D. Kenna
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View article: Genomic insights and phenotypic characterization of three multidrug resistant <i>Cupriavidus</i> strains from the cystic fibrosis lung
Genomic insights and phenotypic characterization of three multidrug resistant <i>Cupriavidus</i> strains from the cystic fibrosis lung Open
Aims We aimed to investigate phenotypic and genomic traits of three Cupriavidus spp. isolates recovered from people with cystic fibrosis (PWCF). These bacteria are recognized as emerging pathogens in PWCF. Methods and results Using short a…
View article: Outbreak of Ralstonia pickettii associated with contamination of saline products distributed internationally, the United Kingdom, 2024
Outbreak of Ralstonia pickettii associated with contamination of saline products distributed internationally, the United Kingdom, 2024 Open
We describe an outbreak of Ralstonia pickettii in the United Kingdom, with isolates genetically indistinguishable from a 2023 Australian outbreak linked to internationally distributed saline solutions. Confirmed cases (n = 3) had bacteraem…
View article: Identification of <i>Burkholderia cepacia</i> strains that express a <i>Burkholderia pseudomallei</i> -like capsular polysaccharide
Identification of <i>Burkholderia cepacia</i> strains that express a <i>Burkholderia pseudomallei</i> -like capsular polysaccharide Open
Burkholderia pseudomallei and Burkholderia cepacia are Gram-negative, soil-dwelling bacteria that are found in a wide variety of environmental niches. While B. pseudomallei is the causative agent of melioidosis in humans and animals, membe…
View article: P109 When is Burkholderia cepacia complex truly eradicated in adults with cystic fibrosis? a 20-year follow up study
P109 When is Burkholderia cepacia complex truly eradicated in adults with cystic fibrosis? a 20-year follow up study Open
Introduction and Objectives Due to increased morbidity associated with Burkholderia cepacia complex (BCC) infection in cystic fibrosis (CF), it is recommended that patients are segregated to prevent cross-infection. To date there ar…
View article: Polymyxin Resistance and Heteroresistance Are Common in Clinical Isolates of <i>Achromobacter</i> Species and Correlate with Modifications of the Lipid A Moiety of Lipopolysaccharide
Polymyxin Resistance and Heteroresistance Are Common in Clinical Isolates of <i>Achromobacter</i> Species and Correlate with Modifications of the Lipid A Moiety of Lipopolysaccharide Open
Achromobacter species can cause chronic and potentially severe infections in immunocompromised patients, especially in those with cystic fibrosis. Bacteria cannot be eradicated due to Achromobacter 's intrinsic multidrug resistance.
View article: Melioidosis Manifesting as Chronic Femoral Osteomyelitis in Patient from Ghana
Melioidosis Manifesting as Chronic Femoral Osteomyelitis in Patient from Ghana Open
A 33-year-old man from Ghana who had diabetes had chronic osteomyelitis of the femoral shaft develop. Tissue samples from surgical debridement grew Burkholderia pseudomallei. He received meropenem, followed by oral trimethoprim/sulfamethox…
View article: Intravenous or oral antibiotic treatment in adults and children with cystic fibrosis and Pseudomonas aeruginosa infection: the TORPEDO-CF RCT
Intravenous or oral antibiotic treatment in adults and children with cystic fibrosis and Pseudomonas aeruginosa infection: the TORPEDO-CF RCT Open
Background People with cystic fibrosis are susceptible to pulmonary infection with Pseudomonas aeruginosa . This may become chronic and lead to increased mortality and morbidity. If treatment is commenced promptly, infection may be eradica…
View article: Variability in Bacteriophage and Antibiotic Sensitivity in Serial Pseudomonas aeruginosa Isolates from Cystic Fibrosis Airway Cultures over 12 Months
Variability in Bacteriophage and Antibiotic Sensitivity in Serial Pseudomonas aeruginosa Isolates from Cystic Fibrosis Airway Cultures over 12 Months Open
Antibiotic treatment for Pseudomonas aeruginosa (Pa) in cystic fibrosis is limited in efficacy and may lead to multi-drug resistance (MDR). Alternatives such as bacteriophages are being explored but well designed, and controlled trials are…
View article: Transmission, adaptation and geographical spread of the Pseudomonas aeruginosa Liverpool epidemic strain
Transmission, adaptation and geographical spread of the Pseudomonas aeruginosa Liverpool epidemic strain Open
The Liverpool epidemic strain (LES) is an important transmissible clonal lineage of Pseudomonas aeruginosa that chronically infects the lungs of people with cystic fibrosis (CF). Previous studies have focused on the genomics of the LES in …
View article: Imported melioidosis in the United Kingdom: Increasing incidence but continued under-reporting
Imported melioidosis in the United Kingdom: Increasing incidence but continued under-reporting Open
Introduction: Melioidosis, caused by the environmentally-acquired bacterium Burkholderia pseudomallei, is increasingly recognised as a globally significant public health problem, although difficult to diagnose and manage. We aimed to revie…
View article: Intravenous versus oral antibiotics for eradication of Pseudomonas aeruginosa in cystic fibrosis (TORPEDO-CF): a randomised controlled trial
Intravenous versus oral antibiotics for eradication of Pseudomonas aeruginosa in cystic fibrosis (TORPEDO-CF): a randomised controlled trial Open
National Institute for Health Research Health Technology Assessment Programme.
View article: Structured surveillance of Achromobacter, Pandoraea and Ralstonia species from patients in England with cystic fibrosis
Structured surveillance of Achromobacter, Pandoraea and Ralstonia species from patients in England with cystic fibrosis Open
View article: P150 Achromobacter prevalence, species distribution and infection status results from a large UK adult cystic fibrosis centre
P150 Achromobacter prevalence, species distribution and infection status results from a large UK adult cystic fibrosis centre Open
View article: P045 Strain and antibiogram changes, over time, in paediatric cystic fibrosis patients colonised with Pseudomonas aeruginosa
P045 Strain and antibiogram changes, over time, in paediatric cystic fibrosis patients colonised with Pseudomonas aeruginosa Open
View article: Ralstonia infection in cystic fibrosis
Ralstonia infection in cystic fibrosis Open
Summary This study aimed to determine prevalence of Ralstonia spp. in cystic fibrosis patients, look for any evidence of cross infection and to describe clinical outcomes for patients infected by Ralstonia spp. Prevalence of Ralstonia spp.…
View article: 138 Use of rpoB sequence clustering for species-level identification of the Elizabethkingia genus from UK CF patients, and an investigation of associated antimicrobial susceptibility
138 Use of rpoB sequence clustering for species-level identification of the Elizabethkingia genus from UK CF patients, and an investigation of associated antimicrobial susceptibility Open
View article: P275 Prevalence and Strain Typing Results Of Gram-negative Emerging Bacterial Pathogens in Patients Attending a Large UK Adult CF Centre
P275 Prevalence and Strain Typing Results Of Gram-negative Emerging Bacterial Pathogens in Patients Attending a Large UK Adult CF Centre Open
Introduction In recent years Gram-negative bacterial emerging pathogens (EP) have been noted to infect the airways of patients with CF. Prevalence of EP is increasing but much remains unknown. This study aimed to determine prevalence of EP…
View article: An international, multicentre evaluation and description of Burkholderia pseudomallei infection in cystic fibrosis
An international, multicentre evaluation and description of Burkholderia pseudomallei infection in cystic fibrosis Open
View article: Clinical utilization of genomics data produced by the international Pseudomonas aeruginosa consortium
Clinical utilization of genomics data produced by the international Pseudomonas aeruginosa consortium Open
The International Pseudomonas aeruginosa Consortium is sequencing over 1000 genomes and building an analysis pipeline for the study of Pseudomonas genome evolution, antibiotic resistance and virulence genes. Metadata, including genomic and…
View article: 59 Ralstonia mannitolilytica – an emerging threat in cystic fibrosis and lung transplantation
59 Ralstonia mannitolilytica – an emerging threat in cystic fibrosis and lung transplantation Open
View article: 43 Gram-negative emerging pathogens: Prevalence and strain typing results from a large UK adult CF centre
43 Gram-negative emerging pathogens: Prevalence and strain typing results from a large UK adult CF centre Open
View article: 77 Whole genome sequencing of multiple isolates of the Pseudomonas aeruginosa Liverpool epidemic strain reveals transmission and geographical clustering
77 Whole genome sequencing of multiple isolates of the Pseudomonas aeruginosa Liverpool epidemic strain reveals transmission and geographical clustering Open
View article: A novel culture medium for isolation of rapidly-growing mycobacteria from the sputum of patients with cystic fibrosis
A novel culture medium for isolation of rapidly-growing mycobacteria from the sputum of patients with cystic fibrosis Open