David González
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View article: Overview of systematic reviews on behavioral determinants of physical activity and healthy eating in schoolchildren
Overview of systematic reviews on behavioral determinants of physical activity and healthy eating in schoolchildren Open
View article: Technological Model to Optimize the Request for Radiological Studies
Technological Model to Optimize the Request for Radiological Studies Open
View article: The relationship between lower limb alignment and physical fitness in children aged 10–12: A sex-specific analysis using the ALPHA-fitness test battery
The relationship between lower limb alignment and physical fitness in children aged 10–12: A sex-specific analysis using the ALPHA-fitness test battery Open
Sex and BMI were the main determinants of physical fitness. Despite some musculoskeletal factors having some influence, their relationship with physical fitness is not as direct as sex and BMI. Clinical practice should prioritise weight co…
View article: Acute Effect of High-Intensity Interval Training on Postprandial Glycemia in Overweight and Obese Individuals: A Scoping Review
Acute Effect of High-Intensity Interval Training on Postprandial Glycemia in Overweight and Obese Individuals: A Scoping Review Open
Background/Objectives: High-intensity interval training (HIIT) has emerged as an effective strategy for mitigating postprandial glycemia in overweight or obese individuals. This scoping review aims to examine randomized controlled trials (…
View article: Systemic anticancer therapy near the end of life: an analysis of factors influencing treatment in advanced cancer patients
Systemic anticancer therapy near the end of life: an analysis of factors influencing treatment in advanced cancer patients Open
View article: Antioxidantes presentes en el Theobroma cacao L. y su efecto en la nutrición humana
Antioxidantes presentes en el Theobroma cacao L. y su efecto en la nutrición humana Open
El Theobroma cacao L es una especie arbustiva de América, rica en polifenoles, que contribuye alrededor del 10 % del peso seco del grano entero y su chocolate derivado, particularmente el negro, se considera uno de los principales contribu…
View article: Comprehensive genetic analysis by targeted sequencing identifies risk factors and predicts patient outcome in Mantle Cell Lymphoma: results from the EU-MCL network trials
Comprehensive genetic analysis by targeted sequencing identifies risk factors and predicts patient outcome in Mantle Cell Lymphoma: results from the EU-MCL network trials Open
Recent studies highlighted genetic aberrations associated with prognosis in Mantle Cell lymphoma (MCL), yet, comprehensive testing is not implemented in clinical routine. We conducted a comprehensive genomic characterization of 180 patient…
View article: Gender Gaps in Knowledge, Attitudes, and Practices Related to Environmental Degradation in Colombia
Gender Gaps in Knowledge, Attitudes, and Practices Related to Environmental Degradation in Colombia Open
View article: The relationship between body mass index and lower extremity biomechanics in children aged 10-12 years: a comprehensive analysis
The relationship between body mass index and lower extremity biomechanics in children aged 10-12 years: a comprehensive analysis Open
Childhood obesity has emerged as a global health concern leading to complications, such as bones and muscles misalignment of knees, flat feet and changes in walking patterns. Although some studies have individually linked these conditions …
View article: DISC1 and Reelin interact to alter cognition, inhibition, and neurogenesis in a novel mouse model of schizophrenia
DISC1 and Reelin interact to alter cognition, inhibition, and neurogenesis in a novel mouse model of schizophrenia Open
Full datasets for the publication "DISC1 and Reelin interact to alter cognition, inhibition, and neurogenesis in a novel mouse model of schizophrenia"
View article: Practical Guidance on Establishing a Molecular Testing Pathway for Alterations in Homologous Recombination Repair Genes in Clinical Practice for Patients with Metastatic Prostate Cancer
Practical Guidance on Establishing a Molecular Testing Pathway for Alterations in Homologous Recombination Repair Genes in Clinical Practice for Patients with Metastatic Prostate Cancer Open
View article: Molecular characterization of diffuse large‐B cell lymphoma by liquid biopsy at diagnosis and during follow‐up. OBO "Euroclonality‐NGS group" & "Grupo Colaborativo Linfomas y SLP de CyL"
Molecular characterization of diffuse large‐B cell lymphoma by liquid biopsy at diagnosis and during follow‐up. OBO "Euroclonality‐NGS group" & "Grupo Colaborativo Linfomas y SLP de CyL" Open
Introduction: Circulating tumor DNA (ctDNA) is the leading liquid biopsy approach in lymphomas for genotyping and minimal residual disease (MRD) detection. In the present study we evaluated the clinical and prognostic value of ctDNA in a s…
View article: A novel next-generation sequencing capture-based strategy to report somatic hypermutation status using genomic regions downstream to immunoglobulin rearrangements
A novel next-generation sequencing capture-based strategy to report somatic hypermutation status using genomic regions downstream to immunoglobulin rearrangements Open
The somatic hypermutation (SHM) status of the clonotypic, rearranged immunoglobulin heavy variable (IGHV) gene is an established prognostic and predictive marker in chronic lymphocytic leukemia (CLL). Analysis of SHM is generally performed…
View article: Immunoglobulin/T Cell Receptor Capture Strategy for Comprehensive Immunogenetics
Immunoglobulin/T Cell Receptor Capture Strategy for Comprehensive Immunogenetics Open
In the era of genomic medicine, targeted next generation sequencing strategies (NGS) are becoming increasingly adopted by clinical molecular diagnostic laboratories to identify genetic diagnostic and prognostic biomarkers in hemato-oncolog…
View article: Enhanced Activity of Alzheimer Disease-associated Variant ofProtein Kinase Cα Drives Cognitive Decline
Enhanced Activity of Alzheimer Disease-associated Variant ofProtein Kinase Cα Drives Cognitive Decline Open
Exquisitely tuned activity of protein kinase C (PKC) isozymes is essential to maintaining cellular homeostasis. Whereas loss-of-function mutations are generally associated with cancer, gain-of-function variants in one isozyme, PKCα, are as…
View article: The New EU Regulation on In Vitro Diagnostic Medical Devices: Implications and Preparatory Actions for Diagnostic Laboratories
The New EU Regulation on In Vitro Diagnostic Medical Devices: Implications and Preparatory Actions for Diagnostic Laboratories Open
On May 26, 2022, after a transitional period of 5 years, the new Regulation (EU) 2017/746 on in vitro diagnostic medical devices1 (IVDR; Table 1) will fully replace Directive 98/79/EC on in vitro diagnostic medical devices2 (IVDD). The aim…
View article: Inhibition of casein kinase 1 δ/ε improves cognitive performance in adult C57BL/6J mice
Inhibition of casein kinase 1 δ/ε improves cognitive performance in adult C57BL/6J mice Open
View article: Practical considerations for optimising homologous recombination repair mutation testing in patients with metastatic prostate cancer
Practical considerations for optimising homologous recombination repair mutation testing in patients with metastatic prostate cancer Open
Analysis of the genomic landscape of prostate cancer has identified different molecular subgroups with relevance for novel or existing targeted therapies. The recent approvals of the poly(ADP‐ribose) polymerase (PARP) inhibitors olaparib a…
View article: Homologous recombination repair deficiency (HRD): From biology to clinical exploitation
Homologous recombination repair deficiency (HRD): From biology to clinical exploitation Open
Significant advances in cancer precision medicine over the last decade have led to a number of treatment options that have significantly improved patient outcomes. The underlying concept integrates detailed insights into disease mechanisms…
View article: Detection of Structural Variants in Circulating Cell-Free DNA from Sarcoma Patients Using Next Generation Sequencing
Detection of Structural Variants in Circulating Cell-Free DNA from Sarcoma Patients Using Next Generation Sequencing Open
Circulating tumour DNA (ctDNA) analysis using next generation sequencing (NGS) is being implemented in clinical practice for treatment stratification and disease monitoring. However, using ctDNA to detect structural variants, a common occu…
View article: A tailored molecular profiling programme for children with cancer to identify clinically actionable genetic alterations
A tailored molecular profiling programme for children with cancer to identify clinically actionable genetic alterations Open
View article: Quality control and quantification in IG/TR next-generation sequencing marker identification: protocols and bioinformatic functionalities by EuroClonality-NGS
Quality control and quantification in IG/TR next-generation sequencing marker identification: protocols and bioinformatic functionalities by EuroClonality-NGS Open
View article: Relevance of TP53 for CLL diagnostics
Relevance of TP53 for CLL diagnostics Open
TP53 disruption in chronic lymphocytic leukaemia (CLL) is a well-established prognostic marker and informs on the appropriate course of treatment for patients. TP53 status is commonly assessed by fluorescence in situ hybridisation for del(…
View article: Disease‐biased and shared characteristics of the immunoglobulin gene repertoires in marginal zone B cell lymphoproliferations
Disease‐biased and shared characteristics of the immunoglobulin gene repertoires in marginal zone B cell lymphoproliferations Open
The B cell receptor immunoglobulin (Ig) gene repertoires of marginal zone (MZ) lymphoproliferations were analyzed in order to obtain insight into their ontogenetic relationships. Our cohort included cases with MZ lymphomas ( n = 488), i.e.…
View article: EXPLORING ALIGNMENT-FREE SEQUENCE COMPARISON METHODS TO ELUCIDATE PATTERNS OF EVOLUTION AND HETEROGENEITY IN LONGITUDINAL GLIOMA PATIENT COHORTS
EXPLORING ALIGNMENT-FREE SEQUENCE COMPARISON METHODS TO ELUCIDATE PATTERNS OF EVOLUTION AND HETEROGENEITY IN LONGITUDINAL GLIOMA PATIENT COHORTS Open
Longitudinal glioma patient samples can reveal critical information relating to gliomagenesis, tumour evolution and therapy resistance. Previous studies examining tumour heterogeneity and evolution in these cohorts have focused solely on t…
View article: The role of somatosensory input in target localization during binocular and monocular viewing while performing a high precision reaching and placement task
The role of somatosensory input in target localization during binocular and monocular viewing while performing a high precision reaching and placement task Open
View article: Saccade latency delays in young apolipoprotein E (APOE) epsilon 4 carriers
Saccade latency delays in young apolipoprotein E (APOE) epsilon 4 carriers Open
View article: Evaluation of the Leap Motion Controller during the performance of visually-guided upper limb movements
Evaluation of the Leap Motion Controller during the performance of visually-guided upper limb movements Open
Kinematic analysis of upper limb reaching provides insight into the central nervous system control of movements. Until recently, kinematic examination of motor control has been limited to studies conducted in traditional research laborator…
View article: HER2 testing of gastro-oesophageal adenocarcinoma: a commentary and guidance document from the Association of Clinical Pathologists Molecular Pathology and Diagnostics Committee
HER2 testing of gastro-oesophageal adenocarcinoma: a commentary and guidance document from the Association of Clinical Pathologists Molecular Pathology and Diagnostics Committee Open
The use of biologics targeted to the human epidermal growth factor receptor 2 (HER2) protein is the latest addition to the armamentarium used to fight advanced gastric or gastro-oesophageal junction adenocarcinoma. The decision to treat wi…
View article: ERIC recommendations for TP53 mutation analysis in chronic lymphocytic leukemia—update on methodological approaches and results interpretation
ERIC recommendations for TP53 mutation analysis in chronic lymphocytic leukemia—update on methodological approaches and results interpretation Open