Dina Mansour Aly
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View article: Digital twins as global learning health and disease models for preventive and personalized medicine
Digital twins as global learning health and disease models for preventive and personalized medicine Open
Ineffective medication is a major healthcare problem causing significant patient suffering and economic costs. This issue stems from the complex nature of diseases, which involve altered interactions among thousands of genes across multipl…
View article: Digital Twins as Global Learning Health and Disease Models of Individuals
Digital Twins as Global Learning Health and Disease Models of Individuals Open
Emerging molecular and computational techniques may allow construction and computational treatment of dynamic digital twins on the scale of populations to individuals. This approach may pave the way for predictive, preventive, and personal…
View article: An interactive atlas of genomic, proteomic, and metabolomic biomarkers promotes the potential of proteins to predict complex diseases
An interactive atlas of genomic, proteomic, and metabolomic biomarkers promotes the potential of proteins to predict complex diseases Open
Multiomics analyses have identified multiple potential biomarkers of the incidence and prevalence of complex diseases. However, it is not known which type of biomarker is optimal for clinical purposes. Here, we make a systematic comparison…
View article: Transcript and protein signatures derived from shared molecular interactions across cancers are associated with mortality
Transcript and protein signatures derived from shared molecular interactions across cancers are associated with mortality Open
Background Characterization of shared cancer mechanisms have been proposed to improve therapy strategies and prognosis. Here, we aimed to identify shared cell–cell interactions (CCIs) within the tumor microenvironment across multiple solid…
View article: Transcript and protein signatures derived from shared molecular interactions across cancers are associated with mortality
Transcript and protein signatures derived from shared molecular interactions across cancers are associated with mortality Open
Background Characterization of shared cancer mechanisms have been proposed to improve therapy strategies and prognosis. Here, we aimed to identify shared cell-cell interactions (CCIs) within the tumor microenvironment across multiple solid…
View article: An interactive atlas of genomic, proteomic, and metabolomic biomarkers promotes the potential of proteins to predict complex diseases
An interactive atlas of genomic, proteomic, and metabolomic biomarkers promotes the potential of proteins to predict complex diseases Open
Multiomics analyses have identified multiple potential biomarkers of the incidence and prevalence of complex diseases. However, it is not known which type of biomarker is optimal for clinical purposes. Here, we make a systematic comparison…
View article: Genetic dissection of serum vaspin highlights its causal role in lipid metabolism
Genetic dissection of serum vaspin highlights its causal role in lipid metabolism Open
Objective Vaspin (visceral adipose tissue derived serine protease inhibitor, SERPINA12 ) is associated with obesity‐related metabolic traits, but its causative role is still elusive. The role of genetics in serum vaspin variability to esta…
View article: Incidence of LADA and type 2 diabetes in relation to tobacco use and genetic susceptibility to type 2 diabetes and related traits: findings from a Swedish case-control study and the Norwegian HUNT Study
Incidence of LADA and type 2 diabetes in relation to tobacco use and genetic susceptibility to type 2 diabetes and related traits: findings from a Swedish case-control study and the Norwegian HUNT Study Open
Objective Smoking and Swedish smokeless tobacco (snus) are associated with latent autoimmune diabetes in adults (LADA) and type 2 diabetes (T2D). Our aim was to investigate whether genetic susceptibility to type 2 diabetes, insulin resi…
View article: Incidence of LADA and type 2 diabetes in relation to tobacco use and genetic susceptibility to type 2 diabetes and related traits: findings from a Swedish case-control study and the Norwegian HUNT Study
Incidence of LADA and type 2 diabetes in relation to tobacco use and genetic susceptibility to type 2 diabetes and related traits: findings from a Swedish case-control study and the Norwegian HUNT Study Open
Objective Smoking and Swedish smokeless tobacco (snus) are associated with latent autoimmune diabetes in adults (LADA) and type 2 diabetes (T2D). Our aim was to investigate whether genetic susceptibility to type 2 diabetes, insulin resi…
View article: Incidence of LADA and Type 2 Diabetes in Relation to Tobacco Use and Genetic Susceptibility to Type 2 Diabetes and Related Traits: Findings From a Swedish Case-Control Study and the Norwegian HUNT Study
Incidence of LADA and Type 2 Diabetes in Relation to Tobacco Use and Genetic Susceptibility to Type 2 Diabetes and Related Traits: Findings From a Swedish Case-Control Study and the Norwegian HUNT Study Open
OBJECTIVE Smoking and Swedish smokeless tobacco (snus) are associated with latent autoimmune diabetes in adults (LADA) and type 2 diabetes (T2D). Our aim was to investigate whether genetic susceptibility to T2D, insulin resistance (IR), an…
View article: Four missense genetic variants in CUBN are associated with higher levels of eGFR in non-diabetes but not in diabetes mellitus or its subtypes: A genetic association study in Europeans
Four missense genetic variants in CUBN are associated with higher levels of eGFR in non-diabetes but not in diabetes mellitus or its subtypes: A genetic association study in Europeans Open
Aim Rare genetic variants in the CUBN gene encoding the main albumin-transporter in the proximal tubule of the kidneys have previously been associated with microalbuminuria and higher urine albumin levels, also in diabetes. Sequencing stud…
View article: Distinct Molecular Signatures of Clinical Clusters in People with Type 2 Diabetes: an IMI-RHAPSODY Study
Distinct Molecular Signatures of Clinical Clusters in People with Type 2 Diabetes: an IMI-RHAPSODY Study Open
Type 2 diabetes is a multifactorial disease with multiple underlying aetiologies. To address this heterogeneity a previous study clustered people with diabetes into five diabetes subtypes. The aim of the current study is to investigate the…
View article: Distinct Molecular Signatures of Clinical Clusters in People with Type 2 Diabetes: an IMI-RHAPSODY Study
Distinct Molecular Signatures of Clinical Clusters in People with Type 2 Diabetes: an IMI-RHAPSODY Study Open
Type 2 diabetes is a multifactorial disease with multiple underlying aetiologies. To address this heterogeneity a previous study clustered people with diabetes into five diabetes subtypes. The aim of the current study is to investigate the…
View article: Distinct Molecular Signatures of Clinical Clusters in People With Type 2 Diabetes: An IMI-RHAPSODY Study
Distinct Molecular Signatures of Clinical Clusters in People With Type 2 Diabetes: An IMI-RHAPSODY Study Open
Type 2 diabetes is a multifactorial disease with multiple underlying aetiologies. To address this heterogeneity, investigators of a previous study clustered people with diabetes according to five diabetes subtypes. The aim of the current s…
View article: Replication and cross-validation of type 2 diabetes subtypes based on clinical variables: an IMI-RHAPSODY study
Replication and cross-validation of type 2 diabetes subtypes based on clinical variables: an IMI-RHAPSODY study Open
Aims/hypothesis Five clusters based on clinical characteristics have been suggested as diabetes subtypes: one autoimmune and four subtypes of type 2 diabetes. In the current study we replicate and cross-validate these type 2 diabetes clust…
View article: Novel biomarkers for glycaemic deterioration in type 2 diabetes: an IMI RHAPSODY study
Novel biomarkers for glycaemic deterioration in type 2 diabetes: an IMI RHAPSODY study Open
We have deployed a multi-omics approach in large cohorts of patients with existing type 2 diabetes to identify biomarkers for disease progression across three molecular classes, metabolites, lipids and proteins. A Cox regression analysis f…
View article: Replication and cross-validation of T2D subtypes based on clinical variables: an IMI-RHAPSODY study
Replication and cross-validation of T2D subtypes based on clinical variables: an IMI-RHAPSODY study Open
Aims/hypothesis Five clusters based on clinical characteristics have been suggested as diabetes subtypes: one autoimmune and four subtypes of type 2 diabetes (T2D). In the current study we replicate and cross-validate these T2D clusters in…
View article: Genetic analysis of obstructive sleep apnoea discovers a strong association with cardiometabolic health
Genetic analysis of obstructive sleep apnoea discovers a strong association with cardiometabolic health Open
There is currently limited understanding of the genetic aetiology of obstructive sleep apnoea (OSA). We aimed to identify genetic loci associated with OSA risk, and to test if OSA and its comorbidities share a common genetic background. We…
View article: Aetiological differences between novel subtypes of diabetes derived from genetic associations
Aetiological differences between novel subtypes of diabetes derived from genetic associations Open
Background Type 2 diabetes (T2D) is a multi-organ disease defined by hyperglycemia resulting from different disease mechanisms. Using clinical parameters measured at diagnosis (age, BMI, HbA1c, HOMA2-B, HOMA2-IR and GAD autoantibodies) adu…
View article: Genetic analysis of obstructive sleep apnoea discovers a strong association with cardiometabolic health
Genetic analysis of obstructive sleep apnoea discovers a strong association with cardiometabolic health Open
There is currently only limited understanding of the genetic aetiology of obstructive sleep apnoea (OSA). The aim of our study is to identify genetic loci associated with OSA risk and to test if OSA and its comorbidities share a common gen…
View article: Clustering of adult-onset diabetes into novel subgroups guides therapy and improves prediction of outcome
Clustering of adult-onset diabetes into novel subgroups guides therapy and improves prediction of outcome Open
Background Diabetes is presently classified into two main forms, type 1 (T1D) and type 2 diabetes (T2D), but especially T2D is highly heterogeneous. A refined classification could provide a powerful tool individualize treatment regimes and…