David L. Smith
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View article: Impact of a one-year interruption to vector control on Bioko Island, Equatorial Guinea
Impact of a one-year interruption to vector control on Bioko Island, Equatorial Guinea Open
Over the last 20 years, malaria transmission on Bioko Island, Equatorial Guinea has declined dramatically thanks to the implementation of robust malaria control activities, centered around island-wide indoor residual spraying (IRS). In 202…
View article: Testing indoor residual spraying coverage targets for malaria control, Bioko, Equatorial Guinea
Testing indoor residual spraying coverage targets for malaria control, Bioko, Equatorial Guinea Open
There was no evidence that 50% coverage was inferior in preventing malaria, which supports the use of this target in settings where this level makes indoor residual spraying feasible by increasing the cost-effectiveness and equity of the i…
View article: Clinical utility of companion diagnostic biomarker results below the limit of detection in comprehensive genomic profiling of patients with advanced non-small cell lung cancer
Clinical utility of companion diagnostic biomarker results below the limit of detection in comprehensive genomic profiling of patients with advanced non-small cell lung cancer Open
Background When the limit of blank (LoB) of comprehensive genomic profiling (CGP) for a given biomarker is acceptably demonstrated (ie, α ≤ 0.05 or LoB equal to zero), biomarkers detected below the assay limit of detection (LoD) can be rep…
View article: Reconsidering indoor residual spraying coverage targets: A retrospective analysis of high-resolution programmatic malaria control data
Reconsidering indoor residual spraying coverage targets: A retrospective analysis of high-resolution programmatic malaria control data Open
Indoor residual spraying (IRS) is one of the core vector control interventions available to malaria control programs. Normative and scientific guidance has long held that very high IRS coverage (at least 80 to 85% houses sprayed) is necess…
View article: A Probabilistic Synthesis of Malaria Epidemiology: Exposure, Infection, Parasite Densities, and Detection
A Probabilistic Synthesis of Malaria Epidemiology: Exposure, Infection, Parasite Densities, and Detection Open
The epidemiology of Plasmodium falciparum malaria presents a unique set of challenges due to the complicated dynamics of infection, immunity, disease, and detection. Studies of malaria epidemiology commonly measure malaria parasite densiti…
View article: Mosquito Dispersal in Context
Mosquito Dispersal in Context Open
Mosquito dispersal plays an important role in mosquito ecology and mosquito-borne pathogen transmission. While reaction-diffusion and patch-based models with simple flux assumptions for emigration have played a predominant role in modeling…
View article: Mapping the global prevalence, incidence, and mortality of Plasmodium falciparum and Plasmodium vivax malaria, 2000–22: a spatial and temporal modelling study
Mapping the global prevalence, incidence, and mortality of Plasmodium falciparum and Plasmodium vivax malaria, 2000–22: a spatial and temporal modelling study Open
Bill & Melinda Gates Foundation and Australian National Health and Medical Research Council.
View article: Projected ecological and disruptive impacts of climate change on malaria in Africa
Projected ecological and disruptive impacts of climate change on malaria in Africa Open
The implications of climate change for malaria eradication in the 21 st century remain poorly resolved. Many studies have focussed on parasite and vector ecology in isolation, neglecting the interactions between climate, malaria control, a…
View article: The challenge of improving long-lasting insecticidal nets coverage on Bioko Island: using data to adapt distribution strategies
The challenge of improving long-lasting insecticidal nets coverage on Bioko Island: using data to adapt distribution strategies Open
Striking a better balance between LLIN distribution efficiency and coverage represents a major challenge as LLIN retention and use rates remain low despite high access resulting from MDC. The cost-benefit of fixed distribution points in Ma…
View article: Impact of six-month COVID-19 travel moratorium on Plasmodium falciparum prevalence on Bioko Island, Equatorial Guinea
Impact of six-month COVID-19 travel moratorium on Plasmodium falciparum prevalence on Bioko Island, Equatorial Guinea Open
Importation of malaria infections is a suspected driver of sustained malaria prevalence on areas of Bioko Island, Equatorial Guinea. Quantifying the impact of imported infections is difficult because of the dynamic nature of the disease an…
View article: Climate Change and Malaria: A Call for Robust Analytics
Climate Change and Malaria: A Call for Robust Analytics Open
Mosquito ecology and behavior and malaria parasite development display marked sensitivity to weather, in particular to temperature and precipitation. Therefore, climate change is expected to profoundly affect malaria epidemiology in its tr…
View article: Pan-tumor validation of a NGS fraction-based MSI analysis as a predictor of response to Pembrolizumab
Pan-tumor validation of a NGS fraction-based MSI analysis as a predictor of response to Pembrolizumab Open
Microsatellite instability high (MSI-H) and mismatch repair deficient (dMMR) tumor status have been demonstrated to predict patient response to immunotherapies. We developed and validated a next-generation sequencing (NGS)-based companion …
View article: MGSurvE: A framework to optimize trap placement for genetic surveillance of mosquito populations
MGSurvE: A framework to optimize trap placement for genetic surveillance of mosquito populations Open
Genetic surveillance of mosquito populations is becoming increasingly relevant as genetics-based mosquito control strategies advance from laboratory to field testing. Especially applicable are mosquito gene drive projects, the potential sc…
View article: Impact of a six-month COVID-19 travel moratorium on Plasmodium falciparum malaria prevalence on Bioko Island, Equatorial Guinea
Impact of a six-month COVID-19 travel moratorium on Plasmodium falciparum malaria prevalence on Bioko Island, Equatorial Guinea Open
Importation of malaria infections has long been suspected as a driver of sustained malaria prevalence on areas of Bioko Island, Equatorial Guinea. However, quantifying the impact of imported infections is difficult because of the dynamic n…
View article: The challenge of improving long-lasting insecticidal nets coverage on Bioko Island: using data to adapt distribution strategies
The challenge of improving long-lasting insecticidal nets coverage on Bioko Island: using data to adapt distribution strategies Open
Background: Since 2015, malaria vector control on Bioko Island has relied heavily upon long-lasting insecticidal nets (LLIN) to complement other interventions. Despite significant resources utilised, however, achieving and maintaining high…
View article: Volume 44 Number 3
Volume 44 Number 3 Open
The Sustainable Development Goals (SDGs) adopted by the United Nations in 2015 constitute a 'universal call to action to end poverty, protect the planet, and ensure that by 2030 all people enjoy peace and prosperity'.The 17 SDGs are integr…
View article: MGSurvE: A framework to optimize trap placement for genetic surveillance of mosquito population
MGSurvE: A framework to optimize trap placement for genetic surveillance of mosquito population Open
Genetic surveillance of mosquito populations is becoming increasingly relevant as genetics-based mosquito control strategies advance from laboratory to field testing. Especially applicable are mosquito gene drive projects, the potential sc…
View article: Spatial dynamics of malaria transmission
Spatial dynamics of malaria transmission Open
The Ross-Macdonald model has exerted enormous influence over the study of malaria transmission dynamics and control, but it lacked features to describe parasite dispersal, travel, and other important aspects of heterogeneous transmission. …
View article: Volume 43 Number 4
Volume 43 Number 4 Open
Australia, the official journal of The Australian Society for Microbiology, continues to provide highly accessible peer-reviewed information that informs readers about useful microbiology information including the latest advances in the br…
View article: Estimating the malaria attributable fraction of fever in cohort studies through a before and after comparison of impact: Nagongera, Tororo, Uganda, 2011-2019
Estimating the malaria attributable fraction of fever in cohort studies through a before and after comparison of impact: Nagongera, Tororo, Uganda, 2011-2019 Open
A bstract Background Malaria is an important cause of fever across much of sub-Saharan Africa and other places where Plasmodium falciparum infection is highly prevalent. Here, we estimate the fraction of fever that is attributable to malar…
View article: Spatial Dynamics of Malaria Transmission
Spatial Dynamics of Malaria Transmission Open
The Ross-Macdonald model has exerted enormous influence over the study of malaria transmission dynamics and control, but it lacked features to describe parasite dispersal, travel, and other important aspects of heterogeneous transmission. …
View article: East Africa International Center of Excellence for Malaria Research: Summary of Key Research Findings
East Africa International Center of Excellence for Malaria Research: Summary of Key Research Findings Open
The Program for Resistance, Immunology, Surveillance, and Modeling of Malaria (PRISM) has been conducting malaria research in Uganda since 2010 to improve the understanding of the disease and measure the impact of population-level control …
View article: Simulating the Impacts of Augmenting Intensive Vector Control with Mass Drug Administration or Test-and-Treat Strategies on the Malaria Infectious Reservoir
Simulating the Impacts of Augmenting Intensive Vector Control with Mass Drug Administration or Test-and-Treat Strategies on the Malaria Infectious Reservoir Open
Highly effective vector control can reduce malaria burden significantly, but individuals with parasitemia provide a potential reservoir for onward transmission. We performed an empirical, non-parametric simulation based on cohort data from…
View article: Acknowledgments
Acknowledgments Open
me their advice, support, and friendship.I owe special thanks to Jervis Langdon Jr
View article: Current dichotomous metrics obscure trends in severe and extreme child growth failure
Current dichotomous metrics obscure trends in severe and extreme child growth failure Open
Historically, the prevalence of child growth failure (CGF) has been tracked dichotomously as the proportion of children more than 2 SDs below the median of the World Health Organization growth standards. However, this conventional “thresho…
View article: Real-time, spatial decision support to optimize malaria vector control: The case of indoor residual spraying on Bioko Island, Equatorial Guinea
Real-time, spatial decision support to optimize malaria vector control: The case of indoor residual spraying on Bioko Island, Equatorial Guinea Open
Public health interventions require evidence-based decision-making to maximize impact. Spatial decision support systems (SDSS) are designed to collect, store, process and analyze data to generate knowledge and inform decisions. This paper …