Jeffrey D. Jenks
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View article: Sequential serum galactomannan as outcome marker for invasive aspergillosis—An exploratory study from the FungiScope registry
Sequential serum galactomannan as outcome marker for invasive aspergillosis—An exploratory study from the FungiScope registry Open
Serum GMI is a non-invasive, predictive tool for estimating survival probability at onset of IA. Early GMI changes correlate with survival and could prompt timely AFT adjustment, potentially improving clinical outcomes. Additionally, GMI c…
View article: Paradoxical worsening on olorofim in patients undergoing treatment for invasive fungal diseases
Paradoxical worsening on olorofim in patients undergoing treatment for invasive fungal diseases Open
Paradoxical reactions to appropriate antimicrobial therapy are infrequently observed in systemic fungal diseases. Similar responses are seen in the treatment of both tuberculosis (TB) (worsening of lymphadenitis) and leprosy (reversal reac…
View article: Let’s not forget about Mycoplasma genitalium
Let’s not forget about Mycoplasma genitalium Open
In the August issue of Sexual Health, a public health ethics analysis for and against doxycycline pre-exposure prophylaxis (Doxy-PEP) to prevent sexually transmitted infections in men who have sex with men was published. The authors discus…
View article: Universal digital high-resolution melting for the detection of pulmonary mold infections
Universal digital high-resolution melting for the detection of pulmonary mold infections Open
Invasive mold infections (IMIs) are associated with high morbidity, particularly in immunocompromised patients, with mortality rates between 40% and 80%. Early initiation of appropriate antifungal therapy can substantially improve outcomes…
View article: Novel antifungals and treatment approaches to tackle resistance and improve outcomes of invasive fungal disease
Novel antifungals and treatment approaches to tackle resistance and improve outcomes of invasive fungal disease Open
SUMMARY Fungal infections are on the rise, driven by a growing population at risk and climate change. Currently available antifungals include only five classes, and their utility and efficacy in antifungal treatment are limited by one or m…
View article: Impact of climate change and natural disasters on fungal infections
Impact of climate change and natural disasters on fungal infections Open
The effects of climate change and natural disasters on fungal pathogens and the risks for fungal diseases remain incompletely understood. In this literature review, we examined how fungi are adapting to an increase in the Earth's temperatu…
View article: 1327. The Diagnosis of Subarachnoid Neurocysticercosis Is Often Delayed And Other Findings of a Multicenter Retrospective in the USA
1327. The Diagnosis of Subarachnoid Neurocysticercosis Is Often Delayed And Other Findings of a Multicenter Retrospective in the USA Open
Background Subarachnoid (racemose) neurocysticercosis (SANCC) is an uncommon but severe form of Taenia solium infection. There is limited evidence to guide clinical management of these patients. Methods We performed a multicenter retrospec…
Social determinants of health as drivers of fungal disease Open
Disparities in social determinants of health (SDOH) play a significant role in causing health inequities globally. The physical environment, including housing and workplace environment, can increase the prevalence and spread of fungal infe…
View article: Universal Digital High Resolution Melt for the detection of pulmonary mold infections
Universal Digital High Resolution Melt for the detection of pulmonary mold infections Open
Background Invasive mold infections (IMIs) such as aspergillosis, mucormycosis, fusariosis, and lomentosporiosis are associated with high morbidity and mortality, particularly in immunocompromised patients, with mortality rates as high as …
View article: An update on current and novel molecular diagnostics for the diagnosis of invasive fungal infections
An update on current and novel molecular diagnostics for the diagnosis of invasive fungal infections Open
PCR is highly sensitive and specific, although performance can be impacted by prior/concurrent antifungal use. PCR assays can identify mutations associated with antifungal resistance, non-Aspergillus mold infections, and infections from en…
View article: Fungal Endocarditis: Pathophysiology, Epidemiology, Clinical Presentation, Diagnosis, and Management
Fungal Endocarditis: Pathophysiology, Epidemiology, Clinical Presentation, Diagnosis, and Management Open
Fungal endocarditis accounts for 1% to 3% of all infective endocarditis cases, is associated with high morbidity and mortality (>70%), and presents numerous challenges during clinical care. Candida spp. are the most common causes of fungal…
View article: Relationship Between Sexually Transmitted Infections and Social Determinants of Health in Durham County, North Carolina, United States
Relationship Between Sexually Transmitted Infections and Social Determinants of Health in Durham County, North Carolina, United States Open
Background Sexually transmitted infections (STIs) are increasing in the United States, and certain populations are more at risk than others. One explanation for this is inequities in underlying social determinants of health (SDOH). Methods…
View article: Race and ethnicity: Risk factors for fungal infections?
Race and ethnicity: Risk factors for fungal infections? Open
Racial and ethnic identities, largely understood as social rather than biologic constructs, may impact risk for acquiring infectious diseases, including fungal infections. Risk factors may include genetic and immunologic differences such a…
View article: Antimicrobial-Resistant <i>Shigella</i> spp. in San Diego, California, USA, 2017–2020
Antimicrobial-Resistant <i>Shigella</i> spp. in San Diego, California, USA, 2017–2020 Open
Annually, Shigella spp. cause ≈188 million cases of diarrheal disease globally, including 500,000 cases in the United States; rates of antimicrobial resistance are increasing. To determine antimicrobial resistance and risk factors in San D…
View article: Let's talk about sex characteristics—As a risk factor for invasive fungal diseases
Let's talk about sex characteristics—As a risk factor for invasive fungal diseases Open
Biological sex, which comprises differences in host sex hormone homeostasis and immune responses, can have a substantial impact on the epidemiology of infectious diseases. Comprehensive data on sex distributions in invasive fungal diseases…
View article: Performance of the Euroimmun Aspergillus Antigen ELISA for the Diagnosis of Invasive Pulmonary Aspergillosis in Bronchoalveolar Lavage Fluid
Performance of the Euroimmun Aspergillus Antigen ELISA for the Diagnosis of Invasive Pulmonary Aspergillosis in Bronchoalveolar Lavage Fluid Open
Invasive pulmonary aspergillosis (IPA) is a life-threatening disease that affects mainly immunocompromised hosts. Galactomannan testing from serum and bronchoalveolar lavage fluid (BALF) represents a cornerstone in diagnosing the disease.
View article: Christian Accommodative Mindfulness: Definition, Current Research, and Group Protocol
Christian Accommodative Mindfulness: Definition, Current Research, and Group Protocol Open
More clinicians are using mindfulness-based therapeutic strategies; however, Evangelical Christian clients sometimes worry about the Buddhist origins of these treatments. Christian accommodative mindfulness (CAM) attempts to address these …
View article: Serum Lateral Flow assay with digital reader for the diagnosis of invasive pulmonary aspergillosis: A two‐centre mixed cohort study
Serum Lateral Flow assay with digital reader for the diagnosis of invasive pulmonary aspergillosis: A two‐centre mixed cohort study Open
Background Detection of galactomannan (GM) from bronchoalveolar lavage fluid (BALF) or serum is broadly used for diagnosis of invasive aspergillosis (IA), although the sensitivity of GM from serum is lower in non‐neutropenic patients. We e…
View article: <i>Aspergillus fumigatus</i>and aspergillosis: From basics to clinics
<i>Aspergillus fumigatus</i>and aspergillosis: From basics to clinics Open
The airborne fungus Aspergillus fumigatus poses a serious health threat to humans by causing numerous invasive infections and a notable mortality in humans, especially in immunocompromised patients. Mould-active azoles are the frontline th…
View article: Invasive aspergillosis in critically ill patients: Review of definitions and diagnostic approaches
Invasive aspergillosis in critically ill patients: Review of definitions and diagnostic approaches Open
Invasive aspergillosis (IA) is an increasingly recognised phenomenon in critically ill patients in the intensive care unit, including in patients with severe influenza and severe coronavirus disease 2019 (COVID‐19) infection. To date, ther…
View article: Drug-Resistant Fungi: An Emerging Challenge Threatening Our Limited Antifungal Armamentarium
Drug-Resistant Fungi: An Emerging Challenge Threatening Our Limited Antifungal Armamentarium Open
The high clinical mortality and economic burden posed by invasive fungal infections (IFIs), along with significant agricultural crop loss caused by various fungal species, has resulted in the widespread use of antifungal agents. Selective …