Debra S. Heller
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View article: Interobserver Variation in Vulvar Squamous Cell Cancer Depth of Invasion Using Two Measurement Methods
Interobserver Variation in Vulvar Squamous Cell Cancer Depth of Invasion Using Two Measurement Methods Open
Objectives Depth of invasion (DOI) in vulvar squamous cell carcinoma (vSCC) predicts risk of nodal metastasis, with measurement >1 mm dictating the need for lymph node diagnostic procedures. In 2021, the International Federation of Gynecol…
View article: Use of p53 immunohistochemistry can improve diagnostic agreement for differentiated vulvar intraepithelial neoplasia ( <scp>dVIN</scp> ): an international reproducibility study
Use of p53 immunohistochemistry can improve diagnostic agreement for differentiated vulvar intraepithelial neoplasia ( <span>dVIN</span> ): an international reproducibility study Open
Aims Differentiated or HPV‐independent vulvar intraepithelial neoplasia (dVIN) can progress rapidly to invasive cancer and accurate pathological diagnosis is essential to facilitate appropriate interventions. Histological similarities of d…
View article: The impact of ovarian stimulation on the human endometrial microenvironment
The impact of ovarian stimulation on the human endometrial microenvironment Open
STUDY QUESTION How does ovarian stimulation (OS), which is used to mature multiple oocytes for ART procedures, impact the principal cellular compartments and transcriptome of the human endometrium in the periovulatory and mid-secretory pha…
View article: Data from Blocking eIF5A Modification in Cervical Cancer Cells Alters the Expression of Cancer-Related Genes and Suppresses Cell Proliferation
Data from Blocking eIF5A Modification in Cervical Cancer Cells Alters the Expression of Cancer-Related Genes and Suppresses Cell Proliferation Open
Cancer etiology is influenced by alterations in protein synthesis that are not fully understood. In this study, we took a novel approach to investigate the role of the eukaryotic translation initiation factor eIF5A in human cervical cancer…
View article: Supplementary Figures 1 through 4 from Blocking eIF5A Modification in Cervical Cancer Cells Alters the Expression of Cancer-Related Genes and Suppresses Cell Proliferation
Supplementary Figures 1 through 4 from Blocking eIF5A Modification in Cervical Cancer Cells Alters the Expression of Cancer-Related Genes and Suppresses Cell Proliferation Open
PDF - 468K, Fig. S1. Inhibition of DOHH by ciclopirox and deferiprone. Fig. S2. Cell cycle analysis. Fig. S3. Effects of CPX and DEF on cell size and morphology. Fig. S4. Effect of CPX and DEF on HeLa cell proteins analyzed by 2D gel elect…
View article: Supplementary Table 1 from Blocking eIF5A Modification in Cervical Cancer Cells Alters the Expression of Cancer-Related Genes and Suppresses Cell Proliferation
Supplementary Table 1 from Blocking eIF5A Modification in Cervical Cancer Cells Alters the Expression of Cancer-Related Genes and Suppresses Cell Proliferation Open
PDF - 74K, Table S1. Identification of drug-dependent spots.
View article: Supplementary Figures 1 through 4 from Blocking eIF5A Modification in Cervical Cancer Cells Alters the Expression of Cancer-Related Genes and Suppresses Cell Proliferation
Supplementary Figures 1 through 4 from Blocking eIF5A Modification in Cervical Cancer Cells Alters the Expression of Cancer-Related Genes and Suppresses Cell Proliferation Open
PDF - 468K, Fig. S1. Inhibition of DOHH by ciclopirox and deferiprone. Fig. S2. Cell cycle analysis. Fig. S3. Effects of CPX and DEF on cell size and morphology. Fig. S4. Effect of CPX and DEF on HeLa cell proteins analyzed by 2D gel elect…
View article: Data from Blocking eIF5A Modification in Cervical Cancer Cells Alters the Expression of Cancer-Related Genes and Suppresses Cell Proliferation
Data from Blocking eIF5A Modification in Cervical Cancer Cells Alters the Expression of Cancer-Related Genes and Suppresses Cell Proliferation Open
Cancer etiology is influenced by alterations in protein synthesis that are not fully understood. In this study, we took a novel approach to investigate the role of the eukaryotic translation initiation factor eIF5A in human cervical cancer…
View article: Supplementary Figure 5 from Blocking eIF5A Modification in Cervical Cancer Cells Alters the Expression of Cancer-Related Genes and Suppresses Cell Proliferation
Supplementary Figure 5 from Blocking eIF5A Modification in Cervical Cancer Cells Alters the Expression of Cancer-Related Genes and Suppresses Cell Proliferation Open
PDF - 109K, Fig. S5. EF-P signals in target protein sequences.
View article: Supplementary Figure 5 from Blocking eIF5A Modification in Cervical Cancer Cells Alters the Expression of Cancer-Related Genes and Suppresses Cell Proliferation
Supplementary Figure 5 from Blocking eIF5A Modification in Cervical Cancer Cells Alters the Expression of Cancer-Related Genes and Suppresses Cell Proliferation Open
PDF - 109K, Fig. S5. EF-P signals in target protein sequences.
View article: Supplementary Table 1 from Blocking eIF5A Modification in Cervical Cancer Cells Alters the Expression of Cancer-Related Genes and Suppresses Cell Proliferation
Supplementary Table 1 from Blocking eIF5A Modification in Cervical Cancer Cells Alters the Expression of Cancer-Related Genes and Suppresses Cell Proliferation Open
PDF - 74K, Table S1. Identification of drug-dependent spots.
View article: The European Society of Gynaecological Oncology (ESGO), the International Society for the Study of Vulvovaginal Disease (ISSVD), the European College for the Study of Vulval Disease (ECSVD), and the European Federation for Colposcopy (EFC) Consensus Statement on the Management of Vaginal Intraepithelial Neoplasia
The European Society of Gynaecological Oncology (ESGO), the International Society for the Study of Vulvovaginal Disease (ISSVD), the European College for the Study of Vulval Disease (ECSVD), and the European Federation for Colposcopy (EFC) Consensus Statement on the Management of Vaginal Intraepithelial Neoplasia Open
The European Society of Gynaecological Oncology (ESGO), the International Society for the Study of Vulvovaginal Disease (ISSVD), the European College for the Study of Vulval Disease (ECSVD), and the European Federation for Colposcopy (EFC)…
View article: Fibroepithelial stromal polyp of bladder-a mimicker of sarcoma or angiomyxoma at uncommon location.
Fibroepithelial stromal polyp of bladder-a mimicker of sarcoma or angiomyxoma at uncommon location. Open
The fibroepithelial stromal polyp is a benign polypoid proliferation of the stroma with overlying epithelium. Because the lesion contains atypical stromal cells, sometimes it can be overdiagnosed as sarcoma or with myxoid stroma, it can be…
View article: The European Society of Gynaecological Oncology (ESGO), the International Society for the Study of Vulvovaginal Disease (ISSVD), the European College for the Study of Vulval Disease (ECSVD) and the European Federation for Colposcopy (EFC) Consensus Statements on Pre-invasive Vulvar Lesions
The European Society of Gynaecological Oncology (ESGO), the International Society for the Study of Vulvovaginal Disease (ISSVD), the European College for the Study of Vulval Disease (ECSVD) and the European Federation for Colposcopy (EFC) Consensus Statements on Pre-invasive Vulvar Lesions Open
The European Society of Gynaecological Oncology (ESGO), the International Society for the Study of Vulvovaginal Disease (ISSVD), the European College for the Study of Vulval Disease (ECSVD), and the European Federation for Colposcopy (EFC)…
View article: Gamma Secretase Inhibitors as Potential Therapeutic Targets for Notch Signaling in Uterine Leiomyosarcoma
Gamma Secretase Inhibitors as Potential Therapeutic Targets for Notch Signaling in Uterine Leiomyosarcoma Open
Uterine leiomyosarcoma (uLMS) is a rare and aggressive cancer with few effective therapeutics. The Notch signaling pathway is evolutionarily conserved with oncogenic properties, but it has not been well studied in uLMS. The purpose of our …
View article: Heterotopic Ossification in Benign and Malignant Renal Neoplasms
Heterotopic Ossification in Benign and Malignant Renal Neoplasms Open
Introduction/Objective Heterotopic bone formation in renal neoplasms is a rare phenomenon. Ossification with or without marrow elements has been reported in both benign and malignant renal tumors. Due to its rarity, the epidemiological and…
View article: Fractionated Carbon Dioxide Laser for the Treatment of Vulvar Lichen Sclerosus
Fractionated Carbon Dioxide Laser for the Treatment of Vulvar Lichen Sclerosus Open
OBJECTIVE: To estimate the efficacy of fractionated carbon dioxide (CO 2 ) laser therapy for vulvar lichen sclerosus. METHODS: We conducted a prospective, double-blind, randomized, sham-controlled, trial conducted in a clinic specializing …
View article: Urban-Rural Differences in Geodetic Distance Between Home and the Nearest Pharmacy Among Older Pennsylvania Adults
Urban-Rural Differences in Geodetic Distance Between Home and the Nearest Pharmacy Among Older Pennsylvania Adults Open
Aim: We examined differences in geodetic or straight line distance between home and the nearest community pharmacy among rural and urban older adults in Pennsylvania. Method: The addresses of 241,398 older adults (≥65 years) and 2,880 comm…
View article: Diagnostic Criteria for Differentiated Vulvar Intraepithelial Neoplasia and Vulvar Aberrant Maturation
Diagnostic Criteria for Differentiated Vulvar Intraepithelial Neoplasia and Vulvar Aberrant Maturation Open
Objective The aim of the study was to describe the features required for diagnosis of differentiated vulvar intraepithelial neoplasia (dVIN) and vulvar aberrant maturation (VAM). Materials and Methods The International Society of the Study…
View article: Fractional CO2 Laser for the Treatment of Vulvar Lichen Sclerosus: a Double-Blind, Sham-Controlled Randomized Trial
Fractional CO2 Laser for the Treatment of Vulvar Lichen Sclerosus: a Double-Blind, Sham-Controlled Randomized Trial Open
Objective To determine the efficacy of fractional carbon dioxide laser (FXCO2) therapy for vulvar lichen sclerosus (VLS). Design Prospective, double-blind, sham-controlled, randomized trial. Setting Clinic specializing in vulvovaginal diso…
View article: Placental Pathology in COVID-19
Placental Pathology in COVID-19 Open
Objectives To describe histopathologic findings in the placentas of women with coronavirus disease 2019 (COVID-19) during pregnancy. Methods Pregnant women with COVID-19 delivering between March 18, 2020, and May 5, 2020, were identifie…
View article: Placental Pathology in Covid-19 Positive Mothers: Preliminary Findings
Placental Pathology in Covid-19 Positive Mothers: Preliminary Findings Open
This study describes the pathology and clinical information on 20 placentas whose mother tested positive for the novel Coronovirus (2019-nCoV) cases. Ten of the 20 cases showed some evidence of fetal vascular malperfusion or fetal vascular…