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View article: P074 Inflammatory Environment-Induced Transcriptomic Alterations in Crohn's Disease Adipose Stem Cells
P074 Inflammatory Environment-Induced Transcriptomic Alterations in Crohn's Disease Adipose Stem Cells Open
Background Crohn’s disease (CD) is characterised by expansion of mesenteric adipose tissue, called creeping fat, which seems to be directly related to disease activity. Adipose stem cells (ASCs) isolated from the creeping fat of CD patient…
View article: P020 Effects of Anti-TNF Treatment on Browning of Mesenteric Adipose Tissue with Crohn's Disease
P020 Effects of Anti-TNF Treatment on Browning of Mesenteric Adipose Tissue with Crohn's Disease Open
Background Crohn's disease (CD) is characterized by the expansion of mesenteric fat, known as creeping fat (CrF), to the inflamed segments of the intestine. Our group observed that CrF showed a conversion to beige tissue, a phenomenon know…
View article: P083 An integrative analysis of DNA methylation and RNA-Seq data in human adipose-stem cells of Crohn’s Disease patients with different clinical activity
P083 An integrative analysis of DNA methylation and RNA-Seq data in human adipose-stem cells of Crohn’s Disease patients with different clinical activity Open
Background Crohn’s disease (CD) is characterized by the expansion of mesenteric fat attached to the inflamed segments of the intestine, also known as “creeping fat” which seems to be directly related to disease activity. Our group revealed…
View article: P042 Succinate promotes the conversion from white to beige adipose tissue in Crohn’s Disease
P042 Succinate promotes the conversion from white to beige adipose tissue in Crohn’s Disease Open
Background Crohn’s disease (CD) is characterized by severe transmural inflammation with subsequent destruction of the intestinal barrier. Bacterial infiltration across this leaky gut facilitates access to the mesenteric fat and the develop…
View article: P050 Effect of biological treatments (anti-TNFs) in the creeping fat of Crohn’s disease patients
P050 Effect of biological treatments (anti-TNFs) in the creeping fat of Crohn’s disease patients Open
Background Crohn’s disease (CD) is characterized by persistent inflammation and ulcerations at the small or large bowel, provoking chronic low-grade systemic inflammation. Adipose tissue (AT) is believed to play an active role in the patho…