David R. Jacobs
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View article: Quantifying the impact of early life growth adversity on later life health
Quantifying the impact of early life growth adversity on later life health Open
Background Early-life growth adversity is important to later-life health, but precision assessment in adulthood is challenging. We evaluated whether the difference between attained and genotype-predicted adult height (“height-GaP”) would a…
View article: Predicting Breath Hold Task Compliance From Head Motion
Predicting Breath Hold Task Compliance From Head Motion Open
Background Cerebrovascular reactivity reflects changes in cerebral blood flow in response to an acute stimulus and is reflective of the brain's ability to match blood flow to demand. Functional MRI with a breath‐hold task can be used to el…
View article: Cardiometabolic Health and Bariatric Surgery: A 25-Year Longitudinal Cohort Study in CARDIA Participants
Cardiometabolic Health and Bariatric Surgery: A 25-Year Longitudinal Cohort Study in CARDIA Participants Open
Objective: Compare longitudinal cardiometabolic health outcomes among individuals who underwent bariatric surgery (BarS) with nonsurgical controls. Background: BarS is well-established for inducing profound weight loss and improving cardio…
View article: Prediabetes transitions to normoglycaemia or type 2 diabetes and associated risk factors in the Obesity, Diabetes and Cardiovascular Disease Collaboration: an individual-level pooled analysis of 19 prospective cohort studies
Prediabetes transitions to normoglycaemia or type 2 diabetes and associated risk factors in the Obesity, Diabetes and Cardiovascular Disease Collaboration: an individual-level pooled analysis of 19 prospective cohort studies Open
Deakin University Postgraduate Research Scholarship.
View article: No Evidence of Metabolomic Disruptions From Real‐World Intakes of Aspartame or Saccharin: The Coronary Artery Risk Development in Young Adults Study
No Evidence of Metabolomic Disruptions From Real‐World Intakes of Aspartame or Saccharin: The Coronary Artery Risk Development in Young Adults Study Open
Background Artificial sweeteners have become ubiquitous additives in the food supply, and yet the safety of their regular consumption remains controversial. The present study examined whether intakes of aspartame or saccharin are related t…
View article: Dietary metabolic signatures and cardiometabolic risk
Dietary metabolic signatures and cardiometabolic risk Open
AIMS: Observational studies of diet in cardiometabolic-cardiovascular disease (CM-CVD) focus on self-reported consumption of food or dietary pattern, with limited information on individual metabolic responses to dietary intake linked to CM…
View article: Trajectories of Physical Activity Before and After Cardiovascular Disease Events in CARDIA Participants
Trajectories of Physical Activity Before and After Cardiovascular Disease Events in CARDIA Participants Open
Importance Moderate to vigorous–intensity physical activity (MVPA) is essential for primary and secondary prevention of cardiovascular disease (CVD), but long-term patterns around CVD events remain underexplored. Objective To evaluate MVPA…
View article: Risk of adverse pregnancy outcomes and impact of statin use in pregnant women with familial hypercholesterolemia
Risk of adverse pregnancy outcomes and impact of statin use in pregnant women with familial hypercholesterolemia Open
Women with FH had lower risk of gestational diabetes and intrapartum hemorrhage, but a higher risk of preeclampsia compared to controls. No adverse birth outcomes were observed for offspring of mothers with FH, but the association between …
View article: Arterial Stiffness in Heart‐Healthy Indigenous Tsimane Forager‐Horticulturalists
Arterial Stiffness in Heart‐Healthy Indigenous Tsimane Forager‐Horticulturalists Open
Background Little is known about arterial stiffness in rural subsistence populations that experience few cardiovascular risk factors. We conducted a cross‐sectional study comparing 3 arterial stiffness metrics among Tsimane forager‐horticu…
View article: Education, Race/Ethnicity, and Causes of Premature Mortality Among Middle-Aged Adults in 4 US Urban Communities: Results From CARDIA, 1985-2017.
Education, Race/Ethnicity, and Causes of Premature Mortality Among Middle-Aged Adults in 4 US Urban Communities: Results From CARDIA, 1985-2017. Open
Objectives. To assess causes of premature death and whether race/ethnicity or education is more strongly and independently associated with premature mortality in a diverse sample of middle-aged adults in the United States.Methods. The Coro…
View article: Thirty-Year Glycemic Trajectories From Young Adulthood Through Middle Age
Thirty-Year Glycemic Trajectories From Young Adulthood Through Middle Age Open
Importance Type 2 diabetes prevalence is increasing, and currently 24% of young adults have prediabetes. Little is known regarding timing and progression from normoglycemia to diabetes starting in young adulthood. Objective To examine glyc…
View article: Quantifying the impact of early-life growth adversity on later-life health
Quantifying the impact of early-life growth adversity on later-life health Open
Background Early-life growth adversity is important to later-life health, but precision assessment in adulthood is challenging. We evaluated whether the difference between attained and genotype-predicted adult height (“height-GaP”) would a…
View article: Impaired lung function is associated with elevated blood biomarkers of AD/ADRD: Unraveling the interplay with risk of dementia
Impaired lung function is associated with elevated blood biomarkers of AD/ADRD: Unraveling the interplay with risk of dementia Open
Rationale We hypothesize that impaired lung function contributes to dementia risk via biological mechanisms reflected in AD/ADRD-related protein biomarkers, and aim to evaluate their role in mediating this relationship. Methods Serum p-Tau…
View article: Dietary carbohydrate quality, fibre-rich food intake, and left ventricular structure and function: the CARDIA study
Dietary carbohydrate quality, fibre-rich food intake, and left ventricular structure and function: the CARDIA study Open
Background and Aims Identifying lifestyle risk factors related to abnormal cardiac phenotypes, including structure and function, will be essential to prevent or slow down the progression to heart failure. Little is known about intakes of m…
View article: Genome-wide association study and multi-ancestry meta-analysis identify common variants associated with carotid artery intima-media thickness
Genome-wide association study and multi-ancestry meta-analysis identify common variants associated with carotid artery intima-media thickness Open
Carotid artery intima-media thickness (cIMT) is a measurement of subclinical atherosclerosis that predicts future cardiovascular events, including stroke and myocardial infarction. Genome-wide association studies (GWAS) have identified onl…
View article: Validation of a Time-to-Exhaustion-Derived VO2max Prediction Equation and Secondary Criteria Agreement: The CARDIA Study
Validation of a Time-to-Exhaustion-Derived VO2max Prediction Equation and Secondary Criteria Agreement: The CARDIA Study Open
Introduction Measuring maximal oxygen consumption (V˙O 2max ) during a graded exercise test (GXT) poses challenges in population-based studies. We examined the relationship between GXT duration (GXTd) and V˙O 2max to create a prediction eq…
View article: 182 Micro-credentials and translational workforce development: Motivation and benefits
182 Micro-credentials and translational workforce development: Motivation and benefits Open
Objectives/Goals: Micro-credentials (MCs) or digital badges are short programs designed to allow learners to gain knowledge and skills at their own pace to tailor their professional development. This study aims to examine the characteristi…
View article: Contribution of social, behavioral, and contextual exposures to Black‐White disparities in incident obesity: The CARDIA study
Contribution of social, behavioral, and contextual exposures to Black‐White disparities in incident obesity: The CARDIA study Open
OBJECTIVE: The aim of this study was to quantify the contributions of socioeconomic, psychosocial, behavioral, reproductive, and neighborhood exposures in young adulthood to Black-White differences in incident obesity. METHODS: In the Coro…
View article: Pulmonary emphysema subtypes defined by unsupervised machine learning on CT scans
Pulmonary emphysema subtypes defined by unsupervised machine learning on CT scans Open
BACKGROUND: Treatment and preventative advances for chronic obstructive pulmonary disease (COPD) have been slow due, in part, to limited subphenotypes. We tested if unsupervised machine learning on CT images would discover CT emphysema sub…
View article: The association of childhood HDL cholesterol with atherosclerotic cardiovascular disease events in adults: findings from the International Childhood Cardiovascular Cohort Consortium
The association of childhood HDL cholesterol with atherosclerotic cardiovascular disease events in adults: findings from the International Childhood Cardiovascular Cohort Consortium Open
Aims The role of adult HDL-C in atherosclerotic cardiovascular disease (ASCVD) faces challenges from Mendelian randomizations and drug trials. However, the association between childhood HDL-C and its changes and adult ASCVD remains undefin…