D. Joseph Jerry
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View article: Inducible estrogen receptor alpha in normal breast epithelial cells demonstrate estrogen receptor-dependent DNA damage
Inducible estrogen receptor alpha in normal breast epithelial cells demonstrate estrogen receptor-dependent DNA damage Open
Background : Signaling by estrogen-receptor alpha (ERα) plays a major role in breast cancer initiation and ERα-mediated DNA damage has been implicated in development of resistance to endocrine therapies. Investigations of the mechanism of …
View article: Supplementary Table 1 from Age-Associated Gene Expression in Normal Breast Tissue Mirrors Qualitative Age-at-Incidence Patterns for Breast Cancer
Supplementary Table 1 from Age-Associated Gene Expression in Normal Breast Tissue Mirrors Qualitative Age-at-Incidence Patterns for Breast Cancer Open
PDF file, 59K, The complete list of genes significantly associated with age are given along with the average fold change comparing the median centered data for the youngest patients (<30, n=20) to that of the oldest patients (>49, n=6).
View article: Supplementary Data from Activation of Host Wound Responses in Breast Cancer Microenvironment
Supplementary Data from Activation of Host Wound Responses in Breast Cancer Microenvironment Open
Supplementary Data from Activation of Host Wound Responses in Breast Cancer Microenvironment
View article: Data from Activation of Host Wound Responses in Breast Cancer Microenvironment
Data from Activation of Host Wound Responses in Breast Cancer Microenvironment Open
Purpose: Cancer progression is mediated by processes that are also important in wound repair. As a result, cancers have been conceptualized as overhealing wounds or wounds that do not heal, and gene expression signatures reflective …
View article: Data from Activation of Host Wound Responses in Breast Cancer Microenvironment
Data from Activation of Host Wound Responses in Breast Cancer Microenvironment Open
Purpose: Cancer progression is mediated by processes that are also important in wound repair. As a result, cancers have been conceptualized as overhealing wounds or wounds that do not heal, and gene expression signatures reflective …
View article: Data from Age-Associated Gene Expression in Normal Breast Tissue Mirrors Qualitative Age-at-Incidence Patterns for Breast Cancer
Data from Age-Associated Gene Expression in Normal Breast Tissue Mirrors Qualitative Age-at-Incidence Patterns for Breast Cancer Open
Background: Age is the strongest breast cancer risk factor, with overall breast cancer risk increasing steadily beginning at approximately 30 years of age. However, while breast cancer risk is lower among younger women, young women'…
View article: Supplementary Table 1 from Age-Associated Gene Expression in Normal Breast Tissue Mirrors Qualitative Age-at-Incidence Patterns for Breast Cancer
Supplementary Table 1 from Age-Associated Gene Expression in Normal Breast Tissue Mirrors Qualitative Age-at-Incidence Patterns for Breast Cancer Open
PDF file, 59K, The complete list of genes significantly associated with age are given along with the average fold change comparing the median centered data for the youngest patients (<30, n=20) to that of the oldest patients (>49, n=6).
View article: Data from Age-Associated Gene Expression in Normal Breast Tissue Mirrors Qualitative Age-at-Incidence Patterns for Breast Cancer
Data from Age-Associated Gene Expression in Normal Breast Tissue Mirrors Qualitative Age-at-Incidence Patterns for Breast Cancer Open
Background: Age is the strongest breast cancer risk factor, with overall breast cancer risk increasing steadily beginning at approximately 30 years of age. However, while breast cancer risk is lower among younger women, young women'…
View article: Supplementary Data from Activation of Host Wound Responses in Breast Cancer Microenvironment
Supplementary Data from Activation of Host Wound Responses in Breast Cancer Microenvironment Open
Supplementary Data from Activation of Host Wound Responses in Breast Cancer Microenvironment
View article: Optimizing Conjugation Chemistry, Antibody Conjugation Site, and Surface Density in Antibody–Nanogel Conjugates (ANCs) for Cell-Specific Drug Delivery
Optimizing Conjugation Chemistry, Antibody Conjugation Site, and Surface Density in Antibody–Nanogel Conjugates (ANCs) for Cell-Specific Drug Delivery Open
Targeted delivery of therapeutics using antibody-nanogel conjugates (ANCs) with a high drug-to-antibody ratio has the potential to overcome some of the inherent limitations of antibody-drug conjugates (ADCs). ANC platforms with simple prep…
View article: Targeted Drug Delivery Using a Plug-to-Direct Antibody–Nanogel Conjugate
Targeted Drug Delivery Using a Plug-to-Direct Antibody–Nanogel Conjugate Open
Targeted drug delivery using antibody-drug conjugates has attracted great attention due to its enhanced therapeutic efficacy compared to traditional chemotherapy. However, the development has been limited due to a low drug-to-antibody rati…
View article: Genetic modifiers of p53: opportunities for breast cancer therapies
Genetic modifiers of p53: opportunities for breast cancer therapies Open
View article: Benzophenone-3 exposure alters composition of tumor infiltrating immune cells and increases lung seeding of 4T1 breast cancer cells
Benzophenone-3 exposure alters composition of tumor infiltrating immune cells and increases lung seeding of 4T1 breast cancer cells Open
View article: Interindividual variation contributes to differential PCB 126 induced gene expression in primary breast epithelial cells and tissues
Interindividual variation contributes to differential PCB 126 induced gene expression in primary breast epithelial cells and tissues Open
View article: Toward a digital analysis of environmental impacts on rodent mammary gland density during critical developmental windows
Toward a digital analysis of environmental impacts on rodent mammary gland density during critical developmental windows Open
View article: Toward a digital analysis of environmental impacts on rodent mammary gland density during critical developmental windows
Toward a digital analysis of environmental impacts on rodent mammary gland density during critical developmental windows Open
While mammographic breast density is associated with breast cancer risk in humans, there is no comparable surrogate risk measure in mouse and rat mammary glands following various environmental exposures. In the current study, mammary gland…
View article: Genetic modifiers regulating DNA replication and double-strand break repair are associated with differences in mammary tumors in mouse models of Li-Fraumeni syndrome
Genetic modifiers regulating DNA replication and double-strand break repair are associated with differences in mammary tumors in mouse models of Li-Fraumeni syndrome Open
View article: Exposure to Propylparaben During Pregnancy and Lactation Induces Long-Term Alterations to the Mammary Gland in Mice
Exposure to Propylparaben During Pregnancy and Lactation Induces Long-Term Alterations to the Mammary Gland in Mice Open
The mammary gland is a hormone sensitive organ that is susceptible to endocrine-disrupting chemicals (EDCs) during the vulnerable periods of parous reorganization (ie, pregnancy, lactation, and involution). Pregnancy is believed to have lo…
View article: The use of patient‐derived breast tissue explants to study macrophage polarization and the effects of environmental chemical exposure
The use of patient‐derived breast tissue explants to study macrophage polarization and the effects of environmental chemical exposure Open
Ex vivo mammary explant systems are an excellent model to study interactions between epithelium and stromal cell types because they contain physiologically relevant heterotypic interactions in the background of genetically diverse patients…
View article: Gene Expression Profiles Identify Features Common to Lobular and Ductal Premalignant Breast Lesions
Gene Expression Profiles Identify Features Common to Lobular and Ductal Premalignant Breast Lesions Open
Premalignant lesions have been identified in both the ductal and lobular units of the breast epithelium. These lesions have a 4-fold increase in risk of progression to invasive breast cancer, but 80% will remain indolent. This may be due, …
View article: Activin Limits Progenitor Capability by Promoting Epithelial Cell Differentiation in the Mammary Gland
Activin Limits Progenitor Capability by Promoting Epithelial Cell Differentiation in the Mammary Gland Open
Transforming growth factor beta (TGF-beta) and activin utilize common signaling pathways, via smad2/3 and smad4, to mediate tumor suppression by effecting cell cycle arrest and apoptosis. Differences in temporal expression patterns suggest…
View article: Creating Devices for Personal Health Monitoring
Creating Devices for Personal Health Monitoring Open
As part of the mini-symposium entitled "Creating Devices for Personalized Health Monitoring," Dr. Jerry introduces the symposium with a presentation about the Center for Personalized Health Monitoring (CPHM). The CPHM is an interdisciplina…
View article: A Case of Mistaken Identity: Biomarkers for High Risk Premalignant Breast Lesions
A Case of Mistaken Identity: Biomarkers for High Risk Premalignant Breast Lesions Open
Discusses projects to develop biomarkers to predict atypical hyperplasias that may progress to invasive breast cancer. This presentation is part of the retreat mini-symposium entitled: Biomarker Discovery and Targeted Therapeutics in Cance…
View article: Pregnancy Induces Persistent Changes that Potentiate Apoptotic Signaling and Responses to DNA Damage
Pregnancy Induces Persistent Changes that Potentiate Apoptotic Signaling and Responses to DNA Damage Open
A full-term pregnancy reduces the lifetime risk of breast cancer by up to 50%. This effect is mediated, in part, by p53-dependent pathways. Gene expression profiling was used to investigate the mechanisms that alter apoptotic responses to …
View article: Estrogen receptor beta selectively restricts proliferation and favors surveillance in mammary epithelial cells
Estrogen receptor beta selectively restricts proliferation and favors surveillance in mammary epithelial cells Open
Estrogen (17β-estradiol) has paradoxical effects in both promoting and preventing breast cancer as estrogen activates proliferation, but also promotes p53-mediated surveillance pathways. Estrogen mediates its effects in target tissues thro…
View article: Inter-Individual Variation in Response to Estrogen in Human Breast Explants
Inter-Individual Variation in Response to Estrogen in Human Breast Explants Open
View article: Effects of Benzophenone-3 and Propylparaben on Estrogen Receptor–Dependent R-Loops and DNA Damage in Breast Epithelial Cells and Mice
Effects of Benzophenone-3 and Propylparaben on Estrogen Receptor–Dependent R-Loops and DNA Damage in Breast Epithelial Cells and Mice Open
Acute exposure to xenoestrogens (PP and BP-3) in mice induce DNA damage mediated by formation of R-loops at concentrations 10-fold lower than those required for transactivation. Exposure to these xenoestrogens may cause deleterious estrog…
View article: Environmental exposures during windows of susceptibility for breast cancer: a framework for prevention research
Environmental exposures during windows of susceptibility for breast cancer: a framework for prevention research Open
View article: Gene expression signature of atypical breast hyperplasia and regulation by SFRP1
Gene expression signature of atypical breast hyperplasia and regulation by SFRP1 Open
The alterations in gene expression were observed in both ductal and lobular AH suggesting shared underlying mechanisms predisposing to AH. Loss of SFRP1 expression is a significant regulator of AH transcriptional profiles driving previousl…
View article: Oxybenzone Alters Mammary Gland Morphology in Mice Exposed During Pregnancy and Lactation
Oxybenzone Alters Mammary Gland Morphology in Mice Exposed During Pregnancy and Lactation Open
Hormones and endocrine-disrupting chemicals are generally thought to have permanent "organizational" effects when exposures occur during development but not adulthood. Yet, an increasing number of studies have shown that pregnant females a…