Devang M. Patel
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View article: Cell based high-throughput screening for small molecule inhibitors of ATE1
Cell based high-throughput screening for small molecule inhibitors of ATE1 Open
Arginyltransferase 1 (ATE1) catalyzes post-translational arginylation, a process implicated in protein stability, cellular function, and disease pathology. Dysregulated arginylation is associated with neurodegenerative disorders, cancer, a…
View article: Abstract 1123 Uncovering the role of Ate1 in the cell cycle
Abstract 1123 Uncovering the role of Ate1 in the cell cycle Open
Arginyltransferase (Ate1) is an enzyme that catalyzes the post-translational addition of an arginine to a target protein or peptide, termed arginylation. Arginylation is an understudied yet emerging area of research that is involved in man…
View article: Key profibrotic and pro-inflammatory pathways in the pathogenesis of diabetic kidney disease
Key profibrotic and pro-inflammatory pathways in the pathogenesis of diabetic kidney disease Open
Diabetes is a noncommunicable disease and arguably represents the greatest pandemic in human history. Diabetic kidney disease (DKD) is seen in both type 1 and type 2 diabetes and can be detected in up to 30–50% of diabetic subjects. DKD is…
View article: Regulation of Mitochondrial Respiratory Chain Complex Levels, Organization, and Function by Arginyltransferase 1
Regulation of Mitochondrial Respiratory Chain Complex Levels, Organization, and Function by Arginyltransferase 1 Open
Arginyltransferase 1 (ATE1) is an evolutionary-conserved eukaryotic protein that localizes to the cytosol and nucleus. It is the only known enzyme in metazoans and fungi that catalyzes posttranslational arginylation. Lack of arginylation h…
View article: Glucose and Blood Pressure-Dependent Pathways–The Progression of Diabetic Kidney Disease
Glucose and Blood Pressure-Dependent Pathways–The Progression of Diabetic Kidney Disease Open
The major clinical associations with the progression of diabetic kidney disease (DKD) are glycemic control and systemic hypertension. Recent studies have continued to emphasize vasoactive hormone pathways including aldosterone and endothel…
View article: Insertion/deletion-activated frame-shift fluorescence protein is a sensitive reporter for genomic DNA editing
Insertion/deletion-activated frame-shift fluorescence protein is a sensitive reporter for genomic DNA editing Open
The insertion/deletion-activated frame-shift fluorescence protein reporter has very low background, high sensitivity, and is quantitative in nature. It will be able to facilitate the development of new genome editing tools as well as the a…
View article: Stress granules counteract senescence by sequestration of PAI‐1
Stress granules counteract senescence by sequestration of PAI‐1 Open
Cellular senescence is a physiological response by which an organism halts the proliferation of potentially harmful and damaged cells. However, the accumulation of senescent cells over time can become deleterious leading to diseases and ph…