
Purpose: Approximately 50% of patients with diffuse large B-cell lymphoma (DLBCL) enter long-term remission after standard chemotherapy. Patients with DLBCL who do not respond to chemotherapy have few treatment options. There remains a cri…
View article: Data Supplement from Inhibition of Bromodomain Proteins for the Treatment of Human Diffuse Large B-cell Lymphoma
Data Supplement from Inhibition of Bromodomain Proteins for the Treatment of Human Diffuse Large B-cell Lymphoma Open
Supplementary Figure S1. Reports cell cycle analysis after 4 days of drug treatment.
View article: Data Supplement from Inhibition of Bromodomain Proteins for the Treatment of Human Diffuse Large B-cell Lymphoma
Data Supplement from Inhibition of Bromodomain Proteins for the Treatment of Human Diffuse Large B-cell Lymphoma Open
Supplementary Figure Legend
View article: Data from Inhibition of Bromodomain Proteins for the Treatment of Human Diffuse Large B-cell Lymphoma
Data from Inhibition of Bromodomain Proteins for the Treatment of Human Diffuse Large B-cell Lymphoma Open
Purpose: Approximately 50% of patients with diffuse large B-cell lymphoma (DLBCL) enter long-term remission after standard chemotherapy. Patients with DLBCL who do not respond to chemotherapy have few treatment options. There remains a cri…
View article: Data Supplement from Inhibition of Bromodomain Proteins for the Treatment of Human Diffuse Large B-cell Lymphoma
Data Supplement from Inhibition of Bromodomain Proteins for the Treatment of Human Diffuse Large B-cell Lymphoma Open
Supplementary Figure S1. Reports cell cycle analysis after 4 days of drug treatment.
View article: Data Supplement from Inhibition of Bromodomain Proteins for the Treatment of Human Diffuse Large B-cell Lymphoma
Data Supplement from Inhibition of Bromodomain Proteins for the Treatment of Human Diffuse Large B-cell Lymphoma Open
Supplementary Figure Legend
View article: NOD-<i>scid IL2rγnull</i> mice lacking TLR4 support human immune system development and the study of human-specific innate immunity
NOD-<i>scid IL2rγnull</i> mice lacking TLR4 support human immune system development and the study of human-specific innate immunity Open
Agents that induce inflammation have been used since the 18th century for the treatment of cancer. The inflammation induced by agents such as Toll-like receptor agonists is thought to stimulate tumor-specific immunity in patients and augme…
View article: An Early Islet Transcriptional Signature Is Associated With Local Inflammation in Autoimmune Diabetes
An Early Islet Transcriptional Signature Is Associated With Local Inflammation in Autoimmune Diabetes Open
Identifying the early islet cellular processes of autoimmune type 1 diabetes (T1D) in humans is challenging given the absence of symptoms during this period and the inaccessibility of the pancreas for sampling. In this article, we study te…
View article: An early islet transcriptional signature is associated with local inflammation in autoimmune diabetes
An early islet transcriptional signature is associated with local inflammation in autoimmune diabetes Open
Identifying the early islet cellular processes of autoimmune type 1 diabetes (T1D) in humans is challenging given the absence of symptoms during this period and the inaccessibility of the pancreas for sampling. Here, we study temporal even…
View article: An early islet transcriptional signature is associated with local inflammation in autoimmune diabetes
An early islet transcriptional signature is associated with local inflammation in autoimmune diabetes Open
Identifying the early islet cellular processes of autoimmune type 1 diabetes (T1D) in humans is challenging given the absence of symptoms during this period and the inaccessibility of the pancreas for sampling. Here, we study temporal even…
View article: Enhanced development of functional human <scp>NK</scp> cells in <scp>NOD‐</scp> <i> scid‐IL2rg <sup>null</sup> </i> mice expressing human <scp>IL15</scp>
Enhanced development of functional human <span>NK</span> cells in <span>NOD‐</span> <i> scid‐IL2rg <sup>null</sup> </i> mice expressing human <span>IL15</span> Open
Human innate immunity plays a critical role in tumor surveillance and in immunoregulation within the tumor microenvironment. Natural killer (NK) cells are innate lymphoid cells that have opposing roles in the tumor microenvironment, includ…
View article: RFX6-mediated dysregulation defines human β cell dysfunction in early type 2 diabetes
RFX6-mediated dysregulation defines human β cell dysfunction in early type 2 diabetes Open
SUMMARY A hallmark of type 2 diabetes (T2D), a major cause of world-wide morbidity and mortality, is dysfunction of insulin-producing pancreatic islet β cells 1–3 . T2D genome-wide association studies (GWAS) have identified hundreds of sig…
View article: Modeling human T1D-associated autoimmune processes
Modeling human T1D-associated autoimmune processes Open
To understand the role of genetic and environmental factors or evaluate immune-modifying therapies in humans, it is critical to develop and apply models in which human cells can be manipulated and their functions studied under conditions t…
View article: Clathrin light <scp>chain‐conjugated</scp> drug delivery for cancer
Clathrin light <span>chain‐conjugated</span> drug delivery for cancer Open
Targeted drug delivery systems hold the remarkable potential to improve the therapeutic index of anticancer medications markedly. Here, we report a targeted delivery platform for cancer treatment using clathrin light chain (CLC)‐conjugated…
View article: A therapeutic convection–enhanced macroencapsulation device for enhancing β cell viability and insulin secretion
A therapeutic convection–enhanced macroencapsulation device for enhancing β cell viability and insulin secretion Open
Significance Type 1 diabetes (T1D) is characterized by the autoimmune destruction of pancreatic β cells and it burdens millions worldwide. T1D patients typically require the life-long administration of insulin or immunosuppressive agents f…