Denis Mongin
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View article: Impact of a clinical encounter time protection program on pain management: a retrospective difference-in-difference study
Impact of a clinical encounter time protection program on pain management: a retrospective difference-in-difference study Open
Background Patient-centred care is a cornerstone for healthcare quality, leading many hospitals to implement programs that prioritize patient, even within time-constrained clinical environments. Effects of these programs are poorly evaluat…
View article: Incidence of Major Adverse Cardiovascular Events in Patients With Rheumatoid Arthritis Treated With <scp>JAK</scp> Inhibitors Compared With Biologic Disease‐Modifying Antirheumatic Drugs: Data From an International Collaboration of Registries
Incidence of Major Adverse Cardiovascular Events in Patients With Rheumatoid Arthritis Treated With <span>JAK</span> Inhibitors Compared With Biologic Disease‐Modifying Antirheumatic Drugs: Data From an International Collaboration of Registries Open
Objective Our objective was to assess the incidence of major adverse cardiovascular events (MACEs) in patients with rheumatoid arthritis (RA) treated with JAK inhibitors (JAKi), tumor necrosis factor inhibitors (TNFi), or biologic disease‐…
View article: Trends and influences in women authorship in randomised controlled trials in rheumatology: a comprehensive analysis of all published RCTs from 2009 to 2023
Trends and influences in women authorship in randomised controlled trials in rheumatology: a comprehensive analysis of all published RCTs from 2009 to 2023 Open
Objectives We examined the evolution and influencing factors of women’s authorship in randomised controlled trials (RCTs) published in rheumatology. Methods We analysed all RCTs published in rheumatology from 2009 to 2023 determining autho…
View article: Large language models for accurate disease detection in electronic health records: the examples of crystal arthropathies
Large language models for accurate disease detection in electronic health records: the examples of crystal arthropathies Open
Objectives We propose and test a framework to detect disease diagnosis using a recent large language model (LLM), Meta’s Llama-3-8B, on French-language electronic health record (EHR) documents. Specifically, it focuses on detecting gout (‘…
View article: Oral Glucocorticoids for Skin Fibrosis in Early Diffuse Systemic Sclerosis: A Target Trial Emulation Study From the European Scleroderma Trials and Research Group Database
Oral Glucocorticoids for Skin Fibrosis in Early Diffuse Systemic Sclerosis: A Target Trial Emulation Study From the European Scleroderma Trials and Research Group Database Open
Objective The objective of this study is to evaluate whether adding oral glucocorticoids to immunosuppressive therapy improves skin scores and ensures safety in patients with early diffuse cutaneous systemic sclerosis (dcSSc). Methods We p…
View article: Prospective registration of trials: where we are, why, and how we could get better
Prospective registration of trials: where we are, why, and how we could get better Open
Randomized controlled clinical trials are a research type where people are randomly assigned to different treatments to see which works best. These treatments can include drugs, surgery, medical devices, or changes in behavior. The results…
View article: Anti-Apolipoprotein A-1 IgG, incident cardiovascular events and lipid paradox in rheumatoid arthritis
Anti-Apolipoprotein A-1 IgG, incident cardiovascular events and lipid paradox in rheumatoid arthritis Open
Objectives To validate the prognostic accuracy of anti-apolipoprotein A-1 IgG (AAA1) for incident major adverse cardiovascular (CV) events (MACE) in rheumatoid arthritis (RA) and study their associations with the lipid paradox at a multice…
View article: Trends and Influences in women authorship of randomized controlled trials in rheumatology: a comprehensive analysis of all published RCTs from 2009 to 2023
Trends and Influences in women authorship of randomized controlled trials in rheumatology: a comprehensive analysis of all published RCTs from 2009 to 2023 Open
Objectives This study aims to examine the evolution and influencing factors of women’s authorship in randomized controlled trials (RCTs) published in rheumatology. Methods This study included all rheumatology RCTs published from 2009 to 20…
View article: Large language models for accurate disease detection in electronic health records
Large language models for accurate disease detection in electronic health records Open
Importance The use of large language models (LLMs) in medicine is increasing, with potential applications in electronic health records (EHR) to create patient cohorts or identify patients who meet clinical trial recruitment criteria. Howev…
View article: Prospective Registration of Trials: Where we are, why, and how we could get better
Prospective Registration of Trials: Where we are, why, and how we could get better Open
Objectives: Transparent trial conduct requires prospective registration of a randomized controlled trial before the enrolment of the first participant. Registration aims to minimize potential biases through unjustified or hidden modificati…
View article: Anti-apolipoprotein A-1 IgG, incident cardiovascular events, and lipid paradox in rheumatoid arthritis
Anti-apolipoprotein A-1 IgG, incident cardiovascular events, and lipid paradox in rheumatoid arthritis Open
Objective To validate the prognostic accuracy of anti-apolipoprotein A-1 (AAA1) IgG for incident major adverse cardiovascular (CV) events (MACE) in rheumatoid arthritis (RA) and study their associations with the lipid paradox at a multicen…
View article: Development and validation of a self-updating gout register from electronic health records data
Development and validation of a self-updating gout register from electronic health records data Open
Objective To develop an automatic gout register from electronic health records (EHRs) data. Methods We analysed the EHR of all patients >18 years old from a tertiary academic hospital (2013–2022) based on six criteria: International Classi…
View article: Enhancing gout management by creating a register using automated queries in electronic health records
Enhancing gout management by creating a register using automated queries in electronic health records Open
Objective To develop an automatic gout register to improve gout management. Methods We analysed the electronic health records (EHR) of all patients >18 years old from a tertiary academic hospital (2013-2022) based on six criteria: Internat…
View article: Comparative effectiveness of baricitinib and alternative biological DMARDs in a Swiss cohort study of patients with RA
Comparative effectiveness of baricitinib and alternative biological DMARDs in a Swiss cohort study of patients with RA Open
Objectives This observational study compares the effectiveness of baricitinib (BARI), a targeted synthetic disease-modifying antirheumatic drug (tsDMARD), with alternative biological DMARDs (bDMARDs) in patients with rheumatoid arthritis (…
View article: Time trends and modifiable factors of COVID-19 contact tracing coverage, Geneva, Switzerland, June 2020 to February 2022
Time trends and modifiable factors of COVID-19 contact tracing coverage, Geneva, Switzerland, June 2020 to February 2022 Open
Background Contact tracing was one of the central non-pharmaceutical interventions implemented worldwide to control the spread of SARS-CoV-2, but its effectiveness depends on its ability to detect contacts. Aim Evaluate the proportion of s…
View article: Evaluation of discontinuation for adverse events of JAK inhibitors and bDMARDs in an international collaboration of rheumatoid arthritis registers (the ‘JAK-pot’ study)
Evaluation of discontinuation for adverse events of JAK inhibitors and bDMARDs in an international collaboration of rheumatoid arthritis registers (the ‘JAK-pot’ study) Open
While JAKi overall were not associated with more treatment discontinuations for AEs, subgroup analyses suggest varying patterns with specific JAKi, such as tofacitinib, compared with TNFi. However, these observations should be interpreted …
View article: Oral glucocorticoid use in patients with rheumatoid arthritis initiating TNF-inhibitors, tocilizumab or abatacept: Results from the international TOCERRA and PANABA observational collaborative studies
Oral glucocorticoid use in patients with rheumatoid arthritis initiating TNF-inhibitors, tocilizumab or abatacept: Results from the international TOCERRA and PANABA observational collaborative studies Open
After initiation of a bDMARD, glucocorticoid use decreased similarly in all treatment groups. However, glucocorticoid withdrawal was much slower than advocated by current international guidelines. More effort should be devoted to glucocort…
View article: Effect of SARS-CoV-2 prior infection and mRNA vaccination on contagiousness and susceptibility to infection
Effect of SARS-CoV-2 prior infection and mRNA vaccination on contagiousness and susceptibility to infection Open
The immunity conferred by SARS-CoV-2 vaccines and infections reduces the transmission of the virus. To answer how the effect of immunity is shared between a reduction of infectiousness and an increased protection against infection, we exam…
View article: Time to Publication and <scp>Time‐Lag</scp> Publication Bias for Randomized Trials on Connective Tissue Diseases
Time to Publication and <span>Time‐Lag</span> Publication Bias for Randomized Trials on Connective Tissue Diseases Open
Objective To assess the time from completion to publication of randomized controlled trials (RCTs) on connective tissue diseases (CTDs), investigate the factors associated with, and explore the influence of significance of study results on…
View article: COVID-19 Vaccination Rate under Different Political Incentive: A Counterfactual Trend Approach Using Nationwide Data
COVID-19 Vaccination Rate under Different Political Incentive: A Counterfactual Trend Approach Using Nationwide Data Open
(1) Background: France implemented a COVID-19 certificate in July 2021 to incentivize the population to uptake COVID-19 vaccines. However, little is known about the variation in its impact across age groups and its dependence on socio-demo…
View article: POS0523 FEASIBILITY STUDY OF AN ELECTRONIC HEALTH RECORD-BASED GOUT REGISTRY
POS0523 FEASIBILITY STUDY OF AN ELECTRONIC HEALTH RECORD-BASED GOUT REGISTRY Open
Background Gout is the most common inflammatory rheumatism worldwide. Despite guidelines on acute and chronic management, it remains largely undertreated [1]. To evaluate the current standard of gout care, there is an unmet need for gout r…