Daniela Mari
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View article: Western Hunter-Gatherer genetic ancestry contributes to human longevity in the Italian population
Western Hunter-Gatherer genetic ancestry contributes to human longevity in the Italian population Open
The genetics of human longevity has been primarily studied using classical methods developed in genome-wide association studies. With the recent advances in paleogenomics, it is now possible to investigate to what extent ancient population…
View article: Inflammaging and the sex-frailty paradox
Inflammaging and the sex-frailty paradox Open
Background The “sex-frailty paradox” is a concept that indicates how women despite being more frail are less susceptible to death than men. The roots of this paradox may lie in the different combination of biological, behavioural, and soci…
View article: Delirium prevalence and delirium literacy across Italian hospital wards: a secondary analysis of data from the World Delirium Awareness Day 2023
Delirium prevalence and delirium literacy across Italian hospital wards: a secondary analysis of data from the World Delirium Awareness Day 2023 Open
Purpose Delirium, a common medical emergency among hospitalized patients, requires effective detection and management protocols. This study aims to evaluate the delirium point prevalence and its management across Italian hospitals, categor…
View article: Feasibility of an exercise-based cardiac telerehabilitation program for patients with ischemic heart disease: a pilot study
Feasibility of an exercise-based cardiac telerehabilitation program for patients with ischemic heart disease: a pilot study Open
Background Telerehabilitation can improve access to cardiac rehabilitation programs, thereby reducing barriers to in-person attendance. Purpose To assess the feasibility of an exercise-based cardiac telerehabilitation program through a mob…
View article: The heterogeneous approach to reach longevity: the experience of Italian centenarians
The heterogeneous approach to reach longevity: the experience of Italian centenarians Open
People reaching old age are increasing exponentially in recent decades, and centenarians represent the fastest-growing group. Aging is characterized by the continuous adaptation of the organism to life-long exposure to stress that leads to…
View article: The influence of inflammation and frailty in the aging continuum
The influence of inflammation and frailty in the aging continuum Open
Inflammaging is a low-grade inflammatory state that can be considered an adaptive process aimed at stimulating appropriate anti-inflammatory response. Frailty is determined by the accumulation of molecular and cellular defects accumulated …
View article: Autonomic function predicts cognitive decline in mild cognitive impairment: Evidence from power spectral analysis of heart rate variability in a longitudinal study
Autonomic function predicts cognitive decline in mild cognitive impairment: Evidence from power spectral analysis of heart rate variability in a longitudinal study Open
Background Despite the emerging clinical relevance of heart rate variability (HRV) as a potential biomarker of cognitive decline and as a candidate target for intervention, there is a dearth of research on the prospective relationship betw…
View article: A scoping review of the changing landscape of geriatric medicine in undergraduate medical education: curricula, topics and teaching methods
A scoping review of the changing landscape of geriatric medicine in undergraduate medical education: curricula, topics and teaching methods Open
Purpose The world’s population is ageing. Therefore, every doctor should receive geriatric medicine training during their undergraduate education. This review aims to summarise recent developments in geriatric medicine that will potentiall…
View article: Novel Insight in Idiopathic Normal Pressure Hydrocephalus (iNPH) Biomarker Discovery in CSF
Novel Insight in Idiopathic Normal Pressure Hydrocephalus (iNPH) Biomarker Discovery in CSF Open
Idiopathic normal pressure hydrocephalus (iNPH) is a potentially reversible neurological disease, causing motor and cognitive dysfunction and dementia. iNPH and Alzheimer’s disease (AD) share similar molecular characteristics, including am…
View article: Whole-genome sequencing analysis of semi-supercentenarians
Whole-genome sequencing analysis of semi-supercentenarians Open
Extreme longevity is the paradigm of healthy aging as individuals who reached the extreme decades of human life avoided or largely postponed all major age-related diseases. In this study, we sequenced at high coverage (90X) the whole genom…
View article: Anti-Inflammatory Effects of Fatty Acid Amide Hydrolase Inhibition in Monocytes/Macrophages from Alzheimer’s Disease Patients
Anti-Inflammatory Effects of Fatty Acid Amide Hydrolase Inhibition in Monocytes/Macrophages from Alzheimer’s Disease Patients Open
Growing evidence shows that the immune system is critically involved in Alzheimer’s disease (AD) pathogenesis and progression. The modulation and targeting of peripheral immune mechanisms are thus promising therapeutic or preventive strate…
View article: Anti-Inflammatory Effects of Fatty Acid Amide Hydrolase Inhibition in Monocytes/Macrophages from Alzheimer's Disease Patients
Anti-Inflammatory Effects of Fatty Acid Amide Hydrolase Inhibition in Monocytes/Macrophages from Alzheimer's Disease Patients Open
Growing evidence shows that the immune system is critically involved in Alzheimer’s disease (AD) pathogenesis and progression. The modulation and targeting of peripheral immune mechanisms are thus promising therapeutic or preventive strate…
View article: Can Serum Nitrosoproteome Predict Longevity of Aged Women?
Can Serum Nitrosoproteome Predict Longevity of Aged Women? Open
Aging is characterized by increase in reactive oxygen (ROS) and nitrogen (RNS) species, key factors of cardiac failure and disuse-induced muscle atrophy. This study focused on serum nitroproteome as a trait of longevity by adopting two com…
View article: Vitamin D Receptor Polymorphisms in Sex-Frailty Paradox
Vitamin D Receptor Polymorphisms in Sex-Frailty Paradox Open
The “male-female health-survival paradox” evidences that the survival advantage observed in women is linked to higher rates of disability and poor health status compared to men, a phenomenon also called the “sex-frailty paradox”. The deple…
View article: Autonomic function in amnestic and non-amnestic mild cognitive impairment: spectral heart rate variability analysis provides evidence for a brain–heart axis
Autonomic function in amnestic and non-amnestic mild cognitive impairment: spectral heart rate variability analysis provides evidence for a brain–heart axis Open
Mild cognitive impairment (MCI) is a heterogeneous syndrome with two main clinical subtypes, amnestic (aMCI) and non-amnestic (naMCI). The analysis of heart rate variability (HRV) is a tool to assess autonomic function. Cognitive and auton…
View article: Supervised Digital Neuropsychological Tests for Cognitive Decline in Older Adults: Usability and Clinical Validity Study
Supervised Digital Neuropsychological Tests for Cognitive Decline in Older Adults: Usability and Clinical Validity Study Open
Background Dementia is a major and growing health problem, and early diagnosis is key to its management. Objective With the ultimate goal of providing a monitoring tool that could be used to support the screening for cognitive decline, thi…
View article: Supervised Digital Neuropsychological Tests for Cognitive Decline in Older Adults: Usability and Clinical Validity Study (Preprint)
Supervised Digital Neuropsychological Tests for Cognitive Decline in Older Adults: Usability and Clinical Validity Study (Preprint) Open
BACKGROUND Dementia is a major and growing health problem, and early diagnosis is key to its management. OBJECTIVE With the ultimate goal of providing a monitoring tool that could be used to support the screening for cognitive decline, …
View article: Corrigendum to “Peripheral Blood Mononuclear Cells as a Laboratory to Study Dementia in the Elderly”
Corrigendum to “Peripheral Blood Mononuclear Cells as a Laboratory to Study Dementia in the Elderly” Open
[This corrects the article DOI: 10.1155/2014/169203.].
View article: Quantitative mitochondrial DNA copy number determination using droplet digital PCR with single-cell resolution
Quantitative mitochondrial DNA copy number determination using droplet digital PCR with single-cell resolution Open
Mitochondria are involved in a number of diverse cellular functions, including energy production, metabolic regulation, apoptosis, calcium homeostasis, cell proliferation, and motility, as well as free radical generation. Mitochondrial DNA…
View article: Telomere length and telomerase activity in T cells are biomarkers of high‐performing centenarians
Telomere length and telomerase activity in T cells are biomarkers of high‐performing centenarians Open
It is generally recognized that the function of the immune system declines with increased age and one of the major immune changes is impaired T‐cell responses upon antigen presentation/stimulation. Some “high‐performing” centenarians (100+…
View article: Particular CSF sphingolipid patterns identify iNPH and AD patients
Particular CSF sphingolipid patterns identify iNPH and AD patients Open
Idiopathic normal pressure hydrocephalus (iNPH) is characterized by reversible neurological symptoms due to an impairment in cerebrospinal fluid (CSF) clearance. In these patients, cognitive functions are severely impaired, with a scenario…