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View article: Autism in Adulthood: Psychiatric Comorbidity in High-Functioning Autistic Adults in an Outpatient Clinical Population
Autism in Adulthood: Psychiatric Comorbidity in High-Functioning Autistic Adults in an Outpatient Clinical Population Open
Background: Autism Spectrum Disorder (ASD) is a complex and heterogeneous neurodevelopmental condition. Diagnosing ASD in adults, especially in milder forms, remains challenging due to camouflaging strategies, adaptive behaviors, and frequ…
View article: Cerebri: A Web-App to Reduce Door-to-Treatment Decision Time and Improve Guideline Adherence in Acute Ischemic Stroke
Cerebri: A Web-App to Reduce Door-to-Treatment Decision Time and Improve Guideline Adherence in Acute Ischemic Stroke Open
BACKGROUND: Clinical decision support systems hold promise for improving adherence to guidelines and reducing decision-making time in acute ischemic stroke management. We developed a stroke-specific clinical decision support system smartph…
View article: Individual Alpha Frequency as an <scp>EEG</scp> Biomarker of Drug‐Related Cognitive Burden in Epilepsy
Individual Alpha Frequency as an <span>EEG</span> Biomarker of Drug‐Related Cognitive Burden in Epilepsy Open
Background EEG alpha rhythm is well‐proven to correlate with cognitive performance in healthy subjects. We aimed to evaluate the potential of EEG background activity, quantified as individual alpha frequency (IAF), as a biomarker of cognit…
View article: Exome Sequencing Uncovers Genetic Drivers of Multiple Sclerosis in a Multiplex Family
Exome Sequencing Uncovers Genetic Drivers of Multiple Sclerosis in a Multiplex Family Open
Background: Multiple Sclerosis (MS) is a chronic, autoimmune, multifactorial, and complex disorder of the central nervous system (CNS), affecting more than 2 million individuals globally. Genome-wide association studies (GWAS) have explain…
View article: Short-latency afferent inhibition and modulation of contralateral and ipsilateral motor output: A neurophysiological study
Short-latency afferent inhibition and modulation of contralateral and ipsilateral motor output: A neurophysiological study Open
These findings emphasize the pivotal role of contralateral thalamo-cortical circuits in sensorimotor integration and provide deeper insights into the mechanisms underlying the short-latency afferent inhibition (SAI) phenomenon.
View article: Corticospinal imbalance following major upper limb amputation is transiently modulated by continuous theta burst stimulation
Corticospinal imbalance following major upper limb amputation is transiently modulated by continuous theta burst stimulation Open
This study provides preliminary evidence of interhemispheric asymmetry in CE after mULA and indicates that cTBS could represent a potential tool to modulate it. Further studies are needed to establish robustness and clinical relevance.
View article: Sympathetic Burden Measured Through a Chest-Worn Sensor Correlates with Spatiotemporal Gait Performances and Global Cognition in Parkinson’s Disease
Sympathetic Burden Measured Through a Chest-Worn Sensor Correlates with Spatiotemporal Gait Performances and Global Cognition in Parkinson’s Disease Open
Autonomic dysfunction is a key non-motor feature of Parkinson’s disease (PD) and may influence motor performance, particularly gait. While heart rate variability (HRV) has been associated with freezing of gait, its relationship with broade…
View article: A Comprehensive Overview of Subacute Combined Degeneration: MRI Diagnostic Challenges and Treatment Pathways
A Comprehensive Overview of Subacute Combined Degeneration: MRI Diagnostic Challenges and Treatment Pathways Open
Subacute combined degeneration (SCD) is a neurological disorder primarily caused by vitamin B12 deficiency. This condition leads to progressive demyelination and axonal damage, predominantly affecting the dorsal and lateral columns of the …
View article: An International, Expert-based, Multispecialty Delphi Consensus Document on Stroke Risk Stratification and the Optimal Management of Patients with Asymptomatic and Symptomatic Carotid Stenosis
An International, Expert-based, Multispecialty Delphi Consensus Document on Stroke Risk Stratification and the Optimal Management of Patients with Asymptomatic and Symptomatic Carotid Stenosis Open
Background The optimal management of patients with asymptomatic (AsxCS) and symptomatic (SxCS) carotid stenosis is controversial and includes intensive medical management (i.e., best medical therapy [BMT]) with/without an additional caroti…
View article: Autism in Adulthood: Psychiatric Comorbidity in High-Functioning Autistic Adults in an Outpatient Clinical Population
Autism in Adulthood: Psychiatric Comorbidity in High-Functioning Autistic Adults in an Outpatient Clinical Population Open
Background: Autism Spectrum Disorder (ASD) is a complex and heterogeneous neurodevelopmental condition. Diagnosing ASD in adults, especially in milder forms, remains challenging due to camouflaging strategies, adaptive behaviors, and frequ…
View article: Epilepsy in MS and its association with cognitive and psychological burden
Epilepsy in MS and its association with cognitive and psychological burden Open
Background Epilepsy is two to three times more common in patients with multiple sclerosis (pwMS) compared to the general population. Patients with MS and epilepsy without other identifiable causes (MS + E) show greater cortical damage than…
View article: Cortical Excitability as a Prognostic and Phenotypic Stratification Biomarker in Amyotrophic Lateral Sclerosis
Cortical Excitability as a Prognostic and Phenotypic Stratification Biomarker in Amyotrophic Lateral Sclerosis Open
Objective Despite its clinical heterogeneity, amyotrophic lateral sclerosis is unified by early and prominent alterations in cortical excitability, increasingly recognized as contributors to disease progression. This study assessed whether…
View article: Subthalamic beta power and gait in Parkinson's disease during unsupervised remote monitoring
Subthalamic beta power and gait in Parkinson's disease during unsupervised remote monitoring Open
View article: Cerebral circuits involved in preferential hand posture representation for action
Cerebral circuits involved in preferential hand posture representation for action Open
The corticospinal evoked activity to different TMS protocols gave cues on the neural basis of body representation and favored posture.
View article: Changes in the thalamocortical component of high frequency oscillations following botulinum toxin treatment in cervical dystonia
Changes in the thalamocortical component of high frequency oscillations following botulinum toxin treatment in cervical dystonia Open
This study provides neurophysiological evidence supporting the central effects of BoNT-A on the somatosensory system and corroborates the idea of a somatosensory involvement in CD pathogenesis. This funding could pave the way for future in…
View article: Altered neural avalanche spreading in people with drug-resistant epilepsy✰
Altered neural avalanche spreading in people with drug-resistant epilepsy✰ Open
View article: Epilepsy and Employment in Europe: A Systematic Review of Literature
Epilepsy and Employment in Europe: A Systematic Review of Literature Open
Background Epilepsy is a chronic disorder affecting all aspects of individual life. People with epilepsy (PwE) reach seizure control in about 60% of cases. However, social integration issues are frequently overlooked. Unemployment and unde…
View article: Deep brain stimulation in Parkinson’s disease: a comparison of accuracy and clinical outcomes of frame-based, frameless and frameless fiducial-less techniques
Deep brain stimulation in Parkinson’s disease: a comparison of accuracy and clinical outcomes of frame-based, frameless and frameless fiducial-less techniques Open
View article: Cenobamate modulates EEG cortical activity and connectivity in individuals with drug-resistant epilepsy: a pharmaco-EEG study
Cenobamate modulates EEG cortical activity and connectivity in individuals with drug-resistant epilepsy: a pharmaco-EEG study Open
Objective Quantitative electroencephalography (qEEG) metrics are demonstrated to correlate with and predict clinical response in individuals with epilepsy. Cenobamate is an effective anti-seizure medication recently approved as an add-on t…
View article: Arterial Spin Labeling MRI in Alzheimer's Disease: A Systematic Review of Cerebral Perfusion Biomarkers
Arterial Spin Labeling MRI in Alzheimer's Disease: A Systematic Review of Cerebral Perfusion Biomarkers Open
Background Alzheimer's disease (AD) is a leading cause of dementia. Arterial spin labeling (ASL) MRI, particularly at 3 Tesla (3T), offers a noninvasive method to assess cerebral blood flow alterations, which are believed to be early indic…
View article: Validating the Accuracy of Parkinson's Disease Clinical Diagnosis: A <scp>UK</scp> Brain Bank Case–Control Study
Validating the Accuracy of Parkinson's Disease Clinical Diagnosis: A <span>UK</span> Brain Bank Case–Control Study Open
Objective Despite diagnostic criteria refinements, Parkinson's disease (PD) clinical diagnosis still suffers from a not satisfying accuracy, with the post‐mortem examination as the gold standard for diagnosis. Seminal clinicopathological s…
View article: Transcranial static magnetic stimulation for amyotrophic lateral sclerosis
Transcranial static magnetic stimulation for amyotrophic lateral sclerosis Open
View article: Using transcutaneous auricular vagus nerve stimulation (taVNS) for promoting neuroplasticity: putative mechanisms, possible biomarkers and potential clinical applications
Using transcutaneous auricular vagus nerve stimulation (taVNS) for promoting neuroplasticity: putative mechanisms, possible biomarkers and potential clinical applications Open
View article: Long-term infective complications of deep brain stimulation in Parkinson’s disease: A 22-year follow-up
Long-term infective complications of deep brain stimulation in Parkinson’s disease: A 22-year follow-up Open
View article: Circuits and mechanisms for TMS-induced corticospinal waves: Connecting sensitivity analysis to the network graph
Circuits and mechanisms for TMS-induced corticospinal waves: Connecting sensitivity analysis to the network graph Open
Transcranial magnetic stimulation (TMS) is a non-invasive, FDA-cleared treatment for neuropsychiatric disorders with broad potential for new applications, but the neural circuits that are engaged during TMS are still poorly understood. Rec…
View article: Real-world safety profile of direct oral anticoagulants (DOACs): Disproportionality analysis of major bleeding events
Real-world safety profile of direct oral anticoagulants (DOACs): Disproportionality analysis of major bleeding events Open
Edoxaban shows a significantly higher risk of major and cerebral haemorrhages compared to other DOACs, while Rivaroxaban demonstrates a lower overall risk of haemorrhage. These findings emphasize the need for careful consideration of bleed…
View article: The effects of transcutaneous auricular vagus nerve stimulation (taVNS) on cholinergic neural networks in humans: A neurophysiological study
The effects of transcutaneous auricular vagus nerve stimulation (taVNS) on cholinergic neural networks in humans: A neurophysiological study Open
Since the influence of VNS on cholinergic neurotransmission has been exhaustively demonstrated in animal models, further studies are mandatory to understand the actual impact of VNS on cholinergic circuits in humans.
View article: Relationship Between DWI-Based Acute Ischemic Stroke Volume, Location and Severity of Dysphagia
Relationship Between DWI-Based Acute Ischemic Stroke Volume, Location and Severity of Dysphagia Open
Background/Objectives: The impact of stroke location and volume on the development of post-stroke dysphagia is not fully understood. The aim of this study is to evaluate the relationship between acute ischemic lesions and the severity of d…
View article: An open-label pilot study of non-invasive cervical vagus nerve stimulation in essential tremor
An open-label pilot study of non-invasive cervical vagus nerve stimulation in essential tremor Open
View article: Neurophysiological biomarkers of Alzheimer's disease: In vivo evaluation of synaptic dysfunction
Neurophysiological biomarkers of Alzheimer's disease: In vivo evaluation of synaptic dysfunction Open