David A. Kessler
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View article: A computational approach for perturbation-induced EMT transitions
A computational approach for perturbation-induced EMT transitions Open
The Epithelial-mesenchymal transition (EMT) is a cellular state transition fundamental to development, wound healing, and cancer metastasis. The gene regulatory mechanisms underlying EMT have been extensively documented, revealing gene reg…
Identification of increased risk of perinatal anxiety: a multi-perspective qualitative study. Open
Background: Perinatal anxiety (PNA) is experienced by about 20% of women throughout the perinatal period. Identifying women at risk of PNA through using routinely collected patient data could enable early intervention to improve treatment …
Sokoban Random Walk: From Environment Reshaping to Trapping Transition Open
We study the dynamics of a $\textit{Sokoban random walker}$ moving in a disordered medium with obstacle density $ρ$. In contrast to the classic model of de Gennes with static obstacles that exhibits a percolation transition, the Sokoban wa…
The dominant–egalitarian transition in species-rich communities Open
Diverse communities of competing species are generally characterized by substantial niche overlap and strongly stochastic dynamics. Abundance fluctuations are proportional to population size, so the dynamics of rare populations is slower. …
Modelling the impact of trenches on soil erosion control using OpenLISEM on Mount Elgon, Uganda Open
Soil erosion, accelerated by anthropogenic activities, is a major driver of land degradation, resulting in the removal of fertile soil, humus and organic matter. On the steep slopes of the densely populated Mount Elgon region (Uganda), sev…
Solutions of first passage times problems: a biscaling approach Open
We study the first-passage time (FPT) problem for widespread recurrent processes in confined though large systems and present a comprehensive framework for characterizing the FPT distribution over many time scales. We find that the FPT sta…
Patients’ reasons for declining a primary care trial online therapy: a mixed-methods study Open
Background Integrating therapist-led sessions and cognitive behavioural therapy (CBT) materials within one online platform may be effective for people with depression. A trial evaluating this mode of delivering CBT is being conducted. To m…
View article: The CO-produced Psychosocial INtervention delivered by GPs to young people after self-harm (COPING): protocol for a feasibility study
The CO-produced Psychosocial INtervention delivered by GPs to young people after self-harm (COPING): protocol for a feasibility study Open
Background Self-harm in young people is a growing concern and reducing rates a global priority. Rates of self-harm documented in general practice have been increasing for young people in the UK in the last two decades, especially in 13–16-…
View article: Pulse instabilities can shape virus-immune coevolution
Pulse instabilities can shape virus-immune coevolution Open
Adaptive immune systems engage in an arms race with evolving viruses, trying to generate new responses to viral strains that continually move away from the set of genetically varying strains that have already elicited a functional immune r…
View article: Beta-blockers for the treatment of anxiety disorders: A systematic review and meta-analysis
Beta-blockers for the treatment of anxiety disorders: A systematic review and meta-analysis Open
Beta-blockers are increasingly prescribed for anxiety, yet there is a lack of robust evidence of effectiveness. There is a need to understand when and why practitioners are using these drugs, and to undertake a large RCT to provide definit…
Numerical Study of Interaction Network Structures in Competitive Ecosystems Open
We present a numerical analysis of local community assembly through weak migration from a regional species pool. At equilibrium, the local community consists of a subset ("clique") of species from the regional community. Our analysis revea…
Patients' and Therapists' Views of Integrated Online CBT for Depression Open
Background CBT is an effective treatment for depression, but access varies across the United Kingdom. Online CBT increases access. The INTERACT platform was designed to support patient engagement in CBT, enabling therapists to deliver high…
A tale of three approaches: dynamical phase transitions for weakly bound Brownian particles Open
We investigate a system of Brownian particles weakly bound by attractive parity-symmetric potentials that grow at large distances as $V(x) \sim |x|^α$, with $0 < α< 1$. The probability density function $P(x,t)$ at long times reaches the Bo…
Dominance to egalitarian transition in diverse communities Open
Diverse communities of competing species are generally characterized by substantial niche overlap and strongly stochastic dynamics. Abundance fluctuations are proportional to population size, so the dynamics of rare populations is slower. …
View article: Pulse Instabilities Can Shape Virus-Immune Co-evolution
Pulse Instabilities Can Shape Virus-Immune Co-evolution Open
Adaptive immune systems engage in an arms race with evolving viruses, trying to generate new responses to viral strains that continually move away from the set of genetically-varying strains that have already elicited a functional immune r…
View article: The CO-produced Psychosocial INtervention delivered by GPs to young people after self-harm (COPING): protocol for a feasibility study
The CO-produced Psychosocial INtervention delivered by GPs to young people after self-harm (COPING): protocol for a feasibility study Open
Background Self-harm in young people is a growing concern and reducing rates a global priority. General practitioners (GPs) can intervene early after self-harm but there are no effective treatments presently available. We developed the GP-…
Properties of Fractionally Quantized Recurrence Times for Interacting Spin Models Open
Recurrence time quantifies the duration required for a physical system to return to its initial state, playing a pivotal role in understanding the predictability of complex systems. In quantum systems with subspace measurements, recurrence…
Why Industry-Wide Standards Matter In Fulfilling the Intent of DSCSA Open
Speakers discuss the importance of standardization in order to digitalize the U.S. pharmaceutical supply chain as motivated by the Drug Supply Chain Security Act (DSCSA). Key topics What is DSCSA? What does FDA’s Stabilization Period mean?…
View article: Multiple possible patterns can emerge from virus-immune coevolution
Multiple possible patterns can emerge from virus-immune coevolution Open
The adaptive immune system engages in an arms race with evolving viruses, trying to generate new responses to viral strains that continually move away from the set of variants that have already elicited a functional immune response. In pre…
Stretched-exponential relaxation in weakly-confined Brownian systems through large deviation theory Open
Stretched-exponential relaxation is a widely observed phenomenon found in ordered ferromagnets as well as glassy systems. One modeling approach connects this behavior to a droplet dynamics described by an effective Langevin equation for th…
Extinction time distributions of populations and genotypes Open
In the long run, the eventual extinction of any biological population is an inevitable outcome. While extensive research has focused on the average time it takes for a population to go extinct under various circumstances, there has been li…
View article: Stability and Fluctuations in Complex Ecological Systems
Stability and Fluctuations in Complex Ecological Systems Open
From 08-12 August, 2022, 32 individuals participated in a workshop, Stability and Fluctuations in Complex Ecological Systems, at the Lorentz Center, located in Leiden, The Netherlands. An interdisciplinary dialogue between ecologists, math…
Designing exceptional-point-based graphs yielding topologically guaranteed quantum search Open
Quantum walks underlie an important class of quantum computing algorithms, and represent promising approaches in various simulations and practical applications. Here we design stroboscopically monitored quantum walks and their subsequent g…
Non-normalizable quasi-equilibrium states under fractional dynamics Open
We study non-normalizable quasi-equilibrium states (NNQE) arising from anomalous diffusion. Initially, particles in contact with a thermal bath are released from an asymptotically flat potential well, with dynamics that is described by fra…
Kicker Transient Field Measurements for Muon g-2 Open
An additional 378 NMR probes, placed at fixed locations outside the vacuum chamber, monitor the field drift in between field scans. A high-accuracy probe was designed for calibrating the probes in the scanner. In this presentation, the mag…
Closing a Key Gap in DSCSA Compliance with Credentialing Open
In this session, the Open Credentialing Initiative (OCI) introduces the concept and practical application of electronic credentials. The audience will learn about their use in the context of DSCSA and how they enable timely compliance with…
Minimal frustration underlies the usefulness of incomplete regulatory network models in biology Open
Regulatory networks as large and complex as those implicated in cell-fate choice are expected to exhibit intricate, very high-dimensional dynamics. Cell-fate choice, however, is a macroscopically simple process. Additionally, regulatory ne…
Brownian particles in periodic potentials: coarse-graining versus fine structure Open
We study the motion of an overdamped particle connected to a thermal heat bath in the presence of an external periodic potential in one dimension. When we coarse-grain, i.e., bin the particle positions using bin sizes that are larger than …
Discrete Sampling of Extreme Events Modifies Their Statistics Open
Extreme value (EV) statistics of correlated systems are widely investigated in many fields, spanning the spectrum from weather forecasting to earthquake prediction. Does the unavoidable discrete sampling of a continuous correlated stochast…