David Ley
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View article: Acoustofluidic Plasmapheresis System Designed for Ultralow Blood Volume Applications
Acoustofluidic Plasmapheresis System Designed for Ultralow Blood Volume Applications Open
We present an integrated acoustofluidic plasmapheresis system designed for ultralow blood volume applications, such as neonatal care, enabling in-line sampling and plasma separation from whole blood. The system combines a two-stage acousto…
View article: Exploring hemoglobin dynamics and scavenging mechanisms in preterm infants and preterm rabbits with cerebral intraventricular hemorrhage
Exploring hemoglobin dynamics and scavenging mechanisms in preterm infants and preterm rabbits with cerebral intraventricular hemorrhage Open
Background Intraventricular hemorrhage (IVH) is a leading cause of neurodevelopmental impairment in preterm infants, driven by vascular rupture, intraventricular blood accumulation, and secondary injury. Hemolysis releases extracellular he…
View article: Acoustophoresis-based blood sampling and plasma separation for potentially minimizing sampling-related blood loss
Acoustophoresis-based blood sampling and plasma separation for potentially minimizing sampling-related blood loss Open
Objectives Frequent blood sampling in vulnerable patient groups, such as prematurely born infants, can lead to significant blood loss and increased transfusion needs. Current pre-analytical technology requires comparably large blood volume…
View article: Economic Impact of Severe Early‐Onset Foetal Growth Restriction: A Multicentre Prospective Cohort Study
Economic Impact of Severe Early‐Onset Foetal Growth Restriction: A Multicentre Prospective Cohort Study Open
Objective Foetal growth restriction (FGR) affects 10% of pregnancies, contributing to 30% of stillbirths. Current management of early‐onset FGR (< 32 + 0 weeks' gestation) delivers the foetus before stillbirth or irreversible organ damage.…
View article: Evaluation of timed dexamethasone eye drops to prevent proliferative retinopathy of prematurity: a study protocol for a randomized intervention, multi-centre, double-blinded trial (DROPROP)
Evaluation of timed dexamethasone eye drops to prevent proliferative retinopathy of prematurity: a study protocol for a randomized intervention, multi-centre, double-blinded trial (DROPROP) Open
Background As the survival rate of preterm infants continues to rise worldwide, more infants are at risk of developing sight-threatening retinopathy of prematurity (ROP). Destructive retinal laser treatment and intravitreal injections of a…
View article: Very Preterm Infants Auditory Event‐Related Potentials at Term Have Low Predictive Value for Cognitive Outcome
Very Preterm Infants Auditory Event‐Related Potentials at Term Have Low Predictive Value for Cognitive Outcome Open
Aim To assess the prognostic value of auditory event‐related potentials (AERPs) registered at term equivalent age in very preterm infants. Methods Infants (26.5 ± 2.0 gestational weeks (GWs), n = 41 of 64 recruited) were enrolled prenatall…
View article: Living in a bubble with profound difficulties—parents' experiences of extremely preterm survivors
Living in a bubble with profound difficulties—parents' experiences of extremely preterm survivors Open
Aim To analyse the challenges faced by parents of extremely preterm infants born before 24 weeks of gestation and the potential buffering effect of perceived resources on the family's health continuum. Methods The qualitative data were obt…
View article: Postnatal betamethasone treatment in extremely preterm infants and risk of neurodevelopmental impairment: a cohort study
Postnatal betamethasone treatment in extremely preterm infants and risk of neurodevelopmental impairment: a cohort study Open
Objective To evaluate if postnatal treatment with betamethasone in extremely preterm infants was associated with neurodevelopmental impairment (NDI) at 6.5 years of age. Design Prospective cohort study. Setting Extremely Preterm Infants in…
View article: Choroid plexus extracellular vesicle transport of blood-borne insulin-like growth factor 1 to the hippocampus of the immature brain
Choroid plexus extracellular vesicle transport of blood-borne insulin-like growth factor 1 to the hippocampus of the immature brain Open
Reduced serum level of insulin-like growth factor 1 (IGF-1), a major regulator of perinatal development, in extremely preterm infants has been shown to be associated with neurodevelopmental impairment. To clarify the mechanism of IGF-1 tra…
View article: Respiratory support and bronchopulmonary dysplasia in infants born at 22–26 weeks gestation in Sweden, 2004–2007 and 2014–2016
Respiratory support and bronchopulmonary dysplasia in infants born at 22–26 weeks gestation in Sweden, 2004–2007 and 2014–2016 Open
Background Our aim was to evaluate if increased survival and new ventilation strategies were accompanied by a changed incidence of bronchopulmonary dysplasia (BPD) in Sweden over a decade. Methods Data from two Swedish population-based stu…
View article: Fetal haemoglobin and oxygen requirement in preterm infants: an observational study
Fetal haemoglobin and oxygen requirement in preterm infants: an observational study Open
Objective To investigate the relationship between the fraction of fetal haemoglobin (HbF(%)) and oxygen requirement as determined by the fraction of inspired oxygen (FiO 2 ) and alveolar–arterial gradient (A–a gradient). Increased alveolar…
View article: Neurofilament light chain associates with IVH and ROP in extremely preterm infants
Neurofilament light chain associates with IVH and ROP in extremely preterm infants Open
Background Neurofilament light chain (NfL) is known for indicating adult brain injury, but the role of NfL in extremely preterm infants is less studied. This study examines the relationship between NfL and neurovascular morbidities in thes…
View article: Centralisation of extremely preterm births and decreased early postnatal mortality in Sweden, 2004‐2007 versus 2014‐2016
Centralisation of extremely preterm births and decreased early postnatal mortality in Sweden, 2004‐2007 versus 2014‐2016 Open
Aim We evaluated the increased centralisation of extremely preterm (EPT) births in Sweden in relation to the changes in mortality and morbidity. Methods Population‐based data covering Swedish live births from 22 + 0 to 26 + 6 weeks of gest…
View article: Proceedings of the 15 <sup>th</sup> International Newborn Brain Conference: Neuroprotection strategies in the neonate
Proceedings of the 15 <sup>th</sup> International Newborn Brain Conference: Neuroprotection strategies in the neonate Open
BACKGROUND: Cerebral intraventricular hemorrhage (IVH) is a major cause of neurodevelopmental impairment in preterm infants.IVH is characterized by vessel rupture and a rapid accumulation of blood within the ventricles.Subsequent hemolysis…
View article: Challenges of parenting children born before 24 weeks of gestation
Challenges of parenting children born before 24 weeks of gestation Open
Aim To assess experience of care, well‐being of parents and children's development in a cohort of extremely premature infants born <24 weeks of gestation in Sweden from 2007 to 2018. Methods A survey based on multiple questionnaires answer…
View article: Author Correction: Evaluation of recombinant human IGF-1/IGFBP-3 on intraventricular hemorrhage prevention and survival in the preterm rabbit pup model
Author Correction: Evaluation of recombinant human IGF-1/IGFBP-3 on intraventricular hemorrhage prevention and survival in the preterm rabbit pup model Open
The original version of this Article contained an error in the Results section, under the subheading 'Treatment with rhIGF-1/rhIGFBP-3 and rate of survival' , "The survival at 48 h following IVH was 63.6% (n = 7 out of 11) in the vehicle a…
View article: Arachidonic acid and docosahexaenoic acid levels correlate with the inflammation proteome in extremely preterm infants
Arachidonic acid and docosahexaenoic acid levels correlate with the inflammation proteome in extremely preterm infants Open
ClinicalTrials.gov (NCT03201588).
View article: Factors associated with the increased incidence of necrotising enterocolitis in extremely preterm infants in Sweden between two population-based national cohorts (2004–2007 vs 2014–2016)
Factors associated with the increased incidence of necrotising enterocolitis in extremely preterm infants in Sweden between two population-based national cohorts (2004–2007 vs 2014–2016) Open
Objective To investigate potential risk factors behind the increased incidence of necrotising enterocolitis (NEC) in Swedish extremely preterm infants. Design Registry data from two population-based national cohorts were studied. NEC diagn…
View article: Early-Onset Fetal Growth Restriction Increases Left Ventricular Sphericity in Adolescents Born Very Preterm
Early-Onset Fetal Growth Restriction Increases Left Ventricular Sphericity in Adolescents Born Very Preterm Open
Left ventricular shape alterations predict cardiovascular outcomes and have been observed in children born preterm and after fetal growth restriction (FGR). The aim was to investigate whether left ventricular shape is altered in adolescent…
View article: Pharmacological pain and sedation interventions for the prevention of intraventricular hemorrhage in preterm infants on assisted ventilation - an overview of systematic reviews
Pharmacological pain and sedation interventions for the prevention of intraventricular hemorrhage in preterm infants on assisted ventilation - an overview of systematic reviews Open
None of the reported studies had an impact on aGMH-IVH, sIVH, ACND, or MND. The certainty of the evidence ranged from moderate to very low. Large RCTs of rigorous methodology are needed to achieve an optimal information size to assess the …
View article: Perioperative brain injury marker concentrations in neonatal open-heart surgery: a prospective observational study
Perioperative brain injury marker concentrations in neonatal open-heart surgery: a prospective observational study Open
Neonates with critical congenital heart defects undergoing open-heart surgery on cardiopulmonary bypass circulation are at risk for white matter brain injury. This article reports on pre- and postoperative plasma concentrations of brain in…
View article: One-year survival and outcomes of infants born at 22 and 23 weeks of gestation in Sweden 2004–2007, 2014–2016 and 2017–2019
One-year survival and outcomes of infants born at 22 and 23 weeks of gestation in Sweden 2004–2007, 2014–2016 and 2017–2019 Open
Objective To explore associations between perinatal activity and survival in infants born at 22 and 23 weeks of gestation in Sweden. Design/Setting Data on all births at 22 and 23 weeks’ gestational age (GA) were prospectively collected in…
View article: Hyper high haemoglobin content in red blood cells and erythropoietic transitions postnatally in infants of 22 to 26 weeks’ gestation: a prospective cohort study
Hyper high haemoglobin content in red blood cells and erythropoietic transitions postnatally in infants of 22 to 26 weeks’ gestation: a prospective cohort study Open
Objective Blood cell populations, including red blood cells (RBC) unique to the extremely preterm (EPT) infant, are potentially lost due to frequent clinical blood sampling during neonatal intensive care. Currently, neonatal RBC population…