Explanipedia

ENOX2 (ecto-NOX disulfide-thiol exchanger 2) Open

Xiaoyu Tang, D. James Morré, D. James Morré · 2014

Review on ENOX2, with data on DNA/RNA, on the protein encoded and where the gene is implicated.

Molecular Cloning and Characterization of a Candidate ENOX Protein of Saccharomyces cerevisiae with a 25 Min Period Insensitive to Simalikalactone D Inhibition and Melatonin Open

Aya Ryuzoji, Debby H. Parisi, Sara Dick, James Kim, Dorothy M. Morré , et al. · 2014

A yeast deletion library was screened based on NADH fluorescence using a 384-well plate assay to identify a yeast isolate lacking a previously identified cell surface oxidase exhibiting an oscillatory pattern with a period length of 25 min…

Molecular cloning and characterization of an ECTO-NOX3 (ENOX3) of Saccharomyces cerevisiae Open

Sara Dick, Connie Phung, Dorothy M. Morré, D. James Morré · 2013

Exfoliated ECTO-NOX3 (ENOX3) proteins, are members of the human TM9 superfamily of transmembrane proteins that generate superoxide, are present in blood and other body fluids, and increase activity with age beginning about age 30, hence ag…

Research highlights from the Purdue-UAB Botanicals Research Center for Age Related Diseases Open

Connie M. Weaver, Stephen Barnes, J. Michael Wyss, Helen Kim, Dorothy M. Morré , et al. · 2009

The Purdue-UAB Botanicals Research Center for Age Related Disease uses multidisciplinary and innovative technologies to investigate the bioavailability of bioactive polyphenolic constituents from botanicals and their relationship to human …

Indolyl‐quinuclidinols inhibit ENOX activity and endothelial cell morphogenesis while enhancing radiation‐mediated control of tumor vasculature Open

Ling Geng, Girish Rachakonda, D. James Morré, Dorothy M. Morré, Peter A. Crooks , et al. · 2009

There is a need for novel strategies that target tumor vasculature, specifically those that synergize with cytotoxic therapy, in order to overcome resistance that can develop with current therapeutics. A chemistry‐driven drug discovery scr…

Cancer Site-Specific Isoforms of ENOX2 (tNOX), A Cancer-Specific Cell Surface Oxidase Open

Brandon Hostetler, Nicole Weston, Chinpal Kim, Dorothy M. Morré, D. James Morré · 2008

Introduction All neoplastic cells express one or more members of a unique family of tumor-associated cell surface ubiquinone (NADH) oxidase proteins with protein disulfide-thiol interchange activity (ENOX2 or tNOX proteins) that are charac…

Early developmental expression of a normally tumor-associated and drug-inhibited cell surface-located NADH oxidase (ENOX2) in non-cancer cells Open

NaMi Cho, D. James Morré · 2008

Pharmacokinetics of Green Tea Catechins in Extract and Sustained-Release Preparations Open

Elsa M. Janle, Dorothy M. Morré, D. James Morré, Qin Zhou, Yongxin Zhu · 2008

Catechins are a major constituent of green tea. For green tea to have cancer therapeutic benefit, catechin concentrations in the range of 100 nM are required continuously until apoptosis (programmed cell death) is induced. To prolong eleva…

Antisense Experiments Demonstrate an Exon 4 Minus Splice Variant mRNA as the Basis for Expression of tNOX, a Cancer-Specific Cell Surface Protein Open

Xiaoyu Tang, D. James Morré, Dorothy M. Morré · 2007

A novel hydroquinone and NADH oxidase with protein disulfide-thiol interchange activity (designated ENOX2 or tNOX), associated exclusively with the outer leaflet of the plasma membrane at the surface of cancer cells and in sera of cancer p…

Structural Changes Revealed by Fourier Transform Infrared and Circular Dichroism Spectroscopic Analyses Underlie tNOX Periodic Oscillations Open

Chinpal Kim, Sara Layman, Dorothy M. Morré, D. James Morré · 2005

A recurring pattern of spectral changes indicative of periodic changes in the proportion of β-structure and a-helix of a recombinant ECTO-NOX fusion protein of tNOX, with a cellulose binding domain peptide, was demonstrated by Fourier tran…

New Combination Treatments for Control of Johnsongrass Along Roadsides Open

D. James Morré · 2004

This project was to develop a cost-effective method for chemical eradication of Johnsongrass along Indiana roadsides. Johnsongrass, together with Canada thistle, represents Indiana’s most serious noxious weed invader where the need for con…

Synergistic Capsicum–tea mixtures with anticancer activity Open

D. James Morré, Dorothy M. Morré · 2003

We have demonstrated a synergy between a decaffeinated green tea concentrate and a vanilloid-containing Capsicum preparation obtained commercially. At a ratio of 25 parts green tea concentrate to 1 part Capsicum preparation, the resultant …

Tea Catechin Synergies in Inhibition of Cancer Cell Proliferation and of a Cancer Specific Cell Surface Oxidase (ECTO‐NOX) Open

D. James Morré, Dorothy M. Morré, Howard Sun, Raymond Cooper, Joseph Chang , et al. · 2003

The anticancer properties of tea catechins are most frequently attributed to the principal catechin (‐)‐epigallocatechin‐3‐gallate (EGCg). Efficacy was evaluated using growth of cultured HeLa cells and inhibition of the enzymatic activity …

Decomposition Analyses Applied to a Complex Ultradian Biorhythm: The Oscillating NADH Oxidase Activity of Plasma Membranes Having a Potential Time-Keeping (Clock) Function Open

Ken A. Foster, Nasim Anwar, Rhea Pogue, Dorothy M. Morré, T. W. Keenan , et al. · 2003

Seasonal decomposition analyses were applied to the statistical evaluation of an oscillating activity for a plasma membrane NADH oxidase activity with a temperature compensated period of 24 min. The decomposition fits were used to validate…

New Treatment Combinations for Control of Brush & Vegetation Management Along Indiana Roadsides Open

D. James Morré · 2000

This report represents results from a project for research to develop and implement new treatment mixtures for control of problem brush, trees and other woody species and herbicide-resistant weeds along Indiana roadsides. An environmentall…

The Hormone-responsive NADH Oxidase of the Plant Plasma Membrane Has Properties of a NADH:Protein Disulfide Reductase Open

Pin Ju Chueh, Dorothy M. Morré, Claude Penel, Tammy DeHahn, D. James Morré · 1997

Plasma membranes of plant cells are characterized by a plant hormone (auxin)-responsive oxidation of NADH. The latter proceeds under argon. Also, when NADH oxidation is stimulated 50% by auxin addition, oxygen consumption is reduced by 40%…

Cell-Free Transfer of Phosphatidylinositol between Membrane Fractions Isolated from Soybean Open

Pia Harryson, D. James Morré, Anna Stina Sandelius · 1996

Transfer of phosphatidylinositol (PI) between membranes was reconstituted in a cell-free system using membrane fractions isolated from dark-grown soybean (Glycine max [L.] Merr.). Donor membrane vesicles contained [3H]myo-inositol-labeled …

Auxin-Modulated Protein Disulfide-Thiol-Interchange Activity from Soybean Plasma Membranes Open

D. James Morré, Rafael de Cabo, Elizabeth R. Jacobs, Dorothy M. Morré · 1995

The renaturation of scrambled (oxidized and inactive) RNase A is catalyzed by soybean (Glycine max cv Williams 82) plasma membranes. The catalysis is stimulated by the auxin herbicide 2,4-dichlorophenoxyacetic acid or by the natural auxin …

New Treatment Combinations for Control of Brush and Vegetation Management Along Indiana Roadsides Open

D. James Morré · 1995

This report represents results from a project for research to develop and implement new treatment mixtures for control of problem brush, trees and other woody species and herbicide-resistant weeds along Indiana roadsides. An environmentall…

Isolation and characterization of the principal ATPase associated with transitional endoplasmic reticulum of rat liver. Open

L Zhang, Curtis L. Ashendel, G. Becker, D. James Morré · 1994

The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (TER). Vesicle budding fro…

Isolation of highly purified, functional endosomes from toad urinary bladder Open

Timothy G. Hammond, D. James Morré, H. William Harris, Mark L. Zeidel · 1993

Endosomes are difficult to isolate as they share size and density properties with much more abundant cellular organelles such as mitochondria. In cultured cell lines the tandem use of charge-dependent isolation techniques and differential …

Isolation and characterization of renal cortical membranes using an aqueous two-phase partition technique Open

Timothy G. Hammond, Rebecca R. Majewski, J J Onorato, Peter C. Brazy, D. James Morré · 1993

The aqueous two-phase partition technique is a simple, rapid and inexpensive method for the fractionation of membrane preparations. Aqueous two-phase partitioning separates according to surface properties such as charge and hydrophobicity,…

Low temperature compartment formation in feline immunodeficiency virus-infected and uninfected feline kidney cells Open

D. James Morré, Mark Paulik · 1993

Temperature- and acceptor-specificity of cell-free vesicular transfer from transitional endoplasmic reticulum to the cis Golgi apparatus Open

S. R. Dunkle, Timothy Reust, D. David Nowack, Lisette P. Waits, Mark Paulik , et al. · 1992

The temperature dependence and specificity of transfer of membrane constituents from donor transitional endoplasmic reticulum to the cis Golgi apparatus were investigated using a cell-free system from rat liver. The radiolabelled transitio…

Growth factor‐stimulated trans plasma membrane electron transport in HL‐60 cells Open

Plácido Navas, Francisco J. Alcaı́n, Isabel Burón, Juan-Carlos Rodríquez-Aguilera, José M. Villalba , et al. · 1992

Electron flow across the plasma membrane of living cells and its rapid modulation by growth factors has been measured continuously through a simple assay procedure whereby the transported electrons are captured by ascorbate free radical to…

Sidedness of Plant Plasma Membrane Vesicles Altered by Conditions of Preparation Open

Andrew O. Brightman, D. James Morré · 1992

Right-side-out vesicles of plasma membrane from soybean (Glycine max Merr.) were isolated by aqueous two-phase partition. Inside-out vesicles were formed when these preparations were diluted or frozen and thawed. Sidedness (orientation) wa…

Stromal Low Temperature Compartment Derived from the Inner Membrane of the Chloroplast Envelope Open

D. James Morré, Gun Selldén, Christer Sundqvist, Anna Stina Sandelius · 1991

Leaf discs of four dicotyledonous species, when incubated at temperatures of 4 to 18 degrees C (optimum at 12 degrees C) for 30 or 60 minutes, responded by accumulations of membranes in the chloroplast stroma in the space between the inner…

Intracellular membrane flow: reconstitution of transition vesicle formation and function in a cell-free system. Open

D. David Nowack, Dorothy M. Morré, Mark Paulik, T.W. Keenan, D. James Morré · 1987

Transfer of membrane between endoplasmic reticulum and Golgi apparatus in situ is considered to occur via 60-nm transition vesicles derived from part-rough, part-smooth transition elements of the endoplasmic reticulum. A procedure is descr…

Cost Reduction and Increased Efficacy of Growth Retardant Mixtures for Vegetation Management along Indiana Roadsides Open

D. James Morré · 1987

A cost-effective program of chemical mowing for use on Indiana roadsides has been developed.,A single spring application of a combination of new materials gives season- long control of seedheads in bluegrass and fescue as well as control o…

Cost Reduction and Increased Efficacy of Growth Retardant Mixtures for Vegetation Management along Indiana Roadsides : Executive Summary Open

D. James Morré · 1987

Program of alternative treatments for use on secondary roads 9Cost of materials for

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