Weidong Han
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View article: Integrative bioinformatics and machine learning approaches identify inflammation-related genes and drug candidates for future preclinical validation in ischemic stroke
Integrative bioinformatics and machine learning approaches identify inflammation-related genes and drug candidates for future preclinical validation in ischemic stroke Open
This study reveals four inflammation-related genes with preliminary diagnostic value and proposes capecitabine and ruxolitinib as candidate drugs for future preclinical research on IS.
View article: Identification of post-translational modification-related biomarkers in ischemic stroke using bioinformatics and machine learning
Identification of post-translational modification-related biomarkers in ischemic stroke using bioinformatics and machine learning Open
Ischemic stroke (IS) remains a major clinical challenge due to the difficulty of early diagnosis and incomplete understanding of its pathological mechanisms. Post-translational modifications (PTMs) regulate key cellular processes in IS, bu…
View article: Intrinsic NPRL2 and NPRL3 regulate the sensitivity of B-cell malignancies to CAR-T cell therapy
Intrinsic NPRL2 and NPRL3 regulate the sensitivity of B-cell malignancies to CAR-T cell therapy Open
Although chimeric antigen receptor (CAR) T-cell therapy has markedly improved outcomes for many patients with B-cell malignancies, a subset experiences limited benefit due to primary or secondary resistance. Building on CRISPR/Cas9 genome-…
View article: Synthesis, function, and therapeutic potential of glycosphingolipids
Synthesis, function, and therapeutic potential of glycosphingolipids Open
Glycosphingolipids (GSLs) constitute the most structurally diverse subgroup of the sphingolipid family and play crucial roles in a wide variety of cellular functions. The expression of GSLs is tightly controlled during development, with ea…
View article: Epi‐Immunotherapy in Cancer Treatment: Mechanisms, Clinical Progress, and Future Directions
Epi‐Immunotherapy in Cancer Treatment: Mechanisms, Clinical Progress, and Future Directions Open
Cancer immunotherapy is a groundbreaking therapeutic strategy, yet it continues to face significant challenges, including limited overall response rates and treatment resistance. Emerging research has demonstrated the pivotal role of epige…
View article: PSMB9 Orchestrates Tumor Immune Landscape and Serves as a Potent Biomarker for Prognosis and T Cell-Based Immunotherapy Response
PSMB9 Orchestrates Tumor Immune Landscape and Serves as a Potent Biomarker for Prognosis and T Cell-Based Immunotherapy Response Open
Proteasome subunit beta type-9 (PSMB9), a member of the proteasome beta subunit family, encodes the pivotal β1i component of the immunoproteasome. PSMB9 plays a crucial role in antigen processing and presentation; however, its comprehensiv…
View article: Balance and management of CRS and infection following CD19-targeted CAR T-cell therapy in primary refractory high-grade B-cell lymphoma: a case report
Balance and management of CRS and infection following CD19-targeted CAR T-cell therapy in primary refractory high-grade B-cell lymphoma: a case report Open
Background CD19-targeted chimeric antigen receptor T (CAR T) cell therapy has revolutionized the treatment of refractory/relapsed B-cell malignancies. However, this therapy introduces significant safety concerns, including cytokine release…
View article: CD2 augmentation enhances CAR-T-cell efficacy via immunological synapse remodeling and T-cell exhaustion mitigation
CD2 augmentation enhances CAR-T-cell efficacy via immunological synapse remodeling and T-cell exhaustion mitigation Open
CAR-T-cell therapy has made significant strides in treating hematological malignancies, yet its efficacy is often hampered by suboptimal T-cell functionality, marked by weak antitumor capabilities and a lack of durability. The immunologica…
View article: Management of Cytokine Release Syndrome (CRS) following CAR T-cell therapy: a comprehensive review
Management of Cytokine Release Syndrome (CRS) following CAR T-cell therapy: a comprehensive review Open
Chimeric antigen receptor T-cell (CAR T-cell) therapy represents a paradigm shift in treating refractory hematological malignancies. Despite its transformative potential, clinical application is frequently complicated by severe, potentiall…
View article: Platelet‐to‐Neutrophil Ratio: A Novel Prognostic Indicator for Anti‐PD‐1‐Based Therapy in Relapsed/Refractory Hodgkin Lymphoma and Solid Tumors
Platelet‐to‐Neutrophil Ratio: A Novel Prognostic Indicator for Anti‐PD‐1‐Based Therapy in Relapsed/Refractory Hodgkin Lymphoma and Solid Tumors Open
Program cell death‐1 (PD‐1) blockade treatment has been shown effective in cases with relapsed/refractory classical Hodgkin Lymphoma (R/R cHL), while prognostic biomarkers remain unclear. Seventy‐seven cases with R/R cHL who received immun…
View article: Dual-Faced Role of GDF6 in Cancer: Mechanistic Insights into Its Context-Dependent Regulation of Metastasis and Immune Evasion Across Human Malignancies
Dual-Faced Role of GDF6 in Cancer: Mechanistic Insights into Its Context-Dependent Regulation of Metastasis and Immune Evasion Across Human Malignancies Open
Growth differentiation factor 6 (GDF6), a member of the TGF-β superfamily, plays multifaceted roles in tumorigenesis, yet its molecular mechanisms and cancer-type-specific regulatory networks remain poorly defined. This study investigates …
View article: Predict and prevent microvascular complications of type 2 diabetes: a cross-sectional and longitudinal study in Chinese communities
Predict and prevent microvascular complications of type 2 diabetes: a cross-sectional and longitudinal study in Chinese communities Open
Purpose This study investigates the incidence, predictors, and preventive strategies for microvascular complications in type 2 diabetes patients in community settings. Methods Data were collected from 3,008 type 2 diabetes patients enrolle…
View article: Combination chemotherapy with sintilimab for treatment of a male patient with primary pulmonary choriocarcinoma: a case report and literature review
Combination chemotherapy with sintilimab for treatment of a male patient with primary pulmonary choriocarcinoma: a case report and literature review Open
Primary pulmonary choriocarcinoma (PPC) is an extremely rare malignant cancer in men with no clinical guidelines for the treatment. Cytotoxic chemotherapy has a limited effect on the prognosis of PPC. Recently, immune checkpoint inhibitors…
View article: High levels of EPHB2 expression predict a poor prognosis and promote tumor progression in endometrial cancer
High levels of EPHB2 expression predict a poor prognosis and promote tumor progression in endometrial cancer Open
Endometrial cancer (EC) exhibits increasing incidence and mortality, necessitating novel prognostic biomarkers and therapeutic targets. This study systematically investigates EPHB2 as a potential biomarker through comprehensive bioinformat…
View article: Clinical surveillance of split renal function in en bloc kidney transplant recipients using 99mTc-diethylenetriamine-pentaacetic acid (DTPA) dynamic renal scintigraphy: preliminary findings and novel insights
Clinical surveillance of split renal function in en bloc kidney transplant recipients using 99mTc-diethylenetriamine-pentaacetic acid (DTPA) dynamic renal scintigraphy: preliminary findings and novel insights Open
In EBKT patients, the medial grafts were more developed than the lateral ones. gGFR may reflect changes in split renal function after EBKT. 99mTc-DTPA dynamic renal scintigraphy monitoring is feasible and effective to assess renal function…
View article: BCMA CAR-T induces complete and durable remission in plasmablastic lymphoma synchronous transformation of chronic lymphocytic leukemia: Case report and literature review
BCMA CAR-T induces complete and durable remission in plasmablastic lymphoma synchronous transformation of chronic lymphocytic leukemia: Case report and literature review Open
Richter transformation is still a serious risk in the era of innovative therapies, despite the fact that targeted therapy with Bruton's tyrosine kinase inhibitor has significantly improved the prognosis for chronic lymphocytic leukemia (CL…
View article: Study on the Consistency of Point-of-Care Ultrasound and Chest X-ray in the Diagnosis of Postoperative Thoracic Abnormalities in Children with Congenital Heart Disease
Study on the Consistency of Point-of-Care Ultrasound and Chest X-ray in the Diagnosis of Postoperative Thoracic Abnormalities in Children with Congenital Heart Disease Open
Objective: This study aimed to explore the consistency of point-of-care ultrasound (POCUS) and chest X-ray in the diagnosis of postoperative thoracic abnormalities in children with congenital heart disease. Methods: The clinical data of 68…
View article: Cross-tissue human fibroblast atlas reveals myofibroblast subtypes with distinct roles in immune modulation
Cross-tissue human fibroblast atlas reveals myofibroblast subtypes with distinct roles in immune modulation Open
Fibroblasts, known for their functional diversity, play crucial roles in inflammation and cancer. In this study, we conduct comprehensive single-cell RNA sequencing analyses on fibroblast cells from 517 human samples, spanning 11 tissue ty…
View article: Manganese boosts natural killer cell function via cGAS–STING mediated UTX expression
Manganese boosts natural killer cell function via cGAS–STING mediated UTX expression Open
Natural killer (NK) cells play a crucial role in both innate immunity and the activation of adaptive immunity. The activating effect of Mn 2+ on cyclic GMP‐AMP(cGAS)–stimulator of interferon genes (STING signaling has been well known, but …
View article: Inhibition of glycosphingolipid synthesis with eliglustat in combination with immune checkpoint inhibitors in advanced cancers: preclinical evidence and phase I clinical trial
Inhibition of glycosphingolipid synthesis with eliglustat in combination with immune checkpoint inhibitors in advanced cancers: preclinical evidence and phase I clinical trial Open
Glycosphingolipids (GSLs) are abundantly expressed in cancer cells. The effects of GSL-targeted immunotherapies are not fully understood. Here, we show that the inhibition of GSL synthesis with the UDP-glucose ceramide glucosyltransferase …
View article: Web-Based Dynamic Nomogram for Predicting Risk of Mortality in Heart Failure with Mildly Reduced Ejection Fraction
Web-Based Dynamic Nomogram for Predicting Risk of Mortality in Heart Failure with Mildly Reduced Ejection Fraction Open
In this study, the dynamic APSELNH nomogram developed serves as an accessible, functional, and effective clinical decision support calculator, offering accurate prognostic assessment for patients with HFmrEF.
View article: Discovery of Highly Selective, Potent, Covalent, and Orally Bioavailable Factor XIIa Inhibitors for the Treatment of Thrombo-Inflammation
Discovery of Highly Selective, Potent, Covalent, and Orally Bioavailable Factor XIIa Inhibitors for the Treatment of Thrombo-Inflammation Open
Thrombo-inflammation is closely associated with a few severe cardiovascular and infectious diseases. Factor XIIa (FXIIa) in the intrinsic coagulation pathway plays a pivotal role in the development of thrombo-inflammation and its inhibitio…
View article: Defining cellular determinants of resistance to PD-1 pathway blockade in non-small-cell lung cancer
Defining cellular determinants of resistance to PD-1 pathway blockade in non-small-cell lung cancer Open
Summary Despite sustained clinical responses to immune-checkpoint blockade (ICB) therapies in non-small-cell lung cancer (NSCLC), the majority of patients derive no clinical benefits, and the cellular and molecular underpinnings of such re…